LincRNA-p21: Implications in human diseases

International Journal of Molecular Sciences

Volumn 16, Issue 8, 2015, Pages 18732-18740

  Tang, Sai Sai ^a   Zheng, Bi Ying ^a   Xiong, Xing Dong ^a,b  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Diseases; Gene regulation; LincRNA p21; Long non coding RNA

Indexed keywords

LONG UNTRANSLATED RNA;

ACETYLATION; APOPTOSIS; CARCINOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; DISEASE COURSE; DNA DAMAGE; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HUMAN; IMMUNE RESPONSE; MASS SPECTROMETRY; MOLECULAR INTERACTION; NEOPLASM; NUCLEAR REPROGRAMMING; REGULATORY MECHANISM; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SOMATIC CELL; ANIMAL; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; METABOLISM;

ANIMALS; APOPTOSIS; CELLULAR REPROGRAMMING; DNA DAMAGE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; RNA, LONG NONCODING;

EID: 84939239272     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160818732     Document Type: Review

References (36)

1. Moran, V.A., Perera, R.J., Khalil, A.M. Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs. Nucleic Acids Res. 2012, 40, 6391-6400.
2. Mercer, T.R., Dinger, M.E., Mattick, J.S. Long non-coding RNAs: Insights into functions. Nat. Rev. Genet. 2009, 70, 155-159.
3. Ponting, C.P., Oliver, P.L., Reik, W. Evolution and functions of long noncoding RNAs. Cell 2009, 736, 629-641.
4. Wilusz, J.E., Sunwoo, H., Spector, D.L. Long noncoding RNAs: Functional surprises from the RNA world. Genes Dev. 2009, 23, 1494-1504.
5. Huarte, M., Guttman, M., Feldser, D., Garber, M., Koziol, M.J., Kenzelmann-Broz, D., Khalil, A.M., Zuk, O., Amit, I., Rabani, M., et al. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 2010, 742, 409-419.
6. Yoon, J.H., Abdelmohsen, K., Srikantan, S., Yang, X., Martindale, J.L., De, S., Huarte, M., Zhan, M., Becker, K.G., Gorospe, M. LincRNA-p21 suppresses target mRNA translation.Mol. Cell 2012, 47, 648-655.
7. Ozgur, E., Mert, U., Isin, M., Okutan, M., Dalay, N., Gezer, U. Differential expression of long non-coding RNAs during genotoxic stress-induced apoptosis in HeLa and MCF-7 cells. Clin. Exp. Med. 2013, 73, 119-126.
8. Yoon, J.H., Srikantan, S., Gorospe, M. Ms2-trap (ms2-tagged RNA affinity purification): Tagging RNA to identify associated miRNAs. Methods 2012, 55, 81-87.
9. Wilusz, C.J., Wilusz, J. HuR and translation—The missing linc(RNA). Mol. Cell 2012, 47, 495-496.
10. Dimitrova, N., Zamudio, J.R., Jong, R.M., Soukup, D., Resnick, R., Sarma, K., Ward, A.J., Raj, A., Lee, J.T., Sharp, P.A., et al. LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint. Mol. Cell 2014, 54, 777-790.
11. Bao, X., Wu, H., Zhu, X., Guo, X., Hutchins, A.P., Luo, Z., Song, H., Chen, Y., Lai, K., Yin, M., et al. The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters. Cell Res. 2015, 25, 80-92.
12. Haupt, Y., Maya, R., Kazaz, A., Oren, M. Mdm2 promotes the rapid degradation of p53. Nature 1997, 357, 296-299.
13. Kubbutat, M.H., Jones, S.N., Vousden, K.H. Regulation of p53 stability by Mdm2. Nature 1997, 357, 299-303.
14. Oliner, J.D., Pietenpol, J.A., Thiagalingam, S., Gyuris, J., Kinzler, K.W., Vogelstein, B. Oncoprotein Mdm2 conceals the activation domain of tumour suppressor p53. Nature 1993, 362, 857-860.
15. Gu, W., Roeder, R.G. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 1997, 90, 595-606.
16. Sakaguchi, K., Herrera, J.E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C.W., Appella, E. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 1998, 72, 2831-2841.
17. Liu, L., Scolnick, D.M., Trievel, R.C., Zhang, H.B., Marmorstein, R., Halazonetis, T.D., Berger, S.L. P53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol. Cell. Biol. 1999, 79, 1202-1209.
18. Wu, G., Cai, J., Han, Y., Chen, J., Huang, Z.P., Chen, C., Cai, Y., Huang, H., Yang, Y., Liu, Y., et al. LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity. Circulation 2014, 730, 1452-1465.
19. Chou, S.D., Murshid, A., Eguchi, T., Gong, J., Calderwood, S.K. HSF1 regulation of ß-catenin in mammary cancer cells through control of HuR/elavL1 expression. Oncogene 2015, 34, 2178-2188.
20. Takahashi, K., Yamanaka, S. Induced pluripotent stem cells in medicine and biology. Development 2013, 740, 2457-2461.
21. Gezer, U., Ozgur, E., Cetinkaya, M., Isin, M., Dalay, N. Long non-coding RNAs with low expression levels in cells are enriched in secreted exosomes. Cell Biol. Int. 2014, 35, 1076-1079.
22. Recio, L., Phillips, S.L., Maynor, T., Waters, M., Jackson, A.F., Yauk, C.L. Differential expression of long noncoding RNAs in the livers of female b6c3f1 mice exposed to the carcinogen furan. Toxicol. Sci. 2013, 735, 369-379.
23. Blume, C.J., Hotz-Wagenblatt, A., Hullein, J., Sellner, L., Jethwa, A., Stolz, T., Slabicki, M., Lee, K., Sharathchandra, A., Benner, A., et al. P53-dependent non-coding RNA networks in chronic lymphocytic leukemia. Leukemia 2015, doi:10.1038/leu.2015.119.
24. Yang, F., Zhang, H., Mei, Y., Wu, M. Reciprocal regulation of HIF-1a and lincRNA-p21 modulates the Warburg effect. Mol. Cell 2014, 53, 88-100.
25. Tran, U.M., Rajarajacholan, U., Soh, J., Kim, T.S., Thalappilly, S., Sensen, C.W., Riabowol, K. LincRNA-p21 acts as a mediator of ING1b-induced apoptosis. Cell Death Dis. 2015, 6, e1668.
26. Hamanaka, R.B., Chandel, N.S. Warburg effect and redox balance. Science 2011, 334, 1219-1220.
27. Zhai, H., Fesler, A., Schee, K., Fodstad, O., Flatmark, K., Ju, J. Clinical significance of long intergenic noncoding RNA-p21 in colorectal cancer. Clin. Colorectal Cancer 2013, 72, 261-266.
28. Wang, G., Li, Z., Zhao, Q., Zhu, Y., Zhao, C., Li, X., Ma, Z., Li, X., Zhang, Y. LincRNA-p21 enhances the sensitivity of radiotherapy for human colorectal cancer by targeting the Wnt/ß-catenin signaling pathway. Oncol. Rep. 2014, 37, 1839-1845.
29. Kendziorra, E., Ahlborn, K., Spitzner, M., Rave-Frank, M., Emons, G., Gaedcke, J., Kramer, F., Wolff, H.A., Becker, H., Beissbarth, T., et al. Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy. Carcinogenesis 2011, 32, 1824-1831.
30. Li, X., Pu, J., Jiang, S., Su, J., Kong, L., Mao, B., Sun, H., Li, Y. Henryin, an ent-kaurane diterpenoid, inhibits Wnt signaling through interference with ß-catenin/TCF4 interaction in colorectal cancer cells. PLoS ONE 2013, 5, e68525.
31. Waaler, J., Machon, O., von Kries, J.P., Wilson, S.R., Lundenes, E., Wedlich, D., Gradl, D., Paulsen, J.E., Machonova, O., Dembinski, J.L., et al. Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res. 2011, 77, 197-205.
32. Jiang, Y.J., Bikle, D.D. LncRNA profiling reveals new mechanism for VDR protection against skin cancer formation. J. SteroidBiochem. Mol. Biol. 2014, 744, 87-90.
33. Hall, J.R., Messenger, Z.J., Tam, H.W., Phillips, S.L., Recio, L., Smart, R.C. Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes. Cell Death Dis. 2015, 6, e1700.
34. Isin, M., Ozgur, E., Cetin, G., Erten, N., Aktan, M., Gezer, U., Dalay, N. Investigation of circulating lncRNAs in B-cell neoplasms. Clin. Chim. Acta 2014, 437, 255-259.
35. Isin, M., Uysaler, E., Ozgur, E., Koseoglu, H., Sanli, O., Yucel, O.B., Gezer, U., Dalay, N. Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease. Front. Genet. 2015, 6, 168.
36. Spurlock, C.F., 3rd; Tossberg, J.T., Matlock, B.K., Olsen, N.J., Aune, T.M. Methotrexate inhibits NF-kB activity via long intergenic (noncoding) RNA-p21 induction. Arthritis Rheumatol. 2014, 66, 2947-2957.