5-HT6 Receptor Recruitment of mTOR Modulates Seizure Activity in Epilepsy

Molecular Neurobiology

Volumn 51, Issue 3, 2015, Pages 1292-1299

  Wang, Liang ^a   Lv, Yaodong ^a,b   Deng, Wanni ^a   Peng, Xi ^c   Xiao, Zheng ^a   Xi, Zhiqin ^a   Chen, Guojun ^a   Wang, Xuefeng ^a  

^a THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^b QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

^c THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

5 HT6 receptor; Epilepsy; Human; mTOR; Rat

Indexed keywords

MTOR PROTEIN, HUMAN; PILOCARPINE; SEROTONIN 6 RECEPTOR; SEROTONIN RECEPTOR; TARGET OF RAPAMYCIN KINASE;

ANIMAL; DISEASE MODEL; ELECTROENCEPHALOGRAPHY; EPILEPSY; HUMAN; MALE; METABOLISM; PATHOPHYSIOLOGY; PROCEDURES; SEIZURES; SPRAGUE DAWLEY RAT;

ANIMALS; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; EPILEPSY; HUMANS; MALE; PILOCARPINE; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; SEIZURES; TOR SERINE-THREONINE KINASES;

EID: 84939232263     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8806-6     Document Type: Article

References (23)

1. Ngugi AK, Kariuki SM, Bottomley C, Kleinschmidt I, Sander JW, Newton CR (2011) Incidence of epilepsy: a systematic review and meta-analysis. Neurology 77(10):1005–1012. doi:10.1212/WNL.0b013e31822cfc90
2. Perucca E, French J, Bialer M (2007) Development of new antiepileptic drugs: challenges, incentives, and recent advances. Lancet Neurol 6(9):793–804. doi:10.1016/S1474-4422(07)70215-6
3. Stefan H, da Silva FH L, Loscher W, Schmidt D, Perucca E, Brodie MJ, Boon PA, Theodore WH, Moshe SL (2006) Epileptogenesis and rational therapeutic strategies. Acta Neurol Scand 113(3):139–155. doi:10.1111/j.1600-0404.2005.00561.x
4. Ruat M, Traiffort E, Arrang JM, Tardivel-Lacombe J, Diaz J, Leurs R, Schwartz JC (1993) A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation. Biochem Biophys Res Commun 193(1):268–276
5. Yoshioka M, Matsumoto M, Togashi H, Mori K, Saito H (1998) Central distribution and function of 5-HT6 receptor subtype in the rat brain. Life Sci 62(17–18):1473–1477
6. Marazziti D, Baroni S, Pirone A, Giannaccini G, Betti L, Testa G, Schmid L, Palego L, Borsini F, Bordi F, Piano I, Gargini C, Castagna M, Catena-Dell'osso M, Lucacchini A (2013) Serotonin receptor of type 6 (5-HT6) in human prefrontal cortex and hippocampus post-mortem: an immunohistochemical and immunofluorescence study. Neurochem Int 62(2):182–188. doi:10.1016/j.neuint.2012.11.013
7. Woolley ML, Marsden CA, Fone KC (2004) 5-ht6 receptors. Curr Drug Targets CNS Neurol Disord 3(1):59–79
8. Quiedeville A, Boulouard M, Da Silva Costa-Aze V, Dauphin F, Bouet V, Freret T (2014) 5-HT6 receptor antagonists as treatment for age-related cognitive decline. Rev Neurosci. doi:10.1515/revneuro-2014-0013
9. Routledge C, Bromidge SM, Moss SF, Price GW, Hirst W, Newman H, Riley G, Gager T, Stean T, Upton N, Clarke SE, Brown AM, Middlemiss DN (2000) Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist. Br J Pharmacol 130(7):1606–1612. doi:10.1038/sj.bjp.0703457
10. Stean TO, Hirst WD, Thomas DR, Price GW, Rogers D, Riley G, Bromidge SM, Serafinowska HT, Smith DR, Bartlett S, Deeks N, Duxon M, Upton N (2002) Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT(6) receptor antagonist. Pharmacol Biochem Behav 71(4):645–654
11. Meffre J, Chaumont-Dubel S, Mannoury La Cour C, Loiseau F, Watson DJ, Dekeyne A, Seveno M, Rivet JM, Gaven F, Deleris P, Herve D, Fone KC, Bockaert J, Millan MJ, Marin P (2012) 5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia. EMBO Mol Med 4(10):1043–1056. doi:10.1002/emmm.201201410
12. Russo E, Citraro R, Donato G, Camastra C, Iuliano R, Cuzzocrea S, Constanti A, De Sarro G, Russo E, Citraro R, Donato G, Camastra C, Iuliano R, Cuzzocrea S, Constanti A, De Sarro G (2013) mTOR inhibition modulates epileptogenesis, seizures and depressive behavior in a genetic rat model of absence epilepsy. Neuropharmacology 69:25–36. doi:10.1016/j.neuropharm.2012.09.019
13. Wong M (2012) mTOR as a potential treatment target for epilepsy. Future Neurol 7(5):537–545. doi:10.2217/fnl.12.45
14. Yin H, Wang L, Xiao F, Huang Z, Huang Y, Zhou C, Han Y, Tao S, Yang H, Wang X (2011) Upregulation of liprin-alpha1 protein in the temporal neocortex of intractable epileptic patients and experimental rats. Synapse 65(8):742–750. doi:10.1002/syn.20894
15. Wang L, Zhou C, Zhu Q, Luo J, Xu Y, Huang Y, Zhang X, Wang X (2010) Up-regulation of serum- and glucocorticoid-induced protein kinase 1 in the brain tissue of human and experimental epilepsy. Neurochem Int 57(8):899–905. doi:10.1016/j.neuint.2010.09.009
16. Racine RJ (1972) Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32(3):281–294
17. Chen G, Kittler JT, Moss SJ, Yan Z (2006) Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. J Neurosci 26(9):2513–2521
18. Zhong P, Gu Z, Wang X, Jiang H, Feng J, Yan Z (2003) Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease. J Biol Chem 278(29):26888–26896
19. Talos DM, Sun H, Zhou X, Fitzgerald EC, Jackson MC, Klein PM, Lan VJ, Joseph A, Jensen FE (2012) The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway. PLoS One 7(5):e35885. doi:10.1371/journal.pone.0035885 PONE-D-12-02255
20. Gerard C, Martres MP, Lefevre K, Miquel MC, Verge D, Lanfumey L, Doucet E, Hamon M, el Mestikawy S (1997) Immuno-localization of serotonin 5-HT6 receptor-like material in the rat central nervous system. Brain Res 746(1–2):207–219
21. Riccioni T (2010) 5-HT6 receptor characterization. Int Rev Neurobiol 94:67–88. doi:10.1016/B978-0-12-384976-2.00003-4
22. Hirst WD, Stean TO, Rogers DC, Sunter D, Pugh P, Moss SF, Bromidge SM, Riley G, Smith DR, Bartlett S, Heidbreder CA, Atkins AR, Lacroix LP, Dawson LA, Foley AG, Regan CM, Upton N (2006) SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur J Pharmacol 553(1–3):109–119. doi:10.1016/j.ejphar.2006.09.049
23. Russo E, Citraro R, Constanti A, De Sarro G (2012) The mTOR signaling pathway in the brain: focus on epilepsy and epileptogenesis. Mol Neurobiol 46(3):662–681. doi:10.1007/s12035-012-8314-5