Alpha-lipoic acid attenuates cerebral ischemia and reperfusion injury via insulin receptor and PI3K/Akt-Dependent inhibition of NADPH oxidase

International Journal of Endocrinology

Volumn 2015, Issue , 2015, Pages

  Dong, Yinhua ^a   Wang, Hongxin ^a   Chen, Zefeng ^a  

^a TIANJIN FOURTH CENTRAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; INSULIN RECEPTOR; MALONALDEHYDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THIOCTIC ACID;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; LATENT PERIOD; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MORRIS WATER MAZE TEST; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

EID: 84939167316     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2015/903186     Document Type: Article

References (26)

1. G. A. Donnan, M. Fisher, M. Macleod, and S. M. Davis, "Stroke, " The Lancet, vol. 371, no. 9624, pp. 1612-1623, 2008.
2. J. E. Cohen and R. R. Leker, "Intravenous thrombolytic therapy for acute ischemic stroke, "TheNewEngland Journal ofMedicine, vol. 365, no. 10, pp. 964-965, 2011.
3. K. A. Radermacher, K. Wingler, P. Kleikers et al. , "The 1027th target candidate in stroke: will NADPH oxidase hold up?" Experimental &Translational Stroke Medicine, vol. 4, no. 1, article 11, 2012.
4. J. -M. Li, N. P. Gall, D. J. Grieve, M. Chen, and A. M. Shah, "Activation of NADPH oxidase during progression of cardiac hypertrophy to failure, " Hypertension, vol. 40, no. 4, pp. 477-484, 2002.
5. H. Chen, G. S. Kim, N. Okami, P. Narasimhan, and P. H. Chan, "NADPH oxidase is involved in post-ischemic brain inflammation, " Neurobiology of Disease, vol. 42, no. 3, pp. 341-348, 2011.
6. J. Du, L. M. Fan, A. Mai, and J. -M. Li, "Crucial roles of Nox2-derived oxidative stress in deteriorating the function of insulin receptors and endothelium in dietary obesity of middle-aged mice, " British Journal of Pharmacology, vol. 170, no. 5, pp. 1064-1077, 2013.
7. C. -Y. Lu, Y. -C. Yang, C. -C. Li, K. -L. Liu, C. -K. Lii, and H. -W. Chen, "Andrographolide inhibits TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells, " Biochemical Pharmacology, vol. 91, no. 1, pp. 40-50, 2014.
8. D. Pandey and D. J. R. Fulton, "Molecular regulation of NADPH oxidase 5 via the MAPK pathway, " American Journal of Physiology-Heart and Circulatory Physiology, vol. 300, no. 4, pp. H1336-H1344, 2011.
9. W. Kim, D. W. Kim, D. Y. Yoo et al. , "Neuroprotective effects of PEP-1-Cu, Zn-SOD against ischemic neuronal damage in the rabbit spinal cord, " Neurochemical Research, vol. 37, no. 2, pp. 307-313, 2012.
10. K. Mizuno, T. Kume, C. Muto et al. , "Glutathione biosynthesis via activation of the nuclear factor E2-related factor 2 (Nrf2)-antioxidant-response element (ARE) pathway is essential for neuroprotective effects of sulforaphane and 6-(methylsulfinyl) hexyl isothiocyanate, " Journal of Pharmacological Sciences, vol. 115, no. 3, pp. 320-328, 2011.
11. M. Sayin, P. Temiz, A. Var, and C. Temiz, "The dose-dependent neuroprotective effect of alpha-lipoic acid in experimental spinal cord injury, " Neurologia i Neurochirurgia Polska, vol. 47, no. 4, pp. 345-351, 2013.
12. A. Ahmadi, N. Mazooji, J. Roozbeh, Z. Mazloom, and J. Hasanzade, "Effect of alpha-lipoic acid and vitamin E supplementation on oxidative stress, inflammation, and malnutrition in hemodialysis patients, " Iranian Journal of Kidney Diseases, vol. 7, no. 6, pp. 461-467, 2013.
13. Y. Yang, W. Wang, Y. Liu et al. , "α-lipoic acid inhibits high glucose-induced apoptosis in HIT-T15 cells, " Development, Growth &Differentiation, vol. 54, no. 5, pp. 557-565, 2012.
14. B. J. Connell, M. Saleh, B. V. Khan, and T. M. Saleh, "Lipoic acid protects against reperfusion injury in the early stages of cerebral ischemia, " Brain Research, vol. 1375, pp. 128-136, 2011.
15. W. M. Clark, L. G. Rinker, N. S. Lessov, S. L. Lowery, and M. J. Cipolla, "Efficacy of antioxidant therapies in transient focal ischemia in mice, " Stroke, vol. 32, no. 4, pp. 1000-1004, 2001.
16. B. Diesel, S. Kulhanek-Heinze, M. Höltje et al. , "α-Lipoic acid as a directly binding activator of the insulin receptor: protection from hepatocyte apoptosis, " Biochemistry, vol. 46, no. 8, pp. 2146-2155, 2007.
17. S. S. Raza, M. M. Khan, A. Ahmad et al. , "Neuroprotective effect of naringenin is mediated through suppression of NF-κB signaling pathway in experimental stroke, " Neuroscience, vol. 230, pp. 157-171, 2013.
18. E. Z. Longa, P. R. Weinstein, S. Carlson, and R. Cummins, "Reversible middle cerebral artery occlusion without craniectomy in rats, " Stroke, vol. 20, no. 1, pp. 84-91, 1989.
19. L. Belayev, O. F. Alonso, R. Busto, W. Zhao, and M. D. Ginsberg, "Middle cerebral artery occlusion in the rat by intraluminal suture: neurological and pathological evaluation of an improved model, " Stroke, vol. 27, no. 9, pp. 1616-1623, 1996.
20. J. -M. Li, A. M. Mullen, S. Yun et al. , "Essential role of the NADPH oxidase subunit p47phox in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-α, " Circulation Research, vol. 90, no. 2, pp. 143-150, 2002.
21. M. -A. Barbacanne, J. -P. Souchard, B. Darblade et al. , "Detection of superoxide anion released extracellularly by endothelial cells using cytochrome c reduction, ESR, fluorescence and lucigeninenhanced chemiluminescence techniques, " Free Radical Biology &Medicine, vol. 29, no. 5, pp. 388-396, 2000.
22. R. Rodrigo, R. Fernández-Gajardo, R. Gutiérrez et al. , "Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities, " CNS &Neurological Disorders-Drug Targets, vol. 12, no. 5, pp. 698-714, 2013.
23. K. Sinha, J. Das, P. B. Pal, and P. C. Sil, "Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis, " Archives of Toxicology, vol. 87, no. 7, pp. 1157-1180, 2013.
24. C. E. Walder, S. P. Green, W. C. Darbonne et al. , "Ischemic stroke injury is reduced in mice lacking a functionalNADPH oxidase, " Stroke, vol. 28, no. 11, pp. 2252-2258, 1997.
25. H. Chen, Y. S. Song, and P. H. Chan, "Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion, " Journal of Cerebral Blood Flow &Metabolism, vol. 29, no. 7, pp. 1262-1272, 2009.
26. D. Konrad, "Utilization of the insulin-signaling network in the metabolic actions of alpha-lipoic acid-reduction or oxidation?" Antioxidants &Redox Signaling, vol. 7, no. 7-8, pp. 1032-1039, 2005.