Rational Design of Multifunctional Gold Nanoparticles via Host-Guest Interaction for Cancer-Targeted Therapy

ACS Applied Materials and Interfaces

Volumn 7, Issue 31, 2015, Pages 17171-17180

  Chen, Wei Hai ^a   Lei, Qi ^a   Luo, Guo Feng ^a   Jia, Hui Zhen ^a   Hong, Sheng ^a   Liu, Yu Xin ^a   Cheng, Yin Jia ^a   Zhang, Xian Zheng ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

gold nanoparticles; host guest interaction; Multifunctional; targeted therapy; triggered release

Indexed keywords

CELL DEATH; CELLS; CHEMOTHERAPY; DRUG INTERACTIONS; FIBER OPTIC SENSORS; GOLD; METAL NANOPARTICLES; MOLECULAR BIOLOGY; NANOCOMPOSITES; NANOPARTICLES;

GOLD NANOPARTICLES; HOST GUEST INTERACTIONS; MULTIFUNCTIONAL; TARGETED THERAPY; TRIGGERED RELEASE;

DISEASES;

ADAMANTANE; ANTINEOPLASTIC AGENT; BETA CYCLODEXTRIN; BETA CYCLODEXTRIN DERIVATIVE; DOXORUBICIN; DRUG CARRIER; GOLD; GRAPHITE; METAL NANOPARTICLE; NANOCOMPOSITE;

ANIMAL; APOPTOSIS; CHEMISTRY; CHLOROCEBUS AETHIOPS; CONFOCAL MICROSCOPY; COS 1 CELL LINE; DRUG EFFECTS; DRUG RELEASE; ENDOCYTOSIS; HUMAN; METABOLISM; TUMOR CELL LINE;

ADAMANTANE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BETA-CYCLODEXTRINS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; DOXORUBICIN; DRUG CARRIERS; DRUG LIBERATION; ENDOCYTOSIS; GOLD; GRAPHITE; HUMANS; METAL NANOPARTICLES; MICROSCOPY, CONFOCAL; NANOCOMPOSITES;

EID: 84939142974     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.5b04031     Document Type: Article

References (50)

1. Zhang, L.; Gu, F. X.; Chan, J. M.; Wang, A. Z.; Langer, R. S.; Farokhzad, O. C. Nanoparticles in Medicine: Therapeutic Applications and Developments Clin. Pharmacol. Ther. 2008, 83, 761-769 10.1038/sj.clpt.6100400
2. Sapsford, K. E.; Algar, W. R.; Berti, L.; Gemmill, K. B.; Casey, B. J.; Oh, E.; Stewart, M. H.; Medintz, I. L. Functionalizing Nanoparticles with Biological Molecules: Developing Chemistries That Facilitate Nanotechnology Chem. Rev. 2013, 113, 1904-2074 10.1021/cr300143v
3. Yang, F.; Jin, C.; Subedi, S.; Lee, C. L.; Wang, Q.; Jiang, Y.; Li, J.; Di, Y.; Fu, D. Emerging Inorganic Nanomaterials for Pancreatic Cancer Diagnosis and Treatment Cancer Treat. Rev. 2012, 38, 566-579 10.1016/j.ctrv.2012.02.003
4. Giljohann, D. A.; Seferos, D. S.; Daniel, W. L.; Massich, M. D.; Patel, P. C.; Mirkin, C. A. Gold Nanoparticles for Biology and Medicine Angew. Chem., Int. Ed. 2010, 49, 3280-3294 10.1002/anie.200904359
5. Bunz, U. H.; Rotello, V. M. Gold Nanoparticle-Fluorophore Complexes: Sensitive and Discerning Noses for Biosystems Sensing Angew. Chem., Int. Ed. 2010, 49, 3268-3279 10.1002/anie.200906928
6. Weintraub, K. Biomedicine: The New Gold Standard Nature 2013, 495, S14-S16 10.1038/495S14a
7. Choi, H. S.; Liu, W.; Misra, P.; Tanaka, E.; Zimmer, J. P.; Itty Ipe, B.; Bawendi, M. G.; Frangioni, J. V. Renal Clearance of Quantum Dots Nat. Biotechnol. 2007, 25, 1165-1170 10.1038/nbt1340
8. Huang, K.; Ma, H.; Liu, J.; Huo, S.; Kumar, A.; Wei, T.; Zhang, X.; Jin, S.; Gan, Y.; Wang, P. C.; He, S.; Zhang, X.; Liang, X. J. Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo ACS Nano 2012, 6, 4483-4493 10.1021/nn301282m
9. Liu, J.; Yu, M.; Zhou, C.; Yang, S.; Ning, X.; Zheng, J. Passive Tumor Targeting of Renal-Clearable Luminescent Gold Nanoparticles: Long Tumor Retention and Fast Normal Tissue Clearance J. Am. Chem. Soc. 2013, 135, 4978-4981 10.1021/ja401612x
10. Liu, J.; Yu, M.; Ning, X.; Zhou, C.; Yang, S.; Zheng, J. PEGylation and Zwitterionization: Pros and Cons in the Renal Clearance and Tumor Targeting of Near-IR-Emitting Gold Nanoparticles Angew. Chem., Int. Ed. 2013, 52, 12572-12576 10.1002/anie.201304465
11. Nicolas, J.; Mura, S.; Brambilla, D.; Mackiewicz, N.; Couvreur, P. Design, Functionalization Strategies and Biomedical Applications of Targeted Biodegradable/Biocompatible Polymer-Based Nanocarriers for Drug Delivery Chem. Soc. Rev. 2013, 42, 1147-1235 10.1039/C2CS35265F
12. Mahmud, A.; Xiong, X. B.; Aliabadi, H. M.; Lavasanifar, A. Polymeric Micelles for Drug Targeting J. Drug Target 2007, 15, 553-584 10.1080/10611860701538586
13. Zou, Y.; Song, Y.; Yang, W.; Meng, F.; Liu, H.; Zhong, Z. Galactose-Installed Photo-Crosslinked pH-Sensitive Degradable Micelles for Active Targeting Chemotherapy of Hepatocellular Carcinoma in Mice J. Controlled Release 2014, 193, 154-161 10.1016/j.jconrel.2014.05.016
14. Chen, W. H.; Xu, X. D.; Luo, G. F.; Jia, H. Z.; Lei, Q.; Cheng, S. X.; Zhuo, R. X.; Zhang, X. Z. Dual-Targeting Pro-Apoptotic Peptide for Programmed Cancer Cell Death via Specific Mitochondria Damage Sci. Rep. 2013, 3, 3468 10.1038/srep03468
15. Dai, J.; Lin, S.; Cheng, D.; Zou, S.; Shuai, X. Interlayer-Crosslinked Micelle with Partially Hydrated Core Showing Reduction and pH Dual Sensitivity for Pinpointed Intracellular Drug Release Angew. Chem., Int. Ed. 2011, 50, 9404-9408 10.1002/anie.201103806
16. Chu, Z.; Dreiss, C. A.; Feng, Y. Smart Wormlike Micelles Chem. Soc. Rev. 2013, 42, 7174-7203 10.1039/c3cs35490c
17. Nakayama, M.; Akimoto, J.; Okano, T. Polymeric Micelles with Stimuli-Triggering Systems for Advanced Cancer Drug Targeting J. Drug Target 2014, 22, 584-599 10.3109/1061186X.2014.936872
18. Mura, S.; Nicolas, J.; Couvreur, P. Stimuli-Responsive Nanocarriers for Drug Delivery Nat. Mater. 2013, 12, 991-1003 10.1038/nmat3776
19. Wang, F.; Wang, Y. C.; Dou, S.; Xiong, M. H.; Sun, T. M.; Wang, J. Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells ACS Nano 2011, 5, 3679-3692 10.1021/nn200007z
20. Zhan, F.; Chen, W.; Wang, Z.; Lu, W.; Cheng, R.; Deng, C.; Meng, F.; Liu, H.; Zhong, Z. Acid-Activatable Prodrug Nanogels for Efficient Intracellular Doxorubicin Release Biomacromolecules 2011, 12, 3612-3620 10.1021/bm200876x
21. Zhou, L.; Cheng, R.; Tao, H.; Ma, S.; Guo, W.; Meng, F.; Liu, H.; Liu, Z.; Zhong, Z. Endosomal pH-Activatable Poly(Ethylene Oxide)-Graft-Doxorubicin Prodrugs: Synthesis, Drug Release, and Biodistribution in Tumor-Bearing Mice Biomacromolecules 2011, 12, 1460-1467 10.1021/bm101340u
22. Song, L.; Ho, V. H.; Chen, C.; Yang, Z.; Liu, D.; Chen, R.; Zhou, D. Efficient, pH-Triggered Drug Delivery Using a pH-Responsive DNA-Conjugated Gold Nanoparticle Adv. Healthcare Mater. 2013, 2, 275-280 10.1002/adhm.201200112
23. Xu, X.; Li, Y.; Li, H.; Liu, R.; Sheng, M.; He, B.; Gu, Z. Smart Nanovehicles Based on pH-Triggered Disassembly of Supramolecular Peptide-Amphiphiles for Efficient Intracellular Drug Delivery Small 2014, 10, 1133-1140 10.1002/smll.201301885
24. Ruan, S.; Cao, X.; Cun, X.; Hu, G.; Zhou, Y.; Zhang, Y.; Lu, L.; He, Q.; Gao, H. Matrix Metalloproteinase-Sensitive Size-Shrinkable Nanoparticles for Deep Tumor Penetration and pH Triggered Doxorubicin Release Biomaterials 2015, 60, 100-110 10.1016/j.biomaterials.2015.05.006
25. Hu, Q. D.; Tang, G. P.; Chu, P. K. Cyclodextrin-Based Host-Guest Supramolecular Nanoparticles for Delivery: from Design to Applications Acc. Chem. Res. 2014, 47, 2017-2025 10.1021/ar500055s
26. Hu, J.; Liu, S. Engineering Responsive Polymer Building Blocks with Host-Guest Molecular Recognition for Functional Applications Acc. Chem. Res. 2014, 47, 2084-2095 10.1021/ar5001007
27. Kang, Y.; Guo, K.; Li, B. J.; Zhang, S. Nanoassemblies Driven by Cyclodextrin-Based Inclusion Complexation Chem. Commun. 2014, 50, 11083-11092 10.1039/C4CC03131H
28. Yu, G.; Jie, K.; Huang, F. Supramolecular Amphiphiles Based on Host-Guest Molecular Recognition Motifs Chem. Rev. 2015, 10.1021/cr5005315
29. Liu, K.; Kang, Y.; Wang, Z.; Zhang, X. 25th Anniversary Article: Reversible and Adaptive Functional Supramolecular Materials: Noncovalent Interaction Matters Adv. Mater. 2013, 25, 5530-5548 10.1002/adma201302015
30. Zhang, J.; Ma, P. X. Host-Guest Interactions Mediated Nano-Assemblies Using Cyclodextrin-Containing Hydrophilic Polymers and Their Biomedical Applications Nano Today 2010, 5, 337-350 10.1016/j.nantod.2010.06.011
31. Shi, Y.; Goodisman, J.; Dabrowiak, J. C. Cyclodextrin Capped Gold Nanoparticles as a Delivery Vehicle for a Prodrug of Cisplatin Inorg. Chem. 2013, 52, 9418-9426 10.1021/ic400989v
32. Aykaç, A.; Martos-Maldonado, M. C.; Casas-Solvas, J. M.; Quesada-Soriano, I.; García-Maroto, F.; García-Fuentes, L.; Vargas-Berenguel, A. β-Cyclodextrin-Bearing Gold Glyconanoparticles for the Development of Site Specific Drug Delivery Systems Langmuir 2014, 30, 234-242 10.1021/la403454p
33. Zitzmann, S.; Ehemann, V.; Schwab, M. Arginine-Glycine-Aspartic Acid (RGD)-Peptide Binds to Both Tumor and Tumor-Endothelial Cells in Vivo Cancer Res. 2002, 62, 5139-5143
34. Luo, G. F.; Chen, W. H.; Liu, Y.; Zhang, J.; Cheng, S. X.; Zhuo, R. X.; Zhang, X. Z. Charge-Reversal Plug Gate Nanovalves on Peptide-Functionalized Mesoporous Silica Nanoparticles for Targeted Drug Delivery J. Mater. Chem. B 2013, 1, 5723-5732 10.1039/c3tb20792g
35. Luo, G. F.; Xu, X. D.; Zhang, J.; Yang, J.; Gong, Y. H.; Lei, Q.; Jia, H. Z.; Li, C.; Zhuo, R. X.; Zhang, X. Z. Encapsulation of an Adamantane-Doxorubicin Prodrug in pH-Responsive Polysaccharide Capsules for Controlled Release ACS Appl. Mater. Interfaces 2012, 4, 5317-5324 10.1021/am301258a
36. Chen, W. H.; Xu, X. D.; Jia, H. Z.; Lei, Q.; Luo, G. F.; Cheng, S. X.; Zhuo, R. X.; Zhang, X. Z. Therapeutic Nanomedicine Based on Dual-Intelligent Functionalized Gold Nanoparticles for Cancer Imaging and Therapy in Vivo Biomaterials 2013, 34, 8798-8807 10.1016/j.biomaterials.2013.07.084
37. Hassan, G. S.; El-Emam, A. A.; Gad, L. M.; Barghash, A. E. Synthesis, Antimicrobial and Antiviral Testing of Some New 1-Adamantyl Analogues Saudi Pharm. J. 2010, 18, 123-128 10.1016/j.jsps.2010.05.004
38. Wang, H.; Chen, Y.; Li, X. Y.; Liu, Y. Synthesis of Oligo(Ethylenediamino)-beta-Cyclodextrin Modified Gold Nanoparticle as a DNA Concentrator Mol. Pharmaceutics 2007, 4, 189-198 10.1021/mp060045s
39. Salerno, M.; Avnet, S.; Bonuccelli, G.; Hosogi, S.; Granchi, D.; Baldini, N. Impairment of Lysosomal Activity as a Therapeutic Modality Targeting Cancer Stem Cells of Embryonal Rhabdomyosarcoma Cell Line RD PLoS One 2014, 9, e110340 10.1371/journal.pone.0110340
40. Li, N.; Chen, Y.; Zhang, Y. M.; Yang, Y.; Su, Y.; Chen, J. T.; Liu, Y. Polysaccharide-Gold Nanocluster Supramolecular Conjugates as a Versatile Platform for the Targeted Delivery of Anticancer Drugs Sci. Rep. 2014, 4, 4164 10.1038/srep04164
41. Sapsford, K. E.; Berti, L.; Medintz, I. L. Materials for Fluorescence Resonance Energy Transfer Analysis: Beyond Traditional Donor-Acceptor Combinations Angew. Chem., Int. Ed. 2006, 45, 4562-4589 10.1002/anie.200503873
42. Darbha, G. K.; Ray, A.; Ray, P. C. Gold Nanoparticle-Based Miniaturized Nanomaterial Surface Energy Transfer Probe for Rapid and Ultrasensitive Detection of Mercury in Soil, Water, and Fish ACS Nano 2007, 1, 208-214 10.1021/nn7001954
43. Chen, W. H.; Luo, G. F.; Xu, X. D.; Jia, H. Z.; Lei, Q.; Han, K.; Zhang, X. Z. Cancer-Targeted Functional Gold Nanoparticles for Apoptosis Induction and Real-Time Imaging Based on FRET Nanoscale 2014, 6, 9531-9535 10.1039/C4NR02516D
44. Kim, D.; Jeong, Y. Y.; Jon, S. A Drug-Loaded Aptamer-Gold Nanoparticle Bioconjugate for Combined CT Imaging and Therapy of Prostate Cancer ACS Nano 2010, 4, 3689-3696 10.1021/nn901877h
45. Huo, S.; Jin, S.; Ma, X.; Xue, X.; Yang, K.; Kumar, A.; Wang, P. C.; Zhang, J.; Hu, Z.; Liang, X. J. Ultrasmall Gold Nanoparticles as Carriers for Nucleus-Based Gene Therapy due to Size-Dependent Nuclear Entry ACS Nano 2014, 8, 5852-5862 10.1021/nn5008572
46. Sousa, A. A.; Morgan, J. T.; Brown, P. H.; Adams, A.; Jayasekara, M. P.; Zhang, G.; Ackerson, C. J.; Kruhlak, M. J.; Leapman, R. D. Synthesis, Characterization, and Direct Intracellular Imaging of Ultrasmall and Uniform Glutathione-Coated Gold Nanoparticles Small 2012, 8, 2277-2286 10.1002/smll.201200071
47. Chapman, R. E.; Munro, S. Retrieval of TGN Proteins from the Cell Surface Requires Endosomal Acidification EMBO J. 1994, 13, 2305-2312
48. Puertollano, R.; Alonso, M. A. MAL, an Integral Element of the Apical Sorting Machinery, is an Itinerant Protein That Cycles Between the Trans-Golgi Network and the Plasma Membrane Mol. Biol. Cell 1999, 10, 3435-3447 10.1091/mbc.10.10.3435
49. Meng, H.; Xue, M.; Xia, T.; Zhao, Y. L.; Tamanoi, F.; Stoddart, J. F.; Zink, J. I.; Nel, A. E. Autonomous in Vitro Anticancer Drug Release from Mesoporous Silica Nanoparticles by pH-Sensitive Nanovalves J. Am. Chem. Soc. 2010, 132, 12690-12697 10.1021/ja104501a
50. Mosure, K. W.; Henderson, A. J.; Klunk, L. J.; Knipe, J. O. Disposition of Conjugate-Bound and Free Doxorubicin in Tumor-Bearing Mice Following Administration of a BR96-Doxorubicin Immunoconjugate (BMS 182248) Cancer Chemother. Pharmacol. 1997, 40, 251-258 10.1007/s002800050655