메뉴 건너뛰기




Volumn 18, Issue 6, 2015, Pages 1-9

Neural effects of cannabinoid CB1 neutral antagonist tetrahydrocannabivarin on food reward and aversion in healthy volunteers

Author keywords

Cannabinoid; fMRI; Obesity; Reward; THCv

Indexed keywords

CANNABINOID 1 RECEPTOR ANTAGONIST; PLACEBO; TETRAHYDROCANNABIVARIN; UNCLASSIFIED DRUG; ANTIOBESITY AGENT; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; CNR1 PROTEIN, HUMAN; DRONABINOL; TETRAHYDROCANNABIVARIN 9;

EID: 84939133069     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1093/ijnp/pyu094     Document Type: Article
Times cited : (50)

References (63)
  • 4
    • 36048995288 scopus 로고    scopus 로고
    • Effcacy and safety of the weight-loss drug rimonabant: A meta-analysis of randomised trials
    • Christensen R, Kristensen PK, Bartels EM, Bliddal H, Astrup A (2007) Effcacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials. Lancet 370:1706-1713.
    • (2007) Lancet , vol.370 , pp. 1706-1713
    • Christensen, R.1    Kristensen, P.K.2    Bartels, E.M.3    Bliddal, H.4    Astrup, A.5
  • 8
    • 84866906358 scopus 로고    scopus 로고
    • Reward circuit function in high BMI individuals with compulsive overeating: Similarities with addiction
    • Filbey FM, Myers US, Dewitt S (2012) Reward circuit function in high BMI individuals with compulsive overeating: similarities with addiction. NeuroImage 63:1800-1806.
    • (2012) NeuroImage , vol.63 , pp. 1800-1806
    • Filbey, F.M.1    Myers, U.S.2    Dewitt, S.3
  • 10
    • 84906312769 scopus 로고    scopus 로고
    • The CB1 receptor as an important mediator of hedonic reward processing
    • Friemel CM, Zimmer A, Schneider M (2014) The CB1 receptor as an important mediator of hedonic reward processing. Neu-ropsychopharmacology 39:2387-2396.
    • (2014) Neu-ropsychopharmacology , vol.39 , pp. 2387-2396
    • Friemel, C.M.1    Zimmer, A.2    Schneider, M.3
  • 13
    • 34249320170 scopus 로고    scopus 로고
    • Anhe-donia in schizophrenia: Distinctions between anticipatory and consummatory pleasure
    • Gard DE, Kring AM, Gard MG, Horan WP, Green MF (2007) Anhe-donia in schizophrenia: distinctions between anticipatory and consummatory pleasure. Schizophr Res 93:253-260.
    • (2007) Schizophr Res , vol.93 , pp. 253-260
    • Gard, D.E.1    Kring, A.M.2    Gard, M.G.3    Horan, W.P.4    Green, M.F.5
  • 14
    • 0020398194 scopus 로고
    • The eating attitudes test: Psychometric features and clinical correlates
    • Garner DM, Olmsted MP, Bohr Y, Garfnkel PE (1982) The eating attitudes test: psychometric features and clinical correlates. Psychol Med 12:871-878.
    • (1982) Psychol Med , vol.12 , pp. 871-878
    • Garner, D.M.1    Olmsted, M.P.2    Bohr, Y.3    Garfnkel, P.E.4
  • 15
    • 13244253872 scopus 로고    scopus 로고
    • Effects of the cannabi-noid CB1 receptor antagonist rimonabant in models of emotional reactivity in rodents
    • Griebel G, Stemmelin J, Scatton B (2005) Effects of the cannabi-noid CB1 receptor antagonist rimonabant in models of emotional reactivity in rodents. Biol Psychiatry 57:261-267.
    • (2005) Biol Psychiatry , vol.57 , pp. 261-267
    • Griebel, G.1    Stemmelin, J.2    Scatton, B.3
  • 16
    • 84874522358 scopus 로고    scopus 로고
    • 'It's the way that you look at it' - A cognitive neuropsychological account of SSRI action in depression
    • Harmer CJ, Cowen PJ (2013) 'It's the way that you look at it'-a cognitive neuropsychological account of SSRI action in depression. Philos Trans R Soc Lond B Biol Sci 368:20120407.
    • (2013) Philos Trans R Soc Lond B Biol Sci , vol.368 , pp. 20120407
    • Harmer, C.J.1    Cowen, P.J.2
  • 17
    • 68049131612 scopus 로고    scopus 로고
    • Lexical ambiguity resolution in Wernicke's area and its right homologue
    • Harpaz Y, Levkovitz Y, Lavidor M (2009) Lexical ambiguity resolution in Wernicke's area and its right homologue. Cortex 45:1097-1103.
    • (2009) Cortex , vol.45 , pp. 1097-1103
    • Harpaz, Y.1    Levkovitz, Y.2    Lavidor, M.3
  • 19
    • 0025802871 scopus 로고
    • Neu-ronal localization of cannabinoid receptors in the basal ganglia of the rat
    • Herkenham M, Lynn AB, de Costa BR, Richfeld EK (1991a) Neu-ronal localization of cannabinoid receptors in the basal ganglia of the rat. Brain Res 547:267-274.
    • (1991) Brain Res , vol.547 , pp. 267-274
    • Herkenham, M.1    Lynn, A.B.2    De Costa, B.R.3    Richfeld, E.K.4
  • 20
    • 0025954862 scopus 로고
    • Characterization and localization of cannabi-noid receptors in rat brain: A quantitative in vitro autoradio-graphic study
    • Herkenham M, Lynn AB, Johnson MR, Melvin LS, de Costa BR, Rice KC (1991b) Characterization and localization of cannabi-noid receptors in rat brain: a quantitative in vitro autoradio-graphic study. J Neurosci 11:563-583.
    • (1991) J Neurosci , vol.11 , pp. 563-583
    • Herkenham, M.1    Lynn, A.B.2    Johnson, M.R.3    Melvin, L.S.4    De Costa, B.R.5    Rice, K.C.6
  • 21
    • 77957223978 scopus 로고    scopus 로고
    • Reduced neural response to reward following 7 days treatment with the cannabinoid CB1 antagonist rimonabant in healthy volunteers
    • Horder J, Harmer CJ, Cowen PJ, McCabe C (2010) Reduced neural response to reward following 7 days treatment with the cannabinoid CB1 antagonist rimonabant in healthy volunteers. Int J Neuropsychopharmacol 13:1103-1113.
    • (2010) Int J Neuropsychopharmacol , vol.13 , pp. 1103-1113
    • Horder, J.1    Harmer, C.J.2    Cowen, P.J.3    McCabe, C.4
  • 24
    • 84878186347 scopus 로고    scopus 로고
    • The root of all value: A neural common currency for choice
    • Levy DJ, Glimcher PW (2012) The root of all value: a neural common currency for choice. Curr Opin Neurobiol 22:1027-1038.
    • (2012) Curr Opin Neurobiol , vol.22 , pp. 1027-1038
    • Levy, D.J.1    Glimcher, P.W.2
  • 25
    • 79951913401 scopus 로고    scopus 로고
    • Common and distinct networks underlying reward valence and processing stages: A meta-analysis of functional neuroimaging studies
    • Liu X, Hairston J, Schrier M, Fan J (2011) Common and distinct networks underlying reward valence and processing stages: a meta-analysis of functional neuroimaging studies. Neurosci Biobehav Rev 35:1219-1236.
    • (2011) Neurosci Biobehav Rev , vol.35 , pp. 1219-1236
    • Liu, X.1    Hairston, J.2    Schrier, M.3    Fan, J.4
  • 26
    • 43449094069 scopus 로고    scopus 로고
    • Suppression by the cannabinoid CB1 receptor antagonist, rimonabant, of the reinforcing and motivational properties of a chocolate-favoured beverage in rats
    • Maccioni P, Pes D, Carai MA, Gessa GL, Colombo G (2008) Suppression by the cannabinoid CB1 receptor antagonist, rimonabant, of the reinforcing and motivational properties of a chocolate-favoured beverage in rats. Behav Pharmacol 19:197-209.
    • (2008) Behav Pharmacol , vol.19 , pp. 197-209
    • Maccioni, P.1    Pes, D.2    Carai, M.A.3    Gessa, G.L.4    Colombo, G.5
  • 27
    • 0041669248 scopus 로고    scopus 로고
    • An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets
    • Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH (2003) An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. NeuroImage 19:1233-1239.
    • (2003) NeuroImage , vol.19 , pp. 1233-1239
    • Maldjian, J.A.1    Laurienti, P.J.2    Kraft, R.A.3    Burdette, J.H.4
  • 28
    • 50649106505 scopus 로고    scopus 로고
    • Cannabinoid-1 receptor antagonists reduce caloric intake by decreasing palatable diet selection in a novel dessert protocol in female rats
    • Mathes CM, Ferrara M, Rowland NE (2008) Cannabinoid-1 receptor antagonists reduce caloric intake by decreasing palatable diet selection in a novel dessert protocol in female rats. Am J Physiol Regul Integr Comp Physiol 295:R67-75.
    • (2008) Am J Physiol Regul Integr Comp Physiol , vol.295 , pp. R67-75
    • Mathes, C.M.1    Ferrara, M.2    Rowland, N.E.3
  • 29
    • 37349043211 scopus 로고    scopus 로고
    • Identifcation of the sites of 2-arachi-donoylglycerol synthesis and action imply retrograde endo-cannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area
    • Matyas F, Urban GM, Watanabe M, Mackie K, Zimmer A, Freund TF, Katona I (2008) Identifcation of the sites of 2-arachi-donoylglycerol synthesis and action imply retrograde endo-cannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area. Neuropharmacol 54:95-107.
    • (2008) Neuropharmacol , vol.54 , pp. 95-107
    • Matyas, F.1    Urban, G.M.2    Watanabe, M.3    Mackie, K.4    Zimmer, A.5    Freund, T.F.6    Katona, I.7
  • 30
    • 68149156543 scopus 로고    scopus 로고
    • Neural representation of reward in recovered depressed patients
    • McCabe C, Cowen PJ, Harmer CJ (2009) Neural representation of reward in recovered depressed patients. Psychopharmacol (Berl) 205:667-677.
    • (2009) Psychopharmacol (Berl) , vol.205 , pp. 667-677
    • McCabe, C.1    Cowen, P.J.2    Harmer, C.J.3
  • 31
    • 75949117878 scopus 로고    scopus 로고
    • Diminished neural processing of aversive and rewarding stimuli during selective serotonin reuptake inhibitor treatment
    • McCabe C, Mishor Z, Cowen PJ, Harmer CJ (2010) Diminished neural processing of aversive and rewarding stimuli during selective serotonin reuptake inhibitor treatment. Biol Psychiatry 67:439-445.
    • (2010) Biol Psychiatry , vol.67 , pp. 439-445
    • McCabe, C.1    Mishor, Z.2    Cowen, P.J.3    Harmer, C.J.4
  • 32
    • 82955182179 scopus 로고    scopus 로고
    • The D2 antagonist sulpiride modulates the neural processing of both rewarding and aversive stimuli in healthy volunteers
    • McCabe C, Huber A, Harmer CJ, Cowen PJ (2011) The D2 antagonist sulpiride modulates the neural processing of both rewarding and aversive stimuli in healthy volunteers. Psy-chopharmacol (Berl) 217:271-278.
    • (2011) Psy-chopharmacol (Berl) , vol.217 , pp. 271-278
    • McCabe, C.1    Huber, A.2    Harmer, C.J.3    Cowen, P.J.4
  • 33
    • 84866014497 scopus 로고    scopus 로고
    • Neural processing of reward and punishment in young people at increased familial risk of depression
    • McCabe C, Woffndale C, Harmer CJ, Cowen PJ (2012) Neural processing of reward and punishment in young people at increased familial risk of depression. Biol Psychiatry 72:588-594.
    • (2012) Biol Psychiatry , vol.72 , pp. 588-594
    • McCabe, C.1    Woffndale, C.2    Harmer, C.J.3    Cowen, P.J.4
  • 34
    • 84898012943 scopus 로고    scopus 로고
    • Care and feeding of the endocannabinoid system: A systematic review of potential clinical interventions that upregulate the endocannabi-noid system
    • McPartland JM, Guy GW, Di Marzo V (2014) Care and feeding of the endocannabinoid system: a systematic review of potential clinical interventions that upregulate the endocannabi-noid system. PloS one 9:e89566.
    • (2014) PloS One , vol.9 , pp. e89566
    • McPartland, J.M.1    Guy, G.W.2    Di Marzo, V.3
  • 35
  • 36
    • 0842322754 scopus 로고    scopus 로고
    • Endocannabinoids mediate presynaptic inhibition of gluta-matergic transmission in rat ventral tegmental area dopamine neurons through activation of CB1 receptors
    • Melis M, Pistis M, Perra S, Muntoni AL, Pillolla G, Gessa GL (2004) Endocannabinoids mediate presynaptic inhibition of gluta-matergic transmission in rat ventral tegmental area dopamine neurons through activation of CB1 receptors. J Neurosci 24:53-62.
    • (2004) J Neurosci , vol.24 , pp. 53-62
    • Melis, M.1    Pistis, M.2    Perra, S.3    Muntoni, A.L.4    Pillolla, G.5    Gessa, G.L.6
  • 38
    • 0030026069 scopus 로고    scopus 로고
    • Preferential activation of mid-brain dopamine neurons by appetitive rather than aversive stimuli
    • Mirenowicz J, Schultz W (1996) Preferential activation of mid-brain dopamine neurons by appetitive rather than aversive stimuli. Nature 379:449-451.
    • (1996) Nature , vol.379 , pp. 449-451
    • Mirenowicz, J.1    Schultz, W.2
  • 39
    • 84919779806 scopus 로고    scopus 로고
    • Opposing neural effects of naltrexone on food reward and aversion: Implications for the treatment of obesity
    • Murray E, Brouwer S, McCutcheon R, Harmer CJ, Cowen PJ, McCabe C (2014) Opposing neural effects of naltrexone on food reward and aversion: implications for the treatment of obesity. Psychopharmacol (Berl) 231:4323-4335.
    • (2014) Psychopharmacol (Berl) , vol.231 , pp. 4323-4335
    • Murray, E.1    Brouwer, S.2    McCutcheon, R.3    Harmer, C.J.4    Cowen, P.J.5    McCabe, C.6
  • 41
  • 42
    • 0015021890 scopus 로고
    • The assessment and analysis of handedness: The Edinburgh inventory
    • Oldfeld RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9:97-113.
    • (1971) Neuropsychologia , vol.9 , pp. 97-113
    • Oldfeld, R.C.1
  • 43
    • 32844469435 scopus 로고    scopus 로고
    • The primate amygdala represents the positive and negative value of visual stimuli during learning
    • Paton JJ, Belova MA, Morrison SE, Salzman CD (2006) The primate amygdala represents the positive and negative value of visual stimuli during learning. Nature 439:865-870.
    • (2006) Nature , vol.439 , pp. 865-870
    • Paton, J.J.1    Belova, M.A.2    Morrison, S.E.3    Salzman, C.D.4
  • 44
    • 12744258029 scopus 로고    scopus 로고
    • Inverse agonism and neutral antagonism at cannabinoid CB1 receptors
    • Pertwee RG (2005) Inverse agonism and neutral antagonism at cannabinoid CB1 receptors. Life Sci 76:1307-1324.
    • (2005) Life Sci , vol.76 , pp. 1307-1324
    • Pertwee, R.G.1
  • 45
    • 10944261748 scopus 로고    scopus 로고
    • Independent presynaptic and postsyn-aptic mechanisms regulate endocannabinoid signaling at multiple synapses in the ventral tegmental area
    • Riegel and Lupica
    • Riegel and Lupica (2004) Independent presynaptic and postsyn-aptic mechanisms regulate endocannabinoid signaling at multiple synapses in the ventral tegmental area. J Neurosci 24:11070-11078.
    • (2004) J Neurosci , vol.24 , pp. 11070-11078
  • 46
    • 34547964063 scopus 로고    scopus 로고
    • Enhanced affective brain representations of chocolate in cravers vs. Non-cravers
    • Rolls ET, McCabe C (2007) Enhanced affective brain representations of chocolate in cravers vs. non-cravers. Eur J Neurosci 26:1067-1076.
    • (2007) Eur J Neurosci , vol.26 , pp. 1067-1076
    • Rolls, E.T.1    McCabe, C.2
  • 47
    • 84898032586 scopus 로고    scopus 로고
    • Regional brain responses associated with drinking water during thirst and after its satiation
    • Saker P, Farrell MJ, Adib FR, Egan GF, McKinley MJ, Denton DA (2014) Regional brain responses associated with drinking water during thirst and after its satiation. PNAS 111:5379-5384.
    • (2014) PNAS , vol.111 , pp. 5379-5384
    • Saker, P.1    Farrell, M.J.2    Adib, F.R.3    Egan, G.F.4    McKinley, M.J.5    Denton, D.A.6
  • 48
    • 33751001942 scopus 로고    scopus 로고
    • Effcacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: A randomised controlled study
    • Scheen AJ, Finer N, Hollander P, Jensen MD, Van Gaal LF (2006) Effcacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. Lancet 368:1660-1672.
    • (2006) Lancet , vol.368 , pp. 1660-1672
    • Scheen, A.J.1    Finer, N.2    Hollander, P.3    Jensen, M.D.4    Van Gaal, L.F.5
  • 49
    • 62749116505 scopus 로고    scopus 로고
    • Binge-eating disorder: Reward sensitivity and brain activation to images of food
    • Schienle A, Schafer A, Hermann A, Vaitl D (2009) Binge-eating disorder: reward sensitivity and brain activation to images of food. Biol Psychiatry 65:654-661.
    • (2009) Biol Psychiatry , vol.65 , pp. 654-661
    • Schienle, A.1    Schafer, A.2    Hermann, A.3    Vaitl, D.4
  • 50
    • 0037183736 scopus 로고    scopus 로고
    • Cellular localization of cannabinoid receptors and activated G-proteins in rat anterior cingulate cortex
    • Sim-Selley LJ, Vogt LJ, Vogt BA, Childers SR (2002) Cellular localization of cannabinoid receptors and activated G-proteins in rat anterior cingulate cortex. Life Sci 71:2217-2226.
    • (2002) Life Sci , vol.71 , pp. 2217-2226
    • Sim-Selley, L.J.1    Vogt, L.J.2    Vogt, B.A.3    Childers, S.R.4
  • 52
    • 43449127219 scopus 로고    scopus 로고
    • The endocannabinoid system in brain reward processes
    • Solinas M, Goldberg SR, Piomelli D (2008) The endocannabinoid system in brain reward processes. Br J Pharmacol 154:369-383.
    • (2008) Br J Pharmacol , vol.154 , pp. 369-383
    • Solinas, M.1    Goldberg, S.R.2    Piomelli, D.3
  • 53
    • 54249101806 scopus 로고    scopus 로고
    • Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele
    • Stice E, Spoor S, Bohon C, Small DM (2008) Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele. Science 322:449-452.
    • (2008) Science , vol.322 , pp. 449-452
    • Stice, E.1    Spoor, S.2    Bohon, C.3    Small, D.M.4
  • 54
    • 77957341494 scopus 로고    scopus 로고
    • Weight gain is associated with reduced striatal response to palatable food
    • Stice E, Yokum S, Blum K, Bohon C (2010) Weight gain is associated with reduced striatal response to palatable food. J Neu-rosci 30:13105-13109.
    • (2010) J Neu-rosci , vol.30 , pp. 13105-13109
    • Stice, E.1    Yokum, S.2    Blum, K.3    Bohon, C.4
  • 55
    • 43549107263 scopus 로고    scopus 로고
    • Endogenous opioids and cannabinoids: System interactions in the regulation of appetite, grooming and scratching
    • Tallett AJ, Blundell JE, Rodgers RJ (2008) Endogenous opioids and cannabinoids: system interactions in the regulation of appetite, grooming and scratching. Physiol Behav 94:422-431.
    • (2008) Physiol Behav , vol.94 , pp. 422-431
    • Tallett, A.J.1    Blundell, J.E.2    Rodgers, R.J.3
  • 56
    • 28444433385 scopus 로고    scopus 로고
    • Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist
    • Thomas A, Stevenson LA, Wease KN, Price MR, Baillie G, Ross RA, Pertwee RG (2005) Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist. Br J Pharmacol 146:917-926.
    • (2005) Br J Pharmacol , vol.146 , pp. 917-926
    • Thomas, A.1    Stevenson, L.A.2    Wease, K.N.3    Price, M.R.4    Baillie, G.5    Ross, R.A.6    Pertwee, R.G.7
  • 58
  • 60
    • 84899620763 scopus 로고    scopus 로고
    • Release of endogenous cannabinoids from ventral tegmental area dopamine neurons and the modulation of synaptic processes
    • Wang H, Lupica CR (2014) Release of endogenous cannabinoids from ventral tegmental area dopamine neurons and the modulation of synaptic processes. Prog Neuropsychophar-macol Biol Psychiatry 52:24-27.
    • (2014) Prog Neuropsychophar-macol Biol Psychiatry , vol.52 , pp. 24-27
    • Wang, H.1    Lupica, C.R.2
  • 63
    • 0036092583 scopus 로고    scopus 로고
    • Neural correlates of tasting concentrated quinine and sugar solutions
    • Zald DH, Hagen MC, Pardo JV (2002) Neural correlates of tasting concentrated quinine and sugar solutions. J Neurophysiol 87:1068-1075.
    • (2002) J Neurophysiol , vol.87 , pp. 1068-1075
    • Zald, D.H.1    Hagen, M.C.2    Pardo, J.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.