Roles of histone H3K27 trimethylase Ezh2 in retinal proliferation and differentiation

Developmental Neurobiology

Volumn 75, Issue 9, 2015, Pages 947-960

  Iida, Atsumi ^a   Iwagawa, Toshiro ^a   Baba, Yukihiro ^a   Satoh, Shinya ^a   Mochizukil, Yujin ^a,b   Nakauchi, Hiromitsu ^a   Furukawa, Takahisa ^c   Koseki, Haruhiko ^d   Murakami, Akira ^b   Watanabe, Sumiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d Institute of Physical and Chemical Research   (Japan)

Author keywords

Differentiation; Histone methylation; Proliferation; Retina

Indexed keywords

ARF PROTEIN; CRE RECOMBINASE; GLUTAMATE AMMONIA LIGASE; INK4A PROTEIN; PROTEIN; RECOVERIN; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG; CYCLIN DEPENDENT KINASE INHIBITOR 2A; EZH2 PROTEIN, MOUSE; POLYCOMB REPRESSIVE COMPLEX 2;

ADULT; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; GENE LOCUS; IMMUNOHISTOCHEMISTRY; MICROPHTHALMIA; MOUSE; NERVE CELL; NONHUMAN; PERINATAL PERIOD; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN FUNCTION; RETINA AMACRINE CELL; RETINA CELL; RETINA DEVELOPMENT; UPREGULATION; ANIMAL; GLIA; GROWTH, DEVELOPMENT AND AGING; INTERNEURON; KNOCKOUT MOUSE; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; NEWBORN; PATHOLOGY; PHYSIOLOGY; RETINA;

ANIMALS; ANIMALS, NEWBORN; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; INTERNEURONS; MICE, KNOCKOUT; NEUROGENESIS; NEUROGLIA; POLYCOMB REPRESSIVE COMPLEX 2; RETINA;

EID: 84938986290     PISSN: 19328451     EISSN: 1932846X     Source Type: Journal    
DOI: 10.1002/dneu.22261     Document Type: Article

References (38)

1. Agger K, Cloos PAC, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, et al. 2007. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 449:731-735.
2. Aldiri I, Moore KB, Hutcheson DA, Zhang J, Vetter ML. 2013. Polycomb repressive complex PRC2 regulates Xenopus retina development downstream of Wnt/b-catenin signaling. Development 140:2867-2878.
3. Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, et al. 2007. The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev 21:525-530.
4. Bramblett DE, Pennesi ME, Wu SM, Tsai MJ. 2004. The transcription factor Bhlhb4 is required for rod bipolar cell maturation. Neuron 43:779-793.
5. Burgold T, Spreafico F, De Sant F, Totaro MG, Prosperini E, Natoli G, Testa G. 2008. The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment. Plos One 3:e3034.
6. Burgold T, Voituron N, Caganova M, Tripathi PP, Menuet C, Tusi BK, Spreafico F, et al. 2012. The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing, and survival. Cell Rep 2:1244-1258.
7. Cao R, Zhang Y. 2004. The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr Opin Genet Dev 14:155-164.
8. Cepko CL. 1999. The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates. Curr Opin Neurorbiol 9:37-46.
9. Chatoo W, Abdouh M, Duparc RH, Bernier G. 2010. Bmi1 distinguishes immature retinal progenitor/stem cells from the amin progenitor cell population and is required for normal retinal development. Stem Cells 28:1412-1423.
10. Chen YH, Hung MC, Li LY. 2014. EZH2: A pivotal regulator in controlling cell differentiation. Am J Transl Res 4:364-375.
11. Chow RL, Volgyi B, Szilard RK, Ng D, McKerlie C, Bloomfield SA, Birch DG, et al. 2004. Control of late off-center cone bipolar cell differentiation and visual signaling by the homeobox gene Vsx1. Proc Natl Acad Sci USA 101:1754-1759.
12. Elshatory Y, Deng M, Xie X, Gan L. 2007. Expression of the LIM-homeodomain protein isl1 in the developing and mature mouse retina. J Comp Neurol 503:182-197.
13. Elshatory Y, Everhart D, Deng M, Xie X, Barlow RB, Lin Gan L. 2007. Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells. J Neurosci 27:12707-12720.
14. Gil J, Peters G. 2006. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: All for one or one for all. Nat Mol Cell Biol 7:667-677.
15. Hansen KH, Bracken AP, Pasini D, Dietrich N, Gehani SS, Monrad A, Rappsilber J, et al. 2008. A model for transmission of the H3K27me3 epigenetic mark. Nat Cell Biol 10:1291-1300.
16. Harris WA. 1997. Cellular diversification in vertebrate retina. Curr Opin Genet Dev 7:651-658.
17. Hirabayashi Y, Suzki N, Tsuboi M, Endo T, Toyoda T, Shinga J, Koseki H, et al. 2009. Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition. Neuron 63:600-613.
18. Hojo M, Ohtsuka T, Hashimoto N, Gradwohl G, Guillemot F, Kageyama R. 2000. Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina. Development 127:2515-2522.
19. Iida A, Iwagawa T, Kuribayashi H, Satoh S, Mochizuki Y, Baba Y, Nakauchi H, et al. 2014. Histone demethylase Jmjd3 is required for the development of subsets of retinal bipolar cells. Proc Natl Acad Sci USA 111:3751-3756.
20. Iida A, Shinoe T, Baba Y, Mano H, Watanabe S. 2011. Dicer plays essential roles for retinal development by regulation of survival and differentiation. Invest. Ophthalmol Vis Sci 52:3008-3017.
21. Jacobs JJL, Kieboom K, Marino S, DePinho RA, van Lohuizen M. 1999. The oncogene and polycomb group gene bmi-1regulates cell proliferation and senescence through the ink4a locus. Nature 397:164-168.
22. Jepsen K, Solum D, Zhou T, McEvilly RJ, Kim H-J, Glass CK, Hermanson O, et al. 2007. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature 450:415-420.
23. Kooistra SM, Helin K. 2012. Molecular mechanisms and potential functions of histone demethylases. Nat Rev Mol Cell Biol 13:305-311.
24. Marquardt T, Gruss P. 2002. Generating neuronal diversity in the retina: One for nearly all. Trends Neurosci 25:32-38.
25. Marqueron R, Justin N, Ohno K, Sharpe ML, Son J, Drury W Jr, Vigt P, et al. 2009. Role of the polycomb protein EED in the propagation of repressive histone marks. Nature 461:762-767.
26. Morey L, Helin K. 2010. Polycomb group protein-mediated repression of transcription. Trends Biochem Sci 35:323-332.
27. Nagao M, Campbell K, Bruns K, Kuan C-Y, Trumpp A, Nakafuku M. 2008. Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19 ARF - p53 pathway. J Cell Biol 183:1243-1257.
28. Ohnuma S, Philpott A, Wang K, Holt CE, Harris WA. 1999. p27Xic1, a Cdk inhibitor, promotes the determination of glial cells in Xenopus retina. Cell 99:499-510.
29. Pereira JD, Sansom SN, Smith J, Debenecker MW, Tarakhovsky A, Livesey FJ. 2010. Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Proc Natl Acad Sci USA 107:15957-15962.
30. Ringrose L, Paro R. 2007. Polycomb/Trithorax response elements and epigenetic memory of cell identity. Development 134:223-232.
31. Sato S, Inoue T, Terada K, Matsuo I, Aizawa S, Tano Y, Fujikado T, Furukawa T. 2007. Dkk3-cre bac transgenic mouse line: A tool for highly efficient gene deletion in retinal progenitor cells. Genesis 45:502-507.
32. Sperka T, Wang J, Rudolph KL. 2012. DNA damage checkpoints in stem cells, ageing and cancer. Nat Mol Cell Biol 13:579-590.
33. Tabata Y, Ouchi Y, Kamiya H, Manabe T, Arai K, Watanabe S. 2004. Retinal fate specification of mouse embryonic stem cells by ectopic expression of Rx/rax, a homeobox gene. Mol Cell Biol 24:4513-4521.
34. Testa G. 2011. The time of timing: How Polycomb proteins regulate neurogenesis. Bioessays 33:519-528.
35. Usui A, Mochizuki Y, Iida A, Miyauchi E, SAtoh S, Sock E, Nakauchi H, et al. 2013. The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells. Development 140:740-750.
36. Voncken JW, Roelen BA, Roefs M, de Vries S, Verhoeven E, Marino S, Deschamps J, et al. 2003. Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition. Proc Natl Acad Sci USA 100:2468-2473.
37. Xu F, Li X. 2012. The role of histone methyltransferase EZH2 in meylodysplastic syndromes. Expert Rev Hematol 5:177-185.
38. Yoo KH, Hennighausen L. 2012. EZH2 methyltransferase and H3K27 methylation in breast cancer. Int J Biol Sci 8:59-65.