A pH-Responsive Carrier System that Generates NO Bubbles to Trigger Drug Release and Reverse P-Glycoprotein-Mediated Multidrug Resistance

Angewandte Chemie - International Edition

Volumn 54, Issue 34, 2015, Pages 9890-9893

  Chung, Ming Fan ^a   Liu, Hung Yi ^a   Lin, Kun Ju ^b   Chia, Wei Tso ^c   Sung, Hsing Wen ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

antitumor agents; cancer; drug delivery; fluorescence microscopy; multidrug resistance

Indexed keywords

CHEMOTHERAPY; DISEASES; DRUG DELIVERY; FLUORESCENCE MICROSCOPY; GLYCOPROTEINS; TISSUE; TUMORS;

ACIDIC ENVIRONMENT; ANTI-CANCER AGENTS; ANTI-TUMOR ACTIVITIES; ANTI-TUMOR AGENTS; CANCER; HOLLOW MICROSPHERE; INTRACELLULAR ACCUMULATION; MULTIDRUG RESISTANCE;

DRUG PRODUCTS;

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; IRINOTECAN; MULTIDRUG RESISTANCE PROTEIN; NITRIC OXIDE;

ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; DRUG RELEASE; DRUG RESISTANCE; FEMALE; HUMAN; MAMMARY NEOPLASMS, EXPERIMENTAL; MCF 7 CELL LINE; METABOLISM; MOUSE; MULTIDRUG RESISTANCE; NUDE MOUSE; PATHOLOGY; PH; SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; DRUG LIBERATION; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; MAMMARY NEOPLASMS, EXPERIMENTAL; MCF-7 CELLS; MICE; MICE, NUDE; NITRIC OXIDE; P-GLYCOPROTEIN;

EID: 84938979624     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201504444     Document Type: Article

References (22)

1. C. J. Ke, W. L. Chiang, Z. X. Liao, H. L. Chen, P. S. Lai, J. S. Sun, H. W. Sung, Biomaterials 2013, 34, 1.
2. Z. Wang, Z. Wang, D. Liu, X. Yan, F. Wang, G. Niu, M. Yang, X. Chen, Angew. Chem. Int. Ed. 2014, 53, 1997
3. Angew. Chem. 2014, 126, 2028.
4. C. Riganti, E. Miraglia, D. Viarisio, C. Costamagna, G. Pescarmona, D. Ghigo, A. Bosia, Cancer Res. 2005, 65, 516
5. D. L. Anastasia, M. Noemi, S. Annalucia, P. Alessandra, P. Anna, Z. P. Jens, P. Raffaele, G. F. Maria, P. Pasquale, M. Gabriella, Biochem. J. 2011, 440, 175.
6. L. J. Ignarro, C. Napoli, J. Loscalzo, Circ. Res. 2002, 90, 21.
7. K. Takasuna, T. Hagiwara, M. Hirohashi, M. Kato, M. Nomura, E. Nagai, T. Yokoi, T. Kamataki, Cancer Res. 1996, 56, 3752
8. J. W. Yoo, E. S. Choe, S. M. Ahn, C. H. Lee, Biomaterials 2010, 31, 552.
9. V. Estrella, T. Chen, M. Lloyd, J. Wojtkowiak, H. H. Cornnell, A. I. Hashim, K. Bailey, Y. Balagurunathan, J. M. Rothberg, B. F. Sloane, Cancer Res. 2013, 73, 1524.
10. M. F. Chung, W. T. Chia, H. Y. Liu, C. W. Hsiao, H. C. Hsiao, C. M. Yang, H. W. Sung, Adv. Healthcare Mater. 2014, 3, 1854.
11. H. A. Hassanin, L. Hannibal, D. W. Jacobsen, M. F. El-Shahat, M. S. Hamza, N. E. Brasch, Angew. Chem. Int. Ed. 2009, 48, 8909
12. Angew. Chem. 2009, 121, 9071.
13. Y. Takashima, J. Hashimoto, Y. Kitamura, S. Shimma, Y. Fujiwara, F. Koizumi, K. Tamura, A. Hamada, Cancer Res. 2014, 74, 1678.
14. H. Wang, H. Xie, J. Wu, X. Wei, L. Zhou, X. Xu, S. Zheng, Angew. Chem. Int. Ed. 2014, 53, 11532
15. Angew. Chem. 2014, 126, 11716.
16. K. J. Chen, E. Y. Chaung, S. P. Wey, K. J. Lin, F. Cheng, C. C. Lin, H. L. Liu, H. W. Tseng, C. P. Liu, M. C. Wei, ACS Nano 2014, 8, 5105.
17. W. L. Chiang, Y. C. Hu, H. Y. Liu, C. W. Hsiao, R. Sureshbabu, C. M. Yang, M. F. Chung, W. T. Chia, H. W. Sung, Small 2014, 10, 4100.
18. W. J. Shi, J. Barber, Y. Zhao, J. Phys. Chem. B 2013, 117, 3976
19. B. E. Hardin, E. T. Hoke, P. B. Armstrong, J. H. Yum, P. Comte, T. Torres, J. M. J. Fréchet, M. K. Nazeeruddin, M. Grätzel, M. D. McGehee, Nat. Photonics 2009, 3, 406
20. C. J. Mu, D. A. Lavan, R. S. Langer, B. R. Zetter, ACS Nano 2010, 4, 1511.
21. S. Maschauer, J. Einsiedel, R. Haubner, C. Hocke, M. Ocker, H. Hübner, T. Kuwert, P. Gmeiner, O. Prante, Angew. Chem. Int. Ed. 2010, 49, 976
22. Angew. Chem. 2010, 122, 988.