Correlation of p16 expression and HPV type with survival in oropharyngeal squamous cell cancer

Oral Oncology

Volumn 51, Issue 9, 2015, Pages 862-869

  Liu, Sandy Z ^a   Zandberg, Dan P ^a,b   Schumaker, Lisa M ^b   Papadimitriou, John C ^a   Cullen, Kevin J ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

HPV p16 linear array; Oropharyngeal squamous cell carcinoma

Indexed keywords

GENOMIC DNA; HEMOGLOBIN BETA CHAIN; PROTEIN P16; VIRUS DNA;

ADULT; AGE; AGED; ALCOHOL CONSUMPTION; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE MARKER; DNA DETERMINATION; FEMALE; GENE AMPLIFICATION; GENOTYPE; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; OROPHARYNGEAL SQUAMOUS CELL CARCINOMA; OROPHARYNX CARCINOMA; OVERALL SURVIVAL; PAPILLOMAVIRUS INFECTION; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RACE DIFFERENCE; SENSITIVITY AND SPECIFICITY; SEX DIFFERENCE; SQUAMOUS CELL CARCINOMA; TOBACCO USE; VERY ELDERLY; VIRUS ONCOGENE; WART VIRUS; CASE CONTROL STUDY; GENETICS; GENOTYPING TECHNIQUE; MIDDLE AGED; OROPHARYNX TUMOR; PROGNOSIS; RETROSPECTIVE STUDY; SURVIVAL ANALYSIS;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; FEMALE; GENOTYPING TECHNIQUES; HUMAN PAPILLOMAVIRUS 16; HUMANS; MALE; MIDDLE AGED; OROPHARYNGEAL NEOPLASMS; POLYMERASE CHAIN REACTION; PROGNOSIS; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; SURVIVAL ANALYSIS;

EID: 84938977150     PISSN: 13688375     EISSN: 18790593     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2015.06.014     Document Type: Article

References (57)

1. R.A. Siegel, D. Naishadham, Fau Jemal, and A. Jemal Cancer statistics 2013 CA Cancer J Clin 63 1 2013 11 30 http://dx.doi.org/10.3322/caac.21166
2. A.K. Chaturvedi, and et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States J Clin Oncol 29 32 2011 4294 4301 (http://dx.doi.org/10.1200/JCO.2011.36.4596)
3. A.K. Chaturvedi, and et al. Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers J Clin Oncol 31 36 2013 4550 4559 (http://dx.doi.org/10.1200/JCO.2013.50.3870
4. A.R. Kreimer, and et al. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review Cancer Epidemiol Biomarkers Prev 14 2 2005 467 475
5. F.X. Bosch, and et al. Comprehensive control of human papillomavirus infections and related diseases Vaccine 31 17 2013 H1 H31 http://dx.doi.org/10.1016/j.vaccine.2013.10.003, pii:S0264-410X(13)01346-7
6. M.L. Gillison, and et al. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers J Natl Cancer Inst 92 9 2000 709 720
7. R. Herrero, and et al. Human papillomavirus and oral cancer: the international agency for research on cancer multicenter study J Natl Cancer Inst 95 23 2003 1772 1783
8. J.L. St Guily, and et al. Human papillomavirus genotype distribution in oroph Human papillomavirus genotype distribution in oropharynx and oral cavity cancer in France-The EDiTH VI study arynx and oral cavity cancer J Clin Virol 51 2 2011 100 104 http://dx.doi.org/10.1016/j.jcv.2011.03.003
9. K.K. Ang, and et al. Human papillomavirus and survival of patients with oropharyngeal cancer N Engl J Med 363 1 2010 24 35 http://dx.doi.org/10.1056/NEJMoa0912217
10. F. Dayyani, and et al. Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC) Head Neck Oncol 2 2010 15 http://dx.doi.org/10.1186/1758-3284-2-15
11. K. Settle, and et al. Racial survival disparity in head and neck cancer results from low prevalence of human papillomavirus infection in black oropharyngeal cancer patients Cancer Prev Res (Phila) 2 9 2009 776 781 http://dx.doi.org/10.1158/1940-6207.CAPR-09-0149
12. C. Fakhry, and et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial J Natl Cancer Inst 100 4 2008 261 269 http://dx.doi.org/10.1093/jnci/djn011
13. D. Rischin, and et al. Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 0202 phase III trial J Clin Oncol 28 27 2010 4142 4148 http://dx.doi.org/10.1200/JCO.2010.29.2904
14. C. Gronhoj Larsen, and et al. Correlation between human papillomavirus and p16 overexpression in oropharyngeal tumours: a systematic review Br J Cancer 110 6 2014 1587 1594 http://dx.doi.org/10.1038/bjc.2014.42
15. C.R. Salazar, and et al. Combined P16 and human papillomavirus testing predicts head and neck cancer survival Int J Cancer 2014
16. R.D. Chernock, and et al. Human papillomavirus-related squamous cell carcinoma of the oropharynx: a comparative study in whites and African Americans Arch Otolaryngol Head Neck Surg 137 2 2011 163 169 http://dx.doi.org/10.1001/archoto.2010.246
17. H. Mellin Dahlstrand, and et al. P16(INK4a) correlates to human papillomavirus presence, response to radiotherapy and clinical outcome in tonsillar carcinoma Anticancer Res 25 6C 2005 4375 4383
18. C. Cai, and et al. Keratinizing-type squamous cell carcinoma of the oropharynx: p16 overexpression Am J Surg Pathol 38 6 2014 809 815 http://dx.doi.org/10.1097/PAS.0000000000000183
19. J.A. Bishop, and et al. Detection of transcriptionally active high-risk HPV in patients with head and neck squamous cell carcinoma as visualized by a novel E6/E7 mRNA in situ hybridization method Am J Surg Pathol 36 12 2012 1874 1882 http://dx.doi.org/10.1097/PAS.0b013e318265fb2b
20. O.C. Ukpo, and et al. High-risk human papillomavirus E6/E7 mRNA detection by a novel in situ hybridization assay strongly correlates with p16 expression and patient outcomes in oropharyngeal squamous cell carcinoma Am J Surg Pathol 35 9 2011 1343 1350 http://dx.doi.org/10.1097/PAS.0b013e318220e59d
21. J.S. Lewis Jr, and et al. p16 positive oropharyngeal squamous cell carcinoma:an entity with a favorable prognosis regardless of tumor HPV status Am J Surg Pathol 34 8 2010 1088 1096 http://dx.doi.org/10.1097/PAS.0b013e3181e84652
22. J.N. Al-Swiahb, and et al. Prognostic impact of p16 p53 epidermal growth factor receptor and human papillomavirus in oropharyngeal cancer in a betel nut-chewing area Arch Otolaryngol Head Neck Surg 136 5 2010 502 508 http://dx.doi.org/10.1001/archoto.2010.47
23. G. Gao, and et al. A novel RT-PCR method for quantification of human papillomavirus transcripts in archived tissues and its application in oropharyngeal cancer prognosis Int J Cancer 132 4 2013 882 890 http://dx.doi.org/10.1002/ijc.27739
24. A.M. Hong, and et al. Human papillomavirus predicts outcome in oropharyngeal cancer in patients treated primarily with surgery or radiation therapy Br J Cancer 103 10 2010 1510 1517 http://dx.doi.org/10.1038/sj.bjc.6605944
25. D. Holzinger, and et al. Viral RNA patterns and high viral load reliably define oropharynx carcinomas with active HPV16 involvement Cancer Res 72 19 2012 4993 5003 http://dx.doi.org/10.1158/0008-5472.CAN-11-3934
26. E. Junor, and et al. Benefit of chemotherapy as part of treatment for HPV DNA-positive but p16-negative squamous cell carcinoma of the oropharynx Br J Cancer 106 2 2012 358 365 http://dx.doi.org/10.1038/bjc.2011.542
27. H. Kawakami, and et al. Human papillomavirus DNA and p16 expression in Japanese patients with oropharyngeal squamous cell carcinoma Cancer Med. 2 6 2013 933 941 http://dx.doi.org/10.1002/cam4.151
28. J.J. Mooren, and et al. P16(INK4A) immunostaining is a strong indicator for high-risk-HPV-associated oropharyngeal carcinomas and dysplasias, but is unreliable to predict low-risk-HPV-infection in head and neck papillomas and laryngeal dysplasias Int J Cancer 134 9 2014 2108 2117 http://dx.doi.org/10.1002/ijc.28534
29. H.W. Walline, and et al. High-risk human papillomavirus detection in oropharyngeal nasopharyngeal and oral cavity cancers: comparison of multiple methods JAMA Otolaryngol Head Neck Surg 139 12 2013 1320 1327 http://dx.doi.org/10.1001/jamaoto.2013.5460
30. T. Isayeva, and et al. African Americans with oropharyngeal carcinoma have significantly poorer outcomes despite similar rates of human papillomavirus-mediated carcinogenesis Hum Pathol 45 2 2014 310 319 http://dx.doi.org/10.1016/j.humpath.2013.09.006, pii:S0046-8177(13)00389-4
31. H. Quon, and et al. Transoral robotic surgery and adjuvant therapy for oropharyngeal carcinomas and the influence of p16 INK4a on treatment outcomes Laryngoscope 123 3 2013 635 640 http://dx.doi.org/10.1002/lary.22172
32. D. van Hamont, and et al. Evaluation of the SPF10-INNO LiPA human papillomavirus (HPV) genotyping test and the roche linear array HPV genotyping test J Clin Microbiol 44 9 2006 3122 3129
33. C.C. Black, and et al. Use of a linear array for the detection of human papillomavirus genotypes in head and neck cancer Arch Pathol Lab Med 134 12 2010 1813 1817 http://dx.doi.org/10.1043/2009-0592-OAR.1
34. R. Shanesmith, and et al. Comparison of 2 line blot assays for defining HPV genotypes in oral and oropharyngeal squamous cell carcinomas Diagn Microbiol Infect Dis 70 2 2011 p. 240 5 http://dx.doi.org/10.1016/j.diagmicrobio.2011.01.011
35. M. Steinau, Dc. Swan, and E.R. Unger Type-specific reproducibility of the Roche linear array HPV genotyping test J Clin Virol 42 4 2008 412 414 http://dx.doi.org/10.1016/j.jcv.2008.03.004
36. F. Farshadpour, and et al. Human papillomavirus and oropharyngeal squamous cell carcinoma: a case-control study regarding tobacco and alcohol consumption Patholog Res Int 2011 806345 http://dx.doi.org/10.4061/2011/806345
37. P. Lohavanichbutr, and et al. Genomewide gene expression profiles of HPV-positive and HPV-negative oropharyngeal cancer: potential implications for treatment choices Arch Otolaryngol Head Neck Surg 135 2 2009 180 188 http://dx.doi.org/10.1001/archoto.2008.540
38. J. Jiron, and et al. Racial disparities in Human Papillomavirus (HPV) associated head and neck cancer Am J Otolaryngol 35 2 2014 147 153 http://dx.doi.org/10.1016/j.amjoto.2013.09.004, pii:S0196-0709(13)00219-6
39. P.M. Weinberger, and et al. Human papillomavirus-active head and neck cancer and ethnic health disparities Laryngoscope 120 8 2010 1531 1537 http://dx.doi.org/10.1002/lary.20984
40. P.M. Weinberger, and et al. Molecular classification identifies a subset of human papillomavirus-associated oropharyngeal cancers with favorable prognosis J Clin Oncol 24 5 2006 736 747
41. E.M. Smith, and et al. P16INK4a expression, human papillomavirus, and survival in head and neck cancer Oral Oncol 44 2 2008 133 142
42. L. Charfi, and et al. Two types of squamous cell carcinoma of the palatine tonsil characterized by distinct etiology, molecular features and outcome Cancer Lett 260 1-2 2008 72 78
43. S.K. El-Mofty, and S. Patil Human papillomavirus (HPV)-related oropharyngeal nonkeratinizing squamous cell carcinoma: characterization of a distinct phenotype Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101 3 2006 339 345
44. M.F. Evans, and et al. Discrimination of 'driver' and 'passenger' HPV in tonsillar carcinomas by the polymerase chain reaction, chromogenic in situ hybridization, and p16(INK4a) immunohistochemistry Head Neck Pathol 5 4 2011 344 348 http://dx.doi.org/10.1007/s12105-011-0282-y
45. S.H. Kim, and et al. HPV integration begins in the tonsillar crypt and leads to the alteration of p16, EGFR and c-myc during tumor formation Int J Cancer 120 7 2007 1418 1425
46. K.T. Kuo, and et al. The biomarkers of human papillomavirus infection in tonsillar squamous cell carcinoma-molecular basis and predicting favorable outcome Mod Pathol 21 4 2008 376 386 http://dx.doi.org/10.1038/modpathol.3800979
47. L. Licitra, and et al. High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma J Clin Oncol 24 36 2006 5630 5636
48. D. Lindquist, and et al. Intense CD44 expression is a negative prognostic factor in tonsillar and base of tongue cancer Anticancer Res 32 1 2012 153 161
49. A.E. Melkane, and et al. HPV-related oropharyngeal squamous cell carcinomas: a comparison between three diagnostic approaches Am J Otolaryngol 35 1 2014 25 32 http://dx.doi.org/10.1016/j.amjoto.2013.08.007, pii:S0196-0709(13)00198-1
50. A.C. Nichols, and et al. Does HPV type affect outcome in oropharyngeal cancer? J Otolaryngol Head Neck Surg 42 2013 9 http://dx.doi.org/10.1186/1916-0216-42-9
51. W.S. Park, and et al. Human papillomavirus in oropharyngeal squamous cell carcinomas in Korea: use of G1 cycle markers as new prognosticators Head Neck 34 10 2012 1408 1417 http://dx.doi.org/10.1002/hed.21939
52. N. Reimers, and et al. Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer Int J Cancer 120 8 2007 1731 1738
53. R. Semrau, and et al. Prognostic impact of human papillomavirus status, survivinand epidermal growth factor receptor expression on survival in patients treated with radiochemotherapy for very advanced nonresectable oropharyngeal cancer Head Neck 35 9 2013 1339 1344 http://dx.doi.org/10.1002/hed.23126
54. S. Thavaraj, and et al. Evaluation of human papillomavirus testing for squamous cell carcinoma of the tonsil in clinical practice J Clin Pathol 64 4 2011 308 312 http://dx.doi.org/10.1136/jcp.2010.088450
55. D. Weiss, and et al. HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently of HPV16 BMC Cancer 12 2012 259 http://dx.doi.org/10.1186/1471-2407-12-259
56. M. Hoffmann, and et al. HPV DNA E6∗ - I-mRNA expression and p16INK4A immunohistochemistry in head and neck cancer - how valid is p16INK4A as surrogate marker? Cancer Lett 323 1 2012 88 96 http://dx.doi.org/10.1016/j.canlet.2012.03.033
57. W. Shi, and et al. Comparative prognostic value of HPV16 E6 mRNA compared with in situ hybridization for human oropharyngeal squamous carcinoma J Clin Oncol 27 36 2009 p. 6213 21 http://dx.doi.org/10.1200/JCO.2009.23.1670