Combined P16 and human papillomavirus testing predicts head and neck cancer survival

International Journal of Cancer

Volumn 135, Issue 10, 2014, Pages 2404-2412

  Salazar, Christian R ^a   Anayannis, Nicole ^a   Smith, Richard V ^a   Wang, Yanhua ^a   Haigentz, Missak ^a   Garg, Madhur ^a   Schiff, Bradley A ^a   Kawachi, Nicole ^a   Elman, Jordan ^a   Belbin, Thomas J ^a   Prystowsky, Michael B ^a   Burk, Robert D ^a   Schlecht, Nicolas F ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

CDKN2A; Head and neck neoplasms; Human papillomavirus; P16; Squamous cell carcinoma; Survival

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; PROTEIN E6; PROTEIN E7; TUMOR MARKER; VIRUS DNA;

ARTICLE; CANCER LOCALIZATION; CANCER MORTALITY; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER SIZE; CANCER STAGING; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SPECIFIC SURVIVAL; DRINKING BEHAVIOR; FEMALE; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS DNA TEST; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN TISSUE; HYPOPHARYNX TUMOR; IMMUNOHISTOCHEMISTRY; LARYNX TUMOR; MAJOR CLINICAL STUDY; MALE; OROPHARYNX TUMOR; OVERALL SURVIVAL; POLYMERASE CHAIN REACTION; PREVALENCE; PROGRESSION FREE SURVIVAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX; SMOKING; ADULT; AGED; CDKN2A; ENZYME IMMUNOASSAY; FOLLOW UP; GENETICS; HEAD AND NECK TUMOR; METABOLISM; MIDDLE AGED; MORTALITY; P16; PAPILLOMA VIRUS; PAPILLOMAVIRUS INFECTION; PROGNOSIS; SQUAMOUS CELL CARCINOMA; SURVIVAL; SURVIVAL RATE; VERY ELDERLY; VIROLOGY; WART VIRUS; YOUNG ADULT;

CDKN2A; HEAD AND NECK NEOPLASMS; HUMAN PAPILLOMAVIRUS; P16; SQUAMOUS CELL CARCINOMA; SURVIVAL;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA, VIRAL; FEMALE; FOLLOW-UP STUDIES; HEAD AND NECK NEOPLASMS; HUMAN PAPILLOMAVIRUS DNA TESTS; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; NEOPLASM STAGING; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; POLYMERASE CHAIN REACTION; PROGNOSIS; PROSPECTIVE STUDIES; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84909981448     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28876     Document Type: Article

References (36)

1. Gillison ML, Shah KV. Human papillomavirus-associated head and neck squamous cell carcinoma: mounting evidence for an etiologic role for human papillomavirus in a subset of head and neck cancers. Curr Opin Oncol 2001;13:183-8.
2. Smith EM, Rubenstein LM, Ritchie JM, et al. Does pretreatment seropositivity to human papillomavirus have prognostic significance for head and neck cancers? Cancer Epidemiol Biomarkers Prev 2008;17:2087-96.
3. Isayeva T, Li Y, Maswahu D, et al. Human papillomavirus in non-oropharyngeal head and neck cancers: a systematic literature review. Head Neck Pathol. 2012;6 Suppl 1:S104-120.
4. Sano T, Oyama T, Kashiwabara K, et al. Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol 1998;153:1741-48.
5. Chellappan S, Kraus VB, Kroger B, et al. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc Natl Acad Sci USA 1992;89:4549-53.
6. Gillison ML, Koch WM, Capone RB, et al. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 2000;92:709-20.
7. Weinberger PM, Yu Z, Haffty BG, et al. Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer. Clin Cancer Res 2004;10:5684-91.
8. Geisler SA, Olshan AF, Weissler MC, et al. p16 and p53 Protein expression as prognostic indicators of survival and disease recurrence from head and neck cancer. Clin Cancer Res 2002;8:3445-53.
9. Wilson DD, Rahimi AS, Saylor DK, et al. p16 not a prognostic marker for hypopharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2012;138:556-61.
10. Smeets SJ, Hesselink AT, Speel EJ, et al. A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen. Int J Cancer 2007;121:2465-72.
11. Adelstein DJ, Ridge JA, Gillison ML, et al. Head and neck squamous cell cancer and the human papillomavirus: summary of a National Cancer Institute State of the Science Meeting, November 9-10, 2008, Washington, D.C. Head Neck 2009; 31:1393-1422.
12. Fakhry C, Westra WH, Li S, et al. Improved survival of patients with human papillomaviruspositive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 2008;100:261-9.
13. Ang KK, Harris J, Wheeler R, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010;363:24-35.
14. Liang C, Marsit CJ, McClean MD, et al. Biomarkers of HPV in head and neck squamous cell carcinoma. Cancer Res 2012;72:5004-5013.
15. Smith EM, Pawlita M, Rubenstein LM, et al. Risk factors and survival by HPV-16 E6 and E7 antibody status in human papillomavirus positive head and neck cancer. Int J Cancer 2010;127:111-7.
16. Schlecht NF, Brandwein-Gensler M, Nuovo GJ, et al. A comparison of clinically utilized human papillomavirus detection methods in head and neck cancer. Mod Pathol 2011;24:1295-305.
17. Singhi AD, Westra WH. Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience. Cancer 2010;116:2166-73.
18. Salazar CR, Smith RV, Garg MK, et al. Human papillomavirus-associated head and neck squamous cell carcinoma survival: a comparison by tumor site and initial treatment. Head Neck Pathol 2014;8:77-87
19. Bauer HM, Ting Y, Greer CE, et al. Genital human papillomavirus infection in female university students as determined by a PCR-based method. JAMA 1991;265:472-7.
20. Hildesheim A, Schiffman MH, Gravitt PE, et al. Persistence of type-specific human papillomavirus infection among cytologically normal women. J Infect Dis 1994;169:235-40.
21. Palefsky JM, Holly EA, Gonzales J, et al. Detection of human papillomavirus DNA in anal intraepithelial neoplasia and anal cancer. Cancer Res 1991;51:1014-9.
22. van Houten VM, Snijders PJ, van den Brekel MW, et al. Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas. Int J Cancer 2001;93:232-5.
23. Braakhuis BJM, Snijders PJF, Keune WJH, et al. Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus. J Natl Cancer Inst 2004;96:998-1006.
24. Kotorashvili A, Ramnauth A, Liu C, et al. Effective DNA/RNA co-extraction for analysis of microRNAs, mRNAs, and genomic DNA from formalin-fixed paraffin-embedded specimens. PloS one 2012;7:e34683.
25. Holzinger D, Flechtenmacher C, Henfling N, et al. Identification of oropharyngeal squamous cell carcinomas with active HPV16 involvement by immunohistochemical analysis of the retinoblastoma protein pathway. Int J Cancer 2013;133:1389-99.
26. Braakhuis BJ, Brakenhoff RH, Leemans CR. Treatment choice for locally advanced head and neck cancers on the basis of risk factors: biological risk factors. Ann Oncol 2012;23 Suppl 10: x173-7.
27. Fischer CA, Kampmann M, Zlobec I, et al. p16 expression in oropharyngeal cancer: its impact on staging and prognosis compared with the conventional clinical staging parameters. Ann Oncol 2010;21:1961-6.
28. Oguejiofor KK, Hall JS, Mani N, et al. The prognostic significance of the biomarker p16 in oropharyngeal squamous cell carcinoma. Clin Oncol 2013;25:630-8.
29. Hoffmann M, Ihloff AS, Görögh T, et al. p16(INK4a) overexpression predicts translational active human papillomavirus infection in tonsillar cancer. Int J Cancer 2010;127:1595-602.
30. Hong A, Jones D, Chatfield M, et al. HPV status of oropharyngeal cancer by combination HPV DNA/p16 testing: biological relevance of discordant results. Ann Surg Oncol 2013;20:S450-8.
31. Marklund L, Nasman A, Ramqvist T, et al. Prevalence of human papillomavirus and survival in oropharyngeal cancer other than tonsil or base of tongue cancer. Cancer Med 2012;1:82-8.
32. Lewis JS, Jr. Not your usual cancer case: variants of laryngeal squamous cell carcinoma. Head Neck Pathol 2011;5:23-30.
33. Holzinger D, Schmitt M, Dyckhoff G, et al. Viral RNA patterns and high viral load reliably define oropharynx carcinomas with active HPV16 involvement. Cancer Res 2012;72:4993-5003.
34. Stephen JK, Divine G, Chen KM, et al. Significance of p16 in Site-specific HPV Positive and HPV Negative Head and Neck Squamous Cell Carcinoma. Cancer Clin Oncol 2013; 2:51-61.
35. Tribius S, Hoffmann M. Human papilloma virus infection in head and neck cancer. Dtsch Arztebl Int 2013;110:184-90, 190e181.
36. Nichols AC, Dhaliwal SS, Palma DA, et al. Does HPV type affect outcome in oropharyngeal cancer? J Otolaryngol Head Neck Surg 2013; 42:9.