High-risk human papillomavirus E6/E7 mRNA detection by a novel in situ hybridization assay strongly correlates with p16 expression and patient outcomes in oropharyngeal squamous cell carcinoma

American Journal of Surgical Pathology

Volumn 35, Issue 9, 2011, Pages 1343-1350

  Ukpo, Odey C ^a   Flanagan, John J ^a   Ma, Xiao Jun ^a   Luo, Yuling ^a   Thorstad, Wade L ^a   Lewis, James S ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Washington University ^*  (United States)

Author keywords

E6; E7; human papillomavirus; in situ hybridization; oropharynx; p16; squamous cell carcinoma

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; MESSENGER RNA; ONCOPROTEIN; TUMOR MARKER; VIRUS RNA;

ADULT; AGED; ARTICLE; CHEMISTRY; DISEASE FREE SURVIVAL; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KAPLAN MEIER METHOD; MALE; METHODOLOGY; MIDDLE AGED; MORTALITY; OROPHARYNX TUMOR; PAPILLOMA VIRUS; PATHOLOGY; PREDICTIVE VALUE; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RISK ASSESSMENT; RISK FACTOR; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE; TIME; TISSUE MICROARRAY; UNITED STATES; VIROLOGY;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MISSOURI; ONCOGENE PROTEINS, VIRAL; OROPHARYNGEAL NEOPLASMS; PAPILLOMAVIRIDAE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RISK ASSESSMENT; RISK FACTORS; RNA, MESSENGER; RNA, VIRAL; SURVIVAL RATE; TIME FACTORS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 81155161063     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318220e59d     Document Type: Article

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