Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia

American Journal of Respiratory Cell and Molecular Biology

Volumn 53, Issue 2, 2015, Pages 184-192

  Nara, Akina ^a   Nagai, Hisashi ^a   Shintani Ishida, Kaori ^a   Ogura, Sayoko ^a,b   Shimosawa, Tatsuo ^c   Kuwahira, Ichiro ^d   Shirai, Mikiyasu ^e   Yoshida, Ken Ichi ^a,f  

^a Graduate School of Biomedical Engineering   (Japan)

^b NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^f TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Age; Arginase; Intermittent hypoxia; Pulmonary arterial hypertension; Sleep apnea syndrome

Indexed keywords

3 NITROTYROSINE; ARGINASE; ARGINASE 1; ISOENZYME; N OMEGA HYDROXY NOR 1 ARGININE; N(G) HYDROXYARGININE; NITRATE; NITRIC OXIDE SYNTHASE; NITRITE; UNCLASSIFIED DRUG; 3-NITROTYROSINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC ACID DERIVATIVE; NOS3 PROTEIN, RAT; TYROSINE;

ADULT; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTERY WALL; ARTICLE; DOPPLER ECHOCARDIOGRAPHY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HEART CATHETER; HEART CATHETERIZATION; HEART RIGHT VENTRICLE; HEART RIGHT VENTRICLE HYPERTROPHY; HEART RIGHT VENTRICLE PRESSURE; INTERMITTENT HYPOXIA; LUNG PARENCHYMA; MALE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; SYSTOLIC BLOOD PRESSURE; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; CELL HYPOXIA; ENZYMOLOGY; HYPERTENSION; LUNG; METABOLISM; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

AGING; ANIMALS; ARGINASE; CELL HYPOXIA; ENZYME ACTIVATION; HYPERTENSION; LUNG; MALE; NITRATES; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; PULMONARY ARTERY; RATS, SPRAGUE-DAWLEY; TYROSINE;

EID: 84938936816     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2014-0163OC     Document Type: Article

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