Persistent antigen and prolonged AKT-mTORC1 activation underlie memory CD8 T cell impairment in the absence of CD4 T cells

Journal of Immunology

Volumn 195, Issue 4, 2015, Pages 1591-1598

  Li, Yingzhong ^a   Shen, Chase ^a,b   Zhu, Bingdong ^b,c   Shi, Feng ^b   Eisen, Herman N ^c   Chen, Jianzhu ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b BIOGEN   (United States)

^c LANZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN KINASE B; RAPAMYCIN; T LYMPHOCYTE RECEPTOR; VIRUS ANTIGEN; ANTIGEN; CD4 ANTIGEN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; CONTROLLED STUDY; EFFECTOR CELL; ENZYME ACTIVATION; ENZYME INHIBITION; INFLUENZA; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; ANIMAL; DRUG EFFECTS; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; IMMUNOPHENOTYPING; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM; ORTHOMYXOVIRIDAE; ORTHOMYXOVIRUS INFECTION; PHENOTYPE; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MULTIPROTEIN COMPLEXES; ORTHOMYXOVIRIDAE; ORTHOMYXOVIRIDAE INFECTIONS; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-AKT; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84938927002     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1500451     Document Type: Article

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