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Volumn 10, Issue , 2015, Pages 125-131

Applications of iPSCs in cancer research

Author keywords

Cancer; Disease modeling; Induced pluripotent stem cells; Tumorigenesis

Indexed keywords

CANCER CELL; CANCER GROWTH; CANCER RESEARCH; CARCINOGENESIS; CELL DIFFERENTIATION; CELL MATURATION; DISEASE MODEL; EPIGENETICS; FAMILIAL CANCER; GENETIC MANIPULATION; HUMAN; MEDICAL TECHNOLOGY; MOLECULAR MODEL; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; REVIEW; TISSUE ENGINEERING; TUMOR SUPPRESSOR GENE; UPREGULATION;

EID: 84938922843     PISSN: None     EISSN: 11772719     Source Type: Journal    
DOI: 10.4137/BMIMI.S20065     Document Type: Review
Times cited : (23)

References (46)
  • 1
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663-76.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 2
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861-72.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3
  • 3
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science. 2007;318:1917-20.
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1    Vodyanik, M.A.2    Smuga-Otto, K.3
  • 5
    • 79955634826 scopus 로고    scopus 로고
    • A more efficient method to generate integration-free human iPS cells
    • Okita K, Matsumura Y, Sato Y, et al. A more efficient method to generate integration-free human iPS cells. Nat Methods. 2011;8:409-12.
    • (2011) Nat Methods , vol.8 , pp. 409-412
    • Okita, K.1    Matsumura, Y.2    Sato, Y.3
  • 6
    • 79958292714 scopus 로고    scopus 로고
    • Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1
    • Maekawa M, Yamaguchi K, Nakamura T, et al. Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1. Nature. 2011;474:225-9.
    • (2011) Nature , vol.474 , pp. 225-229
    • Maekawa, M.1    Yamaguchi, K.2    Nakamura, T.3
  • 7
    • 80655123674 scopus 로고    scopus 로고
    • Glis1, a unique pro-reprogramming factor, may facilitate clinical applications of iPSC technology
    • Maekawa M, Yamanaka S. Glis1, a unique pro-reprogramming factor, may facilitate clinical applications of iPSC technology. Cell Cycle. 2011;10:3613-4.
    • (2011) Cell Cycle , vol.10 , pp. 3613-3614
    • Maekawa, M.1    Yamanaka, S.2
  • 8
    • 84925341709 scopus 로고    scopus 로고
    • A comparison of non-integrating reprogramming methods
    • Schlaeger TM, Daheron L, Brickler TR, et al. A comparison of non-integrating reprogramming methods. Nat Biotechnol. 2015;33:58-63.
    • (2015) Nat Biotechnol , vol.33 , pp. 58-63
    • Schlaeger, T.M.1    Daheron, L.2    Brickler, T.R.3
  • 9
    • 84920747084 scopus 로고    scopus 로고
    • Inhibition of pluripotency networks by the rb tumor suppressor restricts reprogramming and tumorigenesis
    • Kareta MS, Gorges LL, Hafeez S, et al. Inhibition of pluripotency networks by the rb tumor suppressor restricts reprogramming and tumorigenesis. Cell Stem Cell. 2015;16:39-50.
    • (2015) Cell Stem Cell , vol.16 , pp. 39-50
    • Kareta, M.S.1    Gorges, L.L.2    Hafeez, S.3
  • 10
    • 69349098834 scopus 로고    scopus 로고
    • Stem cells: The promises and perils of p53
    • Krizhanovsky V, Lowe SW. Stem cells: the promises and perils of p53. Nature. 2009;460:1085-6.
    • (2009) Nature , vol.460 , pp. 1085-1086
    • Krizhanovsky, V.1    Lowe, S.W.2
  • 11
    • 84878600256 scopus 로고    scopus 로고
    • Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells
    • Liao J, Marumoto T, Yamaguchi S, et al. Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells. Mol Ther. 2013;21:1242-50.
    • (2013) Mol Ther , vol.21 , pp. 1242-1250
    • Liao, J.1    Marumoto, T.2    Yamaguchi, S.3
  • 12
    • 77951878056 scopus 로고    scopus 로고
    • Induced pluripotent stem cells and senescence: Learning the biology to improve the technology
    • Banito A, Gil J. Induced pluripotent stem cells and senescence: learning the biology to improve the technology. EMBO Rep. 2010;11:353-9.
    • (2010) EMBO Rep , vol.11 , pp. 353-359
    • Banito, A.1    Gil, J.2
  • 13
    • 70349093119 scopus 로고    scopus 로고
    • Senescence impairs successful reprogramming to pluripotent stem cells
    • Banito A, Rashid ST, Acosta JC, et al. Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev. 2009;23:2134-9.
    • (2009) Genes Dev , vol.23 , pp. 2134-2139
    • Banito, A.1    Rashid, S.T.2    Acosta, J.C.3
  • 14
    • 84860517655 scopus 로고    scopus 로고
    • iPSCs from cancer cells: Challenges and opportunities
    • Ramos-Mejia V, Fraga MF, Menendez P. iPSCs from cancer cells: challenges and opportunities. Trends Mol Med. 2012;18:245-7.
    • (2012) Trends Mol Med , vol.18 , pp. 245-247
    • Ramos-Mejia, V.1    Fraga, M.F.2    Menendez, P.3
  • 15
    • 52949125268 scopus 로고    scopus 로고
    • Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state
    • Lin SL, Chang DC, Chang-Lin S, et al. Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state. RNA. 2008;14:2115-24.
    • (2008) RNA , vol.14 , pp. 2115-2124
    • Lin, S.L.1    Chang, D.C.2    Chang-Lin, S.3
  • 16
    • 70350380887 scopus 로고    scopus 로고
    • Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells
    • Utikal J, Maherali N, Kulalert W, Hochedlinger K. Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J Cell Sci. 2009;122:3502-10.
    • (2009) J Cell Sci , vol.122 , pp. 3502-3510
    • Utikal, J.1    Maherali, N.2    Kulalert, W.3    Hochedlinger, K.4
  • 17
    • 76249133692 scopus 로고    scopus 로고
    • Defined factors induce reprogramming of gastrointestinal cancer cells
    • Miyoshi N, Ishii H, Nagai K, et al. Defined factors induce reprogramming of gastrointestinal cancer cells. Proc Natl Acad Sci U S A. 2010;107:40-5.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 40-45
    • Miyoshi, N.1    Ishii, H.2    Nagai, K.3
  • 18
    • 77953250105 scopus 로고    scopus 로고
    • Generation of iPSCs from cultured human malignant cells
    • Carette JE, Pruszak J, Varadarajan M, et al. Generation of iPSCs from cultured human malignant cells. Blood. 2010;115:4039-42.
    • (2010) Blood , vol.115 , pp. 4039-4042
    • Carette, J.E.1    Pruszak, J.2    Varadarajan, M.3
  • 19
    • 79959908506 scopus 로고    scopus 로고
    • HIF induces human embryonic stem cell markers in cancer cells
    • Mathieu J, Zhang Z, Zhou W, et al. HIF induces human embryonic stem cell markers in cancer cells. Cancer Res. 2011;71:4640-52.
    • (2011) Cancer Res , vol.71 , pp. 4640-4652
    • Mathieu, J.1    Zhang, Z.2    Zhou, W.3
  • 20
    • 84884849331 scopus 로고    scopus 로고
    • Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway
    • Corominas-Faja B, Cufi S, Oliveras-Ferraros C, et al. Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway. Cell Cycle. 2013;12:3109-24.
    • (2013) Cell Cycle , vol.12 , pp. 3109-3124
    • Corominas-Faja, B.1    Cufi, S.2    Oliveras-Ferraros, C.3
  • 21
    • 84875340771 scopus 로고    scopus 로고
    • Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner
    • Stricker SH, Feber A, Engstrom PG, et al. Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner. Genes Dev. 2013;27:654-69.
    • (2013) Genes Dev , vol.27 , pp. 654-669
    • Stricker, S.H.1    Feber, A.2    Engstrom, P.G.3
  • 22
    • 84877574727 scopus 로고    scopus 로고
    • Terminal differentiation and loss of tumorigenicity of human cancers via pluripotency-based reprogramming
    • Zhang X, Cruz FD, Terry M, Remotti F, Matushansky I. Terminal differentiation and loss of tumorigenicity of human cancers via pluripotency-based reprogramming. Oncogene. 2013;32(18):.e1-21.
    • (2013) Oncogene , vol.32 , Issue.18 , pp. e1-e21
    • Zhang, X.1    Cruz, F.D.2    Terry, M.3    Remotti, F.4    Matushansky, I.5
  • 23
    • 84899930229 scopus 로고    scopus 로고
    • Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells
    • Liu Y, Cheng H, Gao S, et al. Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells. Leukemia. 2014;28:1071-80.
    • (2014) Leukemia , vol.28 , pp. 1071-1080
    • Liu, Y.1    Cheng, H.2    Gao, S.3
  • 24
    • 79953826088 scopus 로고    scopus 로고
    • Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells
    • Hu K, Yu J, Suknuntha K, et al. Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells. Blood. 2011;117:e109-19.
    • (2011) Blood , vol.117 , pp. e109-e119
    • Hu, K.1    Yu, J.2    Suknuntha, K.3
  • 25
    • 84863505092 scopus 로고    scopus 로고
    • Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples
    • Kumano K, Arai S, Hosoi M, et al. Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples. Blood. 2012;119:6234-42.
    • (2012) Blood , vol.119 , pp. 6234-6242
    • Kumano, K.1    Arai, S.2    Hosoi, M.3
  • 26
    • 84881286879 scopus 로고    scopus 로고
    • Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia
    • Gandre-Babbe S, Paluru P, Aribeana C, et al. Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia. Blood. 2013;121:4925-9.
    • (2013) Blood , vol.121 , pp. 4925-4929
    • Gandre-Babbe, S.1    Paluru, P.2    Aribeana, C.3
  • 27
    • 84879798872 scopus 로고    scopus 로고
    • An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression
    • Kim J, Hoffman JP, Alpaugh RK, et al. An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression. Cell Rep. 2013;3:2088-99.
    • (2013) Cell Rep , vol.3 , pp. 2088-2099
    • Kim, J.1    Hoffman, J.P.2    Alpaugh, R.K.3
  • 28
    • 84930943281 scopus 로고    scopus 로고
    • Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells
    • Kotini AG, Chang CJ, Boussaad I, et al. Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells. Nat Biotechnol. 2015;33(6):646-55.
    • (2015) Nat Biotechnol , vol.33 , Issue.6 , pp. 646-655
    • Kotini, A.G.1    Chang, C.J.2    Boussaad, I.3
  • 29
    • 84927155547 scopus 로고    scopus 로고
    • Modeling familial cancer with induced pluripotent stem cells
    • Lee DF, Su J, Kim HS, et al. Modeling familial cancer with induced pluripotent stem cells. Cell. 2015;161:240-54.
    • (2015) Cell , vol.161 , pp. 240-254
    • Lee, D.F.1    Su, J.2    Kim, H.S.3
  • 30
    • 84938934272 scopus 로고    scopus 로고
    • Epigenetic reprogramming and re-differentiation of a Ewing sarcoma cell line
    • Moore JB, Loeb DM, Hong KU, et al. Epigenetic reprogramming and re-differentiation of a Ewing sarcoma cell line. Front Cell Dev Biol. 2015;3:15.
    • (2015) Front Cell Dev Biol , vol.3 , pp. 15
    • Moore, J.B.1    Loeb, D.M.2    Hong, K.U.3
  • 31
    • 3543073392 scopus 로고    scopus 로고
    • Reprogramming of a melanoma genome by nuclear transplantation
    • Hochedlinger K, Blelloch R, Brennan C, et al. Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev. 2004;18:1875-85.
    • (2004) Genes Dev , vol.18 , pp. 1875-1885
    • Hochedlinger, K.1    Blelloch, R.2    Brennan, C.3
  • 32
    • 78149478781 scopus 로고    scopus 로고
    • Aberrant epigenetic landscape in cancer: How cellular identity goes awry
    • Berdasco M, Esteller M. Aberrant epigenetic landscape in cancer: how cellular identity goes awry. Dev Cell. 2010;19:698-711.
    • (2010) Dev Cell , vol.19 , pp. 698-711
    • Berdasco, M.1    Esteller, M.2
  • 33
    • 77955777216 scopus 로고    scopus 로고
    • Aberrant epigenetic silencing of tumor suppressor genes is reversed by direct reprogramming
    • Ron-Bigger S, Bar-Nur O, Isaac S, Bocker M, Lyko F, Eden A. Aberrant epigenetic silencing of tumor suppressor genes is reversed by direct reprogramming. Stem Cells. 2010;28:1349-54.
    • (2010) Stem Cells , vol.28 , pp. 1349-1354
    • Ron-Bigger, S.1    Bar-Nur, O.2    Isaac, S.3    Bocker, M.4    Lyko, F.5    Eden, A.6
  • 34
    • 84894109473 scopus 로고    scopus 로고
    • Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation
    • Ohnishi K, Semi K, Yamamoto T, et al. Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Cell. 2014;156:663-77.
    • (2014) Cell , vol.156 , pp. 663-677
    • Ohnishi, K.1    Semi, K.2    Yamamoto, T.3
  • 35
    • 73049104550 scopus 로고    scopus 로고
    • Will iPS cells enhance therapeutic applicability of cord blood cells and banking?
    • Broxmeyer HE. Will iPS cells enhance therapeutic applicability of cord blood cells and banking? Cell Stem Cell. 2010;6:21-24.
    • (2010) Cell Stem Cell , vol.6 , pp. 21-24
    • Broxmeyer, H.E.1
  • 36
    • 84881415310 scopus 로고    scopus 로고
    • Disease modeling and drug screening for neurological diseases using human induced pluripotent stem cells
    • Xu XH, Zhong Z. Disease modeling and drug screening for neurological diseases using human induced pluripotent stem cells. Acta Pharmacol Sin. 2013;34:755-64.
    • (2013) Acta Pharmacol Sin , vol.34 , pp. 755-764
    • Xu, X.H.1    Zhong, Z.2
  • 37
    • 84919764228 scopus 로고    scopus 로고
    • Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells
    • Drawnel FM, Boccardo S, Prummer M, et al. Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells. Cell Rep. 2014;9:810-21.
    • (2014) Cell Rep , vol.9 , pp. 810-821
    • Drawnel, F.M.1    Boccardo, S.2    Prummer, M.3
  • 38
    • 84880026566 scopus 로고    scopus 로고
    • Genome editing of human pluripotent stem cells to generate human cellular disease models
    • Musunuru K. Genome editing of human pluripotent stem cells to generate human cellular disease models. Dis Model Mech. 2013;6:896-904.
    • (2013) Dis Model Mech , vol.6 , pp. 896-904
    • Musunuru, K.1
  • 39
    • 37549030199 scopus 로고    scopus 로고
    • Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin
    • Hanna J, Wernig M, Markoulaki S, et al. Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science. 2007;318:1920-3.
    • (2007) Science , vol.318 , pp. 1920-1923
    • Hanna, J.1    Wernig, M.2    Markoulaki, S.3
  • 40
    • 84885115285 scopus 로고    scopus 로고
    • Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors
    • Doulatov S, Vo LT, Chou SS, et al. Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Cell Stem Cell. 2013;13:459-70.
    • (2013) Cell Stem Cell , vol.13 , pp. 459-470
    • Doulatov, S.1    Vo, L.T.2    Chou, S.S.3
  • 41
    • 84929746565 scopus 로고    scopus 로고
    • Cellular reprogramming allows generation of autologous hematopoietic progenitors from AML patients that are devoid of patient-specific genomic aberrations
    • Salci KR, Lee JH, Laronde S, et al. Cellular reprogramming allows generation of autologous hematopoietic progenitors from AML patients that are devoid of patient-specific genomic aberrations. Stem Cells. 2015;33(6):1839-49.
    • (2015) Stem Cells , vol.33 , Issue.6 , pp. 1839-1849
    • Salci, K.R.1    Lee, J.H.2    Laronde, S.3
  • 42
    • 84900870089 scopus 로고    scopus 로고
    • Induced pluripotent stem cells: Challenges and opportunities for cancer immunotherapy
    • Sachamitr P, Hackett S, Fairchild PJ. Induced pluripotent stem cells: challenges and opportunities for cancer immunotherapy. Front Immunol. 2014;5:176.
    • (2014) Front Immunol , vol.5 , pp. 176
    • Sachamitr, P.1    Hackett, S.2    Fairchild, P.J.3
  • 43
    • 85015639659 scopus 로고    scopus 로고
    • Development of an inducible caspase-9 safety switch for pluripotent stem cell-based therapies
    • Wu C, Hong SG, Winkler T, et al. Development of an inducible caspase-9 safety switch for pluripotent stem cell-based therapies. Mol Ther Methods Clin Dev. 2014;1:14053.
    • (2014) Mol Ther Methods Clin Dev , vol.1
    • Wu, C.1    Hong, S.G.2    Winkler, T.3
  • 44
    • 80052395354 scopus 로고    scopus 로고
    • Safeguarding nonhuman primate iPS cells with suicide genes
    • Zhong B, Watts KL, Gori JL, et al. Safeguarding nonhuman primate iPS cells with suicide genes. Mol Ther. 2011;19:1667-75.
    • (2011) Mol Ther , vol.19 , pp. 1667-1675
    • Zhong, B.1    Watts, K.L.2    Gori, J.L.3
  • 45
    • 84904396621 scopus 로고    scopus 로고
    • Organogenesis in a dish: Modeling development and disease using organoid technologies
    • Lancaster MA, Knoblich JA. Organogenesis in a dish: modeling development and disease using organoid technologies. Science. 2014;345:1247125.
    • (2014) Science , vol.345
    • Lancaster, M.A.1    Knoblich, J.A.2
  • 46
    • 56749175044 scopus 로고    scopus 로고
    • Induction of drug metabolism: Species differences and toxicological relevance
    • Graham MJ, Lake BG. Induction of drug metabolism: species differences and toxicological relevance. Toxicology. 2008;254:184-91.
    • (2008) Toxicology , vol.254 , pp. 184-191
    • Graham, M.J.1    Lake, B.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.