Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells

Leukemia

Volumn 28, Issue 5, 2014, Pages 1071-1080

  Liu, Y ^a   Cheng, H ^a   Gao, S ^b,b   Lu, X ^c,d   He, F ^c   Hu, L ^a   Hou, D ^a   Zou, Z ^c,d   Li, Y ^a   Zhang, H ^a   Xu, J ^a   Kang, L ^b   Wang, Q ^c   Yuan, W ^a   Cheng, T ^a  

^a INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

^b NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

^c Chinese Academy of Sciences and China National Center for Bioinformation   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

iPS cells; MLL AF9; primary leukemia cells; reprogramming

Indexed keywords

DOXYCYCLINE;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CHIMERA; CONTROLLED STUDY; EMBRYONIC STEM CELL; FLUORESCENCE ACTIVATED CELL SORTING; FUSION GENE; GENE ACTIVATION; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL; LEUKEMOGENESIS; LEUKOCYTE COUNT; MLL AF9 GENE; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; ONCOGENE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SPLENOMEGALY; TERATOMA;

CELL DIFFERENTIATION; GENE SILENCING; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LEUKEMIA; MYELOID-LYMPHOID LEUKEMIA PROTEIN; PLURIPOTENT STEM CELLS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTOME;

EID: 84899930229     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.304     Document Type: Article

References (37)

1. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-676.
2. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K. et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131: 861-872.
3. Daley GQ. Common themes of dedifferentiation in somatic cell reprogramming and cancer. Cold Spring Harb Symp Quant Biol 2008; 73: 171-174.
4. Hochedlinger K, Yamada Y, Beard C, Jaenisch R. Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell 2005; 121: 465-477.
5. Chen Y, Shi L, Zhang L, Li R, Liang J, Yu W. et al. The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. J Biol Chem 2008; 283: 17969-17978.
6. Wang J, Xie LY, Allan S, Beach D, Hannon GJ. Myc activates telomerase. Genes Dev 1998; 12: 1769-1774.
7. Wei D, Kanai M, Huang S, Xie K. Emerging role of KLF4 in human gastrointestinal cancer. Carcinogenesis 2006; 27: 23-31.
8. Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M. et al. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 2009; 460: 1132-1135.
9. Kawamura T, Suzuki J, Wang YV, Menendez S, Morera LB, Raya A. et al. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 2009; 460: 1140-1144.
10. Tapia N, Scholer HR. p53 connects tumorigenesis and reprogramming to pluripotency. J Exp Med 2010; 207: 2045-2048.
11. Mintz B, Illmensee K. Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc Natl Acad Sci USA 1975; 72: 3585-3589.
12. Blelloch RH, Hochedlinger K, Yamada Y, Brennan C, Kim M, Mintz B. et al. Nuclear cloning of embryonal carcinoma cells. Proc Natl Acad Sci USA 2004; 101: 13985-13990.
13. Hochedlinger K, Blelloch R, Brennan C, Yamada Y, Kim M, Chin L. et al. Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev 2004; 18: 1875-1885.
14. Carette JE, Pruszak J, Varadarajan M, Blomen VA, Gokhale S, Camargo FD. et al. Generation of iPSCs from cultured human malignant cells. Blood 2010; 115: 4039-4042.
15. Miyoshi N, Ishii H, Nagai K, Hoshino H, Mimori K, Tanaka F. et al. Defined factors induce reprogramming of gastrointestinal cancer cells. Proc Natl Acad Sci USA 2010; 107: 40-45.
16. Kumano K, Arai S, Hosoi M, Taoka K, Takayama N, Otsu M. et al. Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples. Blood 2012; 119: 6234-6242.
17. Hu K, Yu J, Suknuntha K, Tian S, Montgomery K, Choi KD. et al. Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells. Blood 2011; 117: E109-e119.
18. Liu H, Takeda S, Kumar R, Westergard TD, Brown EJ, Pandita TK. et al. Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint. Nature 2010; 467: 343-346.
19. Brambrink T, Foreman R, Welstead GG, Lengner CJ, Wernig M, Suh H. et al. Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell 2008; 2: 151-159.
20. Kang L, Wang J, Zhang Y, Kou Z, Gao S. iPS cells can support full-Term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell 2009; 5: 135-138.
21. Li Y, Liu Y, He J, Wang F, Liu S, Zhang Y. et al. Long-Term survival of exogenous embryonic stem cells in adult bone marrow. Cell Res 2011; 21: 1148-1151.
22. Trapnell C, Williams BA, Pertea G, Mortazavi A, Kwan G, van Baren MJ. et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol 2010; 28: 511-515.
23. Huang da W, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 2009; 37: 1-13.
24. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA. et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005; 102: 15545-15550.
25. Ross ME, Mahfouz R, Onciu M, Liu HC, Zhou X, Song G. et al. Gene expression profiling of pediatric acute myelogenous leukemia. Blood 2004; 104: 3679-3687.
26. Li Z, Huang H, Chen P, He M, Li Y, Arnovitz S. et al. miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia. Nat Commun 2012; 3: 688.
27. Stubbs MC, Kim YM, Krivtsov AV, Wright RD, Feng Z, Agarwal J. et al. MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: Development of a model for rapid therapeutic assessment. Leukemia 2008; 22: 66-77.
28. Somervaille TC, Cleary ML. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell 2006; 10: 257-268.
29. Jahner D, Stuhlmann H, Stewart CL, Harbers K, Lohler J, Simon I. et al. De novo methylation and expression of retroviral genomes during mouse embryogenesis. Nature 1982; 298: 623-628.
30. Challita PM, Kohn DB. Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo. Proc Natl Acad Sci USA 1994; 91: 2567-2571.
31. Yoder JA, Walsh CP, Bestor TH. Cytosine methylation and the ecology of intragenomic parasites. Trends Genet 1997; 13: 335-340.
32. Stadtfeld M, Maherali N, Breault DT, Hochedlinger K. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell 2008; 2: 230-240.
33. Wolf D, Goff SP. TRIM28 mediates primer binding site-Targeted silencing of murine leukemia virus in embryonic cells. Cell 2007; 131: 46-57.
34. Rowe HM, Jakobsson J, Mesnard D, Rougemont J, Reynard S, Aktas T. et al. KAP1 controls endogenous retroviruses in embryonic stem cells. Nature 2010; 463: 237-240.
35. Krivtsov AV, Armstrong SA. MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer 2007; 7: 823-833.
36. Illmensee K, Mintz B. Totipotency and normal differentiation of single teratocarcinoma cells cloned by injection into blastocysts. Proc Natl Acad Sci USA 1976; 73: 549-553.
37. Bernt KM, Armstrong SA. Targeting epigenetic programs in MLL-rearranged leukemias. Hematology Am Soc Hematol Educ Program 2011; 2011: 354-360.