메뉴 건너뛰기




Volumn 10, Issue 9, 2015, Pages 937-944

Academic drug discovery: Current status and prospects

Author keywords

academic; drug discovery; high throughput screening; molecular probes; pan assay interference compounds

Indexed keywords

ACADEMIC ACHIEVEMENT; BIOINFORMATICS; DRUG DEVELOPMENT; DRUG INDUSTRY; EXPERIENCE; FUTUROLOGY; HIGH THROUGHPUT SCREENING; HUMAN; MOLECULAR PROBE; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; REVIEW; COOPERATION; DRUG DESIGN; ORGANIZATION AND MANAGEMENT; UNIVERSITY;

EID: 84938910122     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.2015.1059816     Document Type: Review
Times cited : (38)

References (56)
  • 1
    • 84947024020 scopus 로고    scopus 로고
    • New drug discovery: Extraordinary opportunities in an uncertain time
    • Kinch MS, Flath R. New drug discovery: extraordinary opportunities in an uncertain time. Drug Discov Today 2014. 10.1016/j.drudis.2014.12
    • (2014) Drug Discov Today
    • Kinch, M.S.1    Flath, R.2
  • 2
    • 84927172971 scopus 로고    scopus 로고
    • 2014 fda drug approvals
    • Mullard A. 2014 fda drug approvals. Nat Rev Drug Discov 2015; 14 (2): 77-81
    • (2015) Nat Rev Drug Discov , vol.14 , Issue.2 , pp. 77-81
    • Mullard, A.1
  • 3
    • 79960982560 scopus 로고    scopus 로고
    • The impact of mergers on pharmaceutical RandD
    • LaMattina JL. The impact of mergers on pharmaceutical RandD. Nature Reviews Drug Discovery 2011; 10 (8): 559-60
    • (2011) Nature Reviews Drug Discovery , vol.10 , Issue.8 , pp. 559-560
    • LaMattina, J.L.1
  • 4
    • 84872253177 scopus 로고    scopus 로고
    • Mergers and innovation in the pharmaceutical industry
    • Comanor WS, Scherer FM. Mergers and innovation in the pharmaceutical industry. J Health Econ 2013; 32 (1): 106-13
    • (2013) J Health Econ , vol.32 , Issue.1 , pp. 106-113
    • Comanor, W.S.1    Scherer, F.M.2
  • 5
    • 77649234756 scopus 로고    scopus 로고
    • How to improve randd productivity: The pharmaceutical industrys grand challenge
    • Paul SM, Mytelka DS, Dunwiddie CT, et al. How to improve randd productivity: The pharmaceutical industrys grand challenge. Nat Rev Drug Discov 2010; 9 (3): 203-14
    • (2010) Nat Rev Drug Discov , vol.9 , Issue.3 , pp. 203-214
    • Paul, S.M.1    Mytelka, D.S.2    Dunwiddie, C.T.3
  • 6
    • 84860690620 scopus 로고    scopus 로고
    • Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving phase II survival
    • Morgan P, Van der Graaf PH, Arrowsmith J, et al. Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving phase ii survival. Drug Discov Today 2012; 17 (9-10): 419-24
    • (2012) Drug Discov Today , vol.17 , Issue.910 , pp. 419-424
    • Morgan, P.1    Van Der Graaf, P.H.2    Arrowsmith, J.3
  • 7
    • 80053999955 scopus 로고    scopus 로고
    • Phase II failures: 2008-2010
    • Arrowsmith J. Phase II failures: 2008-2010. Nat Rev Drug Discov 2011; 10 (5): 1
    • (2011) Nat Rev Drug Discov , vol.10 , Issue.5 , pp. 1
    • Arrowsmith, J.1
  • 8
    • 84888022790 scopus 로고    scopus 로고
    • Big pharma, little science? A bibliometric perspective on big pharmas randd decline
    • Rafols I, Hopkins MM, Hoekman J, et al. Big pharma, little science? A bibliometric perspective on big pharmas randd decline. Technol Forecast Soc Change 2014; 81: 22-38
    • (2014) Technol Forecast Soc Change , vol.81 , pp. 22-38
    • Rafols, I.1    Hopkins, M.M.2    Hoekman, J.3
  • 9
    • 84908480931 scopus 로고    scopus 로고
    • The role of public-private partnerships in addressing the biomedical innovation challenge
    • Said M, Zerhouni E. The role of public-private partnerships in addressing the biomedical innovation challenge. Nature Reviews Drug Discovery 2014; 13 (11): 789-90
    • (2014) Nature Reviews Drug Discovery , vol.13 , Issue.11 , pp. 789-790
    • Said, M.1    Zerhouni, E.2
  • 10
    • 84857237851 scopus 로고    scopus 로고
    • The innovative medicines initiative: A european response to the innovation challenge
    • Goldman M. The innovative medicines initiative: A european response to the innovation challenge. Clin Pharmacol Ther 2012; 91 (3): 418-25
    • (2012) Clin Pharmacol Ther , vol.91 , Issue.3 , pp. 418-425
    • Goldman, M.1
  • 11
    • 0142146222 scopus 로고
    • Early years of the penicillin discovery
    • Chain E. Early years of the penicillin discovery. Trends Pharmacol Sci 1979; 1 (1): 6-11
    • (1979) Trends Pharmacol Sci , vol.1 , Issue.1 , pp. 6-11
    • Chain, E.1
  • 12
    • 0025796673 scopus 로고
    • Early discoveries in the penicillin series
    • Nayler JHC. Early discoveries in the penicillin series. Trends Biochem Sci 1991; 16 (5): 195-7
    • (1991) Trends Biochem Sci , vol.16 , Issue.5 , pp. 195-197
    • Nayler, J.H.C.1
  • 13
    • 0015247310 scopus 로고
    • Structure-activity relationships in semi-synthetic penicillins
    • Nayler JHC. Structure-activity relationships in semi-synthetic penicillins. Proc R Soc Lond B Biol Sci 1971; 179 (1057): 357-67
    • (1971) Proc R Soc Lond B Biol Sci , vol.179 , Issue.1057 , pp. 357-367
    • Nayler, J.H.C.1
  • 14
    • 77956796338 scopus 로고    scopus 로고
    • Drug discovery in academia: The third way?
    • Frearson J, Wyatt P. Drug discovery in academia: The third way? Expert Opin Drug Discov 2010; 5 (10): 909-19
    • (2010) Expert Opin Drug Discov , vol.5 , Issue.10 , pp. 909-919
    • Frearson, J.1    Wyatt, P.2
  • 15
    • 79851477450 scopus 로고    scopus 로고
    • The role of public-sector research in the discovery of drugs and vaccines
    • Stevens AJ, Jensen JJ, Wyller K, et al. The role of public-sector research in the discovery of drugs and vaccines. N Engl J Med 2011; 364 (6): 535-41
    • (2011) N Engl J Med , vol.364 , Issue.6 , pp. 535-541
    • Stevens, A.J.1    Jensen, J.J.2    Wyller, K.3
  • 17
    • 84887076597 scopus 로고    scopus 로고
    • Bringing together the academic drug discovery community
    • Slusher BS, Conn PJ, Frye S, et al. Bringing together the academic drug discovery community. Nat Rev Drug Discov 2013; 12 (11): 811-12
    • (2013) Nat Rev Drug Discov , vol.12 , Issue.11 , pp. 811-812
    • Slusher, B.S.1    Conn, P.J.2    Frye, S.3
  • 18
    • 84938918928 scopus 로고    scopus 로고
    • Last accessed 2 June 2015
    • Academic drug discovery consortium (ad2c). 2015. Available from: http://addconsortium.Org/index.Php. [Last accessed 2 June 2015]
    • (2015) Academic Drug Discovery Consortium (ad2c)
  • 20
    • 84885003207 scopus 로고    scopus 로고
    • Contributions of academic laboratories to the discovery and development of chemical biology tools
    • Huryn DM, Resnick LO, Wipf P. Contributions of academic laboratories to the discovery and development of chemical biology tools. J Med Chem 2013; 56 (18): 7161-76
    • (2013) J Med Chem , vol.56 , Issue.18 , pp. 7161-7176
    • Huryn, D.M.1    Resnick, L.O.2    Wipf, P.3
  • 21
    • 84875166951 scopus 로고    scopus 로고
    • European lead factory opens for business
    • Mullard A. European lead factory opens for business. Nat Rev Drug Discov 2013; 12 (3): 173-5
    • (2013) Nat Rev Drug Discov , vol.12 , Issue.3 , pp. 173-175
    • Mullard, A.1
  • 22
    • 84922917237 scopus 로고    scopus 로고
    • The joint european compound library: Boosting precompetitive research
    • Besnard J, Jones PS, Hopkins AL, Pannifer AD. The joint european compound library: Boosting precompetitive research. Drug discov today 2015; 20 (2): 181-6
    • (2015) Drug Discov Today , vol.20 , Issue.2 , pp. 181-186
    • Besnard, J.1    Jones, P.S.2    Hopkins, A.L.3    Pannifer, A.D.4
  • 24
    • 84899120561 scopus 로고    scopus 로고
    • Eu-openscreen -a european infrastructure of open screening platforms for chemical biology
    • Frank R. Eu-openscreen-a european infrastructure of open screening platforms for chemical biology. ACS Chem Biol 2014; 9 (4): 853-4
    • (2014) ACS Chem Biol , vol.9 , Issue.4 , pp. 853-854
    • Frank, R.1
  • 26
    • 84910630218 scopus 로고    scopus 로고
    • Academic drug discovery centres: The economic and organisational sustainability of an emerging model
    • Schultz Kirkegaard H, Valentin F. Academic drug discovery centres: The economic and organisational sustainability of an emerging model. Drug discov today 2014; 19 (11): 1699-710
    • (2014) Drug Discov Today , vol.19 , Issue.11 , pp. 1699-1710
    • Schultz Kirkegaard, H.1    Valentin, F.2
  • 27
    • 84899010611 scopus 로고    scopus 로고
    • The current status of non-biopharma drug discovery
    • Comley J. The current status of non-biopharma drug discovery. Drug Discovery World 2014; 62-9
    • (2014) Drug Discovery World , pp. 62-69
    • Comley, J.1
  • 28
    • 84869486398 scopus 로고    scopus 로고
    • Challenges for academic drug discovery
    • Jorgensen WL. Challenges for academic drug discovery. Angew Chem Int Ed Engl 2012; 51 (47): 11680-4
    • (2012) Angew Chem Int Ed Engl , vol.51 , Issue.47 , pp. 11680-11684
    • Jorgensen, W.L.1
  • 29
    • 84875178774 scopus 로고    scopus 로고
    • Drug discovery in an academic setting: Playing to the strengths
    • Huryn DM. Drug discovery in an academic setting: Playing to the strengths. ACS Med Chem Lett 2013; 4 (3): 313-15
    • (2013) ACS Med Chem Lett , vol.4 , Issue.3 , pp. 313-315
    • Huryn, D.M.1
  • 30
    • 84926291678 scopus 로고    scopus 로고
    • Mitigating risk in academic preclinical drug discovery
    • Dahlin JL, Inglese J, Walters MA. Mitigating risk in academic preclinical drug discovery. Nat Rev Drug Discov 2015; 14: 279-94
    • (2015) Nat Rev Drug Discov , vol.14 , pp. 279-294
    • Dahlin, J.L.1    Inglese, J.2    Walters, M.A.3
  • 31
    • 77958044565 scopus 로고    scopus 로고
    • Observations on screening-based research and some concerning trends in the literature
    • Baell JB. Observations on screening-based research and some concerning trends in the literature. Future Med Chem 2010; 2 (10): 1529-46
    • (2010) Future Med Chem , vol.2 , Issue.10 , pp. 1529-1546
    • Baell, J.B.1
  • 32
    • 84908530414 scopus 로고    scopus 로고
    • Chemical con artists foil drug discovery
    • Baell J, Walters MA. Chemical con artists foil drug discovery. Nature 2014; 513 (7519): 481-3
    • (2014) Nature , vol.513 , Issue.7519 , pp. 481-483
    • Baell, J.1    Walters, M.A.2
  • 33
    • 84880699803 scopus 로고    scopus 로고
    • Plate-based diversity subset screening: An efficient paradigm for high throughput screening of a large screening file
    • Bell AS, Bradley J, Everett JR, et al. Plate-based diversity subset screening: An efficient paradigm for high throughput screening of a large screening file. Mol Divers 2013; 17 (2): 319-35
    • (2013) Mol Divers , vol.17 , Issue.2 , pp. 319-335
    • Bell, A.S.1    Bradley, J.2    Everett, J.R.3
  • 34
    • 33645665186 scopus 로고    scopus 로고
    • Synergy and antagonism of promiscuous inhibition in multiple-compound mixtures
    • Feng BY, Shoichet BK. Synergy and antagonism of promiscuous inhibition in multiple-compound mixtures. J Med Chem 2006; 49 (7): 2151-4
    • (2006) J Med Chem , vol.49 , Issue.7 , pp. 2151-2154
    • Feng, B.Y.1    Shoichet, B.K.2
  • 35
    • 84870040454 scopus 로고    scopus 로고
    • Shaping a screening file for maximal. Lead discovery efficiency and effectiveness: Elimination of molecular redundancy
    • Bakken GA, Bell AS, Boehm M, et al. Shaping a screening file for maximal. Lead discovery efficiency and effectiveness: Elimination of molecular redundancy. J Chem Inf Model 2012; 52 (11): 2937-49
    • (2012) J Chem Inf Model , vol.52 , Issue.11 , pp. 2937-2949
    • Bakken, G.A.1    Bell, A.S.2    Boehm, M.3
  • 36
    • 77950571108 scopus 로고    scopus 로고
    • New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays
    • Baell JB, Holloway GA. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. J Med Chem 2010; 53 (7): 2719-40
    • (2010) J Med Chem , vol.53 , Issue.7 , pp. 2719-2740
    • Baell, J.B.1    Holloway, G.A.2
  • 37
    • 79958701058 scopus 로고    scopus 로고
    • Growing pains in academic drug discovery
    • Whitty A. Growing pains in academic drug discovery. Future Med Chem 2011; 3 (7): 797-801
    • (2011) Future Med Chem , vol.3 , Issue.7 , pp. 797-801
    • Whitty, A.1
  • 38
    • 33645366993 scopus 로고    scopus 로고
    • Defining and maintaining a high quality screening collection: The GSK experience
    • Lane SJ, Eggleston DS, Brinded KA, et al. Defining and maintaining a high quality screening collection: The GSK experience. Drug Discov Today 2006; 11 (5-6): 267-72
    • (2006) Drug Discov Today , vol.11 , Issue.56 , pp. 267-272
    • Lane, S.J.1    Eggleston, D.S.2    Brinded, K.A.3
  • 39
    • 84861016686 scopus 로고    scopus 로고
    • Discovery of selective small molecule romk inhibitors as potential new mechanism diuretics
    • Tang H, Walsh SP, Yan Y, et al. Discovery of selective small molecule romk inhibitors as potential new mechanism diuretics. ACS Med Chem Lett 2012; 3 (5): 367-72
    • (2012) ACS Med Chem Lett , vol.3 , Issue.5 , pp. 367-372
    • Tang, H.1    Walsh, S.P.2    Yan, Y.3
  • 40
    • 84903273093 scopus 로고    scopus 로고
    • Pharmacophore reassignment for induction of the immunosurveillance cytokine trail
    • Jacob NT, Lockner JW, Kravchenko VV, Janda KD. Pharmacophore reassignment for induction of the immunosurveillance cytokine trail. Angew Chem Int Ed Engl 2014; 53 (26): 6628-31
    • (2014) Angew Chem Int Ed Engl , vol.53 , Issue.26 , pp. 6628-6631
    • Jacob, N.T.1    Lockner, J.W.2    Kravchenko, V.V.3    Janda, K.D.4
  • 42
    • 84938936789 scopus 로고    scopus 로고
    • Last accessed 3 June 2015
    • Molecular libraries program. 2007. Available from: http://www.Mli.Nih.Gov/mli/. [Last accessed 3 June 2015]
    • (2007) Molecular Libraries Program
  • 43
    • 84921436071 scopus 로고    scopus 로고
    • Diagnostic effectiveness of quantitative 18F flutemetamol pet imaging for detection of fibrillar amyloid beta using cortical biopsy histopathology as the standard of truth in subjects with idiopathic normal pressure hydrocephalus
    • Leinonen V, Rinne JO, Wong DF, et al. Diagnostic effectiveness of quantitative 18F flutemetamol pet imaging for detection of fibrillar amyloid beta using cortical biopsy histopathology as the standard of truth in subjects with idiopathic normal pressure hydrocephalus. Acta neuropathol commun 2014; 2: 46
    • (2014) Acta Neuropathol Commun , vol.2 , pp. 46
    • Leinonen, V.1    Rinne, J.O.2    Wong, D.F.3
  • 44
    • 84938909161 scopus 로고    scopus 로고
    • Last accessed 3 June 2015
    • Rpc1063 for rms. 2015. Available from: http://receptos.Com/clinical-pipeline/rpc1063-for-rms/. [Last accessed 3 June 2015]
    • (2015) Rpc1063 for Rms
  • 45
    • 67650308267 scopus 로고    scopus 로고
    • A crowdsourcing evaluation of the NIH chemical probes
    • Oprea TI, Bologa CG, Boyer S, et al. A crowdsourcing evaluation of the NIH chemical probes. Nat Chem Biol 2009; 5 (7): 441-7
    • (2009) Nat Chem Biol , vol.5 , Issue.7 , pp. 441-447
    • Oprea, T.I.1    Bologa, C.G.2    Boyer, S.3
  • 47
    • 33746584053 scopus 로고    scopus 로고
    • Sildenafil: From angina to erectile dysfunction to pulmonary hypertension and beyond
    • Ghofrani HA, Osterloh IH, Grimminger F. Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat Rev Drug Discov 2006; 5 (8): 689-702
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.8 , pp. 689-702
    • Ghofrani, H.A.1    Osterloh, I.H.2    Grimminger, F.3
  • 49
    • 84873732994 scopus 로고    scopus 로고
    • Drug repurposing gets a boost as academic researchers join the search for novel uses of existing drugs
    • Nair P. Drug repurposing gets a boost as academic researchers join the search for novel uses of existing drugs. Proc Natl Acad Sci USA 2013; 110 (7): 2430-2
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.7 , pp. 2430-2432
    • Nair, P.1
  • 50
    • 84930042702 scopus 로고    scopus 로고
    • Fyn inhibition rescues established memory and synapse loss in Alzheimer mice
    • Kaufman AC, Salazar SVH, Laura T, et al. Fyn inhibition rescues established memory and synapse loss in alzheimer mice. Ann Neurol 2015; 77 (6): 953-71
    • (2015) Ann Neurol , vol.77 , Issue.6 , pp. 953-971
    • Kaufman, A.C.1    Salazar, S.V.H.2    Laura, T.3
  • 52
    • 84865468939 scopus 로고    scopus 로고
    • Systems drug discovery: A quantitative, objective approach for safer drug development
    • Bickle M. Systems drug discovery: A quantitative, objective approach for safer drug development. Expert Opin Drug Discov 2012; 7 (9): 757-9
    • (2012) Expert Opin Drug Discov , vol.7 , Issue.9 , pp. 757-759
    • Bickle, M.1
  • 53
    • 0034368580 scopus 로고    scopus 로고
    • Metabonomics: Metabolic processes studied by NMR spectroscopy of biofluids
    • Lindon J, Nicholson J, Holmes E, Everett J. Metabonomics: Metabolic processes studied by NMR spectroscopy of biofluids. Concepts Magn Reson 2000; 12 (5): 289-320
    • (2000) Concepts Magn Reson , vol.12 , Issue.5 , pp. 289-320
    • Lindon, J.1    Nicholson, J.2    Holmes, E.3    Everett, J.4
  • 55
    • 84891762026 scopus 로고    scopus 로고
    • The ChEMBL bioactivity database: An update
    • Bento AP, Gaulton A, Hersey A, et al. The ChEMBL bioactivity database: An update. Nucleic Acids Res 2014; 42 (D1): D1083-90
    • (2014) Nucleic Acids Res , vol.42 , Issue.D1 , pp. 1083-1090
    • Bento, A.P.1    Gaulton, A.2    Hersey, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.