Anti-amnesic activity of Citrus aurantium flowers extract against scopolamine-induced memory impairments in rats

Neurological Sciences

Volumn 36, Issue 4, 2015, Pages 553-560

  Rahnama, Samira ^a   Rabiei, Zahra ^a   Alibabaei, Zahra ^a   Mokhtari, Shiva ^a   Rafieian kopaei, Mahmoud ^a   Deris, Fatemeh ^a  

^a SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Alzheimer s disease; Citrus aurantium; MDA; Memory impairment; Scopolamine; Shuttlebox

Indexed keywords

ACETYLCHOLINESTERASE; ANTIOXIDANT; CHOLINERGIC RECEPTOR BLOCKING AGENT; FERRIC ION; MALONALDEHYDE; PLANT EXTRACT; SCOPOLAMINE BROMIDE;

ANALYSIS OF VARIANCE; ANIMAL; AVOIDANCE BEHAVIOR; BLOOD; BRAIN; CHEMICALLY INDUCED; CHEMISTRY; CITRUS; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; FLOWER; MALE; MEMORY DISORDERS; METABOLISM; PATHOLOGY; RAT; REACTION TIME; SPATIAL LEARNING;

ACETYLCHOLINESTERASE; ANALYSIS OF VARIANCE; ANIMALS; ANTIOXIDANTS; AVOIDANCE LEARNING; BRAIN; CHOLINERGIC ANTAGONISTS; CITRUS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FERRIC COMPOUNDS; FLOWERS; MALE; MALONDIALDEHYDE; MEMORY DISORDERS; PLANT EXTRACTS; RATS; REACTION TIME; SCOPOLAMINE HYDROBROMIDE; SPATIAL LEARNING;

EID: 84938893629     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-014-1991-2     Document Type: Article

References (23)

1. Parihar MS, Hemnani T (2004) Alzheimer’s disease pathogenesis and therapeutic interventions. J Clin Neurosci 11(5):456–467
2. Nie K, Yu J-C, Fu Y, Cheng H-Y, Chen F-Y, Qu Y et al (2009) Age-related decrease in constructive activation of Akt/PKB in SAMP10 hippocampus. Biochem Biophys Res 378(1):103–107
3. Small G, Bullock R (2011) Defining optimal treatment with cholinesterase inhibitors in Alzheimer’s disease. Alzheimers Dement 7(2):177–184
4. Rezvani AH, Cauley M, Sexton H, Xiao Y, Brown ML, Paige MA et al (2011) Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats. Psychopharmacology 215(4):621–630
5. Hashimoto M, Hashimoto T, Kuriyama K (1991) Protective effect of WEB 1881 FU on AF64A (ethylcholine aziridinium ion)-induced impairment of hippocampal cholinergic neurons and learning acquisition. Eur J Pharmacol 209(1):9–14
6. Kvaltinova Z, Juranek I, Machova J, Stolc S (1993) Effect of oxidative stress on (3H) N-methylscopolamine binding and production of thiobarbituric acid reactive substances in rat cerebral cortex membranes. Gen Physiol Biophys 12:155–164
7. Vasco VRL (2012) Phosphoinositide pathway and the signal transduction network in neural development. J Neurosci Res 28(6):789–800
8. Floyd RA, Hensley K (2002) Oxidative stress in brain aging: implications for therapeutics of neurodegenerative diseases. Neurobiol Aging 23(5):795–807
9. Zhang Z-J (2004) Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders. Life Sci 75(14):1659–1699
10. Akhlaghi M, Shabanian G, Rafieian-Kopaei M, Parvin N, Saadat M, Akhlaghi M (2011) Citrus aurantium blossom and preoperative anxiety. Rev Bras Anestesiol 61(6):702–712
11. Pereira R, Andrades N, Paulino N, Sawaya A, Eberlin M, Marcucci M et al (2011) Synthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicity. Molecules 12(7):1352–1366
12. Tundis R, Loizzo MR, Bonesi M, Menichini F, Mastellone V, Colica C et al (2012) Comparative study on the antioxidant capacity and cholinesterase inhibitory activity of Citrus aurantifolia swingle, C. aurantium L., and C. bergamia Risso and Poit. Peel essential oils. J Food Sci 77(1):40–46
13. Jazayeri B, Amanlou A, Ghanadian N, Pasalar P, Amanlou M (2014) A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine. DARU J PharmSci 22:17
14. Rabiei Z, Rafieian-kopaei M, Heidarian E, Saghaei E, Mokhtari S (2013) Effects of Zizyphus jujube extract on memory and learning impairment induced by bilateral electric lesions of the nucleus basalis of meynert in rat. Neurochem Res 36:1–8
15. Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11(1):47–60
16. Ellman GL, Courtney KD, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharm 7(2):88–95
17. Ballard CG, Greig NH, Guillozet-Bongaarts AL, Enz A, Darvesh S (2005) Cholinesterases: roles in the brain during health and disease. Curr Alzheimer Res 2(3):307–318
18. Yamada N, Hattori A, Hayashi T, Nishikawa T, Fukuda H, Fujino T (2004) Improvement of scopolamine-induced memory impairment by Z-ajoene in the water maze in mice. Pharmacol Biochem Behav 78:787–791
19. Lorenzini CA, Baldi E, Bucherelli C, Sacchetti B, Tassoni G (1996) Role of dorsal hippocampus in acquisition, consolidation and retrieval of rat’s passive avoidance response: a tetrodotoxin functional inactivation study. Brain Res 730(1–2):32–39
20. Nakajima A, Yamakuni T, Matsuzaki K, Nakata N, Onozuka H, Yokosuka A et al (2007) Nobiletin, a citrus flavonoid, reverses learning impairment associated with N-methyl-D-aspartate receptor antagonism by activation of extracellular signal-regulated kinase signaling. J Pharm Exp Ther 321(2):784–790
21. Pereira R, Andrades N, Paulino N, Sawaya A, Eberlin M, Marcucci M et al (2007) Synthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicity. Molecules 12(7):1352–1366
22. Carvalho-Freitas MIR, Costa M (2002) Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L. Biol Pharm Bull 25(12):1629–1633
23. A receptors modulate acetylcholine release in feline basal forebrain. Eur J Neurosci 17:249–259