Phosphoinositide pathway and the signal transduction network in neural development

Neuroscience Bulletin

Volumn 28, Issue 6, 2012, Pages 789-800

  Lo Vasco, Vincenza Rita ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Calcium release; CNS development; Phospholipase C

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CADHERIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CELL ADHESION MOLECULE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EPIDERMAL GROWTH FACTOR; HOMOCYSTEINE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; INTEGRIN; METABOTROPIC RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MUSCARINIC RECEPTOR; NERVE CELL ADHESION MOLECULE; PAPAVERINE; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C; PLATELET DERIVED GROWTH FACTOR; SEROTONIN; TENASCIN; PHOSPHATIDYLINOSITOL;

APOPTOSIS; CELL CYCLE REGULATION; CELL GROWTH; CYTOSKELETON; ENZYME STRUCTURE; HORMONE RELEASE; HUMAN; LIPID METABOLISM; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; ANIMAL; CALCIUM SIGNALING; DRUG EFFECT; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; NERVOUS SYSTEM; PHYSIOLOGY;

ANIMALS; CALCIUM SIGNALING; HUMANS; NERVOUS SYSTEM; NEURAL STEM CELLS; NEUROGENESIS; PHOSPHATIDYLINOSITOLS; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; TYPE C PHOSPHOLIPASES;

EID: 84904528751     PISSN: 16737067     EISSN: 19958218     Source Type: Journal    
DOI: 10.1007/s12264-012-1283-x     Document Type: Review

References (107)

1. Annunziato L, Amoroso S, Pannaccione A, Cataldi M, Pignataro G, D'Alessio A, et al. Apoptosis induced in neuronal cells by oxidative stress: role played by caspases and intracellular calcium ions. Toxicol Lett 2003, 139: 125-133.
2. Kiryushko D, Novitskaya V, Soroka V, Klingelhofer J, Lukanidin E, Berezin V, et al. Molecular mechanisms of Ca(2+) signaling in neurons induced by the S100A4 protein. Mol Cell Biol 2006, 26: 3625-3638.
3. Frebel K, Wiese S. Signalling molecules essential for neuronal survival and differentiation. Biochem Soc Trans 2006, 34: 1287-1290.
4. Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, et al. Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep 2008, 41: 415-434.
5. Schmid RS, Pruitt WM, Maness PF. A MAP kinase-signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis. J Neurosci 2000, 20: 4177-4188.
6. Ledeen RW, Wu G. Nuclear lipids: key signaling effectors in the nervous system and other tissues. J Lipid Res 2004, 45: 1-8.
7. Comer FI, Parent CA. Phosphoinositides specify polarity during epithelial organ development. Cell 2007, 128: 239-240.
8. Hokin MR, Hokin LE. Enzyme secretion and the incorporation of P32 into phospholipides of pancreas slices. J Biol Chem 1953, 203: 967-977.
9. Berridge MJ, Irvine RF. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 1984, 312: 315-321.
10. Noh DY, Shin SH, Rhee SG. Phosphoinositide-specific phospholipase C and mitogenic signaling. Biochim Biophys Acta 1995, 1242: 99-113.
11. Bunney TD, Katan M. PLC regulation: emerging pictures for molecular mechanisms. Trends Biochem Sci 2011, 36: 88-96.
12. Tang CH, Yang RS, Fu WM. Prostaglandin E2 stimulates fibronectin expression through EP1 receptor, phospholipase C, protein kinase Calpha, and c-Src pathway in primary cultured rat osteoblasts. J Biol Chem 2005, 280: 22907-22916.
13. Hisatsune C, Nakamura K, Kuroda Y, Nakamura T, Mikoshiba K. Amplification of Ca2+ signaling by diacylglycerol-mediated inositol 1, 4, 5-trisphosphate production. J Biol Chem 2005, 280: 11723-11730.
14. Katan M. New insights into the families of PLC enzymes: looking back and going forward. Biochem J 2005, 391: e7-9.
15. Cockcroft S, Thomas GM. Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors. Biochem J 1992, 288 (Pt 1): 1-14.
16. Irino Y, Cho H, Nakamura Y, Nakahara M, Furutani M, Suh PG, et al. Phospholipase C delta-type consists of three isozymes: bovine PLCdelta2 is a homologue of human/mouse PLCdelta4. Biochem Biophys Res Commun 2004, 320: 537-543.
17. Stewart AJ, Mukherjee J, Roberts SJ, Lester D, Farquharson C. Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes. Int J Mol Med 2005, 15: 117-121.
18. Suh BC, Hille B. Regulation of ion channels by phosphatidylinositol 4, 5-bisphosphate. Curr Opin Neurobiol 2005, 15: 370-378.
19. Exton JH. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 1996, 36: 481-509.
20. Gratacap MP, Payrastre B, Viala C, Mauco G, Plantavid M, Chap H. Phosphatidylinositol 3, 4, 5-trisphosphate-dependent stimulation of phospholipase C-gamma2 is an early key event in FcgammaRIIAmediated activation of human platelets. J Biol Chem 1998, 273: 24314-24321.
21. Mizuguchi M, Yamada M, Kim SU, Rhee SG. Phospholipase C isozymes in neurons and glial cells in culture: an immunocytochemical and immunochemical study. Brain Res 1991, 548: 35-40.
22. Adamski FM, Timms KM, Shieh BH. A unique isoform of phospholipase Cbeta4 highly expressed in the cerebellum and eye. Biochim Biophys Acta 1999, 1444: 55-60.
23. Miyata M, Kashiwadani H, Fukaya M, Hayashi T, Wu D, Suzuki T, et al. Role of thalamic phospholipase C[beta]4 mediated by metabotropic glutamate receptor type 1 in inflammatory pain. J Neurosci 2003, 23: 8098-8108.
24. Marzban H, Chung S, Watanabe M, Hawkes R. Phospholipase Cbeta4 expression reveals the continuity of cerebellar topography through development. J Comp Neurol 2007, 502: 857-871.
25. McOmish CE, Burrows E, Howard M, Scarr E, Kim D, Shin HS, et al. Phospholipase C-beta1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration. Mol Psychiatry 2008, 13: 661-672.
26. McOmish CE, Burrows EL, Howard M, Hannan AJ. PLC-beta1 knockout mice as a model of disrupted cortical development and plasticity: behavioral endophenotypes and dysregulation of RGS4 gene expression. Hippocampus 2008, 18: 824-834.
27. Ruiz de Azua I, del Olmo E, Pazos A, Salles J. Transmembrane signaling through phospholipase C-beta in the developing human prefrontal cortex. J Neurosci Res 2006, 84: 13-26.
28. Fukaya M, Uchigashima M, Nomura S, Hasegawa Y, Kikuchi H, Watanabe M. Predominant expression of phospholipase Cbeta1 in telencephalic principal neurons and cerebellar interneurons, and its close association with related signaling molecules in somatodendritic neuronal elements. Eur J Neurosci 2008, 28: 1744-1759.
29. Pawelczyk T. Isozymes delta of phosphoinositide-specific phospholipase C. Acta Biochim Pol 1999, 46: 91-98.
30. Ananthanarayanan B, Das S, Rhee SG, Murray D, Cho W. Membrane targeting of C2 domains of phospholipase C-delta isoforms. J Biol Chem 2002, 277: 3568-3575.
31. Lawson ND, Mugford JW, Diamond BA, Weinstein BM. phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development. Genes Dev 2003, 17: 1346-1351.
32. Mi LY, Ettenson DS, Edelman ER. Phospholipase C-delta extends intercellular signalling range and responses to injury-released growth factors in non-excitable cells. Cell Prolif 2008, 41: 671-690.
33. Maffucci T, Falasca M. Phosphoinositide 3-kinase-dependent regulation of phospholipase Cgamma. Biochem Soc Trans 2007, 35: 229-230.
34. Crooke CE, Pozzi A, Carpenter GF. PLC-gamma1 regulates fibronectin assembly and cell aggregation. Exp Cell Res 2009, 315: 2207-2214.
35. Diakonova M, Chilov D, Arnaoutov A, Alexeyev V, Nikolsky N, Medvedeva N. Intracellular distribution of phospholipase C gamma 1 in cell lines with different levels of transformation. Eur J Cell Biol 1997, 73: 360-367.
36. McBride K, Rhee SG, Jaken S. Immunocytochemical localization of phospholipase C-gamma in rat embryo fibroblasts. Proc Natl Acad Sci U S A 1991, 88: 7111-7115.
37. Hwang JI, Oh YS, Shin KJ, Kim H, Ryu SH, Suh PG. Molecular cloning and characterization of a novel phospholipase C, PLC-eta. Biochem J 2005, 389: 181-186.
38. Wing MR, Bourdon DM, Harden TK. PLC-epsilon: a shared effector protein in Ras-, Rho-, and G alpha beta gamma-mediated signaling. Mol Interv 2003, 3: 273-280.
39. Saunders CM, Larman MG, Parrington J, Cox LJ, Royse J, Blayney LM, et al. PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development. Development 2002, 129: 3533-3544.
40. Zhou Y, Wing MR, Sondek J, Harden TK. Molecular cloning and characterization of PLC-eta2. Biochem J 2005, 391: 667-676.
41. Lo Vasco VR, Fabrizi C, Fumagalli L, Cocco L. Expression of phosphoinositide-specific phospholipase C isoenzymes in cultured astrocytes activated after stimulation with lipopolysaccharide. J Cell Biochem 2010, 109: 1006-1012.
42. Lo Vasco VR, Fabrizi C, Artico M, Cocco L, Billi AM, Fumagalli L, et al. Expression of phosphoinositide-specific phospholipase C isoenzymes in cultured astrocytes. J Cell Biochem 2007, 100: 952-959.
43. Ross CA, MacCumber MW, Glatt CE, Snyder SH. Brain phospholipase C isozymes: differential mRNA localizations by in situ hybridization. Proc Natl Acad Sci U S A 1989, 86: 2923-2927.
44. Vitale M, Rezzani R, Gobbi G, Ponti C, Matteucci A, Cacchioli A, et al. Phospholipase-C beta1 is predominantely expressed in the granular layer of rat cerebellar cortex. Int J Mol Med 2004, 14: 161-164.
45. Hannan AJ, Blakemore C, Katsnelson A, Vitalis T, Huber KM, Bear M, et al. PLC-beta1, activated via mGluRs, mediates activitydependent differentiation in cerebral cortex. Nat Neurosci 2001, 4: 282-288.
46. Spires TL, Molnar Z, Kind PC, Cordery PM, Upton AL, Blakemore C, et al. Activity-dependent regulation of synapse and dendritic spine morphology in developing barrel cortex requires phospholipase C-beta1 signalling. Cereb Cortex 2005, 15: 385-393.
47. Kim D, Jun KS, Lee SB, Kang NG, Min DS, Kim YH, et al. Phospholipase C isozymes selectively couple to specific neurotransmitter receptors. Nature 1997, 389: 290-293.
48. Wallace MA, Claro E. A novel role for dopamine: inhibition of muscarinic cholinergic-stimulated phosphoinositide hydrolysis in rat brain cortical membranes. Neurosci Lett 1990, 110: 155-161.
49. Kurian MA, Meyer E, Vassallo G, Morgan NV, Prakash N, Pasha S, et al. Phospholipase C beta 1 deficiency is associated with earlyonset epileptic encephalopathy. Brain 2010, 133: 2964-2970.
50. Lo Vasco VR, Cardinale G, Polonia P. Deletion of PLCB1 gene in schizophrenia-affected patients. J Cell Mol Med 2012, 16: 844-851.
51. Miyoshi MA, Abe K, Emori Y. IP(3) receptor type 3 and PLCbeta2 are co-expressed with taste receptors T1R and T2R in rat taste bud cells. Chem Senses 2001, 26: 259-265.
52. Ferreira PA, Pak WL. Bovine phospholipase C highly homologous to the norpA protein of Drosophila is expressed specifically in cones. J Biol Chem 1994, 269: 3129-3131.
53. Tanaka O, Kondo H. Localization of mRNAs for three novel members (beta 3, beta 4 and gamma 2) of phospholipase C family in mature rat brain. Neurosci Lett 1994, 182: 17-20.
54. Watanabe M, Nakamura M, Sato K, Kano M, Simon MI, Inoue Y. Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase Cbeta in mouse brain. Eur J Neurosci 1998, 10: 2016-2025.
55. Kano M, Hashimoto K, Watanabe M, Kurihara H, Offermanns S, Jiang H, et al. Phospholipase cbeta4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum. Proc Natl Acad Sci U S A 1998, 95: 15724-15729.
56. Chung SH, Marzban H, Watanabe M, Hawkes R. Phospholipase Cbeta4 expression identifies a novel subset of unipolar brush cells in the adult mouse cerebellum. Cerebellum 2009, 8: 267-276.
57. Bertelli E, Regoli M, Gambelli F, Lucattelli M, Lungarella G, Bastianini A. GFAP is expressed as a major soluble pool associated with glucagon secretory granules in A-cells of mouse pancreas. J Histochem Cytochem 2000, 48: 1233-1242.
58. Medina DL, Sciarretta C, Calella AM, Von Bohlen Und Halbach O, Unsicker K, Minichiello L. TrkB regulates neocortex formation through the Shc/PLCgamma-mediated control of neuronal migration. EMBO J 2004, 23: 3803-3814.
59. Minichiello L, Calella AM, Medina DL, Bonhoeffer T, Klein R, Korte M. Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron 2002, 36: 121-137.
60. Margolis B, Rhee SG, Felder S, Mervic M, Lyall R, Levitzki A, et al. EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling. Cell 1989, 57: 1101-1107.
61. Schmidt M, Evellin S, Weernink PA, von Dorp F, Rehmann H, Lomasney JW, et al. A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase. Nat Cell Biol 2001, 3: 1020-1024.
62. Vaccarino FM, Schwartz ML, Raballo R, Nilsen J, Rhee J, Zhou M, et al. Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. Nat Neurosci 1999, 2: 246-253.
63. Itoh K, Ishima T, Kehler J, Hashimoto K. Potentiation of NGFinduced neurite outgrowth in PC12 cells by papaverine: role played by PLC-gamma, IP3 receptors. Brain Res 2011, 1377: 32-40.
64. Zhu JJ, Qin Y, Zhao M, Van Aelst L, Malinow R. Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Cell 2002, 110: 443-455.
65. Lo Vasco VR. Role of phosphoinositide-specific phospholipase C eta2 in isolated and syndromic mental retardation. Eur Neurol 2011, 65: 264-269.
66. Carey MB, Matsumoto SG. Spontaneous calcium transients are required for neuronal differentiation of murine neural crest. Dev Biol 1999, 215: 298-313.
67. Bai Y, Meng Z, Cui M, Zhang X, Chen F, Xiao J, et al. An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation. Neuroscience 2009, 160: 371-381.
68. Nakamura Y, Fukami K. Roles of phospholipase C isozymes in organogenesis and embryonic development. Physiology (Bethesda) 2009, 24: 332-341.
69. Poncet C, Frances V, Gristina R, Scheiner C, Pellissier JF, Figarella-Branger D. CD24, a glycosylphosphatidylinositol-anchored molecules is transiently expressed during the development of human central nervous system and is a marker of human neural cell lineage tumors. Acta Neuropathol 1996, 91: 400-408.
70. Jung H, Kim HJ, Lee SK, Kim R, Kopachik W, Han JK, et al. Negative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled. Exp Mol Med 2009, 41: 695-706.
71. Wu Y, Peng H, Cui M, Whitney NP, Huang Y, Zheng JC. CXCL12 increases human neural progenitor cell proliferation through Akt-1/ FOXO3a signaling pathway. J Neurochem 2009, 109: 1157-1167.
72. Belcheva MM, Clark AL, Haas PD, Serna JS, Hahn JW, Kiss A, et al. Mu and kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes. J Biol Chem 2005, 280: 27662-27669.
73. Bilecki W, Zapart G, Ligeza A, Wawrzczak-Bargiela A, Urbanski MJ, Przewlocki R. Regulation of the extracellular signal-regulated kinases following acute and chronic opioid treatment. Cell Mol Life Sci 2005, 62: 2369-2375.
74. Fazeli S, Wells DJ, Hobbs C, Walsh FS. Altered secondary myogenesis in transgenic animals expressing the neural cell adhesion molecule under the control of a skeletal muscle alpha-actin promoter. J Cell Biol 1996, 135: 241-251.
75. Jessen U, Novitskaya V, Pedersen N, Serup P, Berezin V, Bock E. The transcription factors CREB and c-Fos play key roles in NCAM-mediated neuritogenesis in PC12-E2 cells. J Neurochem 2001, 79: 1149-1160.
76. Krog L, Bock E. Glycosylation of neural cell adhesion molecules of the immunoglobulin superfamily. APMIS Suppl 1992, 27: 53-70.
77. Yamamoto N, Higashi S, Toyama K. Stop and branch behaviors of geniculocortical axons: a time-lapse study in organotypic cocultures. J Neurosci 1997, 17: 3653-3663.
78. Yamamoto N, Inui K, Matsuyama Y, Harada A, Hanamura K, Murakami F, et al. Inhibitory mechanism by polysialic acid for lamina-specific branch formation of thalamocortical axons. J Neurosci 2000, 20: 9145-9151.
79. Tang J, Landmesser L, Rutishauser U. Polysialic acid influences specific pathfinding by avian motoneurons. Neuron 1992, 8: 1031-1044.
80. Edvardsen K, Chen W, Rucklidge G, Walsh FS, Obrink B, Bock E. Transmembrane neural cell-adhesion molecule (NCAM), but not glycosyl-phosphatidylinositol-anchored NCAM, down-regulates secretion of matrix metalloproteinases. Proc Natl Acad Sci U S A 1993, 90: 11463-11467.
81. Barton CH, Dickson G, Gower HJ, Rowett LH, Putt W, Elsom V, et al. Complete sequence and in vitro expression of a tissue-specific phosphatidylinositol-linked N-CAM isoform from skeletal muscle. Development 1988, 104: 165-173.
82. Asou H, Ono K, Uemura I, Sugawa M, Uyemura K. Axonal growth-related cell surface molecule, neurin-1, involved in neuronglia interaction. J Neurosci Res 1996, 45: 571-587.
83. Struyk AF, Canoll PD, Wolfgang MJ, Rosen CL, D'Eustachio P, Salzer JL. Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules. J Neurosci 1995, 15: 2141-2156.
84. Gil OD, Zanazzi G, Struyk AF, Salzer JL. Neurotrimin mediates bifunctional effects on neurite outgrowth via homophilic and heterophilic interactions. J Neurosci 1998, 18: 9312-9325.
85. Nicot A, DiCicco-Bloom E. Regulation of neuroblast mitosis is determined by PACAP receptor isoform expression. Proc Natl Acad Sci U S A 2001, 98: 4758-4763.
86. Dejda A, Jozwiak-Bebenista M, Nowak JZ. PACAP, VIP, and PHI: effects on AC-, PLC-, and PLD-driven signaling systems in the primary glial cell cultures. Ann N Y Acad Sci 2006, 1070: 220-225.
87. Melliti K, Meza U, Fisher R, Adams B. Regulators of G protein signaling attenuate the G protein-mediated inhibition of N-type Ca channels. J Gen Physiol 1999, 113: 97-110.
88. Wang KH, Brose K, Arnott D, Kidd T, Goodman CS, Henzel W, et al. Biochemical purification of a mammalian slit protein as a posi tive regulator of sensory axon elongation and branching. Cell 1999, 96: 771-784.
89. Salles J, Wallace MA, Fain JN. Modulation of the phospholipase C activity in rat brain cortical membranes by simultaneous activation of distinct monoaminergic and cholinergic muscarinic receptors. Brain Res Mol Brain Res 1993, 20: 111-117.
90. Zhang H, Craciun LC, Mirshahi T, Rohacs T, Lopes CM, Jin T, et al. PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents. Neuron 2003, 37: 963-975.
91. Ikeda SR, Kammermeier PJ. M current mystery messenger revealed? Neuron 2002, 35: 411-412.
92. Sekar MC, Hokin LE. Phosphoinositide metabolism and cGMP levels are not coupled to the muscarinic-cholinergic receptor in human erythrocyte. Life Sci 1986, 39: 1257-1262.
93. Chuang SC, Bianchi R, Wong RK. Group I mGluR activation turns on a voltage-gated inward current in hippocampal pyramidal cells. J Neurophysiol 2000, 83: 2844-2853.
94. Floyd CL, Rzigalinski BA, Sitterding HA, Willoughby KA, Ellis EF. Antagonism of group I metabotropic glutamate receptors and PLC attenuates increases in inositol trisphosphate and reduces reactive gliosis in strain-injured astrocytes. J Neurotrauma 2004, 21: 205-216.
95. Rao TS, Lariosa-Willingham KD, Lin FF, Yu N, Tham CS, Chun J, et al. Growth factor pre-treatment differentially regulates phosphoinositide turnover downstream of lysophospholipid receptor and metabotropic glutamate receptors in cultured rat cerebrocortical astrocytes. Int J Dev Neurosci 2004, 22: 131-135.
96. Baskys A, Bayazitov I, Fang L, Blaabjerg M, Poulsen FR, Zimmer J. Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis. Neuropharmacology 2005, 49: 146-156.
97. Li YC, Liu G, Hu JL, Gao WJ, Huang YQ. Dopamine D(1) receptor-mediated enhancement of NMDA receptor trafficking requires rapid PKC-dependent synaptic insertion in the prefrontal neurons. J Neurochem 2010, 114: 62-73.
98. Smallridge RC, Kiang JG, Gist ID, Fein HG, Galloway RJ. U-73122, an aminosteroid phospholipase C antagonist, noncompetitively inhibits thyrotropin-releasing hormone effects in GH3 rat pituitary cells. Endocrinology 1992, 131: 1883-1888.
99. Farias NR, Fiore AM, Pedersen JZ, Incerpi S. Nongenomic actions of thyroid hormones: focus on membrane transport systems. Immunol Endocr Metab Agents Med Chem 2006, 6: 241-254.
100. Venkatachalam K, Zheng F, Gill DL. Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C. J Biol Chem 2003, 278: 29031-29040.
101. Zisch AH, D'Alessandri L, Ranscht B, Falchetto R, Winterhalter KH, Vaughan L. Neuronal cell adhesion molecule contactin/F11 binds to tenascin via its immunoglobulin-like domains. J Cell Biol 1992, 119: 203-213.
102. Jones NP, Peak J, Brader S, Eccles SA, Katan M. PLCgamma1 is essential for early events in integrin signalling required for cell motility. J Cell Sci 2005, 118: 2695-2706.
103. Rigato F, Garwood J, Calco V, Heck N, Faivre-Sarrailh C, Faissner A. Tenascin-C promotes neurite outgrowth of embryonic hippocampal neurons through the alternatively spliced fibronectin type III BD domains via activation of the cell adhesion molecule F3/ contactin. J Neurosci 2002, 22: 6596-6609.
104. Hasbi A, Fan T, Alijaniaram M, Nguyen T, Perreault ML, O'Dowd BF, et al. Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth. Proc Natl Acad Sci U S A 2009, 106: 21377-21382.
105. Jope RS, Song L, Powers R. [3H]PtdIns hydrolysis in postmortem human brain membranes is mediated by the G-proteins Gq/11 and phospholipase C-beta. Biochem J 1994, 304 (Pt 2): 655-659.
106. Jose PA, Yu PY, Yamaguchi I, Eisner GM, Mouradian MM, Felder CC, et al. Dopamine D1 receptor regulation of phospholipase C. Hypertens Res 1995, 18 (Suppl 1): S39-42.
107. Udawela M, Scarr E, Hannan AJ, Thomas EA, Dean B. Phospholipase C beta 1 expression in the dorsolateral prefrontal cortex from patients with schizophrenia at different stages of illness. Aust N Z J Psychiatry 2011, 45: 140-147.