Production of water-soluble quercetin formulations by antisolvent precipitation and supercritical drying

Journal of Supercritical Fluids

Volumn 104, Issue , 2015, Pages 281-290

  De Paz, Esther ^a,b   Martín, Ángel ^b   Every, Hayley ^a   Cocero, María José ^b  

^a FeyeCon Development and Implementation BV   (Netherlands)

^b UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

Antioxidant; Antisolvent precipitation; Lecithin; Quercetin; Supercritical CO2< inf> drying; Turbulent mixing

Indexed keywords

ANTIOXIDANTS; ATMOSPHERIC MOVEMENTS; ATMOSPHERIC PRESSURE; BIOCHEMISTRY; DISPERSIONS; DRYING; EFFICIENCY; ENCAPSULATION; FLAVONOIDS; LECITHIN; MIXING; PARTICLE SIZE; SHEAR FLOW; SHOCK TUBES; SUSPENSIONS (FLUIDS); TURBULENT FLOW;

ANTI-SOLVENT PRECIPITATIONS; ENCAPSULATION EFFICIENCY; HIGH PRESSURE AND HIGH TEMPERATURE; PHARMACEUTICAL INDUSTRY; QUERCETIN; SUPERCRITICAL CO; THREE DIFFERENT TECHNIQUES; TURBULENT MIXING;

PHENOLS;

EID: 84938849012     PISSN: 08968446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.supflu.2015.07.006     Document Type: Article

References (36)

1. A. Kumari, S.K. Yadav, Y.B. Pakade, B. Singh, and S.C. Yadav Development of biodegradable nanoparticles for delivery of quercetin Colloids Surf. B: Biointerfaces 80 2010 184 192
2. A. Priprem, J. Watanatorn, S. Sutthiparinyanont, W. Phachonpai, and S. Muchimapura Anxiety and cognitive effects of quercetin liposomes in rats Nanomedicine 4 2008 70 78
3. B. Li, S. Konecke, K. Harich, L. Wegiel, L.S. Taylor, and K.J. Edgar Solid dispersion of quercetin in cellulose derivative matrices influences both solubility and stability Carbohydr. Polym. 92 2013 2033 2040
4. A.W. Boots, G.R. Haenen, and A. Bast Health effects of quercetin: from antioxidant to nutraceutical Eur. J. Pharmacol. 585 2008 325 337
5. K. Srinivas, J.W. King, L.R. Howard, and J.K. Monrad Solubility and solution thermodynamic properties of quercetin and quercetin dehydrate in subcritical water J. Food Eng. 100 2010 208 218
6. R.H. Khaled, Y.M. El-Sayed, and B.M. Al-Hadiya Disposition of the flavonoid quercetin in rats after single intravenous and oral doses Drug Dev. Ind. Pharm. 29 2003 397 403
7. R. Gugler, M. Leschik, and J.H. Dengler Disposition of quercetin in man after single oral and intravenous doses Eur. J. Clin. Pharmacol. 9 1975 229 234
8. O.I. Parisi, F. Puoci, D. Restuccia, G. Farina, F. Iemma, and N. Picci Polyphenols and their formulations: different strategies to overcome the drawbacks associated with their poor stability and bioavailability Polyphenols in Human Health and Disease 1 2014 29 45 Chapter 4
9. A.J. Vargas, and R. Burd Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management Nutr. Rev. 68 2010 418 428
10. L. Biasutto, E. Marotta, S. Garbisa, M. Zoratti, and C. Paradisi Determination of quercetin and resveratrol in whole blood-implications for bioavailability studies Molecules 15 2010 6570 6579
11. M. Kakran, N.G. Sahoo, and L. Li Dissolution enhancement of quercetin through nanofabrication, complexation and solid dispersion Colloids Surf. B: Biointerfaces 88 2011 121 130
12. L. Gao, G. Liu, X. Wang, F. Liu, Y. Xu, and J. Ma Preparation of a chemically stable quercetin formulation using nanosuspension technology Int. J. Pharm. 404 2011 231 237
13. M. Fraile, R. Buratto, B. Gómez, Á. Martín, and M.J. Cocero Enhanced delivery of quercetin by encapsulation in poloxamers by supercritical antisolvent process Ind. Eng. Chem. Res. 53 2014 4318 4327
14. H. Li, X. Zhao, Y. Ma, G. Zhai, L. Li, and H. Lou Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles J. Control. Release 133 2009 238 244
15. G. Chen-yu, Y. Chun-fen, L. Qi-lu, T. Qi, X. Yan-wei, L. Wei-na, and Z. Guang-xi Development of a quercetin-loaded nanostructured lipid carrier formulation for topical delivery Int. J. Pharm. 430 2012 292 298
16. S. Bose, and B. Michniak-Kohn Preparation and characterization of lipid based nanosystems for topical delivery of quercetin Eur. J. Pharm. Sci. 48 2013 442 452
17. H.K. Ha, J.W. Kim, M.R. Lee, and W.J. Lee Formation and characterization of quercetin-loaded chitosan oligosaccharide/β-lactoglobulin nanoparticle Food Res. Int. 52 2013 82 90
18. T.H. Wu, F.L. Yen, L.T. Lin, T.R. Tsai, C.C. Lin, and T.M. Cham Preparation, physicochemical characterization and antioxidant effects of quercetin nanoparticles Int. J. Pharm. 346 2008 160 168
19. N.P. Aditya, A.S. Macedo, S. Doktorovova, E.B. Souto, S. Kim, P.S. Chang, and S. Ko Development and evaluation of lipid nanocarriers for quercetin delivery: a comparative study of solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid nanoemulsions (LNE) LWT - Food Sci. Technol. 59 2014 115 121
20. D. Meterc, M. Petermann, and E. Weidner Drying of aqueous green tea extracts using a supercritical fluid spray process J. Supercritical Fluids 45 2008 253 259
21. Á. Martín, and E. Weidner PGSS-drying: mechanisms and modeling J. Supercritical Fluids 55 2010 271 281
22. Á. Martín, H.M. Pham, Á. Kilzer, S. Kareth, and E. Weidner Micronization of polyethylene glycol by PGSS (particles from gas saturated solutions)-drying of aqueous solutions Chem. Eng. Process. 49 2010 1259 1266
23. E. de Paz, Á. Martín, and M.J. Cocero Formulation of β-carotene with soyban lecithin by PGSS (particles from gas saturated solutions)-drying J. Supercritical Fluids 72 2012 125 133
24. O. Nuchuchua, H.A. Every, G.W. Hofland, and W. Jiskoot Scalable organic solvent free supercritical fluid spray drying process for producing dry protein formulations Eur. J. Pharm. Biopharm. 88 2014 919 930
25. E.V. Batrakova, and A.V. Kabanov Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers J. Control. Release 130 2008 98 106
26. A. Soottitantawat, H. Yoshii, T. Furuta, M. Ohgawara, P. Forssell, R. Partanen, K. Poutanen, and P. Linko Effect of water activity on the release characteristics and oxidative stability of D-limonene encapsulated by spray drying J. Agric. Food Chem. 52 2004 1269 1276
27. R. Baranauskiene, E. Bylaite, J. Zukauskaite, and R.P. Venskutonis Flavor retention of peppermint (Mentha piperita L.) essential oil spraydried in modified starches during encapsulation and storage J. Agric. Food Chem. 55 2007 3027 3036
28. H. Yu, and Q. Huang Enhanced in vitro anti-cancer activity of curcumin encapsulated in hydrophobically modified starch Food Chem. 119 2010 669 674
29. S. Varona, Á. Martín, and M.J. Cocero Formulation of a natural biocide based on lavandin essential oil by emulsification using modified starches Chem. Eng. Process. 48 2009 1121 1128
30. M.F. Ramadan Antioxidant characteristics of phenolipids (quercetin-enriched lecithin) in lipid matrices Ind. Crops Prod. 36 2012 363 369
31. M. Takahashi, K. Inafuku, T. Miyagi, H. Oku, K. Wada, T. Imura, and D. Kitamoto Preparation of liposomes encapsulating food materials using lecithins by a mechanochemical method J. Oleo Sci. 56 2007 35 42
32. E. De Paz, Á. Martín, A. Estrella, S. Rodríguez-Rojo, A.A. Matias, C.M.M. Duarte, and M.J. Cocero Formulation of β-carotene by precipitation from pressurized ethyl acetate-on-water emulsions for application as natural colorant Food Hydrocolloids 26 2012 17 27
33. E. De Paz, Á. Martín, Á. Bartolomé, and M.J. Cocero Development of water-soluble β-carotene formulations of by high temperature, high-pressure emulsification and antisolvent precipitation Food Hydrocolloids 37 2014 14 24
34. L. Chebil, C. Humeau, J. Anthoni, F. Dehez, J.M. Engasser, and M. Ghoul Solubility of flavonoids in organic solvents J. Chem. Eng. Data 52 2007 1552 1556
35. B. Ou, D. Huang, M. Hampsch-Woodill, J.A. Flanagan, and E.K. Deemer Analysis of antioxidant activities of common vegetables employing oxygen radical absorbance capacity (ORAC) and ferric reducing antioxidant power (FRAP) assays: a comparative study J. Agric. Food Chem. 50 2002 3122 3128
36. R.S. Nasibullin, T.I. Nikitina, Y.G. Afanaseva, T.R. Nasibullin, and L.V. Spirikhin Complex of 3, 5,7,3′,4′-pentahydroxyflavonol with phosphatidylcholine Pharm. Chem. J. 36 2002 492 496