Structural evidence for asymmetric ligand binding to transthyretin

Acta Crystallographica Section D: Biological Crystallography

Volumn 71, Issue , 2015, Pages 1582-1592

  Cianci, Michele ^a   Folli, Claudia ^b   Zonta, Francesco ^c   Florio, Paola ^b   Berni, Rodolfo ^b   Zanotti, Giuseppe ^d  

^a DESY   (Germany)

^b UNIVERSITY OF PARMA   (Italy)

^c SHANGHAITECH UNIVERSITY   (China)

^d UNIVERSITY OF PADOVA   (Italy)

Author keywords

Amyloidosis; Fibrillogenesis inhibitors; Negative cooperativity; Protein misfolding; Transthyretin; Transthyretin stabilizers

Indexed keywords

LIGAND; POLYPHENOL; PREALBUMIN; PROTEIN BINDING;

AMYLOIDOSIS; BINDING SITE; CHEMISTRY; DRUG DEVELOPMENT; HUMAN; METABOLISM; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; X RAY CRYSTALLOGRAPHY;

AMYLOIDOSIS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; HUMANS; LIGANDS; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; POLYPHENOLS; PREALBUMIN; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STABILITY;

EID: 84938837564     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S1399004715010585     Document Type: Article

References (45)

1. Adams, P. D. et al. (2010). Acta Cryst. D66, 213-221.
2. Adamski-Werner, S. L., Palaninathan, S. K., Sacchettini, J. C. & Kelly, J. W. (2004). J. Med. Chem. 47, 355-374.
3. Berendsen, H. J. C., Postma, J. P. M., van Gunsteren,W. F., DiNola, A. & Haak, J. R. (1984). J. Chem. Phys. 81, 3684-3688.
4. Blake, C. C., Geisow, M. J., Oatley, S. J., Rérat, B. & Rérat, C. (1978). J. Mol. Biol. 121, 339-356.
5. Bulawa, C. E., Connelly, S., Devit, M., Wang, L., Weigel, C., Fleming, J. A., Packman, J., Powers, E. T., Wiseman, R. L., Foss, T. R., Wilson, I. A., Kelly, J. W. & Labaudinière, R. (2012). Proc. Natl Acad. Sci. USA, 109, 9629-9634.
6. Cendron, L., Trovato, A., Seno, F., Folli, C., Alfieri, B., Zanotti, G. & Berni, R. (2009). J. Biol. Chem. 284, 25832-25841.
7. Cheng, S.-Y., Pages, R. A., Saroff, H. A., Edelhoch, H. & Robbins, J. (1977). Biochemistry, 16, 3707-3713.
8. Choi, S., Reixach, N., Connelly, S., Johnson, S. M., Wilson, I. A. & Kelly, J. W. (2010). J. Am. Chem. Soc. 132, 1359-1370.
9. Coelho, T., Maia, L. F., da Silva, A. M., Cruz, M. W., Planté-Bordeneuve, V., Suhr, O. B., Conceiçao, I., Schmidt, H. H.-J., Trigo, P., Kelly, J. W., Labaudinière, R., Chan, J., Packman, J. & Grogan, D. R. (2013). J. Neurol. 260, 2802-2814.
10. Connelly, S., Choi, S., Johnson, S. M., Kelly, J. W. & Wilson, I. A. (2010). Curr. Opin. Struct. Biol. 20, 54-62.
11. Darden, T., York, D. & Pedersen, L. (1993). J. Chem. Phys. 98, 10089-10092.
12. Duan, Y., Wu, C., Chowdhury, S., Lee, M. C., Xiong, G., Zhang, W., Yang, R., Cieplak, P., Luo, R., Lee, T., Caldwell, J., Wang, J. & Kollman, P. (2003). J. Comput. Chem. 24, 1999-2012.
13. Emsley, P. & Cowtan, K. (2004). Acta Cryst. D60, 2126-2132.
14. Evans, P. (2006). Acta Cryst. D62, 72-82.
15. Ferguson, R. N., Edelhoch, H., Saroff, H. A., Robbins, J. & Cahnmann, H. J. (1975). Biochemistry, 14, 282-289.
16. Green, N. S., Foss, T. R. & Kelly, J. W. (2005). Proc. Natl Acad. Sci. USA, 102, 14545-14550.
17. Haupt, M., Blakeley, M. P., Fisher, S. J., Mason, S. A., Cooper, J. B., Mitchell, E. P. & Forsyth, V. T. (2014). IUCrJ, 1, 429-438.
18. Hö rnberg, A., Eneqvist, T., Olofsson, A., Lundgren, E. & Sauer-Eriksson, A. E. (2000). J. Mol. Biol. 302, 649-669.
19. Hurshman Babbes, A. R., Powers, E. T. & Kelly, J. W. (2008). Biochemistry, 47, 6969-6984.
20. Johnson, S. M., Connelly, S., Fearns, C., Powers, E. T. & Kelly, J. W. (2012). J. Mol. Biol. 421, 185-203.
21. Johnson, S. M., Wiseman, R. L., Sekijima, Y., Green, N. S., Adamski-Werner, S. L. & Kelly, J. W. (2005). Acc. Chem. Res. 38, 911-921.
22. Kabsch, W. (2010). Acta Cryst. D66, 125-132.
23. Klabunde, T., Petrassi, H. M., Oza, V. B., Raman, P., Kelly, J. W. & Sacchettini, J. C. (2000). Nature Struct. Mol. Biol. 7, 312-321.
24. Kolstoe, S. E. &Wood, S. P. (2010). Biochem. Soc. Trans. 38, 466-470.
25. Monaco, H. L., Rizzi, M. & Coda, A. (1995). Science, 268, 1039-1041.
26. Neumann, P., Cody, V. & Wojtczak, A. (2001). Acta Biochim. Pol. 48, 867-875.
27. Obici, L. & Merlini, G. (2014). Expert Opin. Investig. Drugs, 23, 1239-1251.
28. Painter, J. & Merritt, E. A. (2006). Acta Cryst. D62, 439-450.
29. Palaninathan, S. K. (2012). Curr. Med. Chem. 19, 2324-2342.
30. Palaninathan, S. K., Mohamedmohaideen, N. N., Orlandini, E., Ortore, G., Nencetti, S., Lapucci, A., Rossello, A., Freundlich, J. S. & Sacchettini, J. C. (2009). PLoS One, 4, e6290.
31. Pasquato, N., Berni, R., Folli, C., Alfieri, B., Cendron, L. & Zanotti, G. (2007). J. Mol. Biol. 366, 711-719.
32. Pronk, S., Páll, S., Schulz, R., Larsson, P., Bjelkmar, P., Apostolov, R., Shirts, M. R., Smith, J. C., Kasson, P. M., van der Spoel, D., Hess, B. & Lindahl, E. (2013). Bioinformatics, 29, 845-854.
33. Reid, D. G., MacLachlan, L. K., Voyle, M. & Leeson, P. D. (1989). J. Biol. Chem. 264, 2013-2023.
34. Suhre, K. & Sanejouand, Y.-H. (2004). Nucleic Acids Res. 32, W610-W614.
35. Tomar, D., Khan, T., Singh, R. R., Mishra, S., Gupta, S., Surolia, A. & Salunke, D. M. (2012). PLoS One, 7, e43522.
36. Trivella, D. B. B., Bleicher, L., Palmieri, L. de C., Wiggers, H. J., Montanari, C. A., Kelly, J. W., Lima, L. M. T. R., Foguel, D. & Polikarpov, I. (2010). J. Struct. Biol. 170, 522-531.
37. Trivella, D. B. B., dos Reis, C. V., Lima, L. M. T. R., Foguel, D. & Polikarpov, I. (2012). J. Struct. Biol. 180, 143-153.
38. Wang, H., Tang, Y. & Lei, M. (2007). Arch. Biochem. Biophys. 466, 85-97.
39. Weiss, M. S. (2001). J. Appl. Cryst. 34, 130-135.
40. Westermark, P., Sletten, K., Johansson, B. & Cornwell, G. G. (1990). Proc. Natl Acad. Sci. USA, 87, 2843-2845.
41. Winn, M. D. et al. (2011). Acta Cryst. D67, 235-242.
42. Wojtczak, A., Cody, V., Luft, J. R. & Pangborn, W. (1996). Acta Cryst. D52, 758-765.
43. Wojtczak, A., Neumann, P. & Cody, V. (2001). Acta Cryst. D57, 957-967.
44. Zanotti, G., Cendron, L., Folli, C., Florio, P., Imbimbo, B. P. & Berni, R. (2013). FEBS Lett. 587, 2325-2331.
45. Zonta, F., Girotto, G., Buratto, D., Crispino, G., Morgan, A., Abdulhadi, K., Alkowari, M., Badii, R., Gasparini, P. & Mammano, F. (2015). Hum. Mol. Genet. 24, 2641-2648.