메뉴 건너뛰기




Volumn 6, Issue 11, 2014, Pages 5280-5297

Evidence and mechanisms of fat depletion in cancer

Author keywords

Adipose tissue; Cancer; Computed tomography; Fat mobilization

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

EID: 84938830218     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu6115280     Document Type: Review
Times cited : (107)

References (74)
  • 1
    • 74049159942 scopus 로고    scopus 로고
    • Subcutaneous and visceral adipose tissue: Structural and functional differences
    • Ibrahim, M.M. Subcutaneous and visceral adipose tissue: Structural and functional differences. Obes. Rev. 2010, 11, 11–18.
    • (2010) Obes. Rev. , vol.11 , pp. 11-18
    • Ibrahim, M.M.1
  • 2
    • 0034535853 scopus 로고    scopus 로고
    • Adipocyte differentiation and gene expression
    • Ntambi, J.M.; Young-Cheul, K. Adipocyte differentiation and gene expression. J. Nutr.2000, 130, 3122–3126.
    • (2000) J. Nutr. , vol.130 , pp. 3122-3126
    • Ntambi, J.M.1    Young-Cheul, K.2
  • 3
    • 80052178280 scopus 로고    scopus 로고
    • Paracrine and endocrine effects of adipose tissue on cancer development and progression
    • Park, J.; Euhus, D.M.; Scherer, P.E. Paracrine and endocrine effects of adipose tissue on cancer development and progression. Endocr. Rev.2011, 32, 550–570.
    • (2011) Endocr. Rev. , vol.32 , pp. 550-570
    • Park, J.1    Euhus, D.M.2    Scherer, P.E.3
  • 4
    • 42449097289 scopus 로고    scopus 로고
    • Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
    • Guilherme, A.; Virbasius, J.V.; Puri, V.; Czech, M.P. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat. Rev. Mol. Cell Biol.2008, 9, 367–377.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 367-377
    • Guilherme, A.1    Virbasius, J.V.2    Puri, V.3    Czech, M.P.4
  • 5
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms
    • Calle, E.E.; Kaaks, R. Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms. Nat. Rev. Cancer 2004, 4, 579–591.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 7
    • 43449104499 scopus 로고    scopus 로고
    • Cancer cachexia: Developing multimodal therapy for a multidimensional problem
    • Fearon, K.C. Cancer cachexia: Developing multimodal therapy for a multidimensional problem. Eur. J. Cancer 2008, 44, 1124–1132.
    • (2008) Eur. J. Cancer , vol.44 , pp. 1124-1132
    • Fearon, K.C.1
  • 9
    • 18044361914 scopus 로고    scopus 로고
    • Body composition and time course changes in regional distribution of fat and lean tissue in unselected cancer patients on palliative care—Correlations with food intake, metabolism, exercise capacity, and hormones
    • Fouladiun, M.; Korner, U.; Bosaeus, I.; Daneryd, P.; Hyltander, A.; Lundholm, K.G. Body composition and time course changes in regional distribution of fat and lean tissue in unselected cancer patients on palliative care—Correlations with food intake, metabolism, exercise capacity, and hormones. Cancer2005, 103, 2189–2198.
    • (2005) Cancer , vol.103 , pp. 2189-2198
    • Fouladiun, M.1    Korner, U.2    Bosaeus, I.3    Daneryd, P.4    Hyltander, A.5    Lundholm, K.G.6
  • 11
    • 33750217510 scopus 로고    scopus 로고
    • Adipose atrophy in cancer cachexia: Morphologic and molecular analysis of adipose tissue in tumour-bearing mice
    • Bing, C.; Russell, S.; Becket, E.; Pope, M.; Tisdale, M.J.; Trayhurn, P.; Jenkins, J.R. Adipose atrophy in cancer cachexia: Morphologic and molecular analysis of adipose tissue in tumour-bearing mice. Br. J. Cancer2006, 95, 1028–1037.
    • (2006) Br. J. Cancer , vol.95 , pp. 1028-1037
    • Bing, C.1    Russell, S.2    Becket, E.3    Pope, M.4    Tisdale, M.J.5    Trayhurn, P.6    Jenkins, J.R.7
  • 12
    • 12144281235 scopus 로고    scopus 로고
    • Adipose tissue in walker 256 tumour-induced cachexia: Possible association between decreased leptin concentration and mononuclear cell infiltration
    • Machado, A.P.; Costa Rosa, L.F.; Seelaender, M.C. Adipose tissue in walker 256 tumour-induced cachexia: Possible association between decreased leptin concentration and mononuclear cell infiltration. Cell Tissue Res. 2004, 318, 503–514.
    • (2004) Cell Tissue Res , vol.318 , pp. 503-514
    • Machado, A.P.1    Costa Rosa, L.F.2    Seelaender, M.C.3
  • 13
    • 0035458317 scopus 로고    scopus 로고
    • Heterogeneous response of adipose tissue to cancer cachexia
    • Bertevello, P.S.; Seelaender, M.C. Heterogeneous response of adipose tissue to cancer cachexia. Braz. J. Med. Biol. Res.2001, 34, 1161–1167.
    • (2001) Braz. J. Med. Biol. Res. , vol.34 , pp. 1161-1167
    • Bertevello, P.S.1    Seelaender, M.C.2
  • 16
    • 54049151993 scopus 로고    scopus 로고
    • Lipolysis—Not inflammation, cell death, or lipogenesis—Is involved in adipose tissue loss in cancer cachexia
    • Ryden, M.; Agustsson, T.; Laurencikiene, J.; Britton, T.; Sjolin, E.; Isaksson, B.; Permert, J.; Arner, P. Lipolysis—Not inflammation, cell death, or lipogenesis—Is involved in adipose tissue loss in cancer cachexia. Cancer2008, 113, 1695–1704.
    • (2008) Cancer , vol.113 , pp. 1695-1704
    • Ryden, M.1    Agustsson, T.2    Laurencikiene, J.3    Britton, T.4    Sjolin, E.5    Isaksson, B.6    Permert, J.7    Arner, P.8
  • 18
    • 79551597254 scopus 로고    scopus 로고
    • Enhanced ZAG production by subcutaneous adipose tissue is linked to weight loss in gastrointestinal cancer patients
    • Mracek, T.; Stephens, N.A.; Gao, D.; Bao, Y.; Ross, J.A.; Ryden, M.; Arner, P.; Trayhurn, P.; Fearon, K.C.; Bing, C. et al. Enhanced ZAG production by subcutaneous adipose tissue is linked to weight loss in gastrointestinal cancer patients. Br. J. Cancer2011, 104, 441–447.
    • (2011) Br. J. Cancer , vol.104 , pp. 441-447
    • Mracek, T.1    Stephens, N.A.2    Gao, D.3    Bao, Y.4    Ross, J.A.5    Ryden, M.6    Arner, P.7    Trayhurn, P.8    Fearon, K.C.9    Bing, C.10
  • 19
    • 21044459814 scopus 로고    scopus 로고
    • Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: Evidence for participation of insulin resistance
    • Otake, S.; Takeda, H.; Suzuki, Y.; Fukui, T.; Watanabe, S.; Ishihama, K.; Saito, T.; Togashi, H.; Nakamura, T.; Matsuzawa, Y. et al. Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: Evidence for participation of insulin resistance. Clin. Cancer Res.2005, 11, 3642–3646.
    • (2005) Clin. Cancer , vol.11 , pp. 3642-3646
    • Otake, S.1    Takeda, H.2    Suzuki, Y.3    Fukui, T.4    Watanabe, S.5    Ishihama, K.6    Saito, T.7    Togashi, H.8    Nakamura, T.9    Matsuzawa, Y.10
  • 20
    • 0026691717 scopus 로고
    • Mechanisms for differences in lipolysis between human subcutaneous and omental fat cells
    • Hellmer, J.; Marcus, C.; Sonnenfeld, T.; Arner, P. Mechanisms for differences in lipolysis between human subcutaneous and omental fat cells. J. Clin. Endocrinol. Metab.1992, 75, 15–20.
    • (1992) J. Clin. Endocrinol. Metab. , vol.75 , pp. 15-20
    • Hellmer, J.1    Marcus, C.2    Sonnenfeld, T.3    Arner, P.4
  • 24
    • 63649151886 scopus 로고    scopus 로고
    • Viscerally driven cachexia syndrome in patients with advanced colorectal cancer: Contributions of organ and tumor mass to whole-body energy demands
    • Lieffers, J.R.; Mourtzakis, M.; Hall, K.D.; McCargar, L.J.; Prado, C.M.; Baracos, V.E. A viscerally driven cachexia syndrome in patients with advanced colorectal cancer: Contributions of organ and tumor mass to whole-body energy demands. Am. J. Clin. Nutr.2009, 89, 1173–1179.
    • (2009) Am. J. Clin. Nutr. , vol.89 , pp. 1173-1179
    • Lieffers, J.R.1    Mourtzakis, M.2    Hall, K.D.3    McCargar, L.J.4    Prado, C.M.5    Baracos, V.6
  • 26
    • 84864528329 scopus 로고    scopus 로고
    • Adipose tissue volume is decreased in recently diagnosed cancer patients with cachexia
    • Agustsson, T.; Wikrantz, P.; Ryden, M.; Brismar, T.; Isaksson, B. Adipose tissue volume is decreased in recently diagnosed cancer patients with cachexia. Nutrition2012, 28, 851–855.
    • (2012) Nutrition , vol.28 , pp. 851-855
    • Agustsson, T.1    Wikrantz, P.2    Ryden, M.3    Brismar, T.4    Isaksson, B.5
  • 28
    • 84873025841 scopus 로고    scopus 로고
    • Accelerated muscle and adipose tissue loss may predict survival in pancreatic cancer patients: The relationship with diabetes and anaemia
    • Di Sebastiano, K.M.; Yang, L.; Zbuk, K.; Wong, R.K.; Chow, T.; Koff, D.; Moran, G.R.; Mourtzakis, M. Accelerated muscle and adipose tissue loss may predict survival in pancreatic cancer patients: The relationship with diabetes and anaemia. Br. J. Nutr. 2013, 109, 302–312.
    • (2013) Br. J. Nutr. , vol.109 , pp. 302-312
    • Di Sebastiano, K.M.1    Yang, L.2    Zbuk, K.3    Wong, R.K.4    Chow, T.5    Koff, D.6    Moran, G.R.7    Mourtzakis, M.8
  • 29
    • 0002924156 scopus 로고
    • The clinical and metabolic consequences of total gastrectomy. I. Morbidity, weight, and nutrition
    • Adams, J.F. The clinical and metabolic consequences of total gastrectomy. I. Morbidity, weight, and nutrition. Scand. J. Gastroenterol.1967, 2, 137–149.
    • (1967) Scand. J. Gastroenterol. , vol.2 , pp. 137-149
    • Adams, J.F.1
  • 30
    • 0030968303 scopus 로고    scopus 로고
    • Changes in body composition after gastrectomy: Results of a controlled, prospective clinical trial
    • Liedman, B.; Andersson, H.; Bosaeus, I.; Hugosson, I.; Lundell, L. Changes in body composition after gastrectomy: Results of a controlled, prospective clinical trial. World J. Surg.1997, 21, 416–421.
    • (1997) World J. Surg. , vol.21 , pp. 416-421
    • Liedman, B.1    Andersson, H.2    Bosaeus, I.3    Hugosson, I.4    Lundell, L.5
  • 32
    • 79953697417 scopus 로고    scopus 로고
    • Altered expression of genes in adipose tissues associated with reduced fat mass in patients with pancreatic cancer
    • Haugen, F.; Labori, K.J.; Noreng, H.J.; Buanes, T.; Iversen, P.O.; Drevon, C.A. Altered expression of genes in adipose tissues associated with reduced fat mass in patients with pancreatic cancer. Arch. Physiol. Biochem.2011, 117, 78–87.
    • (2011) Arch. , vol.117 , pp. 78-87
    • Haugen, F.1    Labori, K.J.2    Noreng, H.J.3    Buanes, T.4    Iversen, P.O.5    Drevon, C.A.6
  • 33
    • 84856216341 scopus 로고    scopus 로고
    • Marked changes in body composition following neoadjuvant chemotherapy for oesophagogastric cancer
    • Awad, S.; Tan, B.H.; Cui, H.; Bhalla, A.; Fearon, K.C.; Parsons, S.L.; Catton, J.A.; Lobo, D.N. Marked changes in body composition following neoadjuvant chemotherapy for oesophagogastric cancer. Clin. Nutr.2012, 31, 74–77.
    • (2012) Clin. Nutr. , vol.31 , pp. 74-77
    • Awad, S.1    Tan, B.H.2    Cui, H.3    Bhalla, A.4    Fearon, K.C.5    Parsons, S.L.6    Catton, J.A.7    Lobo, D.N.8
  • 34
    • 84864580287 scopus 로고    scopus 로고
    • Relationships among body mass index, longitudinal body composition alterations, and survival in patients with locally advanced pancreatic cancer receiving chemoradiation: A pilot study
    • Dalal, S.; Hui, D.; Bidaut, L.; Lem, K.; del Fabbro, E.; Crane, C.; Reyes-Gibby, C.C.; Bedi, D.; Bruera, E. Relationships among body mass index, longitudinal body composition alterations, and survival in patients with locally advanced pancreatic cancer receiving chemoradiation: A pilot study. J. Pain Symptom Manag. 2012, 44, 181–191.
    • (2012) J. Pain Symptom Manag. , vol.44 , pp. 181-191
    • Dalal, S.1    Hui, D.2    Bidaut, L.3    Lem, K.4    Del Fabbro, E.5    Crane, C.6    Reyes-Gibby, C.C.7    Bedi, D.8    Bruera, E.9
  • 35
    • 84885403137 scopus 로고    scopus 로고
    • Abdominal visceral and subcutaneous fat increase, insulin resistance and hyperlipidemia in testicular cancer patients treated with cisplatin-based chemotherapy
    • Willemse, P.P.; van der Meer, R.W.; Burggraaf, J.; van Elderen, S.G.; de Kam, M.L.; de Roos, A.; Lamb, H.J.; Osanto, S. Abdominal visceral and subcutaneous fat increase, insulin resistance and hyperlipidemia in testicular cancer patients treated with cisplatin-based chemotherapy. Acta Oncol. 2014, 53, 351–360.
    • (2014) Acta Oncol , vol.53 , pp. 351-360
    • Willemse, P.P.1    Van Der Meer, R.W.2    Burggraaf, J.3    Van Elderen, S.G.4    De Kam, M.L.5    De Roos, A.6    Lamb, H.J.7    Osanto, S.8
  • 36
    • 84884840514 scopus 로고    scopus 로고
    • Central tenet of cancer cachexia therapy: Do patients with advanced cancer have exploitable anabolic potential
    • Prado, C.M.; Sawyer, M.B.; Ghosh, S.; Lieffers, J.R.; Esfandiari, N.; Antoun, S.; Baracos, V.E. Central tenet of cancer cachexia therapy: Do patients with advanced cancer have exploitable anabolic potential? Am. J. Clin. Nutr.2013, 98, 1012–1019.
    • (2013) Am. J. Clin. Nutr. , vol.98 , pp. 1012-1019
    • Prado, C.M.1    Sawyer, M.B.2    Ghosh, S.3    Lieffers, J.R.4    Esfandiari, N.5    Antoun, S.6    Baracos, V.E.7
  • 37
    • 72549086598 scopus 로고    scopus 로고
    • Sarcopenia in an overweight or obese patient is an adverse prognostic factor in pancreatic cancer
    • Tan, B.H.; Birdsell, L.A.; Martin, L.; Baracos, V.E.; Fearon, K.C. Sarcopenia in an overweight or obese patient is an adverse prognostic factor in pancreatic cancer. Clin. Cancer Res.2009, 15, 6973–6979.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 6973-6979
    • Tan, B.H.1    Birdsell, L.A.2    Martin, L.3    Baracos, V.E.4    Fearon, K.C.5
  • 40
    • 0036830917 scopus 로고    scopus 로고
    • Cachexia in cancer patients
    • Tisdale, M.J. Cachexia in cancer patients. Nat. Rev. Cancer2002, 2, 862–871.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 862-871
    • Tisdale, M.J.1
  • 41
    • 33846621473 scopus 로고    scopus 로고
    • Fat loss in cachexia—Is there a role for adipocyte lipolysis?
    • Ryden, M.; Arner, P. Fat loss in cachexia—Is there a role for adipocyte lipolysis? Clin. Nutr.2007, 26, 1–6.
    • (2007) Clin. Nutr. , vol.26 , pp. 1-6
    • Ryden, M.1    Arner, P.2
  • 42
  • 43
    • 0021739158 scopus 로고
    • Sequential changes in the activities of lipoprotein lipase and lipogenic enzymes during tumor growth in rats
    • Lanza-Jacoby, S.; Lansey, S.C.; Miller, E.E.; Cleary, M.P. Sequential changes in the activities of lipoprotein lipase and lipogenic enzymes during tumor growth in rats. Cancer Res. 1984, 44, 5062–5067.
    • (1984) Cancer Res , vol.44 , pp. 5062-5067
    • Lanza-Jacoby, S.1    Lansey, S.C.2    Miller, E.E.3    Cleary, M.P.4
  • 45
    • 0343487644 scopus 로고    scopus 로고
    • Sequential changes in lipoprotein lipase activity and lipaemia induced by the Yoshida AH-130 ascites hepatoma in rats
    • Lopez-Soriano, J.; Argiles, J.M.; Lopez-Soriano, F.J. Sequential changes in lipoprotein lipase activity and lipaemia induced by the Yoshida AH-130 ascites hepatoma in rats. Cancer Lett. 1997, 116, 159–165.
    • (1997) Cancer Lett , vol.116 , pp. 159-165
    • Lopez-Soriano, J.1    Argiles, J.M.2    Lopez-Soriano, F.J.3
  • 46
  • 47
    • 0019513846 scopus 로고
    • Modified lipoprotein lipase activities, rates
    • Thompson, M.P.; Koons, J.E.; Tan, E.T.; Grigor, M.R. Modified lipoprotein lipase activities, rates of lipogenesis, and lipolysis as factors leading to lipid depletion in C57BL mice bearing the preputial gland tumor, ESR-586. Cancer Res. 1981, 41, 3228–3232.
    • (1981) Cancer Res , vol.41 , pp. 3228-3232
    • Thompson, M.P.1    Koons, J.E.2    Tan, E.T.3    Grigor, M.R.4
  • 48
    • 84857047403 scopus 로고    scopus 로고
    • Low levels of lipogenic enzymes in peritumoral adipose tissue of colorectal cancer patients
    • Notarnicola, M.; Miccolis, A.; Tutino, V.; Lorusso, D.; Caruso, M.G. Low levels of lipogenic enzymes in peritumoral adipose tissue of colorectal cancer patients. Lipids2012, 47, 59–63.
    • (2012) Lipids , vol.47 , pp. 59-63
    • Notarnicola, M.1    Miccolis, A.2    Tutino, V.3    Lorusso, D.4    Caruso, M.G.5
  • 49
    • 0025803843 scopus 로고
    • Changes in activity of lipoprotein lipase, plasma free fatty acids and triglycerides with weight loss in a cachexia model
    • Briddon, S.; Beck, S.A.; Tisdale, M.J. Changes in activity of lipoprotein lipase, plasma free fatty acids and triglycerides with weight loss in a cachexia model. Cancer Lett. 1991, 57, 49–53.
    • (1991) Cancer Lett , vol.57 , pp. 49-53
    • Briddon, S.1    Beck, S.A.2    Tisdale, M.J.3
  • 50
    • 80051585152 scopus 로고    scopus 로고
    • Animal models of the cancer anorexia-cachexia syndrome
    • Bennani-Baiti, N.; Walsh, D. Animal models of the cancer anorexia-cachexia syndrome. Support. Care Cancer2011, 19, 1451–1463.
    • (2011) Support. Care Cancer , vol.19 , pp. 1451-1463
    • Bennani-Baiti, N.1    Walsh, D.2
  • 51
    • 0036845198 scopus 로고    scopus 로고
    • Dietary intake, resting energy expenditure, weight loss andsurvival in cancer patients
    • Bosaeus, I.; Daneryd, P.; Lundholm, K. Dietary intake, resting energy expenditure, weight loss and survival in cancer patients. J. Nutr.2002, 132, 3465–3466.
    • (2002) J. Nutr. , vol.132 , pp. 3465-3466
    • Bosaeus, I.1    Daneryd, P.2    Lundholm, K.3
  • 52
    • 75949118156 scopus 로고    scopus 로고
    • Resting energy expenditure and body composition in patients with newly detected cancer
    • Cao, D.X.; Wu, G.H.; Zhang, B.; Quan, Y.J.; Wei, J.; Jin, H.; Jiang, Y.; Yang, Z.A. Resting energy expenditure and body composition in patients with newly detected cancer. Clin. Nutr.2010, 29, 72–77.
    • (2010) Clin. Nutr. , vol.29 , pp. 72-77
    • Cao, D.X.1    Wu, G.H.2    Zhang, B.3    Quan, Y.J.4    Wei, J.5    Jin, H.6    Jiang, Y.7    Yang, Z.A.8
  • 55
    • 0025119711 scopus 로고
    • Whole-body lipolysis and triglyceride-fatty acid cycling in cachectic patients with esophageal cancer
    • Klein, S.; Wolfe, R.R. Whole-body lipolysis and triglyceride-fatty acid cycling in cachectic patients with esophageal cancer. J. Clin. Investig.1990, 86, 1403–1408.
    • (1990) J. Clin. Investig. , vol.86 , pp. 1403-1408
    • Klein, S.1    Wolfe, R.R.2
  • 56
    • 0022499688 scopus 로고
    • Cancer cachexia and the rate of whole body lipolysis in man
    • Jeevanandam, M.; Horowitz, G.D.; Lowry, S.F.; Brennan, M.F. Cancer cachexia and the rate of whole body lipolysis in man. Metabolism1986, 35, 304–310.
    • (1986) Metabolism , vol.35 , pp. 304-310
    • Jeevanandam, M.1    Horowitz, G.D.2    Lowry, S.F.3    Brennan, M.F.4
  • 58
    • 42949140834 scopus 로고    scopus 로고
    • Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity
    • Jocken, J.W.; Blaak, E.E. Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity. Physiol. Behav.2008, 94, 219–230.
    • (2008) Physiol. Behav. , vol.94 , pp. 219-230
    • Jocken, J.W.1    Blaak, E.E.2
  • 59
    • 0348049843 scopus 로고    scopus 로고
    • Molecular mechanisms regulating hormone-sensitive lipase and lipolysis
    • Holm, C. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Biochem. Soc. Trans.2003, 31, 1120–1124.
    • (2003) Biochem , vol.31 , pp. 1120-1124
    • Holm, C.1
  • 60
    • 0027526182 scopus 로고
    • Increased expression of the mRNA for hormone-sensitive lipase in adipose tissue of cancer patients
    • Thompson, M.P.; Cooper, S.T.; Parry, B.R.; Tuckey, J.A. Increased expression of the mRNA for hormone-sensitive lipase in adipose tissue of cancer patients. Biochim. Biophys. Acta1993, 1180, 236–242.
    • (1993) Biochim. Biophys. Acta , vol.1180 , pp. 236-242
    • Thompson, M.P.1    Cooper, S.T.2    Parry, B.R.3    Tuckey, J.A.4
  • 61
    • 84877134318 scopus 로고    scopus 로고
    • The role of triglyceride lipases in cancer associated cachexia
    • Das, S.K.; Hoefler, G. The role of triglyceride lipases in cancer associated cachexia. Trends Mol. Med.2013, 19, 292–301.
    • (2013) Trends Mol. Med. , vol.19 , pp. 292-301
    • Das, S.K.1    Hoefler, G.2
  • 62
    • 84899747167 scopus 로고    scopus 로고
    • Depletion of white adipose tissue in cancer cachexia syndrome is associated with inflammatory signaling and disrupted circadian regulation
    • Tsoli, M.; Schweiger, M.; Vanniasinghe, A.S.; Painter, A.; Zechner, R.; Clarke, S.; Robertson, G. Depletion of white adipose tissue in cancer cachexia syndrome is associated with inflammatory signaling and disrupted circadian regulation. PLoS One2014, 9, doi:10.1371/journal.pone.0092966.
    • (2014) Plos One , vol.9
    • Tsoli, M.1    Schweiger, M.2    Vanniasinghe, A.S.3    Painter, A.4    Zechner, R.5    Clarke, S.6    Robertson, G.7
  • 63
    • 84887431711 scopus 로고    scopus 로고
    • Brown and beige fat: Development, function and therapeutic potential
    • Harms, M.; Seale, P. Brown and beige fat: Development, function and therapeutic potential. Nat. Med. 2013, 19, 1252–1263.
    • (2013) Nat. Med. , vol.19 , pp. 1252-1263
    • Harms, M.1    Seale, P.2
  • 64
    • 84906934662 scopus 로고    scopus 로고
    • Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia
    • Kir, S.; White, J.P.; Kleiner, S.; Kazak, L.; Cohen, P.; Baracos, V.E.; Spiegelman, B.M. Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature2014, 513, 100–104.
    • (2014) Nature , vol.513 , pp. 100-104
    • Kir, S.1    White, J.P.2    Kleiner, S.3    Kazak, L.4    Cohen, P.5    Baracos, V.E.6    Spiegelman, B.M.7
  • 65
    • 0032810337 scopus 로고    scopus 로고
    • Metabolic and morphologic characteristics of adipose tissue associated with the growth of malignant tumors
    • Ishiko, O.; Nishimura, S.; Yasui, T.; Sumi, T.; Hirai, K.; Honda, K.; Ogita, S. Metabolic and morphologic characteristics of adipose tissue associated with the growth of malignant tumors. Jpn. J. Cancer Res.1999, 90, 655–659.
    • (1999) Jpn. J. Cancer Res. , vol.90 , pp. 655-659
    • Ishiko, O.1    Nishimura, S.2    Yasui, T.3    Sumi, T.4    Hirai, K.5    Honda, K.6    Ogita, S.7
  • 66
    • 34250748977 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4 (TCF7L2)-dependent pathway
    • Cawthorn, W.P.; Heyd, F.; Hegyi, K.; Sethi, J.K. Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4 (TCF7L2)-dependent pathway. Cell Death Differ. 2007, 14, 1361–1373.
    • (2007) Cell Death Differ , vol.14 , pp. 1361-1373
    • Cawthorn, W.P.1    Heyd, F.2    Hegyi, K.3    Sethi, J.K.4
  • 67
    • 77949325739 scopus 로고    scopus 로고
    • New insights into adipose tissue atrophy in cancer cachexia
    • Bing, C.; Trayhurn, P. New insights into adipose tissue atrophy in cancer cachexia. Proc. Nutr. Soc.2009, 68, 385–392.
    • (2009) Proc. Nutr. Soc. , vol.68 , pp. 385-392
    • Bing, C.1    Trayhurn, P.2
  • 68
    • 34248141100 scopus 로고    scopus 로고
    • A cytokine-mediated link between innate immunity, inflammation, and cancer
    • Lin, W.W.; Karin, M. A cytokine-mediated link between innate immunity, inflammation, and cancer. J. Clin. Investig.2007, 117, 1175–1183.
    • (2007) J. Clin. Investig. , vol.117 , pp. 1175-1183
    • Lin, W.W.1    Karin, M.2
  • 70
    • 2042480671 scopus 로고    scopus 로고
    • Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans
    • Fain, J.N.; Madan, A.K.; Hiler, M.L.; Cheema, P.; Bahouth, S.W. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology2004, 145, 2273–2282.
    • (2004) Endocrinology , vol.145 , pp. 2273-2282
    • Fain, J.N.1    Madan, A.K.2    Hiler, M.L.3    Cheema, P.4    Bahouth, S.W.5
  • 74
    • 84856920747 scopus 로고    scopus 로고
    • Lipid mobilization in cachexia: Mechanisms and mediators
    • Bing, C. Lipid mobilization in cachexia: Mechanisms and mediators. Curr. Opin. Support. Palliat. Care2011, 5, 356–360.
    • (2011) Curr. Opin. Support. Palliat. Care , vol.5 , pp. 356-360
    • Bing, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.