Abdominal visceral and subcutaneous fat increase, insulin resistance and hyperlipidemia in testicular cancer patients treated with cisplatin-based chemotherapy

Acta Oncologica

Volumn 53, Issue 3, 2014, Pages 351-360

  Willemse, Peter Paul M ^a   Van Der Meer, Rutger W ^a   Burggraaf, Jacobus ^b   Van Elderen, Saskia G C ^a   De Kam, Marieke L ^b   De Roos, Albert ^a   Lamb, Hildo J ^a   Osanto, Susanne ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b CENTRE FOR HUMAN DRUG RESEARCH   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; CISPLATIN; DEXAMETHASONE; ESTRADIOL; ETOPOSIDE; FOLLITROPIN; GLUCOSE; GRANISETRON; IFOSFAMIDE; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUTEINIZING HORMONE; PACLITAXEL; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; TRIACYLGLYCEROL; VINBLASTINE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; CREATININE; GAMMA GLUTAMYLTRANSFERASE; GLOBULIN; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LACTATE DEHYDROGENASE; LIPID;

ABDOMINAL AORTA; ABDOMINAL SUBCUTANEOUS FAT; ADULT; ALCOHOL CONSUMPTION; ARTERIAL STIFFNESS; ARTICLE; BLOOD SAMPLING; BODY MASS; CANCER CHEMOTHERAPY; CANCER STAGING; CANCER SURVIVOR; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; COHORT ANALYSIS; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG EFFECT; DRUG MEGADOSE; DYSLIPIDEMIA; FOLLOW UP; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HIGH RISK PATIENT; HISTOPATHOLOGY; HUMAN; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LIPID BLOOD LEVEL; MALE; MEDICAL HISTORY; METABOLIC SYNDROME X; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OBESITY; ORCHIECTOMY; PRIORITY JOURNAL; PULSE RATE; PULSE WAVE; SMOKING; SYSTOLIC BLOOD PRESSURE; TESTIS CANCER; TRIACYLGLYCEROL BLOOD LEVEL; YOUNG ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CREATININE BLOOD LEVEL; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLOBULIN BLOOD LEVEL; INSULIN BLOOD LEVEL; LACTATE DEHYDROGENASE BLOOD LEVEL; PROTON NUCLEAR MAGNETIC RESONANCE; SIDE EFFECT; TREATMENT DURATION;

ABDOMINAL FAT; ADULT; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BODY MASS INDEX; CHOLESTEROL; CISPLATIN; HUMANS; HYPERLIPIDEMIAS; INSULIN RESISTANCE; LIVER; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; SUBCUTANEOUS FAT; TESTICULAR NEOPLASMS;

EID: 84885403137     PISSN: 0284186X     EISSN: 1651226X     Source Type: Journal    
DOI: 10.3109/0284186X.2013.819116     Document Type: Article

References (33)

1. Einhorn EH. Testicular cancer: An oncological success story. Clin Cancer Res 1997;3:2630-2.
2. Nuver J, Smit AJ, Wolffenbuttel BH, Sluiter WJ, Hoekstra HJ, Sleijfer DT, et al. The metabolic syndrome and disturbances in hormone levels in long-term survivors of disseminated testicular cancer. J Clin Oncol 2005;23:3718-25.
3. Haugnes HS, Aass N, Fossa SD, Dahl O, Klepp O, Wist EA, et al. Components of the metabolic syndrome in long-term survivors of testicular cancer. Ann Oncol 2007;18:241-8.
4. Stefenelli T, Kuzmits R, Ulrich W, Glogar D. Acute vascular toxicity after combination chemotherapy with cisplatin, vinblastine, and bleomycin for testicular cancer. Eur Heart J 1988;9:552-6.
5. Weijl NI, Rutten MF, Zwinderman AH, Keizer HJ, Nooy MA, Rosendaal FR, et al. Thromboembolic events during chemotherapy for germ cell cancer: A cohort study and review of the literature. J Clin Oncol 2000;18:2169-78.
6. Huddart RA, Norman A, Shahidi M, Horwich A, Coward D, Nicholls J, et al. Cardiovascular disease as a long-term complication of treatment for testicular cancer. J Clin Oncol 2003;21:1513-23.
7. Pollera CF, Ameglio F, Nardi M, Vitelli G, Marolla P. Cisplatin-induced hepatic toxicity. J Clin Oncol 1987;5: 318-9.
8. Bjorntorp P. Metabolic implications of body fat distribution. Diabetes Care 1991;14:1132-43.
9. Brook RD, Bard RL, Rubenfire M, Ridker PM, Rajagopalan S. Usefulness of visceral obesity (waist/hip ratio) in predicting vascular endothelial function in healthy overweight adults. Am J Cardiol 2001;88:1264-9.
10. Despres.P. Cardiovascular disease under the influence of excess visceral fat. Crit Pathw Cardiol 2007;6:51-9.
11. Ritchie SA, Connell JM. The link between abdominal obesity, metabolic syndrome and cardiovascular disease. Nutr Metab Cardiovasc Dis 2007;17:319-26.
12. Montiel M, Urso L, de la Blanca EP, Marsigliante S, Jimenez E. Cisplatin reduces endothelial cell migration via regulation of type 2-matrix metalloproteinase activity. Cell Physiol Biochem 2009;23:441-8.
13. Nuver J, de Haas EC, van Zweeden M, Gietema JA, Meijer C. Vascular damage in testicular cancer patients: A study on endothelial activation by bleomycin and cisplatin in vitro. Oncol Rep 2010;23:247-53.
14. Heier MS, Nilsen T, Graver V, Aass N, Fossa SD. Raynauds phenomenon after combination chemotherapy of testicular cancer, measured by laser Doppler flowmetry. A pilot study. Br J Cancer 1991;63:550-2.
15. Fischbach F, Bruhn H. Assessment of in vivo 1H magnetic resonance spectroscopy in the liver: A review. Liver Int 2008;28:297-307.
16. van der Meer RW, Hammer S, Lamb HJ, Frolich M, Dia-mant M, Rijzewijk LJ, et al. Effects of short-term high-fat, high-energy diet on hepatic and myocardial triglyceride content in healthy men. J Clin Endocrinol Metab 2008;93:2702-8.
17. Hamaguchi M, Kojima T, Takeda N, Nakagawa T, Taniguchi H, Fujii K, et al. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann Intern Med 2005;143:722-8.
18. De Haas EC, Oosting SF, Lefrandt JD, Wolffenbuttel BH, Sleijfer DT, Gietema JA. The metabolic syndrome in cancer survivors. Lancet Oncol 2010;11:193-203.
19. Amar J, Ruidavets JB, Chamontin B, Drouet L, Ferrieres J. Arterial stiffness and cardiovascular risk factors in a population-based study. J Hypertens 2001;19:381-7.
20. Maldonado J, Pereira T, Polonia J, Silva JA, Morais J, Marques M. Arterial stiffness predicts cardiovascular outcome in a low-to-moderate cardiovascular risk population: The EDIVA (Estudo de DIstensibilidade VAscular) project. J Hypertens 2011;29:669-75.
21. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-9.
22. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998;15:539-53.
23. van der Meer RW, Doornbos J, Kozerke S, Schar M, Bax JJ, Hammer S, et al. Metabolic imaging of myocardial triglyceride content: Reproducibility of 1H MR spectroscopy with respiratory navigator gating in volunteers. Radiology 2007; 245:251-7.
24. Szczepaniak LS, Nurenberg P, Leonard D, Browning JD, Reingold JS, Grundy S, et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: Prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 2005;288:E462-8.
25. Mahmood S, Taketa K, Imai K, Kajihara Y, Imai S, Yokobayashi T, et al. Association of fatty liver with increased ratio of visceral to subcutaneous adipose tissue in obese men. Acta Med Okayama 1998;52:225-31.
26. Machann J, Thamer C, Schnoedt B, Stefan N, Haring HU, Claussen CD, et al. Hepatic lipid accumulation in healthy subjects: A comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopy. Magn Reson Med 2006;55:913-7.
27. Qi J, Fong Y, Saltz L, DAngelica MI, Kemeny NE, Gonen M, et al. Serial measurement of hepatic lipids during chemotherapy in patients with colorectal cancer: A 1 H MRS study. NMR Biomed 2013;26:204-12.
28. Peiris AN, Sothmann MS, Hoffmann RG, Hennes MI, Wilson CR, Gustafson AB, et al. Adiposity, fat distribution, and cardiovascular risk. Ann Intern Med 1989; 110:867-72.
29. Kohn S, Fradis M, Podoshin L, Ben-David J, Zidan J, Robinson E. Endothelial injury of capillaries in the stria vascularis of guinea pigs treated with cisplatin and gentamicin. Ultrastruct Pathol 1997;21:289-99.
30. Webb DR, Khunti K, Silverman R, Gray LJ, Srinivasan B, Lacy PS, et al. Impact of metabolic indices on central artery stiffness: Independent association of insulin resistance and glucose with aortic pulse wave velocity. Diabetologia 2010; 53:1190-8.
31. van der Meer RW, Hammer S, Smit JW, Frolich M, Bax JJ, Diamant M, et al. Short-term caloric restriction induces accumulation of myocardial triglycerides and decreases left ventricular diastolic function in healthy subjects. Diabetes 2007;56:2849-53.
32. Haugnes HS, Wethal T, Aass N, Dahl O, Klepp O, Langberg CW, et al. Cardiovascular risk factors and morbidity in long-term survivors of testicular cancer: A 20-year follow-up study. J Clin Oncol 2010;28:4649-57.
33. Fong AC, Cheung NW. The high incidence of steroid-induced hyperglycaemia in hospital. Diabetes Res Clin Pract 2013;99:277-80.