Adipose tissue volume is decreased in recently diagnosed cancer patients with cachexia

Nutrition

Volumn 28, Issue 9, 2012, Pages 851-855

  Agustsson, Thorhallur ^a   Wikrantz, Pal ^a   Rydén, Mikael ^b   Brismar, Torkel ^a   Isaksson, Bengt ^a  

^a Intervention and Technology ^*  (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cachexia; Computed tomography; Gastrointestinal cancer; Subcutaneous adipose tissue; Visceral adipose tissue

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; LEPTIN; SOMATOMEDIN C; TRIACYLGLYCEROL;

ADULT; ALBUMIN BLOOD LEVEL; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; CACHEXIA; CANCER PATIENT; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY EXPENDITURE; GASTROINTESTINAL OBSTRUCTION; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INTRAABDOMINAL FAT; LEAN BODY WEIGHT; LIPOPROTEIN BLOOD LEVEL; METABOLIC RATE; MUSCLE TISSUE; NUTRITIONAL STATUS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SUBCUTANEOUS FAT; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION;

AGED; BODY FLUID COMPARTMENTS; BODY MASS INDEX; BODY WATER; BODY WEIGHT; CACHEXIA; ENERGY METABOLISM; FEMALE; GASTROINTESTINAL DISEASES; HUMANS; INTRA-ABDOMINAL FAT; MALE; MIDDLE AGED; NEOPLASMS; SUBCUTANEOUS FAT; WEIGHT LOSS;

EID: 84864528329     PISSN: 08999007     EISSN: 18731244     Source Type: Journal    
DOI: 10.1016/j.nut.2011.11.026     Document Type: Article

References (25)

1. Tisdale M.J. The 'cancer cachectic factor'. Support Care Cancer 2003, 11:73-78.
2. Cabal-Manzano R., Bhargava P., Torres-Duarte A., Marshall J., Wainer I.W. Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss. Br J Cancer 2001, 84:1599-1601.
3. Argiles J.M., Alvarez B., Lopez-Soriano F.J. The metabolic basis of cancer cachexia. Med Res Rev 1997, 17:477-498.
4. Costa G. Cachexia, the metabolic component of neoplastic diseases. Cancer Res 1977, 37(7 Pt 2):2327-2335.
5. Costa G.L., Vincent R.G., Siebold J.A., Argon M., Bewley P.T. Weight loss and cachexia in lung cancer. Nutr Cancer 1980, 2:98-103.
6. Kotler D.P. Cachexia. Ann Intern Med 2000, 133:622-634.
7. Feron K.C. Cancer cachexia. Ann Surg 1988, 208:1-5.
8. Tisdale M.J. Cancer cachexia. Br J Cancer 1991, 63:337-342.
9. Ryden M., Agustsson T., Laurencikiene J., Britton T., Sjolin E., Isaksson B., et al. Lipolysis-not inflammation, cell death, or lipogenesis-is involved in adipose tissue loss in cancer cachexia. Cancer 2008, 113:1695-1704.
10. Agustsson T., Ryden M., Hoffstedt J., van Harmelen V., Dicker A., Laurencikiene J., et al. Mechanism of increased lipolysis in cancer cachexia. Cancer Res 2007, 67:5531-5537.
11. Pouliot M.C., Despres J.P., Nadeau A., Moorjani S., Prud'Homme D., Lupien P.J., et al. Visceral obesity in men. Associations with glucose tolerance, plasma insulin, and lipoprotein levels. Diabetes 1992, 41:826-834.
12. Nakajima T., Fujioka S., Tokunaga K., Matsuzawa Y., Tarui S. Correlation of intraabdominal fat accumulation and left ventricular performance in obesity. Am J Cardiol 1989, 64:369-373.
13. Zamboni M., Armellini F., Sheiban I., De Marchi M., Todesco T., Bergamo-Andreis I.A., et al. Relation of body fat distribution in men and degree of coronary narrowings in coronary artery disease. Am J Cardiol 1992, 70:1135-1138.
14. Imbeault P., Lemieux S., Prud'homme D., Tremblay A., Nadeau A., Despres J.P., Mauriege P. Relationship of visceral adipose tissue to metabolic risk factors for coronary heart disease: is there a contribution of subcutaneous fat cell hypertrophy?. Metabolism 1999, 48:355-362.
15. Isaksson B.S., Friess H., Buchler M.W., Herrington M.K., Wang F., Zierath J.R., et al. Impaired insulin action on phosphatidylinositol 3-kinase activity and glucose transport I skeletal muscle of pancreatic cancer patients. Pancreas 2002, 26:173-177.
16. Ferland M., Despres J.P., Tremblay A., Pinault S., Nadeau A., Moorjani S., et al. Assessment of adipose tissue distribution by computed axial tomography in obese women: association with body density and anthropometric measurements. Br J Nutr 1989, 61:139-148.
17. Brochu M., Starling R.D., Tchernof A., Matthews D.E., Garcia-Rubi E., Poehlman E.T. Visceral adipose tissue is an independent correlate of glucose disposal in older obese postmenopausal women. J Clin Endocrinol Metab 2000, 85:2378-2384.
18. Prognostic factors in cancer 2001, Wiley-Liss, New York. E.A. Gospodarowicz (Ed.).
19. Harris J.B. A biometric study of basal metabolism in man 1919, Carnegie Institution of Washington, Washington, DC.
20. Ottery F.D. Rethinking nutritional support of the cancer patient: the new field of nutritional oncology. Semin Oncol 1994, 21:770-778.
21. Ottery F.D. Definition of standardized nutritional assessment and interventional pathways in oncology. Nutrition 1996, 12(1 suppl):S15-S19.
22. Fouladiun M., Korner U., Bosaeus I., Daneryd P., Hyltander A., Lundholm K.G. Body composition and time course changes in regional distribution of fat and lean tissue in unselected cancer patients on palliative care-correlations with food intake, metabolism, exercise capacity, and hormones. Cancer 2005, 103:2189-2198.
23. Ogiwara H., Takahashi S., Kato Y., Uyama I., Takahara T., Kikuchi K., Iida S. Diminished visceral adipose tissue in cancer cachexia. J Surg Oncol 1994, 57:129-133.
24. Bays H.E., Gonzalez-Campoy J.M., Bray G.A., Kitabchi A.E., Bergman D.A., Schorr A.B., et al. Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity. Expert Rev Cardiovasc Ther 2008, 6:343-368.
25. Heymsfield S.B., McManus C.B. Tissue components of weight loss in cancer patients. A new method of study and preliminary observations. Cancer 1985, 55(1 suppl):238-249.