-
1
-
-
46849115787
-
Autophagy is essential for preimplantation development of mouse embryos
-
Tsukamoto S, Kuma A, Murakami M, Kishi C, Yamamoto A, Mizushima N. 2008. Autophagy is essential for preimplantation development of mouse embryos. Science 321:117-120. http://dx.doi.org/10.1126/science.1154822.
-
(2008)
Science
, vol.321
, pp. 117-120
-
-
Tsukamoto, S.1
Kuma, A.2
Murakami, M.3
Kishi, C.4
Yamamoto, A.5
Mizushima, N.6
-
2
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
Mizushima N, Levine B, Cuervo AM, Klionsky DJ. 2008. Autophagy fights disease through cellular self-digestion. Nature 451:1069-1075. http://dx.doi.org/10.1038/nature06639.
-
(2008)
Nature
, vol.451
, pp. 1069-1075
-
-
Mizushima, N.1
Levine, B.2
Cuervo, A.M.3
Klionsky, D.J.4
-
3
-
-
34447099450
-
Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion
-
Nakatogawa H, Ichimura Y, Ohsumi Y. 2007. Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell 130:165-178. http://dx.doi.org/10.1016/j.cell.2007.05.021.
-
(2007)
Cell
, vol.130
, pp. 165-178
-
-
Nakatogawa, H.1
Ichimura, Y.2
Ohsumi, Y.3
-
4
-
-
77955901317
-
The role of membrane proteins in mammalian autophagy
-
Tooze SA. 2010. The role of membrane proteins in mammalian autophagy. Semin Cell Dev Biol 21:677-682. http://dx.doi.org/10.1016/j.semcdb.2010.03.007.
-
(2010)
Semin Cell Dev Biol
, vol.21
, pp. 677-682
-
-
Tooze, S.A.1
-
5
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine B, Kroemer G. 2008. Autophagy in the pathogenesis of disease. Cell 132:27-42. http://dx.doi.org/10.1016/j.cell.2007.12.018.
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
6
-
-
84871903696
-
Maturation of autophagosomes and endosomes: a key role for Rab7
-
Hyttinen JM, Niittykoski M, Salminen A, Kaarniranta K. 2013. Maturation of autophagosomes and endosomes: a key role for Rab7. Biochim Biophys Acta 1833:503-510. http://dx.doi.org/10.1016/j.bbamcr.2012.11.018.
-
(2013)
Biochim Biophys Acta
, vol.1833
, pp. 503-510
-
-
Hyttinen, J.M.1
Niittykoski, M.2
Salminen, A.3
Kaarniranta, K.4
-
7
-
-
78650419576
-
Rab7: role of its protein interaction cascades in endo-lysosomal traffic
-
Wang T, Ming Z, Xiaochun W, Hong W. 2011. Rab7: role of its protein interaction cascades in endo-lysosomal traffic. Cell Signal 23:516-521. http://dx.doi.org/10.1016/j.cellsig.2010.09.012.
-
(2011)
Cell Signal
, vol.23
, pp. 516-521
-
-
Wang, T.1
Ming, Z.2
Xiaochun, W.3
Hong, W.4
-
8
-
-
84877886601
-
CORVET and HOPS tethering complexes-coordinators of endosome and lysosome fusion
-
Balderhaar HJ, Ungermann C. 2013. CORVET and HOPS tethering complexes-coordinators of endosome and lysosome fusion. J Cell Sci 126:1307-1316. http://dx.doi.org/10.1242/jcs.107805.
-
(2013)
J Cell Sci
, vol.126
, pp. 1307-1316
-
-
Balderhaar, H.J.1
Ungermann, C.2
-
9
-
-
0345118282
-
Roc, a Ras/GTPase domain in complex proteins
-
Bosgraaf L, Van Haastert PJ. 2003. Roc, a Ras/GTPase domain in complex proteins. Biochim Biophys Acta 1643:5-10. http://dx.doi.org/10.1016/j.bbamcr.2003.08.008.
-
(2003)
Biochim Biophys Acta
, vol.1643
, pp. 5-10
-
-
Bosgraaf, L.1
Van Haastert, P.J.2
-
10
-
-
59649089328
-
The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration
-
Ho CC, Rideout HJ, Ribe E, Troy CM, Dauer WT. 2009. The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration. J Neurosci 29:1011-1016. http://dx.doi.org/10.1523/JNEUROSCI.5175-08.2009.
-
(2009)
J Neurosci
, vol.29
, pp. 1011-1016
-
-
Ho, C.C.1
Rideout, H.J.2
Ribe, E.3
Troy, C.M.4
Dauer, W.T.5
-
11
-
-
51949090816
-
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
-
Imai Y, Gehrke S, Wang HQ, Takahashi R, Hasegawa K, Oota E, Lu B. 2008. Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J 27:2432-2443. http://dx.doi.org/10.1038/emboj.2008.163.
-
(2008)
EMBO J
, vol.27
, pp. 2432-2443
-
-
Imai, Y.1
Gehrke, S.2
Wang, H.Q.3
Takahashi, R.4
Hasegawa, K.5
Oota, E.6
Lu, B.7
-
12
-
-
77955152366
-
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
-
Gehrke S, Imai Y, Sokol N, Lu B. 2010. Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. Nature 466:637-641. http://dx.doi.org/10.1038/nature09191.
-
(2010)
Nature
, vol.466
, pp. 637-641
-
-
Gehrke, S.1
Imai, Y.2
Sokol, N.3
Lu, B.4
-
13
-
-
45549085874
-
The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules
-
Gandhi PN, Wang X, Zhu X, Chen SG, Wilson-Delfosse AL. 2008. The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules. J Neurosci Res 86:1711-1720. http://dx.doi.org/10.1002/jnr.21622.
-
(2008)
J Neurosci Res
, vol.86
, pp. 1711-1720
-
-
Gandhi, P.N.1
Wang, X.2
Zhu, X.3
Chen, S.G.4
Wilson-Delfosse, A.L.5
-
14
-
-
68949218403
-
Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability-a point of convergence in Parkinsonian neurodegeneration?
-
Gillardon F. 2009. Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability-a point of convergence in Parkinsonian neurodegeneration? J Neurochem 110:1514-1522. http://dx.doi.org/10.1111/j.1471-4159.2009.06235.x.
-
(2009)
J Neurochem
, vol.110
, pp. 1514-1522
-
-
Gillardon, F.1
-
15
-
-
79951534656
-
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool
-
Piccoli G, Condliffe SB, Bauer M, Giesert F, Boldt K, De Astis S, Meixner A, Sarioglu H, Vogt-Weisenhorn DM, Wurst W, Gloeckner CJ, Matteoli M, Sala C, Ueffing M. 2011. LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. J Neurosci 31:2225-2237. http://dx.doi.org/10.1523/JNEUROSCI.3730-10.2011.
-
(2011)
J Neurosci
, vol.31
, pp. 2225-2237
-
-
Piccoli, G.1
Condliffe, S.B.2
Bauer, M.3
Giesert, F.4
Boldt, K.5
De Astis, S.6
Meixner, A.7
Sarioglu, H.8
Vogt-Weisenhorn, D.M.9
Wurst, W.10
Gloeckner, C.J.11
Matteoli, M.12
Sala, C.13
Ueffing, M.14
-
16
-
-
70349991886
-
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
-
Alegre-Abarrategui J, Christian H, Lufino MM, Mutihac R, Venda LL, Ansorge O, Wade-Martins R. 2009. LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum Mol Genet 18:4022-4034. http://dx.doi.org/10.1093/hmg/ddp346.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 4022-4034
-
-
Alegre-Abarrategui, J.1
Christian, H.2
Lufino, M.M.3
Mutihac, R.4
Venda, L.L.5
Ansorge, O.6
Wade-Martins, R.7
-
17
-
-
84888852586
-
Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation
-
Manzoni C, Mamais A, Dihanich S, McGoldrick P, Devine MJ, Zerle J, Kara E, Taanman JW, Healy DG, Marti-Masso JF, Schapira AH, Plun-Favreau H, Tooze S, Hardy J, Bandopadhyay R, Lewis PA. 2013. Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation. Biochem Biophys Res Commun 441:862-866. http://dx.doi.org/10.1016/j.bbrc.2013.10.159.
-
(2013)
Biochem Biophys Res Commun
, vol.441
, pp. 862-866
-
-
Manzoni, C.1
Mamais, A.2
Dihanich, S.3
McGoldrick, P.4
Devine, M.J.5
Zerle, J.6
Kara, E.7
Taanman, J.W.8
Healy, D.G.9
Marti-Masso, J.F.10
Schapira, A.H.11
Plun-Favreau, H.12
Tooze, S.13
Hardy, J.14
Bandopadhyay, R.15
Lewis, P.A.16
-
18
-
-
39549117093
-
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
-
Plowey ED, Cherra SJ, III, Liu YJ, Chu CT. 2008. Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J Neurochem 105:1048-1056. http://dx.doi.org/10.1111/j.1471-4159.2008.05217.x.
-
(2008)
J Neurochem
, vol.105
, pp. 1048-1056
-
-
Plowey, E.D.1
Cherra, S.J.2
Liu, Y.J.3
Chu, C.T.4
-
19
-
-
79953758383
-
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2
-
Ramonet D, Daher JP, Lin BM, Stafa K, Kim J, Banerjee R, Westerlund M, Pletnikova O, Glauser L, Yang L, Liu Y, Swing DA, Beal MF, Troncoso JC, McCaffery JM, Jenkins NA, Copeland NG, Galter D, Thomas B, Lee MK, Dawson TM, Dawson VL, Moore DJ. 2011. Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. PLoS One 6:e18568. http://dx.doi.org/10.1371/journal.pone.0018568.
-
(2011)
PLoS One
, vol.6
-
-
Ramonet, D.1
Daher, J.P.2
Lin, B.M.3
Stafa, K.4
Kim, J.5
Banerjee, R.6
Westerlund, M.7
Pletnikova, O.8
Glauser, L.9
Yang, L.10
Liu, Y.11
Swing, D.A.12
Beal, M.F.13
Troncoso, J.C.14
McCaffery, J.M.15
Jenkins, N.A.16
Copeland, N.G.17
Galter, D.18
Thomas, B.19
Lee, M.K.20
Dawson, T.M.21
Dawson, V.L.22
Moore, D.J.23
more..
-
20
-
-
84863294414
-
Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
-
Tong Y, Giaime E, Yamaguchi H, Ichimura T, Liu Y, Si H, Cai H, Bonventre JV, Shen J. 2012. Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway. Mol Neurodegener 7:2. http://dx.doi.org/10.1186/1750-1326-7-2.
-
(2012)
Mol Neurodegener
, vol.7
, pp. 2
-
-
Tong, Y.1
Giaime, E.2
Yamaguchi, H.3
Ichimura, T.4
Liu, Y.5
Si, H.6
Cai, H.7
Bonventre, J.V.8
Shen, J.9
-
21
-
-
33847617975
-
Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease
-
Taylor JP, Hulihan MM, Kachergus JM, Melrose HL, Lincoln SJ, Hinkle KM, Stone JT, Ross OA, Hauser R, Aasly J, Gasser T, Payami H, Wszolek ZK, Farrer MJ. 2007. Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease. Neurogenetics 8:95-102. http://dx.doi.org/10.1007/s10048-006-0075-8.
-
(2007)
Neurogenetics
, vol.8
, pp. 95-102
-
-
Taylor, J.P.1
Hulihan, M.M.2
Kachergus, J.M.3
Melrose, H.L.4
Lincoln, S.J.5
Hinkle, K.M.6
Stone, J.T.7
Ross, O.A.8
Hauser, R.9
Aasly, J.10
Gasser, T.11
Payami, H.12
Wszolek, Z.K.13
Farrer, M.J.14
-
22
-
-
84910004657
-
LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity
-
Gómez-Suaga P, Rivero-Rios P, Fdez E, Blanca Ramirez M, Ferrer I, Aiastui A, Lopez De Munain A, Hilfiker S. 2014. LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity. Hum Mol Genet 23:6779-6796. http://dx.doi.org/10.1093/hmg/ddu395.
-
(2014)
Hum Mol Genet
, vol.23
, pp. 6779-6796
-
-
Gómez-Suaga, P.1
Rivero-Rios, P.2
Fdez, E.3
Blanca Ramirez, M.4
Ferrer, I.5
Aiastui, A.6
Lopez De Munain, A.7
Hilfiker, S.8
-
23
-
-
84873281274
-
RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk
-
MacLeod DA, Rhinn H, Kuwahara T, Zolin A, Di Paolo G, McCabe BD, Marder KS, Honig LS, Clark LN, Small SA, Abeliovich A. 2013. RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. Neuron 77:425-439. http://dx.doi.org/10.1016/j.neuron.2012.11.033.
-
(2013)
Neuron
, vol.77
, pp. 425-439
-
-
MacLeod, D.A.1
Rhinn, H.2
Kuwahara, T.3
Zolin, A.4
Di Paolo, G.5
McCabe, B.D.6
Marder, K.S.7
Honig, L.S.8
Clark, L.N.9
Small, S.A.10
Abeliovich, A.11
-
24
-
-
41049102001
-
Preparation, culture, and immortalization of mouse embryonic fibroblasts
-
Xu, J. 2005. Preparation, culture, and immortalization of mouse embryonic fibroblasts. Curr Protoc Mol Biol Chapter 28:Unit 28.1.
-
(2005)
Curr Protoc Mol Biol Chapter 28:Unit 28.1
-
-
Xu, J.1
-
25
-
-
33748993710
-
Kinase activity of mutant LRRK2 mediates neuronal toxicity
-
Smith WW, Pei Z, Jiang H, Dawson VL, Dawson TM, Ross CA. 2006. Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nat Neurosci 9:1231-1233. http://dx.doi.org/10.1038/nn1776.
-
(2006)
Nat Neurosci
, vol.9
, pp. 1231-1233
-
-
Smith, W.W.1
Pei, Z.2
Jiang, H.3
Dawson, V.L.4
Dawson, T.M.5
Ross, C.A.6
-
26
-
-
78049288601
-
Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity
-
Zach S, Felk S, Gillardon F. 2010. Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity. PLoS One 5:e13191. http://dx.doi.org/10.1371/journal.pone.0013191.
-
(2010)
PLoS One
, vol.5
-
-
Zach, S.1
Felk, S.2
Gillardon, F.3
-
27
-
-
39549098329
-
Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease
-
Spinosa MR, Progida C, De Luca A, Colucci AM, Alifano P, Bucci C. 2008. Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease. J Neurosci 28:1640-1648. http://dx.doi.org/10.1523/JNEUROSCI.3677-07.2008.
-
(2008)
J Neurosci
, vol.28
, pp. 1640-1648
-
-
Spinosa, M.R.1
Progida, C.2
De Luca, A.3
Colucci, A.M.4
Alifano, P.5
Bucci, C.6
-
28
-
-
0023065242
-
Intracellular protein catabolism and its control during nutrient deprivation and supply
-
Mortimore GE, Poso AR. 1987. Intracellular protein catabolism and its control during nutrient deprivation and supply. Annu Rev Nutr 7:539-564. http://dx.doi.org/10.1146/annurev.nu.07.070187.002543.
-
(1987)
Annu Rev Nutr
, vol.7
, pp. 539-564
-
-
Mortimore, G.E.1
Poso, A.R.2
-
29
-
-
11144245626
-
The role of autophagy during the early neonatal starvation period
-
Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N. 2004. The role of autophagy during the early neonatal starvation period. Nature 432:1032-1036. http://dx.doi.org/10.1038/nature03029.
-
(2004)
Nature
, vol.432
, pp. 1032-1036
-
-
Kuma, A.1
Hatano, M.2
Matsui, M.3
Yamamoto, A.4
Nakaya, H.5
Yoshimori, T.6
Ohsumi, Y.7
Tokuhisa, T.8
Mizushima, N.9
-
30
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. 2000. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19:5720-5728. http://dx.doi.org/10.1093/emboj/19.21.5720.
-
(2000)
EMBO J
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
Mizushima, N.2
Ueno, T.3
Yamamoto, A.4
Kirisako, T.5
Noda, T.6
Kominami, E.7
Ohsumi, Y.8
Yoshimori, T.9
-
31
-
-
59249105964
-
Monitoring autophagic degradation of p62/SQSTM1
-
Bjørkøy G, Lamark T, Pankiv S, Overvatn A, Brech A, Johansen T. 2009. Monitoring autophagic degradation of p62/SQSTM1. Methods Enzymol 452:181-197. http://dx.doi.org/10.1016/S0076-6879(08)03612-4.
-
(2009)
Methods Enzymol
, vol.452
, pp. 181-197
-
-
Bjørkøy, G.1
Lamark, T.2
Pankiv, S.3
Overvatn, A.4
Brech, A.5
Johansen, T.6
-
32
-
-
77949915406
-
2+ increase
-
2+ increase. Cell Signal 22:914-925. http://dx.doi.org/10.1016/j.cellsig.2010.01.015.
-
(2010)
Cell Signal
, vol.22
, pp. 914-925
-
-
Grotemeier, A.1
Alers, S.2
Pfisterer, S.G.3
Paasch, F.4
Daubrawa, M.5
Dieterle, A.6
Viollet, B.7
Wesselborg, S.8
Proikas-Cezanne, T.9
Stork, B.10
-
33
-
-
33845459165
-
Autophagy is activated for cell survival after endoplasmic reticulum stress
-
Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K, Shiosaka S, Hammarback JA, Urano F, Imaizumi K. 2006. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 26:9220-9231. http://dx.doi.org/10.1128/MCB.01453-06.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 9220-9231
-
-
Ogata, M.1
Hino, S.2
Saito, A.3
Morikawa, K.4
Kondo, S.5
Kanemoto, S.6
Murakami, T.7
Taniguchi, M.8
Tanii, I.9
Yoshinaga, K.10
Shiosaka, S.11
Hammarback, J.A.12
Urano, F.13
Imaizumi, K.14
-
34
-
-
34247161367
-
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
-
Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC. 2007. Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem 282:5641-5652. http://dx.doi.org/10.1074/jbc.M609532200.
-
(2007)
J Biol Chem
, vol.282
, pp. 5641-5652
-
-
Sarkar, S.1
Davies, J.E.2
Huang, Z.3
Tunnacliffe, A.4
Rubinsztein, D.C.5
-
35
-
-
34548077575
-
Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
-
Kimura S, Noda T, Yoshimori T. 2007. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 3:452-460. http://dx.doi.org/10.4161/auto.4451.
-
(2007)
Autophagy
, vol.3
, pp. 452-460
-
-
Kimura, S.1
Noda, T.2
Yoshimori, T.3
-
36
-
-
0033169080
-
A novel acidotropic pH indicator and its potential application in labeling acidic organelles of live cells
-
Diwu Z, Chen CS, Zhang C, Klaubert DH, Haugland RP. 1999. A novel acidotropic pH indicator and its potential application in labeling acidic organelles of live cells. Chem Biol 6:411-418. http://dx.doi.org/10.1016/S1074-5521(99)80059-3.
-
(1999)
Chem Biol
, vol.6
, pp. 411-418
-
-
Diwu, Z.1
Chen, C.S.2
Zhang, C.3
Klaubert, D.H.4
Haugland, R.P.5
-
37
-
-
33845934490
-
Ankyrin repeat: a unique motif mediating protein-protein interactions
-
Li J, Mahajan A, Tsai MD. 2006. Ankyrin repeat: a unique motif mediating protein-protein interactions. Biochemistry 45:15168-15178. http://dx.doi.org/10.1021/bi062188q.
-
(2006)
Biochemistry
, vol.45
, pp. 15168-15178
-
-
Li, J.1
Mahajan, A.2
Tsai, M.D.3
-
38
-
-
0035692811
-
The leucine-rich repeat as a protein recognition motif
-
Kobe B, Kajava AV. 2001. The leucine-rich repeat as a protein recognition motif. Curr Opin Struct Biol 11:725-732. http://dx.doi.org/10.1016/S0959-440X(01)00266-4.
-
(2001)
Curr Opin Struct Biol
, vol.11
, pp. 725-732
-
-
Kobe, B.1
Kajava, A.V.2
-
39
-
-
70450224446
-
Multiple roles of the vesicular-SNARE TI-VAMP in post-Golgi and endosomal trafficking
-
Chaineau M, Danglot L, Galli T. 2009. Multiple roles of the vesicular-SNARE TI-VAMP in post-Golgi and endosomal trafficking. FEBS Lett 583:3817-3826. http://dx.doi.org/10.1016/j.febslet.2009.10.026.
-
(2009)
FEBS Lett
, vol.583
, pp. 3817-3826
-
-
Chaineau, M.1
Danglot, L.2
Galli, T.3
-
41
-
-
47949102446
-
Sequential binding of cytosolic Phox complex to phagosomes through regulated adaptor proteins: evaluation using the novel monomeric Kusabira-Green System and live imaging of phagocytosis
-
Ueyama T, Kusakabe T, Karasawa S, Kawasaki T, Shimizu A, Son J, Leto TL, Miyawaki A, Saito N. 2008. Sequential binding of cytosolic Phox complex to phagosomes through regulated adaptor proteins: evaluation using the novel monomeric Kusabira-Green System and live imaging of phagocytosis. J Immunol 181:629-640. http://dx.doi.org/10.4049/jimmunol.181.1.629.
-
(2008)
J Immunol
, vol.181
, pp. 629-640
-
-
Ueyama, T.1
Kusakabe, T.2
Karasawa, S.3
Kawasaki, T.4
Shimizu, A.5
Son, J.6
Leto, T.L.7
Miyawaki, A.8
Saito, N.9
-
42
-
-
3242877218
-
Rab7 is required for the normal progression of the autophagic pathway in mammalian cells
-
Gutierrez MG, Munafo DB, Beron W, Colombo MI. 2004. Rab7 is required for the normal progression of the autophagic pathway in mammalian cells. J Cell Sci 117:2687-2697. http://dx.doi.org/10.1242/jcs.01114.
-
(2004)
J Cell Sci
, vol.117
, pp. 2687-2697
-
-
Gutierrez, M.G.1
Munafo, D.B.2
Beron, W.3
Colombo, M.I.4
-
43
-
-
7244255989
-
Role for Rab7 in maturation of late autophagic vacuoles
-
Jäger S, Bucci C, Tanida I, Ueno T, Kominami E, Saftig P, Eskelinen EL. 2004. Role for Rab7 in maturation of late autophagic vacuoles. J Cell Sci 117:4837-4848. http://dx.doi.org/10.1242/jcs.01370.
-
(2004)
J Cell Sci
, vol.117
, pp. 4837-4848
-
-
Jäger, S.1
Bucci, C.2
Tanida, I.3
Ueno, T.4
Kominami, E.5
Saftig, P.6
Eskelinen, E.L.7
-
44
-
-
84876416302
-
The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy
-
Carroll B, Mohd-Naim N, Maximiano F, Frasa MA, McCormack J, Finelli M, Thoresen SB, Perdios L, Daigaku R, Francis RE, Futter C, Dikic I, Braga VM. 2013. The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy. Dev Cell 25:15-28. http://dx.doi.org/10.1016/j.devcel.2013.03.005.
-
(2013)
Dev Cell
, vol.25
, pp. 15-28
-
-
Carroll, B.1
Mohd-Naim, N.2
Maximiano, F.3
Frasa, M.A.4
McCormack, J.5
Finelli, M.6
Thoresen, S.B.7
Perdios, L.8
Daigaku, R.9
Francis, R.E.10
Futter, C.11
Dikic, I.12
Braga, V.M.13
-
45
-
-
34249018367
-
GEFs and GAPs: critical elements in the control of small G proteins
-
Bos JL, Rehmann H, Wittinghofer A. 2007. GEFs and GAPs: critical elements in the control of small G proteins. Cell 129:865-877. http://dx.doi.org/10.1016/j.cell.2007.05.018.
-
(2007)
Cell
, vol.129
, pp. 865-877
-
-
Bos, J.L.1
Rehmann, H.2
Wittinghofer, A.3
-
46
-
-
54549088877
-
Rac activation and inactivation control plasticity of tumor cell movement
-
Sanz-Moreno V, Gadea G, Ahn J, Paterson H, Marra P, Pinner S, Sahai E, Marshall CJ. 2008. Rac activation and inactivation control plasticity of tumor cell movement. Cell 135:510-523. http://dx.doi.org/10.1016/j.cell.2008.09.043.
-
(2008)
Cell
, vol.135
, pp. 510-523
-
-
Sanz-Moreno, V.1
Gadea, G.2
Ahn, J.3
Paterson, H.4
Marra, P.5
Pinner, S.6
Sahai, E.7
Marshall, C.J.8
-
47
-
-
75749140509
-
Armus is a Rac1 effector that inactivates Rab7 and regulates Ecadherin degradation
-
Frasa MA, Maximiano FC, Smolarczyk K, Francis RE, Betson ME, Lozano E, Goldenring J, Seabra MC, Rak A, Ahmadian MR, Braga VM. 2010. Armus is a Rac1 effector that inactivates Rab7 and regulates Ecadherin degradation. Curr Biol 20:198-208. http://dx.doi.org/10.1016/j.cub.2009.12.053.
-
(2010)
Curr Biol
, vol.20
, pp. 198-208
-
-
Frasa, M.A.1
Maximiano, F.C.2
Smolarczyk, K.3
Francis, R.E.4
Betson, M.E.5
Lozano, E.6
Goldenring, J.7
Seabra, M.C.8
Rak, A.9
Ahmadian, M.R.10
Braga, V.M.11
-
48
-
-
0034634476
-
The Ras/p120 GTPase-activating protein (GAP) interaction is regulated by the p120 GAP pleckstrin homology domain
-
Drugan JK, Rogers-Graham K, Gilmer T, Campbell S, Clark GJ. 2000. The Ras/p120 GTPase-activating protein (GAP) interaction is regulated by the p120 GAP pleckstrin homology domain. J Biol Chem 275:35021-35027. http://dx.doi.org/10.1074/jbc.M004386200.
-
(2000)
J Biol Chem
, vol.275
, pp. 35021-35027
-
-
Drugan, J.K.1
Rogers-Graham, K.2
Gilmer, T.3
Campbell, S.4
Clark, G.J.5
-
49
-
-
68049105101
-
Rab GTPases as coordinators of vesicle traffic
-
Stenmark H. 2009. Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol 10:513-525. http://dx.doi.org/10.1038/nrm2728.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 513-525
-
-
Stenmark, H.1
-
50
-
-
0041806509
-
A dual mechanism controlling the localization and function of exocytic v-SNAREs
-
Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T. 2003. A dual mechanism controlling the localization and function of exocytic v-SNAREs. Proc Natl Acad Sci U S A 100:9011-9016. http://dx.doi.org/10.1073/pnas.1431910100.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 9011-9016
-
-
Martinez-Arca, S.1
Rudge, R.2
Vacca, M.3
Raposo, G.4
Camonis, J.5
Proux-Gillardeaux, V.6
Daviet, L.7
Formstecher, E.8
Hamburger, A.9
Filippini, F.10
D'Esposito, M.11
Galli, T.12
-
51
-
-
50549086057
-
Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the Arf-GAP Hrb
-
Pryor PR, Jackson L, Gray SR, Edeling MA, Thompson A, Sanderson CM, Evans PR, Owen DJ, Luzio JP. 2008. Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the Arf-GAP Hrb. Cell 134:817-827. http://dx.doi.org/10.1016/j.cell.2008.07.023.
-
(2008)
Cell
, vol.134
, pp. 817-827
-
-
Pryor, P.R.1
Jackson, L.2
Gray, S.R.3
Edeling, M.A.4
Thompson, A.5
Sanderson, C.M.6
Evans, P.R.7
Owen, D.J.8
Luzio, J.P.9
-
52
-
-
77954237882
-
Network organization of the human autophagy system
-
Behrends C, Sowa ME, Gygi SP, Harper JW. 2010. Network organization of the human autophagy system. Nature 466:68-76. http://dx.doi.org/10.1038/nature09204.
-
(2010)
Nature
, vol.466
, pp. 68-76
-
-
Behrends, C.1
Sowa, M.E.2
Gygi, S.P.3
Harper, J.W.4
-
53
-
-
84861396483
-
Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers
-
Popovic D, Akutsu M, Novak I, Harper JW, Behrends C, Dikic I. 2012. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. Mol Cell Biol 32:1733-1744. http://dx.doi.org/10.1128/MCB.06717-11.
-
(2012)
Mol Cell Biol
, vol.32
, pp. 1733-1744
-
-
Popovic, D.1
Akutsu, M.2
Novak, I.3
Harper, J.W.4
Behrends, C.5
Dikic, I.6
-
54
-
-
84894322830
-
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
-
Beilina A, Rudenko IN, Kaganovich A, Civiero L, Chau H, Kalia SK, Kalia LV, Lobbestael E, Chia R, Ndukwe K, Ding J, Nalls MA, Olszewski M, Hauser DN, Kumaran R, Lozano AM, Baekelandt V, Greene LE, Taymans JM, Greggio E, Cookson MR. 2014. Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. Proc Natl Acad Sci U S A 111:2626-2631. http://dx.doi.org/10.1073/pnas.1318306111.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 2626-2631
-
-
Beilina, A.1
Rudenko, I.N.2
Kaganovich, A.3
Civiero, L.4
Chau, H.5
Kalia, S.K.6
Kalia, L.V.7
Lobbestael, E.8
Chia, R.9
Ndukwe, K.10
Ding, J.11
Nalls, M.A.12
Olszewski, M.13
Hauser, D.N.14
Kumaran, R.15
Lozano, A.M.16
Baekelandt, V.17
Greene, L.E.18
Taymans, J.M.19
Greggio, E.20
Cookson, M.R.21
more..
-
55
-
-
77957231342
-
The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7
-
Nordmann M, Cabrera M, Perz A, Brocker C, Ostrowicz C, Engelbrecht-Vandre S, Ungermann C. 2010. The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7. Curr Biol 20:1654-1659. http://dx.doi.org/10.1016/j.cub.2010.08.002.
-
(2010)
Curr Biol
, vol.20
, pp. 1654-1659
-
-
Nordmann, M.1
Cabrera, M.2
Perz, A.3
Brocker, C.4
Ostrowicz, C.5
Engelbrecht-Vandre, S.6
Ungermann, C.7
-
56
-
-
77952764666
-
Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence
-
Peralta ER, Martin BC, Edinger AL. 2010. Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence. J Biol Chem 285:16814-16821. http://dx.doi.org/10.1074/jbc.M110.111633.
-
(2010)
J Biol Chem
, vol.285
, pp. 16814-16821
-
-
Peralta, E.R.1
Martin, B.C.2
Edinger, A.L.3
-
57
-
-
77951918362
-
Identification of the switch in early-to-late endosome transition
-
Poteryaev D, Datta S, Ackema K, Zerial M, Spang A. 2010. Identification of the switch in early-to-late endosome transition. Cell 141:497-508. http://dx.doi.org/10.1016/j.cell.2010.03.011.
-
(2010)
Cell
, vol.141
, pp. 497-508
-
-
Poteryaev, D.1
Datta, S.2
Ackema, K.3
Zerial, M.4
Spang, A.5
-
58
-
-
33750931271
-
The Parkinson disease gene LRRK2: evolutionary and structural insights
-
Marín I. 2006. The Parkinson disease gene LRRK2: evolutionary and structural insights. Mol Biol Evol 23:2423-2433. http://dx.doi.org/10.1093/molbev/msl114.
-
(2006)
Mol Biol Evol
, vol.23
, pp. 2423-2433
-
-
Marín, I.1
-
59
-
-
84863241584
-
Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning
-
Dodson MW, Zhang T, Jiang C, Chen S, Guo M. 2012. Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning. Hum Mol Genet 21:1350-1363. http://dx.doi.org/10.1093/hmg/ddr573.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 1350-1363
-
-
Dodson, M.W.1
Zhang, T.2
Jiang, C.3
Chen, S.4
Guo, M.5
|