The efficacy of stereotactic body radiation therapy on huge hepatocellular carcinoma unsuitable for other local modalities

Radiation Oncology

Volumn 9, Issue 1, 2014, Pages

  Que, Jenny Y ^a   Lin, Li Ching ^a   Lin, Kuei Li ^a   Lin, Chia Hui ^a   Lin, Yu Wei ^a   Yang, Ching Chieh ^a  

^a CHI MEI MEDICAL CENTER   (Taiwan)

Author keywords

Hepatocellular carcinoma; Huge; Stereotactic body radiation therapy

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; BILIRUBIN;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CANCER RADIOTHERAPY; CANCER SIZE; CANCER SURVIVAL; CHILD PUGH SCORE; CLINICAL ARTICLE; CYBERKNIFE; FATIGUE; FEMALE; FOLLOW UP; HUMAN; KAPLAN MEIER METHOD; LIVER CELL CARCINOMA; LIVER DISEASE; MALE; NAUSEA; OVERALL SURVIVAL; PAIN; PROGRESSION FREE SURVIVAL; RADIATION DERMATITIS; RADIATION DOSE; RADIATION INDUCED LIVER DISEASE; RADIATION INJURY; RIB PAIN; SKIN INDURATION; STEREOTACTIC BODY RADIATION THERAPY; THROMBOCYTOPENIA; TREATMENT RESPONSE; VOMITING; AGED; CANCER STAGING; CARCINOMA, HEPATOCELLULAR; LIVER NEOPLASMS; MIDDLE AGED; MORTALITY; NEOPLASM RECURRENCE, LOCAL; PATHOLOGY; PROGNOSIS; RADIATION DOSE FRACTIONATION; RADIOSURGERY; SURVIVAL RATE; TUMOR VOLUME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; DOSE FRACTIONATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROGNOSIS; RADIOSURGERY; SURVIVAL RATE; TUMOR BURDEN;

EID: 84902254239     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-9-120     Document Type: Article

References (38)

1. Poon D, Anderson BO, Chen LT, Tanaka K, Lau WY, Cutsem EV, Singh H, Chow WC, Ooi LL, Chow P, Khin MW, Koo WH. Management of hepatocellular carcinoma in Asia: consensus statement from the Asean Oncology summit 2009. Lancet Oncol 2009, 10:1111-1118. 10.1016/S1470-2045(09)70241-4, 19880065.
2. Krishnan S, Dawson LA, Seong J, Akine Y, Beddar S, Briere TM, Crane CH, Mornex F. Radiotherapy for hepatocellular carcinoma: an overview. Ann Surg Oncol 2008, 15:1015-1024. 10.1245/s10434-007-9729-5, 18236114.
3. Choi GH, Han DH, Kim DH, Choi SB, Kang CM, Kim KS, Choi JS, Park YN, Park JY, Kim DY, Han KH, Chon CY, Lee WJ. Outcome after curative resection for a huge (≥10 cm) hepatocellualr carcinoma and prognostic significance of gross tumor classification. Am J Surg 2009, 198(5):693-701. 10.1016/j.amjsurg.2008.09.019, 19268907.
4. Pandey D, Lee KH, Wai CT, Wagholikar G, Tan KC. Long term outcome and prognostic factors for large hepatocellular carcinoma (10 cm or more) after surgical resection. Ann Surg Oncol 2007, 14:2817-2823. 10.1245/s10434-007-9518-1, 17690940.
5. Yamashita Y, Taketomi A, Shirabe K, Aishima S, Tsuijita E, Morita K, Kayahima H, Maehara Y. Outcome of hepatic resection for huge hepatocellular carcinoma (≥10 cm in diameter). J Surg Oncol 2011, 104:292-298. 10.1002/jso.21931, 21465490.
6. Liau KH, Ruo L, Shia J, Padela A, Gonen M, Jarnagin WR, Fong Y, Angelica MI, Blumgart LH, DeMatteo RP. Outcome of partial hepatectomy for large (≥10 cm) hepatocellular carcinoma. Cancer 2005, 104:1948-1955. 10.1002/cncr.21415, 16196045.
7. Shah SS, Wei AC, Cleary SP, Yang I, McGilvray ID, Gallinger S, Grant DR, Greig PD. Prognosis and results after resection of very large (≥10 cm) hepatocellular carcinoma. J Gastrointest Surg 2007, 11:589-595. 10.1007/s11605-007-0154-7, 17393258.
8. Maluccio A, Covey AM, Porat LB, Schubert J, Brody LA, Sofocleous CT, Getrajdman GI, Jarnagin W, Dematteo R, Blumgart LH, Fong Y, Brown KT. Transcatheter arterial embolization with only particle for treatment of unresectable hepatocellular carcinoma. J Vasc Interv Radiol 2008, 19:862-869. 10.1016/j.jvir.2008.02.013, 18503900.
9. Llado L, Virgili J, Figueras J, Valls C, Dominguez J, Rafecas A, Torras J, Fabregat J, Guardiola J, Jaurrieta E. A prognostic index of the survival of patients with unresectable hepatocellular carcinoma after transcatheter arterial embolization. Cancer 2000, 88:50-57. 10.1002/(SICI)1097-0142(20000101)88:1<50::AID-CNCR8>3.0.CO;2-I, 10618605.
10. Lee SG, Hwang S, Jung JP, Lee YJ, Kim KH, Ahn CS. Outcome of patients with huge hepatocellular carcinoma after primary resection and treatment of recurrent lesions. Br J Surg 2007, 94:320-326. 10.1002/bjs.5622, 17205495.
11. Huang WY, Jen YM, Lee MS, Chang LP, Chen CM, Ko KS, Lin KT, Lin JC, Chao HL, Lin CS, Su YF, Fan CY, Chang YW. Stereotactic body radiation therapy in recurrent hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 2012, 84:355-361. 10.1016/j.ijrobp.2011.11.058, 22342300.
12. Tse RV, Hawkins M, Lockwood G, Kim JJ, Cummings B, Knox J, Sherman M, Dawson LA. Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. J Clin Oncol 2008, 26:657-664. 10.1200/JCO.2007.14.3529, 18172187.
13. Mendez Romero A, Wunderink W, Hussain SM, De Pooter JA, Heijmen BJM, Nowak P, Nuyttens JJ, Brandwijk RP, Verdoef C, Ijzermans J, Levendag PC. Stereotactic body radiation therapy for primary and metastatic liver tumors: a single institution phase I-II study. Acta Oncol 2006, 45:831-837. 10.1080/02841860600897934, 16982547.
14. Sarfaraz M. Cyberknife robotic arm stereotactic radiosurgery. J Am Coll Radiol 2007, 4:563-565. 10.1016/j.jacr.2007.05.003, 17660122.
15. Dawson LA, Jaffray DA. Advances in image-guide radiation therapy. J Clin Oncol 2007, 25:938-946. 10.1200/JCO.2006.09.9515, 17350942.
16. Nuyttens JJ, Prévost JB, Praag J, Hoogeman M, Van Klaveren RJ, Levendag PC, Pattynama PMT. Lung tumor tracking during stereotactic radiotherapy treatment with the Cyberknife: Marker placement and early results. Acta Oncol 2006, 45:961-965. 10.1080/02841860600902205, 16982564.
17. Shin YJ, Kim MS, Yoo SY, Chul KC, Seo YS, Kang JK, Park SC, Han CJ, Kim SB, Lee BH, Lee DH. Pilot study of stereotactic body radiotherapy for huge hepatocellular carcinoma unsuitable for other therapies. Tumori 2010, 96:65-70.
18. Vautravers-Dewas C, Dewas S, Bonodeau F, Adenis A, Lacornerie T, Penel N, Lartigau E, Mirabel X. Image-guided robotic stereotactic body radiation therapy for liver metastases: is there a dose-response relationship?. Int J Radiat Oncol Biol Phys 2011, 81:39-47.
19. Park HC, Seong J, Han KH, Chon CY, Moon YM, Suh CO. Dose-response relationship in local radiotherapy for hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 2002, 54:150-155.
20. Kim JH, Park JW, Kim TH, Koh DW, Lee WJ, Kim CM. Hepatitis B virus reactivation after three-dimensional conformal radiotherapy in patients with hepatitis B virus-related hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 2007, 69:813-819. 10.1016/j.ijrobp.2007.04.005, 17524569.
21. Yeo W, Johnson PJ. Diagnosis prevention and management of hepatitis B virus reactivation during anticancer therapy. Hepatology 2006, 43:209-220. 10.1002/hep.21051, 16440366.
22. Hoogeman M, Prevost JB, Nuyttens J, Pöll J, Levendag P, Heijmen B. Clinical accuracy of the respiratory tumor tracking system of the cyberknife: Assessment by analysis of log files. Int J Radiat Oncol Biol Phys 2009, 74:297-303. 10.1016/j.ijrobp.2008.12.041, 19362249.
23. Pan CC, Kavanagh BD, Dawson LA, Li XA, Das SK, Miften M, Ten Haken RK. Radiation-associated liver injury. Int J Radiat Oncol Biol Phys 2010, 76:S94-S100. 10.1016/j.ijrobp.2009.06.092, 20171524.
24. Benedict SH, Yenice KM, Follwill D, Galvin JM, Hinson W, Kavanagh B, Keall P, Lovelock M, Meeks S, Papiez L, Purdie T, Sadagopan R, Schell MC, Salter B, Schlesinger DJ, Shiu AS, Solberg T, Song DY, Stieber V, Timmerman R, Tome WA, Verellen D, Wang L, Yin FF. Stereotactic body radiation therapy: the report of AAPM task group 101. Med Phys 2010, 37:4078-4100. 10.1118/1.3438081, 20879569.
25. Cheng JC, Wu JK, Lee PC, Liu WS, Jen JM, Lin YM, Sung JL, Jan GJ. Biologic susceptibility of hepatocellular carcinoma patients treated with radiotherapy to radiation -induced liver disease. Int J Radiat Oncol Biol Phys 2004, 60:1502-1509. 10.1016/j.ijrobp.2004.05.048, 15590181.
26. Wulf J, Guckenberger M, Haedinger U, Oppitz U, Mueller G, Beier K, Flentje M. Stereotactic radiotherapy of primary liver cancer and hepatic metastases. Acta Oncol 2006, 45:838-847. 10.1080/02841860600904821, 16982548.
27. Cheng JC, Wu JK, Huang CM, Huang CM, Cheng SH, Lin YM, Jian JJ, Yang PY, Chuang VP, Huang AT. Radiation-induced liver disease after radiotherapy for hepatocellular carcinoma: clinical manifestation and dosimetric description. Radiother Oncol 2002, 63:41-45. 10.1016/S0167-8140(02)00061-0, 12065102.
28. Cheng JC, Chuang VP, Cheng SH, Lin YM, Cheng TI, Yang PS, Jian JM, You DL, Horng CF, Huang AT. Unresectable hepatocellular carcinoma treated with radiotherapy and/or chemoembolization. Int J Cancer 2001, 96:243-252. 10.1002/ijc.1022, 11474499.
29. Kang JK, Kim MS, Cho CK, Yang KM, Yoo HJ, Kim JH, Bae SH, Jung DH, Kim KB, Lee DH, Han CJ, Kim J, Park SC, Kim YH. Stereotactic body radiation therapy for inoperable hepatocellular carcinoma as a local salvage therapy after incomplete transarterial chemoembolization. Cancer 2012, 118:5424-5431. 10.1002/cncr.27533, 22570179.
30. Choi BY, Choi IB, Jang HS, Kang YN, Jang JS, Bae SH, Yoon SK, Chai GY, Kang KM. Stereotactic body radiation therapy with or without transarterial chemoembolization for patients with primary hepatocellular carcinoma: preliminary analysis. BMC Cancer 2008, 8:35. 10.1186/1471-2407-8-35, 2267803, 18234124.
31. Hawkins MA, Dawson LA. Radiation therapy for hepatocellular carcinoma: from palliation to cure. Cancer 2006, 106:1653-1663. 10.1002/cncr.21811, 16541431.
32. Seong J, Park HC, Han KH, Chon CY. Clinical results and prognostic factors in radiotherapy for unresectable hepatocellular carcinoma: a retrospective study of 158 patients. Int J Radiat Oncol Biol Phys 2002, 54:150-155.
33. Park W, Lim DH, Palk SW, Koh KC, Choi MS, Park CK, Yoo BC, Lee JE, Kang MK, Park YJ, Nam HR, Ahn YC, Huh HJ. Local Radiotherapy for patients with unresectable hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 2005, 61:1143-1150. 10.1016/j.ijrobp.2004.08.028, 15752895.
34. Dawson LA, McGinn CJ, Normolle D, Ten Haken RK, Walker S, Ensminger W, Lawrence TS. Escalated focal liver radiation and concurrent hepatic artery fluorodeoxyuridine for unresectable intrahepatic malignancies. J Clin Oncol 2000, 18:2210-2218.
35. Seo YS, Kim MS, Yoo SY, Cho CK, Choi CW, Kim JH, Han CJ, Park SC, Lee BH, Kim YH, Lee DH. Preliminary result of stereotactic body radiotherapy as a local salvage treatment for inoperable hepatocellular carcinoma. J Surg Oncol 2010, 102:209-214. 10.1002/jso.21593, 20740576.
36. Rushoven KE, Kavanagh BD, Cardenes H, Stieber VW, Burri SH, Feigenberg, Chidel MA, Pugh TJ, Franklin W, Kane M, Gaspar LE, Schefter TE. Multi-institutional phase I/II trial of stereotactic body radiation therapy for liver metastases. J Clin Oncol 2009, 27:1572-1578. 10.1200/JCO.2008.19.6329, 19255321.
37. Chang DT, Swaminath A, Kozak M, Weintraub J, Koong AC, Kim J, Dinniwell R, Brierley J, Kavanagh BD, Dawson LA, Schefter TE. Stereotactic body radiotherapy for colorectal liver metastases: a pooled analysis. Cancer 2011, 117:4060-4069. 10.1002/cncr.25997, 21432842.
38. Dunlap NE, Cai J, Biedermann GB, Yang W, Benedict ST, Ke S, Schefter TE, Kavanagh BD, Larner JM. Chest wall volume receiving >30 Gy predict risk of severe pain and or rib fracture after lung stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys 2010, 76:796-801. 10.1016/j.ijrobp.2009.02.027, 19427740.