-
1
-
-
33748653168
-
Emerging drugs for hepatocellular carcinoma
-
Roberts LR, Gores GJ. Emerging drugs for hepatocellular carcinoma. Expert Opin Emerg Drugs 2006; 11 (3): 469-87
-
(2006)
Expert Opin Emerg Drugs
, vol.11
, Issue.3
, pp. 469-487
-
-
Roberts, L.R.1
Gores, G.J.2
-
2
-
-
33846212284
-
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
-
Dec 15;
-
Liu L, Cao Y, Chen C, et al. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 2006 Dec 15; 66 (24): 11851-8
-
(2006)
Cancer Res
, vol.66
, Issue.24
, pp. 11851-11858
-
-
Liu, L.1
Cao, Y.2
Chen, C.3
-
3
-
-
33749238553
-
Discovery and development of sorafenib: A multikinase inhibitor for treating cancer
-
Oct;
-
Wilhelm S, Carter C, Lynch M, et al. Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug Discov 2006 Oct; 5 (10): 835-44
-
(2006)
Nat Rev Drug Discov
, vol.5
, Issue.10
, pp. 835-844
-
-
Wilhelm, S.1
Carter, C.2
Lynch, M.3
-
4
-
-
33744513575
-
Sorafenib (BAY 43-9006, Nexavar®), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature
-
Adnane L, Trail PA, Taylor I, et al. Sorafenib (BAY 43-9006, Nexavar®), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature. Methods Enzymol 2005; 407: 597-612
-
(2005)
Methods Enzymol
, vol.407
, pp. 597-612
-
-
Adnane, L.1
Trail, P.A.2
Taylor, I.3
-
5
-
-
33947262990
-
Sorafenib in advanced renal cancer
-
McKeage K, Wagstaff AJ. Sorafenib in advanced renal cancer. Drugs 2007; 67 (3): 475-83
-
(2007)
Drugs
, vol.67
, Issue.3
, pp. 475-483
-
-
McKeage, K.1
Wagstaff, A.J.2
-
8
-
-
38149017330
-
-
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology™: hepatobiliary cancers. V.2.2008 [online]. Available from URL: http://www.nccn.org [Accessed 2007 Nov 22]
-
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology™: hepatobiliary cancers. V.2.2008 [online]. Available from URL: http://www.nccn.org [Accessed 2007 Nov 22]
-
-
-
-
9
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Oct 1;
-
Wilhelm SM, Carter C, Tang LY, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004 Oct 1; 64 (19): 7099-109
-
(2004)
Cancer Res
, vol.64
, Issue.19
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.Y.3
-
10
-
-
33747203008
-
Sorafenib is a potent inhibitor of FIP1L1-PDGFR? and the imatinib-resistant FIP1L1-PDGFRα T674I mutant
-
Aug 15;
-
Lierman E, Folens C, Stover EH. Sorafenib is a potent inhibitor of FIP1L1-PDGFR? and the imatinib-resistant FIP1L1-PDGFRα T674I mutant. Blood 2006 Aug 15; 108 (4): 1374-6
-
(2006)
Blood
, vol.108
, Issue.4
, pp. 1374-1376
-
-
Lierman, E.1
Folens, C.2
Stover, E.H.3
-
11
-
-
33749017926
-
Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
-
Sep 10;
-
Abou-Alfa GK, Schwartz L, Ricci S, et al. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006 Sep 10; 24 (26): 4293-300
-
(2006)
J Clin Oncol
, vol.24
, Issue.26
, pp. 4293-4300
-
-
Abou-Alfa, G.K.1
Schwartz, L.2
Ricci, S.3
-
12
-
-
33645648696
-
Lack of effect of ketoconazole-mediated CYP3A inhibition on sorafenib clinical pharmacokinetics
-
May 1;
-
Lathia C, Lettieri J, Cihon F, et al. Lack of effect of ketoconazole-mediated CYP3A inhibition on sorafenib clinical pharmacokinetics. Cancer Chemother Pharmacol 2006 May 1; 57 (5): 685-92
-
(2006)
Cancer Chemother Pharmacol
, vol.57
, Issue.5
, pp. 685-692
-
-
Lathia, C.1
Lettieri, J.2
Cihon, F.3
-
13
-
-
20344362911
-
Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours
-
Awada A, Hendlisz A, Gil T, et al. Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours. Br J Cancer 2005; 92 (10): 1855-61
-
(2005)
Br J Cancer
, vol.92
, Issue.10
, pp. 1855-1861
-
-
Awada, A.1
Hendlisz, A.2
Gil, T.3
-
14
-
-
33646204716
-
Results of a phase I trial of sorafenib (BAY 43-9006) in combination with doxorubicin in patients with refractory solid tumors
-
May;
-
Richly H, Henning BF, Kupsch P, et al. Results of a phase I trial of sorafenib (BAY 43-9006) in combination with doxorubicin in patients with refractory solid tumors. Ann Oncol 2006 May; 17 (5): 866-73
-
(2006)
Ann Oncol
, vol.17
, Issue.5
, pp. 866-873
-
-
Richly, H.1
Henning, B.F.2
Kupsch, P.3
-
15
-
-
38149074288
-
-
Bayer Pharmaceuticals Corporation, online, Available from URL:, Accessed Nov 21
-
Bayer Pharmaceuticals Corporation. Nexavar® (sorafenib) tablets, oral: prescribing information [online]. Available from URL: http://www.press. bayer.com [Accessed 2007 Nov 21]
-
(2007)
Nexavar® (sorafenib) tablets, oral: Prescribing information
-
-
-
17
-
-
59149094763
-
Final results from a phase II (PhII), randomized, double-blind study of sorafenib plus doxorubicin (S+D) versus placebo plus doxorubicin (P+D) in patients (pts) with advanced hepatocellular carcinoma (AHCC)
-
abstract plus slide, Sep 23-27; Barcelona
-
Abou-Alfa G, Johnson P, Knox J, et al. Final results from a phase II (PhII), randomized, double-blind study of sorafenib plus doxorubicin (S+D) versus placebo plus doxorubicin (P+D) in patients (pts) with advanced hepatocellular carcinoma (AHCC) [abstract plus slide presentation]. 14th European Cancer Conference; 2007 Sep 23-27; Barcelona
-
(2007)
presentation]. 14th European Cancer Conference
-
-
Abou-Alfa, G.1
Johnson, P.2
Knox, J.3
-
18
-
-
77952118055
-
-
European Medicines Agency, online, Available from URL:, Accessed Nov 21
-
European Medicines Agency. Sorafenib (Nexavar): summary of product characteristics [online]. Available from URL: http://www.emea.europa.eu [Accessed 2007 Nov 21]
-
(2007)
Sorafenib (Nexavar): Summary of product characteristics
-
-
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