Establishment of Mouse Model of MYH9 Disorders: Heterozygous R702C Mutation Provokes Macrothrombocytopenia with Leukocyte Inclusion Bodies, Renal Glomerulosclerosis and Hearing Disability

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Suzuki, Nobuaki ^a   Kunishima, Shinji ^b   Ikejiri, Makoto ^c,f   Maruyama, Shoichi ^a   Sone, Michihiko ^a   Takagi, Akira ^c   Ikawa, Masahito ^d   Okabe, Masaru ^d   Kojima, Tetsuhito ^c   Saito, Hidehiko ^b   Naoe, Tomoki ^a   Matsushita, Tadashi ^e  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION NAGOYA MEDICAL CENTER   (Japan)

^c NAGOYA UNIVERSITY   (Japan)

^d OSAKA UNIVERSITY   (Japan)

^e NAGOYA UNIVERSITY HOSPITAL   (Japan)

^f MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MYOSIN HEAVY CHAIN; NONMUSCLE MYOSIN HEAVY CHAIN IIA; UNCLASSIFIED DRUG;

ALBUMINURIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING TENDENCY; CATARACT; CELL COUNT; CELL SIZE; DISEASE COURSE; EXON; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; GLOMERULOSCLEROSIS; GRANULOCYTE; HEARING IMPAIRMENT; HETEROZYGOSITY; HOMOZYGOSITY; INTRON; LEUKOCYTE DISORDER; LEUKOCYTE INFUSION BODY; LIVER CELL; MEGAKARYOPOIESIS; MISSENSE MUTATION; MOUSE; MYH9 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN AGGREGATION; PROTEIN LOCALIZATION; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS;

ANIMALS; BLOOD PLATELETS; BRAIN STEM; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; FEMALE; FETUS; GENE KNOCK-IN TECHNIQUES; GRANULOCYTES; HEARING LOSS, SENSORINEURAL; HEPATOCYTES; HETEROZYGOTE; HUMANS; INCLUSION BODIES; KIDNEY; MALE; MICE; MUTATION, MISSENSE; NONMUSCLE MYOSIN TYPE IIA; PRIMARY CELL CULTURE; THROMBOCYTOPENIA;

EID: 84882715634     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071187     Document Type: Article

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