Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology

Toxicology in Vitro

Volumn 29, Issue 7, 2015, Pages 1868-1877

  Mutsaers, Henricus A M ^a,b   Caetano Pinto, Pedro ^a,d   Seegers, Andries E M ^a   Dankers, Anita C A ^a   van den Broek, Petra H H ^a   Wetzels, Jack F M ^a   van den Brand, Jan A J G ^a   van den Heuvel, Lambertus P ^a,c   Hoenderop, Joost G ^a   Wilmer, Martijn J G ^a   Masereeuw, Rosalinde ^a,d,e  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UTRECHT UNIVERSITY   (Netherlands)

^e 3584 CG Utrecht   (Netherlands)

Author keywords

Chronic kidney disease; Efflux transporters; Nephrotoxicity; Proximal tubule cells; Uremic retention solutes

Indexed keywords

4 CRESYL GLUCURONIDE; 4 CRESYL SULFATE; BREAST CANCER RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 4; PARA CRESOL; PROTEIN BCL 2; UNCLASSIFIED DRUG; UREMIC TOXIN; UVOMORULIN; VIMENTIN; 4-CRESOL SULFATE; 4-CRESYLGLUCURONIDE; ABC TRANSPORTER; ABCC4 PROTEIN, HUMAN; ABCG2 PROTEIN, HUMAN; CRESOL; GLUCURONIDE; MULTIDRUG RESISTANCE PROTEIN; SULFATE; TUMOR PROTEIN;

ARTICLE; BIOACCUMULATION; CELL STRESS; CELLULAR STRESS RESPONSE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DISEASE COURSE; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; GLUCURONIDATION; HUMAN; HUMAN CELL; IMMORTALIZED CELL LINE; KIDNEY CLEARANCE; KIDNEY PROXIMAL TUBULE; KIDNEY PROXIMAL TUBULE EPITHELIAL CELL; METABOLITE; NEPHROTOXICITY; PHENOTYPIC PLASTICITY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SOLUTE; SULFATION; TOXIN ANALYSIS; UPREGULATION; URINALYSIS; URINARY EXCRETION; URINE LEVEL; ADULT; AGED; BACULOVIRIDAE; CELL LINE; CHRONIC KIDNEY FAILURE; FEMALE; GENETIC TRANSDUCTION; GENETICS; HEK293 CELL LINE; MALE; METABOLISM; MIDDLE AGED;

ADULT; AGED; ATP-BINDING CASSETTE TRANSPORTERS; BACULOVIRIDAE; CELL LINE; CRESOLS; FEMALE; GLUCURONIDES; HEK293 CELLS; HUMANS; KIDNEY TUBULES, PROXIMAL; MALE; MIDDLE AGED; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; RENAL ELIMINATION; RENAL INSUFFICIENCY, CHRONIC; SULFURIC ACID ESTERS; TRANSDUCTION, GENETIC;

EID: 84938780478     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2015.07.020     Document Type: Article

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