Basolateral transport of the uraemic toxin p-cresyl sulfate: Role for organic anion transporters?

Nephrology Dialysis Transplantation

Volumn 26, Issue 12, 2011, Pages 4149-

  Mutsaers, Henricus A M ^a   Wilmer, Martijn J G ^a   Van Den Heuvel, Lambertus P ^a   Hoenderop, Joost G ^a   Masereeuw, Rosalinde ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOHIPPURIC ACID; ORGANIC ANION TRANSPORTER; PARA CRESYL SULFATE; PROBENECID; SULFATE; UNCLASSIFIED DRUG; UREMIC TOXIN;

HUMAN; KIDNEY CORTEX; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; LETTER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT;

ANIMALS; CRESOLS; HUMANS; KIDNEY CORTEX; KIDNEY TUBULES, PROXIMAL; MALE; ORGANIC ANION TRANSPORTERS; SULFURIC ACID ESTERS; TOXINS, BIOLOGICAL;

EID: 82255185476     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfr562     Document Type: Letter

References (5)

1. Miyamoto Y, Watanabe H, Noguchi T et al. Organic anion transporters play an important role in the uptake of p-cresyl sulfate, a uremic toxin, in the kidney. Nephrol Dial Transplant 2011; 26: 2498-2502
2. VanWert AL, Gionfriddo MR, Sweet DH. Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology. Biopharm Drug Dispos 2010; 31: 1-71
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4. Brown CD, Sayer R, Windass AS et al. Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling. Toxicol Appl Pharmacol 2008; 233: 428-438
5. Yamaguchi H, Sugie M, Okada M et al. Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1. Drug Metab Pharmacokinet 2010; 25: 314-317