Novel method for simultaneous determination of p-cresylsulphate and p-cresylglucuronide: Clinical data and pathophysiological implications

Nephrology Dialysis Transplantation

Volumn 27, Issue 6, 2012, Pages 2388-2396

  Meert, Natalie ^a   Schepers, Eva ^a   Glorieux, Griet ^a   Van Landschoot, Maria ^a   Goeman, Jan L ^b   Waterloos, Marie Anne ^a   Dhondt, Annemieke ^a   Van Der Eycken, Johan ^b   Vanholder, Raymond ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Concentration; Dialysis adequacy; Leucocyte activation; Protein bound uraemic toxins; Removal by dialysis

Indexed keywords

FREE RADICAL; PARA CRESOL; PARA CRESYLGLUCURONIDE; PARA CRESYLSULPHATE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BLOOD LEVEL; CLINICAL STUDY; CONJUGATE; CONTROLLED STUDY; DIALYSIS; FEMALE; FLOW CYTOMETRY; HEMODIAFILTRATION; HEMODIALYSIS PATIENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE; LEUKOCYTE ACTIVATION; LIMIT OF QUANTITATION; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; RESPIRATORY BURST; SOLUTE; UREMIA;

ADULT; AGED; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRESOLS; FEMALE; FOLLOW-UP STUDIES; FREE RADICALS; GLUCURONIDES; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; PROGNOSIS; RENAL DIALYSIS; RESPIRATORY BURST; SULFURIC ACID ESTERS; UREMIA;

EID: 84861917591     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfr672     Document Type: Article

References (38)

1. Vanholder R, De Smet R, Glorieux G et al. Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int 2003; 63: 1934-1943
2. Meyer TW, Hostetter TH. Uremia.NEngl J Med 2007; 357: 1316-1325
3. Vanholder R, De Smet R. Pathophysiologic effects of uremic retention solutes. J Am Soc Nephrol 1999; 10: 1815-1823
4. Jourde-Chiche N, Dou L, Cerini C et al. Protein-bound toxins-update 2009. Semin Dial 2009; 22: 334-339
5. De Loor H, Bammens B, Evenepoel P et al. Gas chromatographicmass spectrometric analysis for measurement of p-cresol and its conjugated metabolites in uremic and normal serum. Clin Chem 2005; 51: 1535-1538
6. Martinez AW, Recht NS, Hostetter TH et al. Removal of P-cresol sulfate by hemodialysis. J Am Soc Nephrol 2005; 16: 3430-3436
7. Schepers E, Meert N, Glorieux G et al. P-cresylsulphate, the main in vivo metabolite of p-cresol, activates leucocyte free radical production. Nephrol Dial Transplant 2007; 22: 592-596
8. Meijers BK, Van Kerckhoven S, Verbeke K et al. The uremic retention solute p-cresyl sulfate and markers of endothelial damage. Am J Kidney Dis 2009; 54: 891-901
9. Liabeuf S, Barreto DV, Barreto FC et al. Free p-cresylsulphate is a predictor of mortality in patients at different stages of chronic kidney disease. Nephrol Dial Transplant 2010; 25: 1183-1191
10. Wang CP, Lu LF, Yu TH et al. Serum levels of total p-cresylsulphate are associated with angiographic coronary atherosclerosis severity in stable angina patients with early stage of renal failure. Atherosclerosis 2010; 211: 579-583
11. Feigenbaum J, Neuberg C. Simplified method for the preparation of aromatic sulfuric acid esters. J Am Chem Soc 1941; 63: 3529-3530
12. Van der Eycken E, Terryn N, Goeman JL et al. Sudan-ß-d-glucuronides and their use for the histochemical localization of ß-glucuronidase activity in transgenic plants. Plant Cell Rep 2000; 19: 966-970
13. Meert N, Eloot S, Waterloos MA et al. Effective removal of proteinbound uraemic solutes by different convective strategies: a prospective trial. Nephrol Dial Transplant 2009; 24: 562-570
14. Meert N, Waterloos MA, Van Landschoot M et al. Prospective evaluation of the change of predialysis protein-bound uremic solute concentration with postdilution online hemodiafiltration. Artif Organs 2010; 34: 580-585
15. Meert N, Eloot S, Schepers E et al. Comparison of removal capacity of two consecutive generations of high-flux dialysers during different treatment modalities. Nephrol Dial Transplant 2011; 26: 2624-2630
16. ICH. International Conference on Harmonization (ICH) of Technical Requirements for the Registration of Pharmaceuticals for Human Use, Validation of Analytical Procedures: Methodology. Geneva, Switzerland: ICH, 1996
17. Cohen G, Glorieux G, Thornalley P et al. Review on uraemic toxins III: recommendations for handling uraemic retention solutes in vitro-towards a standardized approach for research on uraemia. Nephrol Dial Transplant 2007; 22: 3381-3390
18. Glorieux GL, Dhondt AW, Jacobs P et al. In vitro study of the potential role of guanidines in leukocyte functions related to atherogenesis and infection. Kidney Int 2004; 65: 2184-2192
19. Yamamoto H, Tsuruoka S, Ioka T et al. Indoxyl sulfate stimulates proliferation of rat vascular smooth muscle cells. Kidney Int 2006; 69: 1780-1785
20. Barreto FC, Barreto DV, Liabeuf S et al. Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients. Clin J Am Soc Nephrol 2009; 4: 1551-1558
21. Motojima M, Hosokawa A, Yamato H et al. Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells. Kidney Int 2003; 63: 1671-1680
22. Nii-Kono T, Iwasaki Y, Uchida M et al. Indoxyl sulfate induces skeletal resistance to parathyroid hormone in cultured osteoblastic cells. Kidney Int 2007; 71: 738-743
23. Faure V, Dou L, Sabatier F et al. Elevation of circulating endothelial microparticles in patients with chronic renal failure. J Thromb Haemost 2006; 4: 566-573
24. Ito S, Osaka M, Higuchi Y et al. Indoxyl sulfate induces leukocyteendothelial interactions through up-regulation of E-selectin. J Biol Chem 2010; 285: 38869-38875
25. Lekawanvijit S, Adrahtas A, Kelly DJ et al. Does indoxyl sulfate, a uraemic toxin, have direct effects on cardiac fibroblasts and myocytes? Eur Heart J 2010; 31: 1771-1779
26. Aronov PA, Luo FJ, Plummer NS et al. Colonic contribution to uremic solutes. J Am Soc Nephrol 2011; 22: 1769-1776
27. Kikuchi K, Itoh Y, Tateoka R et al. Metabolomic analysis of uremic toxins by liquid chromatography/electrospray ionization-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2010; 878: 1662-1668
28. Vanholder R, Hoefliger N, De Smet R et al. Extraction of protein bound ligands from azotemic sera: comparison of 12 deproteinization methods. Kidney Int 1992; 41: 1707-1712
29. De Loor H, Meijers BK, Meyer TW et al. Sodium octanoate to reverse indoxyl sulfate and p-cresyl sulfate albumin binding in uremic and normal serum during sample preparation followed by fluorescence liquid chromatography. J Chromatogr A 2009; 1216: 4684-4688
30. Vanholder R, Bammens B, de Loor H et al. Warning: the unfortunate end of p-cresol as a uraemic toxin. Nephrol Dial Transplant 2011; 26: 1464-1467
31. Schepers E, Glorieux G, Vanholder R. The gut: the forgotten organ in uremia? Blood Purif 2010; 29: 130-136
32. Niwa T, Miyazaki T, Tsukushi S et al. Accumulation of indoxyl-beta-Dglucuronide in uremic serum: suppression of its production by oral sorbent and efficient removal by hemodialysis. Nephron 1996; 74: 72-78
33. Agatsuma S, Sekino H, Watanabe H. Indoxyl-beta-D-glucuronide and 3-indoxyl sulfate in plasma of hemodialysis patients. Clin Nephrol 1996; 45: 250-256
34. Stenvinkel P, Heimburger O, Paultre F et al. Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure. Kidney Int 1999; 55: 1899-1911
35. Meijers BK, Bammens B, De Moor B et al. Free p-cresol is associated with cardiovascular disease in hemodialysis patients. Kidney Int 2008; 73: 1174-1180
36. Ueda H, Shibahara N, Takagi S et al. AST-120, an oral adsorbent, delays the initiation of dialysis in patients with chronic kidney diseases. Ther Apher Dial 2007; 11: 189-195
37. Akizawa T, Asano Y, Morita S et al. Effect of a carbonaceous oral adsorbent on the progression of CKD: a multicenter, randomized, controlled trial. Am J Kidney Dis 2009; 54: 459-467
38. Ueda H, Shibahara N, Takagi S et al. AST-120 treatment in predialysis period affects the prognosis in patients on hemodialysis. Ren Fail 2008; 30: 856-860