The 18-kDa mitochondrial translocator protein in gliomas: From the bench to bedside

Biochemical Society Transactions

Volumn 43, Issue , 2015, Pages 579-585

  Janczar, Karolina ^a   Su, Zhangjie ^b   Raccagni, Isabella ^a,c   Anfosso, Andrea ^a   Kelly, Charlotte ^d   Durrenberger, Pascal F ^a   Gerhard, Alexander ^b   Roncaroli, Federico ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d CHARING CROSS HOSPITAL   (United Kingdom)

Author keywords

Glioma; Pathology; Positron emission tomography (pet) imaging; Translocator protein

Indexed keywords

MITOCHONDRIAL TRANSLOCATOR PROTEIN; PROTEIN; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; ANTINEOPLASTIC AGENT; TSPO PROTEIN, HUMAN;

ARTICLE; BRAIN; GLIOMA; HUMAN; MACROPHAGE; MICROGLIA; MOLECULAR IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL; BRAIN NEOPLASMS; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PERSONALIZED MEDICINE; PROGNOSIS; UPREGULATION;

ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; GLIOMA; HUMANS; MOLECULAR TARGETED THERAPY; POSITRON-EMISSION TOMOGRAPHY; PRECISION MEDICINE; PROGNOSIS; RECEPTORS, GABA; UP-REGULATION;

EID: 84938771212     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20150064     Document Type: Article

References (33)

1. Dolecek, T.A., Propp, J.M., Stroup, N.E. and Kruchko, C. (2012) CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009. Neuro Oncol. 14 Suppl 5, v1-v49 CrossRef PubMed
2. Louis, D.N., Ohgaki, H., Wiestler, O.D., Cavenee, W.K., Burger, P.C., Jouvet, A., Scheithauer, B.W. and Kleihues, P. (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114, 97-109 CrossRef PubMed
3. Liu, X., Tian, W., Kolar, B., Yeaney, G.A., Qiu, X., Johnson, M.D. and Ekholm, S. (2011) MR diffusion tensor and perfusion-weighted imaging in preoperative grading of supratentorial nonenhancing gliomas. Neuro Oncol. 13, 447-455 CrossRef PubMed
4. Waldman, A.D., Jackson, A., Price, S.J., Clark, C.A., Booth, T.C., Auer, D.P., Tofts, P.S., Collins, D.J., Leach, M.O. and Rees, J.H. (2009) Quantitative imaging biomarkers in neuro-oncology. Nat. Rev. Clin. Oncol. 6, 445-454 CrossRef PubMed
5. Crockford, A., Jamal-Hanjani, M, Hicks, J. and Swanton, C. (2014) Implications of intratumour heterogeneity for treatment stratification. J. Pathol. 232, 264-273 CrossRef PubMed
6. Olar, A. and Aldape, K.D. (2014) Using the molecular classification of glioblastoma to inform personalized treatment. J. Pathol. 232, 165-177 CrossRef PubMed
7. Austin, C.J., Kahlert, J., Kassiou, M. and Rendina, L.M. (2013) The translocator protein (TSPO): a novel target for cancer chemotherapy. Int. J. Biochem. Cell Biol. 45, 1212-1216 CrossRef PubMed
8. Venneti, S., Lopresti, B.J. and Wiley, C.A. (2013) Molecular imaging of microglia/macrophages in the brain. Glia 61, 10-23 CrossRef PubMed
9. Pappata, S., Cornu, P., Samson, Y., Prenant, C., Benavides, J., Scatton, B., Crouzel, C., Hauw, J.J. and Syrota, A. (1991) PET study of carbon-11-PK 11195 binding to peripheral type benzodiazepine sites in glioblastoma: a case report. J. Nucl. Med. 32, 1608-1610 PubMed
10. Ferrarese, C., Pierpaoli, C., Linfante, I., Bobo, R.H., Guthrie, B., Kufta, C., Duhaney, M.O., Melisi, J. and Fulham, M.J. (1994) Peripheral benzodiazepine receptors and glucose metabolism in human gliomas. J. Neurooncol. 22, 15-22 CrossRef PubMed
11. Bode, J., Veenman, L., Caballero, B., Lakomek, M., Kugler, W. and Gavish, M. (2012) The 18 kDa translocator protein influences angiogenesis, as well as aggressiveness, adhesion, migration, and proliferation of glioblastoma cells. Pharmacogenet. Genomics 22, 538-550 CrossRef PubMed
12. Miettinen, H., Kononen, J., Haapasalo, H., Helén, P., Sallinen, P., Harjuntausta, T., Helin, H. and Alho, H. (1995) Expression of peripheral-type benzodiazepine receptor and diazepam binding inhibitor in human astrocytomas: relationship to cell proliferation. Cancer Res. 55, 2691-2695 PubMed
13. Vlodavsky, E. and Soustiel, J.F. (2007) Immunohistochemical expression of peripheral benzodiazepine receptors in human astrocytomas and its correlation with grade of malignancy, proliferation, apoptosis and survival. J. Neurooncol. 81, 1-7 CrossRef PubMed
14. Takaya, S., Hashikawa, K., Turkheimer, F.E., Mottram, N., Deprez, M., Ishizu, K., Kawashima, H., Akiyama, H., Fukuyama, H., Banati, R.B. and Roncaroli, F. (2007) The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas. J. Neurooncol. 85, 95-103 CrossRef PubMed
15. Guo, P., Ma, J., Li, S., Guo, Z., Adams, A.L. and Gallo, J.M. (2001) Targeted delivery of a peripheral benzodiazepine receptor ligand-gemcitabine conjugate to brain tumors in a xenograft model. Cancer Chemother. Pharmacol. 48, 169-176 CrossRef PubMed
16. Reddy, L.H. and Couvreur, P. (2008) Novel approaches to deliver gemcitabine to cancers. Curr. Pharm. Des. 14, 1124-1137 CrossRef PubMed
17. Trapani, G., Laquintana, V., Latrofa, A., Ma, J., Reed, K., Serra, M., Biggio, G., Liso, G. and Gallo, J.M. (2003) Peripheral benzodiazepine receptor ligand-melphalan conjugates for potential selective drug delivery to brain tumors. Bioconjug. Chem. 14, 830-839 CrossRef PubMed
18. Musacchio, T., Laquintana, V., Latrofa, A., Trapani, G. and Torchilin, V.P. (2009) PEG-PE micelles loaded with paclitaxel and surface-modified by a PBR-ligand: synergisticanticancer effect. Mol. Pharm. 6, 468-479 CrossRef PubMed
19. Denora, N., Laquintana, V., Trapani, A., Lopedota, A., Latrofa, A., Gallo, J.M. and Trapani, G. (2010) Translocator protein (TSPO) ligand-Ara-C (cytarabine) conjugates as a strategy to deliver antineoplastic drugs and to enhance drug clinical potential. Mol. Pharm. 7, 2255-2269 CrossRef PubMed
20. Samuelson, L.E., Dukes, M.J., Hunt, C.R., Casey, J.D. and Bornhop, D.J. (2009) TSPO targeted dendrimer imaging agent: synthesis, characterization, and cellular internalization. Bioconjug. Chem. 20, 2082-2089 CrossRef PubMed
21. Terreno, E., Uggeri, F. and Aime, S. (2012) Image guided therapy: the advent of theranostic agents. J. Control. Release 161, 328-337 CrossRef PubMed
22. Ding, H. and Wu, F. (2012) Image guided biodistribution and pharmacokinetic studies of theranostics. Theranostics 2, 1040-1053 CrossRef PubMed
23. Su, Z., Herholz, K., Gerhard, A., Roncaroli, F., Du Plessis, D., Jackson, A., Turkheimer, F. and Hinz, R. (2013) [11C]-(R)PK11195 tracer kinetics in the brain of glioma patients and a comparison of two referencing approaches. Eur. J. Nucl. Med. Mol. Imaging40, 1406-1419 CrossRef PubMed
24. Owen, D.R., Yeo, A.J., Gunn, R.N., Song, K., Wadsworth, G., Lewis, A., Rhodes, C., Pulford, D.J., Bennacef, I., Parker, C.A. et al. (2012) An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28. J. Cereb. Blood Flow Metab. 32, 1-5 CrossRef PubMed
25. Su, Z., Roncaroli, F., Durrenberger, P.F., Coope, D.J., Karabatsou, K., Hinz, R., Thompson, G., Turkheimer, F.E., Janczar, K., Du Plessis, D. et al. (2015) The 18-kDa mitochondrial translocator protein in human gliomas: A 11C-(R)PK11195 PET imaging and neuropathology study. J. Nucl. Med., in the press
26. Yamaguchi, S., Kobayashi, H., Hirata, K., Shiga, T., Tanaka, S., Murata, J. and Terasaka, S. (2011) Detection of histological anaplasia in gliomas with oligodendroglial components using positron emission tomography with (18)F-FDG and (11)C-methionine: report of two cases. J. Neurooncol. 101, 335-341 CrossRef PubMed
27. Shinozaki, N., Uchino, Y., Yoshikawa, K., Matsutani, T., Hasegawa, A., Saeki, N. and Iwadate, Y. (2011) Discrimination between low-grade oligodendrogliomas and diffuse astrocytoma with the aid of 11C-methionine positron emission tomography. J. Neurosurg. 114, 1640-1647 CrossRef PubMed
28. Batarseh, A. and Papadopoulos, V. (2010) Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states. Mol. Cell Endocrinol. 327, 1-12 CrossRef PubMed
29. Chelli, B., Salvetti, A., Da Pozzo, E., Rechichi, M., Spinetti, F., Rossi, L., Costa, B., Lena, A., Rainaldi, G., Scatena, F. et al. (2008) PK 11195 differentially affects cell survival in human wild-type and 18 kDa translocator protein-silenced ADF astrocytoma cells. J. Cell Biochem. 105, 712-723 CrossRef PubMed
30. Charles, N.A., Holland, E.C., Gilbertson, R., Glass, R. and Kettenmann, H. (2012) The brain tumor microenvironment. Glia 60, 502-514 CrossRef PubMed
31. Wei, J., Gabrusiewicz, K. and Heimberger, A. (2013) The controversial role of microglia in malignant gliomas. Clin. Dev. Immunol., in the press
32. Gatliff, J. and Campanella, M. (2012) The 18 kDa translocator protein (TSPO): a new perspective in mitochondrial biology. Curr. Mol. Med. 12, 356-368 PubMed
33. Liu, G.J., Middleton, R.J., Hatty, C.R., Kam, W.W., Chan, R., Pham, T., Harrison-Brown, M, Dodson, E., Veale, K. and Banati, R.B. (2014) The 18 kDa translocator protein, microglia and neuroinflammation. Brain Pathol. 24, 631-653 CrossRef PubMed