Novel detection of DNA-alkylated adducts of antibody-drug conjugates with potentially unique preclinical and biomarker applications

Bioanalysis

Volumn 5, Issue 9, 2013, Pages 1073-1081

  Thevanayagam, Lourdes ^a   Bell, Alasdair ^a   Chakraborty, Indrani ^a   Sufi, Bilal ^b   Gangwar, Sanjeev ^b   Zang, Allen ^b   Rangan, Vangipuram ^a   Rao, Chetana ^a   Wang, Zemin ^a   Pan, Chin ^b   Chong, Coling ^b   Cardarelli, Pina ^b   Deshpande, Shrikant ^a   Srinivasan, Mohan ^a  

^a Bristol Myers Squibb   (United States)

^b Bristol Myers Squibb Company   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY CONJUGATE; MDX 1203; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA ADDUCT; DNA ALKYLATION; DRUG CYTOTOXICITY; DRUG DNA INTERACTION; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MOUSE; NEOPLASM; NONHUMAN; QUANTITATIVE ANALYSIS; SINGLE DRUG DOSE;

ALKYLATION; ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CARCINOMA, RENAL CELL; CHROMATOGRAPHY, LIQUID; DNA ADDUCTS; HUMANS; IMMUNOCONJUGATES; INDOLES; KIDNEY NEOPLASMS; TANDEM MASS SPECTROMETRY; TUMOR MARKERS, BIOLOGICAL;

EID: 84877256505     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.13.57     Document Type: Article

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