Cytomegalovirus-induced thrombotic microangiopathy after renal transplant successfully treated with eculizumab: Case report and review of the literature

Transplant International

Volumn 28, Issue 9, 2015, Pages 1121-1125

  Java, Anuja ^a   Edwards, Angelina ^a   Rossi, Ana ^a   Pandey, Richa ^a   Gaut, Joseph ^a   Delos Santos, Rowena ^a   Miller, Brent ^a   Klein, Christina ^a   Brennan, Daniel ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

atypical hemolytic uremic syndrome; cytomegalovirus; eculizumab; renal transplant thrombotic microangiopathy

Indexed keywords

AZATHIOPRINE; BELATACEPT; CREATININE; ECULIZUMAB; MEROPENEM; METHYLPREDNISOLONE; MYCOPHENOLIC ACID; PREDNISONE; TACROLIMUS; THYMOCYTE ANTIBODY; VALGANCICLOVIR; VANCOMYCIN; CALCINEURIN INHIBITOR; COMPLEMENT; IMMUNOSUPPRESSIVE AGENT; MONOCLONAL ANTIBODY;

ACUTE KIDNEY FAILURE; AGED; BACTEREMIA; CASE REPORT; CITROBACTER; CREATININE BLOOD LEVEL; CYTOMEGALOVIRUS INFECTION; DISEASE ASSOCIATION; DRUG DOSE REDUCTION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; END STAGE RENAL DISEASE; ENTEROCOCCUS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; NAUSEA AND VOMITING; OLIGURIA; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PYELONEPHRITIS; REVIEW; THROMBOTIC THROMBOCYTOPENIC PURPURA; ADVERSE EFFECTS; CHEMISTRY; COMPLICATION; CYTOMEGALOVIRUS; POSTOPERATIVE COMPLICATION; RECURRENT DISEASE; VIROLOGY;

AGED; ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, HUMANIZED; CALCINEURIN INHIBITORS; COMPLEMENT SYSTEM PROTEINS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; POSTOPERATIVE COMPLICATIONS; RECURRENCE; THROMBOTIC MICROANGIOPATHIES;

EID: 84938743746     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/tri.12582     Document Type: Review

References (23)

1. Java A, Atkinson J, Salmon J,. Defective complement inhibitory function predisposes to renal disease. Annu Rev Med 2013; 64: 307.
2. Audard V, Matignon M, Hemery F, et al,. Risk factors and long-term outcome of transplant renal artery stenosis in adult recipients after treatment by percutaneous transluminal angioplasty. Am J Transplant 2006; 6: 95.
3. Reynolds JC, Agodoa LY, Yuan CM, Abbott KC,. Thrombotic microangiopathy after renal transplantation in the United States. Am J Kidney Dis 2003; 42: 1058.
4. Schwimmer J, Nadasdy TA, Spitalnik PF, Kaplan KL, Zand MS,. De novo thrombotic microangiopathy in renal transplant recipients: a comparison of hemolytic uremic syndrome with localized renal thrombotic microangiopathy. Am J Kidney Dis 2003; 41: 471.
5. Zarifian A, Meleg-Smith S, O'Donovan R, Tesi RJ, Batuman V,. Cyclosporine-associated thrombotic microangiopathy in renal allografts. Kidney Int 1999; 55: 2457.
6. Waiser J, Budde K, Rudolph B, Ortner MA, Neumayer HH,. De novo hemolytic uremic syndrome postrenal transplant after cytomegalovirus infection. Am J Kidney Dis 1999; 34: 556.
7. Murer L, Zacchello G, Bianchi D, et al,. Thrombotic microangiopathy associated with parvovirus B 19 infection after renal transplantation. J Am Soc Nephrol 2000; 11: 1132.
8. Petrogiannis-Haliotis T, Sakoulas G, Kirby J, et al,. BK-related polyomavirus vasculopathy in a renal-transplant recipient. N Engl J Med 2001; 345: 1250.
9. Gohh RY, Williams ME, Crosson AW, Federman M, Zambetti FX,. Late renal allograft failure secondary to thrombotic microangiopathy associated with disseminated malignancy. Am J Nephrol 1997; 17: 176.
10. Kavanagh D, Richards A, Atkinson JP,. Complement regulatory genes and hemolytic uremic syndromes. Annu Rev Med 2008; 59: 293.
11. Abarrategui-Garrido C, Melgosa M, Pena-Carrion A, et al,. Mutations in proteins of the alternative pathway of complement and the pathogenesis of atypical hemolytic uremic syndrome. Am J Kidney Dis 2008; 52: 171.
12. Ponticelli C, Banfi G,. Thrombotic microangiopathy after kidney transplantation. Transpl Int 2006; 19: 789.
13. Rahbar A, Soderberg-Naucler C,. Human cytomegalovirus infection of endothelial cells triggers platelet adhesion and aggregation. J Virol 2005; 79: 2211.
14. Liapis H, Storch GA, Hill DA, Rueda J, Brennan DC,. CMV infection of the renal allograft is much more common than the pathology indicates: a retrospective analysis of qualitative and quantitative buffy coat CMV-PCR, renal biopsy pathology and tissue CMV-PCR. Nephrol Dial Transplant 2003; 18: 397.
15. Grim SA, Pereira E, Guzman G, Clark NM,. CMV PCR as a diagnostic tool for CMV gastrointestinal disease after solid organ transplantation. Transplantation 2010; 90: 799.
16. Loenen WA, Bruggeman CA, Wiertz EJ,. Immune evasion by human cytomegalovirus: lessons in immunology and cell biology. Semin Immunol 2001; 13: 41.
17. Zuber J, Fakhouri F, Roumenina LT, Loirat C, Fremeaux-Bacchi V,. Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies. Nat Rev Nephrol 2012; 8: 643.
18. Noris M, Caprioli J, Bresin E, et al,. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Clin J Am Soc Nephrol 2010; 5: 1844.
19. Ardissino G, Testa S, Possenti I, et al,. Discontinuation of eculizumab maintenance treatment for atypical hemolytic uremic syndrome: a report of 10 cases. Am J Kidney Dis 2014; 64: 633.
20. Hochstetler LA, Flanigan MJ, Lager DJ,. Transplant-associated thrombotic microangiopathy: the role of IgG administration as initial therapy. Am J Kidney Dis 1994; 23: 444.
21. Jeejeebhoy FM, Zaltzman JS,. Thrombotic microangiopathy in association with cytomegalovirus infection in a renal transplant patient: a new treatment strategy. Transplantation 1998; 65: 1645.
22. Olie KH, Goodship TH, Verlaak R, et al,. Posttransplantation cytomegalovirus-induced recurrence of atypical hemolytic uremic syndrome associated with a factor H mutation: successful treatment with intensive plasma exchanges and ganciclovir. Am J Kidney Dis 2005; 45: e12.
23. De Keyzer K, Van Laecke S, Peeters P, Vanholder R,. De novo thrombotic microangiopathy induced by cytomegalovirus infection leading to renal allograft loss. Am J Nephrol 2010; 32: 491.