De novo thrombotic microangiopathy in renal transplant recipients: A comparison of hemolytic uremic syndrome with localized renal thrombotic microangiopathy

American Journal of Kidney Diseases

Volumn 41, Issue 2, 2003, Pages 471-479

  Schwimmer, Joshua ^a   Nadasdy, Tibor A ^a   Spitalnik, Patrice F ^a   Kaplan, Karen L ^a   Zand, Martin S ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Acute renal failure (ARF); Calcineurin inhibitor; Cyclosporine (CSA); Hemolytic uremic syndrome (HUS); Plasma exchange; Renal transplant; Tacrolimus (TAC); Thrombotic microangiopathy (TMA)

Indexed keywords

CALCINEURIN INHIBITOR; CYCLOSPORIN A; RAPAMYCIN; TACROLIMUS;

ACUTE KIDNEY FAILURE; ADULT; ARTICLE; CLINICAL ARTICLE; DIABETIC NEPHROPATHY; DISEASE COURSE; DRUG WITHDRAWAL; FEMALE; GRAFT REJECTION; HEMOLYSIS; HEMOLYTIC UREMIC SYNDROME; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; INFUSION; KIDNEY BIOPSY; KIDNEY PANCREAS TRANSPLANTATION; KIDNEY TRANSPLANTATION; MALE; PLASMAPHERESIS; SALVAGE THERAPY; THROMBOCYTOPENIA; THROMBOTIC THROMBOCYTOPENIC PURPURA;

EID: 0037308113     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/ajkd.2003.50058     Document Type: Article

References (37)

1. Hochstetler LA, Flanigan MJ, Lager DJ: Transplant-associated thrombotic microangiopathy: The role of IgG administration as initial therapy. Am J Kidney Dis 23:444-450, 1994
2. Candinas D, Keusch G, Schlumpf R, et al: Prognostic factors of hemolytic uremic syndrome in renal allografts. Transplant Proc 25:1041-1042, 1993
3. Young BA, Marsh CL, Alpers CE, Davis CL: Cyclosporine-associated thrombotic microangiopathy/hemolytic uremic syndrome following kidney and kidney-pancreas transplantation. Am J Kidney Dis 28:561-571, 1996
4. Wiener Y, Nakhleh RE, Lee MW, et al: Prognostic factors and early resumption of cyclosporin A in renal allograft recipients with thrombotic microangiopathy and hemolytic uremic syndrome. Clin Transplant 11:157-162, 1997
5. Zent R, Katz A, Quaggin S, et al: Thrombotic microangiopathy in renal transplant recipients treated with cyclosporin A. Clin Nephrol 47:181-186, 1997
6. Zarifian A, Meleg-Smith S, O'Donovan R, Tesi RJ, Batuman V: Cyclosporine-associated thrombotic microangiopathy in renal allografts. Kidney Int 55:2457-2466, 1999
7. Randhawa PS, Tsamandas AC, Magnone M, et al: Microvascular changes in renal allografts associated with FK506 (tacrolimus) therapy. Am J Surg Pathol 20:306-312, 1996
8. Remuzzi G, Ruggenenti P, Bertani P: Thrombotic microangiopathy, in Tisher CC, Brenner BM (eds): Renal Pathology (ed 2). New York, NY, Lippincott Williams & Wilkins, 1994, pp 1154-1157
9. Remuzzi G, Bertani T: Renal vascular and thrombotic effects of cyclosporine. Am J Kidney Dis 13:261-272, 1989
10. Bren AF, Kandus A, Buturovic J, et al: Cyclosporine-related hemolytic-uremic syndrome in kidney graft recipients: Clinical and histomorphologic evaluation. Transplant Proc 30:1201-1203, 1998
11. Morozumi K, Yoshida A, Suganuma T, et al: Morphological analysis of glomerular lesions in renal transplants immunosuppressed with cyclosporine A (CYA): Has CYA induced a new transplant glomerular lesion? Transplant Proc 21:282-285, 1989
12. Baid S, Pascual M, Williams WW. et al: Renal thrombotic microangiopathy associated with anticardiolipin antibodies in hepatitis C-positive renal allograft recipients. J Am Soc Nephrol 10:146-153, 1999
13. Trimarchi HM, Truong LD, Brennan S, Gonzalez JM, Suki WN: FK506-associated thrombotic microangiopathy: Report of two cases and review of the literature. Transplantation 67:539-544, 1999
14. Gross M, Zand MS, Nadasdy T: Early renal allograft loss in a patient with crescentic glomerulonephritis in the native kidney. Am J Kidney Dis 37:202-209, 2001
15. Schlumpf R, Candinas D, Weder W, et al: Acute vascular rejection with hemolytic uremic syndrome in kidneys from non-heart-beating donors: Associated with secondary grafts and early cyclosporine treatment? Transplant Proc 25:1518-1521, 1993
16. Nadasdy T, Zand MS, Rabie S, et al: Overlap of acute humoral rejection (AHR) and thrombotic microangiopathy (TMA): The value of C4D staining. J Am Soc Nephrol 12:941A, 2001 (abstr)
17. Pham PT, Peng A, Wilkinson AH, et al: Cyclosporine and tacrolimus-associated thrombotic microangiopathy. Am J Kidney Dis 36:844-850, 2000
18. Verpooten GA, Paulus GJ, Roels F, De Broe ME: De novo occurrence of hemolytic-uremic syndrome in a cyclosporine-treated renal allograft patient. Transplant Proc 19: 2943-2945, 1987
19. Curtis JJ: Renovascular elements of the cyclosporine injury. Transplant Proc 28:2094-2096, 1996
20. Grupp C, Schmidt F, Braun F, et al: Haemolytic uraemic syndrome (HUS) during treatment with cyclosporin A after renal transplantationIs tacrolimus the answer? Nephrol Dial Transplant 13:1629-1631, 1998
21. Van den Berg-Wolf MG, Kootte AM, Weening JJ, Paul LC: Recurrent hemolytic uremic syndrome in a renal transplant recipient and review of the Leiden experience. Transplantation 45:248-251, 1988
22. Raife TJ, Lentz SR, Atkinson BS, Vesely SK, Hessner MJ: Factor V Leiden: A genetic risk factor for thrombotic microangiopathy in patients with normal von Willebrand factor-cleaving protease activity. Blood 99:437-442, 2002
23. Schwarz A, Krause PH, Offermann G, Keller F: Recurrent and de novo renal disease after kidney transplantation with or without cyclosporine A. Am J Kidney Dis 17:524-531, 1991
24. Scantlebury VP, Shapiro R, McCauley J, et al: Renal transplantation under cyclosporine and FK506 for hemolytic uremic syndrome. Transplant Proc 27:842-843, 1995
25. Miller RB, Burke BA, Schmidt WJ, et al: Recurrence of haemolytic-uraemic syndrome in renal transplants: A single-centre report. Nephrol Dial Transplant 12:1425-1430, 1997
26. Hariharan S, Adams MB, Brennan DC, et al: Recurrent and de novo glomerular disease after renal transplantation: A report from Renal Allograft Disease Registry (RADR). Transplantation 68:635-641, 1999
27. Asaka M, Ishikawa I, Nakazawa T, et al: Hemolytic uremic syndrome associated with influenza A virus infection in an adult renal allograft recipient: Case report and review of the literature. Nephron 84:258-266, 2000
28. Waiser J, Budde K, Rudolph B, Ortner MA, Neumayer HH: De novo hemolytic uremic syndrome postrenal transplant after cytomegalovirus infection. Am J Kidney Dis 34:556-559, 1999
29. Murer L, Zacchello G, Bianchi D, et al: Thrombotic microangiopathy associated with parvovirus B19 infection after renal transplantation. J Am Soc Nephrol 11:1132-1137, 2000
30. Buturovic J, Kandus A, Malovrh M, Bren A, Drinovec J: Cyclosporine-associated hemolytic uremic syndrome in four renal allograft recipients: Resolution without specific therapy. Transplant Proc 22:1726-1727, 1990
31. Katznelson S, Wilkinson A, Rosenthal TR, et al: Cyclosporine-induced hemolytic uremic syndrome: Factors that obscure its diagnosis. Transplant Proc 26:2608-2609, 1994
32. Venkat KK, Tkach D, Kupin W, et al: Reversal of cyclosporine-associated hemolytic-uremic syndrome by plasma exchange with fresh-frozen plasma replacement in renal transplant recipients. Transplant Proc 23:1256-1257, 1991
33. Franz M, Regele H, Schmaldienst S, et al: Posttransplant hemolytic uremic syndrome in adult retransplanted kidney graft recipients: Advantage of FK506 therapy? Transplantation 66:1258-1262, 1998
34. Kaplan AA: Therapeutic apheresis for renal disorders. Ther Apher 3:25-30, 1999
35. Abraham KA, Little MA, Dorman AM, Walshe JJ: Hemolytic-uremic syndrome in association with both cyclosporine and tacrolimus. Transpl Int 13:443-447, 2000
36. Said T, al-Mousawi M, Samhan M, Lao M: Cyclosporin conversion to CellCept in a cadaveric renal allograft recipient with hemolytic uremic syndrome. Transplant Proc 31:3295-3297, 1999
37. Rizvi MA, Vesely SK, George JN, et al: Complications of plasma exchange in 71 consecutive patients treated for clinically suspected thrombotic thrombocytopenic purpura-hemolytic-uremic syndrome. Transfusion 40:896-901, 2000