De novo thrombotic microangiopathy induced by cytomegalovirus infection leading to renal allograft loss

American Journal of Nephrology

Volumn 32, Issue 5, 2010, Pages 491-496

  De Keyzer, Kristel ^a   Van Laecke, Steven ^a   Peeters, Patrick ^a   Vanholder, Raymond ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Cytomegalovirus infection; Hemolytic uremic syndrome; Kidney transplantation; Thrombotic microangiopathy

Indexed keywords

ANTIVIRUS AGENT; C REACTIVE PROTEIN; CORTICOSTEROID; CREATININE; CYCLOPHOSPHAMIDE; FOSCARNET; HAPTOGLOBIN; HEMOGLOBIN; HYPERIMMUNE GLOBULIN; LACTATE DEHYDROGENASE; MOXIFLOXACIN; POTASSIUM; PROTON PUMP INHIBITOR; VALGANCICLOVIR; VIRUS DNA;

ACUTE GRAFT REJECTION; ACUTE KIDNEY TUBULE NECROSIS; ADULT; ANOREXIA; ARTICLE; ATELECTASIS; CASE REPORT; CAUCASIAN; CHRONIC KIDNEY DISEASE; CLINICAL EXAMINATION; COLOR ULTRASOUND FLOWMETRY; COUGHING; CREATININE BLOOD LEVEL; CYTOMEGALOVIRUS INFECTION; DISEASE ASSOCIATION; DISEASE DURATION; ESOPHAGITIS; ESOPHAGOGASTRODUODENOSCOPY; FEVER; GASTRITIS; GRAFT FAILURE; HEART MURMUR; HELICOBACTER PYLORI; HEMODIALYSIS; HEMOGLOBIN BLOOD LEVEL; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HUMAN; HUMAN TISSUE; HYDROURETER; HYPERPHOSPHATEMIA; HYPONATREMIA; KIDNEY AGENESIS; KIDNEY ALLOGRAFT; KIDNEY BIOPSY; KIDNEY FIBROSIS; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LACTATE DEHYDROGENASE BLOOD LEVEL; LEUKOCYTE COUNT; MALE; NAUSEA; PANCYTOPENIA; PERIPHERAL EDEMA; PLASMAPHERESIS; PLEURA EFFUSION; POLYMERASE CHAIN REACTION; POSTOPERATIVE PERIOD; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; PROTEINURIA; THORAX RADIOGRAPHY; THROMBOCYTE COUNT; THROMBOTIC THROMBOCYTOPENIC PURPURA; TREATMENT DURATION; TREATMENT RESPONSE; URINALYSIS; URINE SEDIMENT; URINE VOLUME; VIRUS LOAD; VOMITING;

CYTOMEGALOVIRUS INFECTIONS; FOSCARNET; GANCICLOVIR; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; THROMBOTIC MICROANGIOPATHIES; TIME FACTORS;

EID: 77958120333     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000321328     Document Type: Article

References (17)

1. Ruggenenti P, Noris M, Remuzzi G: Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Kidney Int 2001;60:831-846. (Pubitemid 34205784)
2. Ruggenenti P: Post-transplant hemolyticuremic syndrome. Kidney Int 2002;62:1093-1104.
3. Schwimmer J, Nadasdy TA, Spitalnik PF, Kaplan KL, Zand MS: De novo thrombotic microangiopathy in renal transplant recipients: a comparison of hemolytic uremic syndrome with localized renal thrombotic microangiopathy. Am J Kidney Dis 2003;41:471-479.
4. Ponticelli C, Banfi G: Thrombotic microangiopathy after kidney transplantation. Transpl Int 2006;19:789-794.
5. Le Quintrec M, Lionet A, Kamar N, Karras A, Barbier S, Buchler M, Fakhouri F, Provost F, Fridman WH, Thervet E, Legendre C, Zuber J, Frémeaux-Bacchi V: Complement mutation-associated de novo thrombotic microangiopathy following kidney transplantation. Am J Transplant 2008;8:1694-1701.
6. Noris M, Remuzzi G: Atypical hemolyticuremic syndrome. N Engl J Med 2009;361:1676-1687.
7. Noris M, Remuzzi G: Thrombotic microangiopathy after kidney transplantation. Am J Transplant 2010;10:1517-1523.
8. Hochstetler LA, Flanigan MJ, Lager DJ: Tra nsplant-associated thrombotic microangiopathy: the role of IgG administration as initial therapy. Am J Kidney Dis 1994;23:444-450.
9. Waiser J, Budde K, Rudolph B, Ortner MA, Neumayer HH: De novo hemolytic uremic syndrome postrenal transplant after cytomegalovirus infection. Am J Kidney Dis 1999;34:556-560.
10. Karthikeyan V, Parasuraman R, Shah V, Vera E, Venkat KK: Outcome of plasma exchange therapy in thrombotic microangiopathy after renal transplantation. Am J Transplant 2003;3:1289-1294.
11. Olie KH, Goodship TH, Verlaak R, Florquin S, Groothoff JW, Strain L, Weening JJ, Davin JC: Posttransplantation cytomegalovirusinduced recurrence of atypical hemolytic syndrome associated with a factor H mutation: successful treatment with intensive plasma exchanges and ganciclovir. Am J Kidney Dis 2005;45: E12-E15.
12. Ariceta G, Besbas N, Johnson S, Karpman D, Landau D, Licht C, Loirat C, Pecoraro C, Taylor CM, Van de Kar N, Vandewalle J, Zimmerhackl LB, European Paediatric Study Group for HUS: Guideline for the investigation and initial therapy of diarrheanegative hemolytic uremic syndrome. Pediatr Nephrol 2009;24:687-696.
13. Besbas N, Karpman D, Landau D, Loirat C, Proesmans W, Remuzzi G, Rizzoni G, Taylor CM, Van de Kar N, Zimmerhackl LB, European Paediatric Research Group for HUS: A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders. Kidney Int 2006;70:423-431. (Pubitemid 44141568)
14. Jeejeebhoy FM, Zaltzman JS: Thrombotic microangiopathy in association with cytomegalovirus infection in a renal transplant patient: a new treatment strategy. Transplantation 1998;65:1645-1648.
15. Noël C, Saunier P, Hazzan M, Pruvot FR, Dracon M, Jude B, Lelièvre G: Incidence and clinical profile of microvascular complications in renal allografted patients treated with cyclosporine. Ann Med Interne 1992;143(suppl 1):33-36.
16. Crough T, Khanna R: Immu nobiology of human cytomegalovirus: from bench to bedside. Clin Microbiol Rev 2009;22:76-98.
17. Kotton CN, Kumar D, Caliendo AM, Åsberg A, Chou S, Snydman DR, Allen U, Humar A, Transplantation Society International CMV Consensus Group: International consensus guidelines on the management of cytomegalovirus in solid organ transplantation. Transplantation 2010;89:779-794.