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Volumn 16, Issue 8, 2015, Pages 1005-1021

Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages

Author keywords

gene trap; lineage map; live imaging; mouse; pre implantation development

Indexed keywords

ANIMAL TISSUE; ARTICLE; CELL LINEAGE; CONTROLLED STUDY; EMBRYO; FEMALE; FLUORESCENCE; GENE EXPRESSION; GENETIC SCREENING; IN VIVO STUDY; INNER CELL MASS; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; UPREGULATION; ANIMAL; BLASTOCYST; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; INTRAVITAL MICROSCOPY; NIDATION; PHYSIOLOGY; REPORTER GENE;

EID: 84938742340     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201540162     Document Type: Article
Times cited : (20)

References (63)
  • 1
    • 0014115998 scopus 로고
    • Development of blastomeres of mouse eggs isolated at the 4- and 8-cell stage
    • Tarkowski AK, Wróblewska J, (1967) Development of blastomeres of mouse eggs isolated at the 4- and 8-cell stage. J Embryol Exp Morphol 18: 155-180
    • (1967) J Embryol Exp Morphol , vol.18 , pp. 155-180
    • Tarkowski, A.K.1    Wróblewska, J.2
  • 2
    • 0019435844 scopus 로고
    • The foundation of two distinct cell lineages within the mouse morula
    • Johnson MH, Ziomek CA, (1981) The foundation of two distinct cell lineages within the mouse morula. Cell 24: 71-80
    • (1981) Cell , vol.24 , pp. 71-80
    • Johnson, M.H.1    Ziomek, C.A.2
  • 4
    • 38049095768 scopus 로고    scopus 로고
    • Stochastic patterning in the mouse pre-implantation embryo
    • Dietrich J-E, Hiiragi T, (2007) Stochastic patterning in the mouse pre-implantation embryo. Development 134: 4219-4231
    • (2007) Development , vol.134 , pp. 4219-4231
    • Dietrich, J.-E.1    Hiiragi, T.2
  • 5
    • 58149118293 scopus 로고    scopus 로고
    • Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst
    • Plusa B, Piliszek A, Frankenberg S, Artus J, Hadjantonakis A-K, (2008) Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst. Development 135: 3081-3091
    • (2008) Development , vol.135 , pp. 3081-3091
    • Plusa, B.1    Piliszek, A.2    Frankenberg, S.3    Artus, J.4    Hadjantonakis, A.-K.5
  • 6
    • 38049045708 scopus 로고    scopus 로고
    • Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo
    • Ralston A, Rossant J, (2008) Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo. Dev Biol 313: 614-629
    • (2008) Dev Biol , vol.313 , pp. 614-629
    • Ralston, A.1    Rossant, J.2
  • 8
    • 84901627728 scopus 로고    scopus 로고
    • GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst
    • Schrode N, Saiz N, Di Talia S, Hadjantonakis A-K, (2014) GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. Dev Cell 29: 454-467
    • (2014) Dev Cell , vol.29 , pp. 454-467
    • Schrode, N.1    Saiz, N.2    Di Talia, S.3    Hadjantonakis, A.-K.4
  • 9
    • 3142672824 scopus 로고    scopus 로고
    • First cleavage plane of the mouse egg is not predetermined but defined by the topology of the two apposing pronuclei
    • Hiiragi T, Solter D, (2004) First cleavage plane of the mouse egg is not predetermined but defined by the topology of the two apposing pronuclei. Nature 430: 360-364
    • (2004) Nature , vol.430 , pp. 360-364
    • Hiiragi, T.1    Solter, D.2
  • 10
    • 1642377939 scopus 로고    scopus 로고
    • Active cell migration drives the unilateral movements of the anterior visceral endoderm
    • Srinivas S, Rodriguez T, Clements M, Smith JC, Beddington RSP, (2004) Active cell migration drives the unilateral movements of the anterior visceral endoderm. Development 131: 1157-1164
    • (2004) Development , vol.131 , pp. 1157-1164
    • Srinivas, S.1    Rodriguez, T.2    Clements, M.3    Smith, J.C.4    Beddington, R.S.P.5
  • 11
    • 13244268317 scopus 로고    scopus 로고
    • Dynamic in vivo imaging and cell tracking using a histone fluorescent protein fusion in mice
    • Hadjantonakis A-K, Papaioannou VE, (2004) Dynamic in vivo imaging and cell tracking using a histone fluorescent protein fusion in mice. BMC Biotechnol 4: 33
    • (2004) BMC Biotechnol , vol.4 , pp. 33
    • Hadjantonakis, A.-K.1    Papaioannou, V.E.2
  • 12
    • 18244396094 scopus 로고    scopus 로고
    • Polarity of the mouse embryo is established at blastocyst and is not prepatterned
    • Motosugi N, Bauer T, Polanski Z, Solter D, Hiiragi T, (2005) Polarity of the mouse embryo is established at blastocyst and is not prepatterned. Genes Dev 19: 1081-1092
    • (2005) Genes Dev , vol.19 , pp. 1081-1092
    • Motosugi, N.1    Bauer, T.2    Polanski, Z.3    Solter, D.4    Hiiragi, T.5
  • 14
    • 77950908516 scopus 로고    scopus 로고
    • Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo
    • Morris SA, Teo RTY, Li H, Robson P, Glover DM, Zernicka-Goetz M, (2010) Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo. Proc Natl Acad Sci 107: 6364-6369
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 6364-6369
    • Morris, S.A.1    Teo, R.T.Y.2    Li, H.3    Robson, P.4    Glover, D.M.5    Zernicka-Goetz, M.6
  • 15
    • 34248171648 scopus 로고    scopus 로고
    • Blastocyst axis is specified independently of early cell lineage but aligns with the ZP shape
    • [Supporting Online Material]
    • Kurotaki Y, Hatta K, Nakao K, Nabeshima Y-I, Fujimori T, (2007) [Supporting Online Material] Blastocyst axis is specified independently of early cell lineage but aligns with the ZP shape. Science 316: 719-723
    • (2007) Science , vol.316 , pp. 719-723
    • Kurotaki, Y.1    Hatta, K.2    Nakao, K.3    Nabeshima, Y.-I.4    Fujimori, T.5
  • 16
    • 84879413598 scopus 로고    scopus 로고
    • A self-organization framework for symmetry brea king in the mammalian embryo
    • Wennekamp S, Mesecke S, Nédélec F, Hiiragi T, (2013) A self-organization framework for symmetry brea king in the mammalian embryo. Nat Rev Mol Cell Biol 14: 454-461
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 454-461
    • Wennekamp, S.1    Mesecke, S.2    Nédélec, F.3    Hiiragi, T.4
  • 17
    • 0038583861 scopus 로고    scopus 로고
    • Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms
    • Hamilton TG, Klinghoffer RA, Corrin PD, Soriano P, (2003) Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms. Mol Cell Biol 23: 4013-4025
    • (2003) Mol Cell Biol , vol.23 , pp. 4013-4025
    • Hamilton, T.G.1    Klinghoffer, R.A.2    Corrin, P.D.3    Soriano, P.4
  • 18
    • 84867896194 scopus 로고    scopus 로고
    • Generation and live imaging of an endogenous Cdx2 reporter mouse line
    • McDole K, Zheng Y, (2012) Generation and live imaging of an endogenous Cdx2 reporter mouse line. Genesis 50: 775-782
    • (2012) Genesis , vol.50 , pp. 775-782
    • McDole, K.1    Zheng, Y.2
  • 19
    • 84924532692 scopus 로고    scopus 로고
    • Heterogeneities in Nanog expression drive stable commitment to pluripotency in the mouse blastocyst
    • Xenopoulos P, Kang M, Puliafito A, Di Talia S, Hadjantonakis A-K, (2015) Heterogeneities in Nanog expression drive stable commitment to pluripotency in the mouse blastocyst. Cell Rep 10: 1508-1520
    • (2015) Cell Rep , vol.10 , pp. 1508-1520
    • Xenopoulos, P.1    Kang, M.2    Puliafito, A.3    Di Talia, S.4    Hadjantonakis, A.-K.5
  • 21
    • 4344636300 scopus 로고    scopus 로고
    • A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish
    • Kawakami K, Takeda H, Kawakami N, Kobayashi M, Matsuda N, Mishina M, (2004) A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish. Dev Cell 7: 133-144
    • (2004) Dev Cell , vol.7 , pp. 133-144
    • Kawakami, K.1    Takeda, H.2    Kawakami, N.3    Kobayashi, M.4    Matsuda, N.5    Mishina, M.6
  • 22
    • 33845218957 scopus 로고    scopus 로고
    • An efficient promoter trap for detection of patterned gene expression and subsequent functional analysis in Drosophila
    • Larsen C, Franch-Marro X, Hartenstein V, Alexandre C, Vincent J-P, (2006) An efficient promoter trap for detection of patterned gene expression and subsequent functional analysis in Drosophila. Proc Natl Acad Sci USA 103: 17813-17817
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 17813-17817
    • Larsen, C.1    Franch-Marro, X.2    Hartenstein, V.3    Alexandre, C.4    Vincent, J.-P.5
  • 23
    • 0035910097 scopus 로고    scopus 로고
    • A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila
    • Morin X, Daneman R, Zavortink M, Chia W, (2001) A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila. Proc Natl Acad Sci USA 98: 15050-15055
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 15050-15055
    • Morin, X.1    Daneman, R.2    Zavortink, M.3    Chia, W.4
  • 24
    • 33846002394 scopus 로고    scopus 로고
    • A mouse for all reasons
    • International Mouse Knockout Consortium
    • International Mouse Knockout Consortium, Collins FS, Rossant J, Wurst W, (2007) A mouse for all reasons. Cell 128: 9-13.
    • (2007) Cell , vol.128 , pp. 9-13
    • Collins, F.S.1    Rossant, J.2    Wurst, W.3
  • 25
    • 0035487038 scopus 로고    scopus 로고
    • Gene-trap mutagenesis: Past, present and beyond
    • Stanford WL, Cohn JB, Cordes SP, (2001) Gene-trap mutagenesis: past, present and beyond. Nat Rev Genet 2: 756-768
    • (2001) Nat Rev Genet , vol.2 , pp. 756-768
    • Stanford, W.L.1    Cohn, J.B.2    Cordes, S.P.3
  • 26
    • 53249133091 scopus 로고    scopus 로고
    • The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages
    • Kwon GS, Viotti M, Hadjantonakis A-K, (2008) The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages. Dev Cell 15: 509-520
    • (2008) Dev Cell , vol.15 , pp. 509-520
    • Kwon, G.S.1    Viotti, M.2    Hadjantonakis, A.-K.3
  • 29
    • 78650046299 scopus 로고    scopus 로고
    • Imaging cell movements in egg-cylinder stage mouse embryos
    • pdb.prot5539
    • Srinivas S, (2010) Imaging cell movements in egg-cylinder stage mouse embryos. Cold Spring Harb Protoc 2010: pdb.prot5539
    • (2010) Cold Spring Harb Protoc , vol.2010
    • Srinivas, S.1
  • 30
    • 84896734807 scopus 로고    scopus 로고
    • Self-organizing properties of mouse pluripotent cells initiate morphogenesis upon implantation
    • Bedzhov I, Zernicka-Goetz M, (2014) Self-organizing properties of mouse pluripotent cells initiate morphogenesis upon implantation. Cell 156: 1032-1044
    • (2014) Cell , vol.156 , pp. 1032-1044
    • Bedzhov, I.1    Zernicka-Goetz, M.2
  • 31
    • 36448961540 scopus 로고    scopus 로고
    • Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms
    • Yamanaka Y, Tamplin OJ, Beckers A, Gossler A, Rossant J, (2007) Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms. Dev Cell 13: 884-896
    • (2007) Dev Cell , vol.13 , pp. 884-896
    • Yamanaka, Y.1    Tamplin, O.J.2    Beckers, A.3    Gossler, A.4    Rossant, J.5
  • 32
    • 84901458853 scopus 로고    scopus 로고
    • Limited predictive value of blastomere angle of division in trophectoderm and inner cell mass specification
    • Watanabe T, Biggins JS, Tannan NB, Srinivas S, (2014) Limited predictive value of blastomere angle of division in trophectoderm and inner cell mass specification. Development 141: 2279-2288
    • (2014) Development , vol.141 , pp. 2279-2288
    • Watanabe, T.1    Biggins, J.S.2    Tannan, N.B.3    Srinivas, S.4
  • 35
    • 0023488840 scopus 로고
    • Detection in situ of genomic regulatory elements in Drosophila
    • O'Kane CJ, Gehring WJ, (1987) Detection in situ of genomic regulatory elements in Drosophila. Proc Natl Acad Sci USA 84: 9123-9127
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 9123-9127
    • O'Kane, C.J.1    Gehring, W.J.2
  • 36
    • 0024542052 scopus 로고
    • Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes
    • Gossler A, Joyner AL, Rossant J, Skarnes WC, (1989) Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. Science 244: 463-465
    • (1989) Science , vol.244 , pp. 463-465
    • Gossler, A.1    Joyner, A.L.2    Rossant, J.3    Skarnes, W.C.4
  • 38
    • 77950223473 scopus 로고    scopus 로고
    • Mechanisms of trophectoderm fate specification in preimplantation mouse development
    • Sasaki H, (2010) Mechanisms of trophectoderm fate specification in preimplantation mouse development. Dev Growth Differ 52: 263-273
    • (2010) Dev Growth Differ , vol.52 , pp. 263-273
    • Sasaki, H.1
  • 40
    • 19744365010 scopus 로고    scopus 로고
    • Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst
    • Strumpf D, Mao C-A, Yamanaka Y, Ralston A, Chawengsaksophak K, Beck F, Rossant J, (2005) Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development 132: 2093-2102
    • (2005) Development , vol.132 , pp. 2093-2102
    • Strumpf, D.1    Mao, C.-A.2    Yamanaka, Y.3    Ralston, A.4    Chawengsaksophak, K.5    Beck, F.6    Rossant, J.7
  • 42
    • 79960128316 scopus 로고    scopus 로고
    • Establishment of conditional reporter mouse lines at ROSA26 locus for live cell imaging
    • Abe T, Kiyonari H, Shioi G, Inoue K-I, Nakao K, Aizawa S, Fujimori T, (2011) Establishment of conditional reporter mouse lines at ROSA26 locus for live cell imaging. Genesis 49: 579-590
    • (2011) Genesis , vol.49 , pp. 579-590
    • Abe, T.1    Kiyonari, H.2    Shioi, G.3    Inoue, K.-I.4    Nakao, K.5    Aizawa, S.6    Fujimori, T.7
  • 44
    • 84903975377 scopus 로고    scopus 로고
    • Initiation of Hippo signaling is linked to polarity rather than to cell position in the pre-implantation mouse embryo
    • Anani S, Bhat S, Honma-Yamanaka N, Krawchuk D, Yamanaka Y, (2014) Initiation of Hippo signaling is linked to polarity rather than to cell position in the pre-implantation mouse embryo. Development 141: 2813-2824
    • (2014) Development , vol.141 , pp. 2813-2824
    • Anani, S.1    Bhat, S.2    Honma-Yamanaka, N.3    Krawchuk, D.4    Yamanaka, Y.5
  • 45
    • 79959238142 scopus 로고    scopus 로고
    • Lineage mapping the pre-implantation mouse embryo by two-photon microscopy, new insights into the segregation of cell fates
    • McDole K, Xiong Y, Iglesias PA, Zheng Y, (2011) Lineage mapping the pre-implantation mouse embryo by two-photon microscopy, new insights into the segregation of cell fates. Dev Biol 355: 239-249
    • (2011) Dev Biol , vol.355 , pp. 239-249
    • McDole, K.1    Xiong, Y.2    Iglesias, P.A.3    Zheng, Y.4
  • 46
    • 76449083746 scopus 로고    scopus 로고
    • FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst
    • Yamanaka Y, Lanner F, Rossant J, (2010) FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst. Development 137: 715-724
    • (2010) Development , vol.137 , pp. 715-724
    • Yamanaka, Y.1    Lanner, F.2    Rossant, J.3
  • 49
    • 84863195203 scopus 로고    scopus 로고
    • Quantitative high-speed imaging of entire developing embryos with simultaneous multiview light-sheet microscopy
    • Tomer R, Khairy K, Amat F, Keller PJ, (2012) Quantitative high-speed imaging of entire developing embryos with simultaneous multiview light-sheet microscopy. Nat Meth 9: 755-763
    • (2012) Nat Meth , vol.9 , pp. 755-763
    • Tomer, R.1    Khairy, K.2    Amat, F.3    Keller, P.J.4
  • 51
    • 8844256589 scopus 로고    scopus 로고
    • Circadian gene expression in individual fibroblasts: Cell-autonomous and self-sustained oscillators pass time to daughter cells
    • Nagoshi E, Saini C, Bauer C, Laroche T, Naef F, Schibler U, (2004) Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells. Cell 119: 693-705
    • (2004) Cell , vol.119 , pp. 693-705
    • Nagoshi, E.1    Saini, C.2    Bauer, C.3    Laroche, T.4    Naef, F.5    Schibler, U.6
  • 52
    • 0032978712 scopus 로고    scopus 로고
    • Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors
    • Zufferey R, Donello JE, Trono D, Hope TJ, (1999) Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J Virol 73: 2886-2892
    • (1999) J Virol , vol.73 , pp. 2886-2892
    • Zufferey, R.1    Donello, J.E.2    Trono, D.3    Hope, T.J.4
  • 53
    • 0026023289 scopus 로고
    • Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
    • Soriano P, Montgomery C, Geske R, Bradley A, (1991) Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64: 693-702
    • (1991) Cell , vol.64 , pp. 693-702
    • Soriano, P.1    Montgomery, C.2    Geske, R.3    Bradley, A.4
  • 54
    • 0025992469 scopus 로고
    • Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice
    • Friedrich G, Soriano P, (1991) Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev 5: 1513-1523
    • (1991) Genes Dev , vol.5 , pp. 1513-1523
    • Friedrich, G.1    Soriano, P.2
  • 55
    • 0023758546 scopus 로고
    • A segment of the 5′ nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation
    • Jang SK, Kräusslich HG, Nicklin MJ, Duke GM, Palmenberg AC, Wimmer E, (1988) A segment of the 5′ nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation. J Virol 62: 2636-2643
    • (1988) J Virol , vol.62 , pp. 2636-2643
    • Jang, S.K.1    Kräusslich, H.G.2    Nicklin, M.J.3    Duke, G.M.4    Palmenberg, A.C.5    Wimmer, E.6
  • 56
    • 0021972533 scopus 로고
    • The FLP recombinase of the 2 micron circle DNA of yeast: Interaction with its target sequences
    • Andrews BJ, Proteau GA, Beatty LG, Sadowski PD, (1985) The FLP recombinase of the 2 micron circle DNA of yeast: interaction with its target sequences. Cell 40: 795-803
    • (1985) Cell , vol.40 , pp. 795-803
    • Andrews, B.J.1    Proteau, G.A.2    Beatty, L.G.3    Sadowski, P.D.4
  • 57
    • 0032541483 scopus 로고    scopus 로고
    • Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination
    • Lee G, Saito I, (1998) Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination. Gene 216: 55-65
    • (1998) Gene , vol.216 , pp. 55-65
    • Lee, G.1    Saito, I.2
  • 58
    • 0017392135 scopus 로고
    • Viral integration and excision: Structure of the lambda att sites
    • Landy A, Ross W, (1977) Viral integration and excision: structure of the lambda att sites. Science 197: 1147-1160
    • (1977) Science , vol.197 , pp. 1147-1160
    • Landy, A.1    Ross, W.2
  • 59
    • 0037162715 scopus 로고    scopus 로고
    • HIV-1 integration in the human genome favors active genes and local hotspots
    • Schröder ARW, Shinn P, Chen H, Berry C, Ecker JR, Bushman F, (2002) HIV-1 integration in the human genome favors active genes and local hotspots. Cell 110: 521-529
    • (2002) Cell , vol.110 , pp. 521-529
    • Schröder, A.R.W.1    Shinn, P.2    Chen, H.3    Berry, C.4    Ecker, J.R.5    Bushman, F.6
  • 60
    • 0029360727 scopus 로고
    • Efficient isolation and mapping of Arabidopsis thaliana T-DNA insert junctions by thermal asymmetric interlaced PCR
    • Liu YG, Mitsukawa N, Oosumi T, Whittier RF, (1995) Efficient isolation and mapping of Arabidopsis thaliana T-DNA insert junctions by thermal asymmetric interlaced PCR. Plant J 8: 457-463
    • (1995) Plant J , vol.8 , pp. 457-463
    • Liu, Y.G.1    Mitsukawa, N.2    Oosumi, T.3    Whittier, R.F.4
  • 61
    • 0028949381 scopus 로고
    • Thermal asymmetric interlaced PCR: Automatable amplification and sequencing of insert end fragments from P1 and YAC clones for chromosome walking
    • Liu YG, Whittier RF, (1995) Thermal asymmetric interlaced PCR: automatable amplification and sequencing of insert end fragments from P1 and YAC clones for chromosome walking. Genomics 25: 674-681
    • (1995) Genomics , vol.25 , pp. 674-681
    • Liu, Y.G.1    Whittier, R.F.2
  • 62
    • 46649088001 scopus 로고    scopus 로고
    • Integration site analysis in transgenic mice by thermal asymmetric interlaced (TAIL)-PCR: Segregating multiple-integrant founder lines and determining zygosity
    • Pillai MM, Venkataraman GM, Kosak S, Torok-Storb B, (2008) Integration site analysis in transgenic mice by thermal asymmetric interlaced (TAIL)-PCR: segregating multiple-integrant founder lines and determining zygosity. Transgenic Res 17: 749-754
    • (2008) Transgenic Res , vol.17 , pp. 749-754
    • Pillai, M.M.1    Venkataraman, G.M.2    Kosak, S.3    Torok-Storb, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.