Plasma levels of mitochondrial DNA in patients presenting to the emergency department with sepsis

Shock

Volumn 38, Issue 4, 2012, Pages 337-340

  Puskarich, Michael A ^a   Shapiro, Nathan I ^b   Trzeciak, Stephen ^c   Kline, Jeffrey A ^a   Jones, Alan E ^d  

^a CAROLINAS MEDICAL CENTER   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c Division of Female Pelvic Medicine and Reconstructive Surgery   (United States)

^d UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

inflammation; mitochondrial DNA; mtDNA; Sepsis; SIRS

Indexed keywords

CYCLOOXYGENASE 3; CYTOCHROME B; INTERLEUKIN 10; INTERLEUKIN 6; MITOCHONDRIAL DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EMERGENCY WARD; FEMALE; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; MULTIPLE ORGAN FAILURE; OBSERVATIONAL STUDY; PROSPECTIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; SEPSIS; SEPTIC SHOCK; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TERTIARY HEALTH CARE;

DNA, MITOCHONDRIAL; EMERGENCY SERVICE, HOSPITAL; FEMALE; HUMANS; HYPOTENSION; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; PROSPECTIVE STUDIES; REAL-TIME POLYMERASE CHAIN REACTION; SEPSIS;

EID: 84866624353     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e318266a169     Document Type: Article

References (11)

1. Angus D, Linde-Zwirble W, Lidicker J, Clermont G, Carcillo J, Pinsky M: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29:1303-1310, 2001.
2. van der Poll T, Opal SM: Host-pathogen interactions in sepsis. Lancet Infect Dis 8:32-43, 2008.
3. Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K, Hauser CJ: Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464(4):104-108, 2010.
4. Fink MP: Bench-to-bedside review: cytopathic hypoxia. Crit Care 6:491-499, 2002.
5. Singer M: Mitochondrial dysfunction in sepsis: acute phase versus multiple organ failure. Crit Care Med 35(9):S441-S448, 2007.
6. Pyle A, Burn DJ, Gordon C, Swan C, Chinnery PF, Baudouin SV: Fall in circulating mononuclear cell mitochondrial DNA content in human sepsis. Intensive Care Med 36:956-962, 2010.
7. Cote HC, Day AG, Heyland DK: Longitudinal increased in mitochondrial DNA levels in blood cells are associated with survival in critically ill patients. Crit Care 11(4):R88, 2007.
8. Huttunen R, Kuparinen T, Jylhava J, Aittoniemi J, Vuento R, Huhtala H, Laine J, Syrjanen J, Hurme M: Fatal outcome in bacteremia is characterized by high plasma cell free DNA concentration and apoptotic DNA fragmentation: a prospective cohort study. PLoS One 6(7):1-8, 2011.
9. Rhodes A, Wort SJ, Thomas H, Collinson P, Bennett ED: Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients. Crit Care 10(2):1-7, 2006.
10. Bone R, Balk RA, Cerra FB, Dellinger RP, Fein AM, Kraus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101:1644-1655, 1992.
11. Haden DW, Suliman HG, Carraway MS, Welty-Wolf KE, Ali AS, Shitara H, Yonekawa H, Piantadosi CA: Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis. Am J Respir Crit Care Med 176 (8):768-777, 2007.