High-fat diet increases autophagic flux in pancreatic beta cells in vivo and ex vivo in mice

Diabetologia

Volumn 58, Issue 9, 2015, Pages 2074-2078

  Chu, Kwan Yi ^a   O’Reilly, Liam ^a   Ramm, Georg ^b   Biden, Trevor J ^a,c  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Autophagic flux; Autophagy; Chloroquine; ER stress; GFP LC3; High fat diet; Lipid droplet; Liver; Pancreatic beta cell

Indexed keywords

CASPASE 3; CHLOROQUINE; GREEN FLUORESCENT PROTEIN; INITIATION FACTOR 2ALPHA; MICROTUBULE ASSOCIATED PROTEIN 1; CASP3 PROTEIN, MOUSE; DDIT3 PROTEIN, MOUSE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2; LIGHT CHAIN 3, HUMAN; LIPID; MICROTUBULE ASSOCIATED PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM STRESS; EX VIVO STUDY; FAT INTAKE; GENE EXPRESSION; IN VIVO STUDY; LIPID DIET; LIVER CELL; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; ANIMAL; BLOOD; C57BL MOUSE; CHEMISTRY; CONFOCAL MICROSCOPY; CYTOLOGY; ENDOPLASMIC RETICULUM; FLUORESCENCE MICROSCOPY; HOMOZYGOTE; LYSOSOME; MALE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; AUTOPHAGY; CASPASE 3; CHLOROQUINE; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; GREEN FLUORESCENT PROTEINS; HOMOZYGOTE; INSULIN-SECRETING CELLS; LIPIDS; LYSOSOMES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; MICROTUBULE-ASSOCIATED PROTEINS; TRANSCRIPTION FACTOR CHOP;

EID: 84938739110     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3665-x     Document Type: Article

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