Induced KCNQ1 autoimmunity accelerates cardiac repolarization in rabbits: Potential significance in arrhythmogenesis and antiarrhythmic therapy

Heart Rhythm

Volumn 11, Issue 11, 2014, Pages 2092-2100

  Li, Jin ^a,b   Maguy, Ange ^a   Duverger, James Elber ^a,c   Vigneault, Patrick ^a   Comtois, Philippe ^a,c   Shi, Yanfen ^a   Tardif, Jean Claude ^a   Thomas, Dierk ^b   Nattel, Stanley ^a  

^a MONTREAL HEART INSTITUTE   (Canada)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Autoimmunity; KCNQ1; Long QT syndrome; QT; Vaccination; Ventricular tachyarrhythmia

Indexed keywords

AUTOANTIBODY; DOFETILIDE; METHOXAMINE; POTASSIUM CHANNEL KCNQ1; POTASSIUM CHANNEL KCNQ1 ANTIBODY; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY TITER; ARRHYTHMOGENESIS; ARTICLE; AUTOIMMUNITY; CARDIAC MUSCLE CELL; CONTROLLED STUDY; CURRENT DENSITY; DEACTIVATION TIME CONSTANT; ELECTROCARDIOGRAM; EXPERIMENTAL RABBIT; EXTRACELLULAR MATRIX; FOLLOW UP; HEART ELECTROPHYSIOLOGY; HEART MUSCLE POTENTIAL; HEART MUSCLE REFRACTORY PERIOD; HEART REPOLARIZATION; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE TACHYCARDIA; MALE; MEMBRANE STEADY POTENTIAL; NONHUMAN; PATCH CLAMP TECHNIQUE; PILOT STUDY; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; TORSADE DES POINTES; VACCINATION; ACTION POTENTIAL; ANIMAL; DISEASE MODEL; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; HEART MUSCLE CELL; IMMUNOLOGY; LONG QT SYNDROME; PATHOPHYSIOLOGY; PHYSIOLOGY; RABBIT;

ACTION POTENTIALS; ANIMALS; AUTOANTIBODIES; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; KCNQ1 POTASSIUM CHANNEL; LONG QT SYNDROME; MALE; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; RABBITS; TACHYCARDIA, VENTRICULAR;

EID: 84938697075     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2014.07.040     Document Type: Article

References (29)

1. Lee, H.C., Huang, K.T., Wang, X.L., Shen, W.K., Autoantibodies and cardiac arrhythmias. Heart Rhythm 8 (2011), 1788–1795.
2. Yoshikawa, T., Baba, A., Nagatomo, Y., Autoimmune mechanisms underlying dilated cardiomyopathy. Circ J 73 (2009), 602–607.
3. Leuschner, F., Li, J., Göser, S., Reinhardt, L., Ottl, R., Bride, P., Zehelein, J., Pfitzer, G., Remppis, A., Giannitsis, E., Katus, H.A., Kaya, Z., Absence of auto-antibodies against cardiac troponin I predicts improvement of left ventricular function after acute myocardial infarction. Eur Heart J 29 (2008), 1949–1955.
4. Nakamura, K., Katayama, Y., Kusano, K.F., et al. Anti-KCNH2 antibody-induced long QT syndrome: novel acquired form of long QT syndrome. J Am Coll Cardiol 50 (2007), 1808–1809.
5. Ks current and are associated with QT interval shortening in dilated cardiomyopathy. Cardiovasc Res 98 (2013), 496–503.
6. Patel, C., Yan, G.X., Antzelevitch, C., Short QT syndrome: from bench to bedside. Circ Arrhythm Electrophysiol 3 (2010), 401–408.
7. Fukuda, Y., Miyoshi, S., Tanimoto, K., Oota, K., Fujikura, K., Iwata, M., Baba, A., Hagiwara, Y., Yoshikawa, T., Mitamura, H., Ogawa, S., Autoimmunity against the second extracellular loop of beta(1)-adrenergic receptors induces early afterdepolarization and decreases in K-channel density in rabbits. J Am Coll Cardiol 43 (2004), 1090–1100.
8. Iwata, M., Yoshikawa, T., Baba, A., Anzai, T., Nakamura, I., Wainai, Y., Takahashi, T., Ogawa, S., Autoimmunity against the second extracellular loop of beta(1)-adrenergic receptors induces beta-adrenergic receptor desensitization and myocardial hypertrophy in vivo. Circ Res 88 (2001), 578–586.
9. Li, J., Göser, S., Leuschner, F., Volz, H.C., Buss, S., Andrassy, M., Öttl, R., Pfitzer, G., Katus, H.A., Kaya, Z., Mucosal tolerance induction in autoimmune myocarditis and myocardial infarction. Int J Cardiol 162 (2013), 245–252.
10. Farkas, A., Batey, A.J., Coker, S.J., How to measure electrocardiographic QT interval in the anaesthetized rabbit. J Pharmacol Toxicol Methods 50 (2004), 175–185.
11. Van de Water, A., Verheyen, J., Xhonneux, R., Reneman, R.S., An improved method to correct the QT interval of the electrocardiogram for changes in heart rate. J Pharmacol Methods 22 (1989), 207–217.
12. Wyatt, J.D., Scott, R.A., Richardson, M.E., The effects of prolonged ketamine-xylazine intravenous infusion on arterial blood pH, blood gases, mean arterial blood pressure, heart and respiratory rates, rectal temperature and reflexes in the rabbit. Lab Anim Sci 39 (1989), 411–416.
13. Odening, K.E., Kirk, M., Brunner, M., Ziv, O., Lorvidhaya, P., Liu, G.X., Schofield, L., Chaves, L., Peng, X., Zehender, M., Choi, B.R., Koren, G., Electrophysiological studies of transgenic long QT type 1 and type 2 rabbits reveal genotype-specific differences in ventricular refractoriness and His conduction. Am J Physiol Heart Circ Physiol 299 (2010), H643–H655.
14. Tsuji, Y., Zicha, S., Qi, X.Y., Kodama, I., Nattel, S., Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changes. Circulation 113 (2006), 345–355.
15. Li, H., Scherlag, B.J., Kem, D.C., Zillner, C., Male, S., Thirunavukkarasu, S., Shen, X., Pitha, J.V., Cunningham, M.W., Lazzara, R., Yu, X., Atrial tachycardia provoked in the presence of activating autoantibodies to beta2-adrenergic receptor in the rabbit. Heart Rhythm 10 (2013), 436–441.
16. Tsuji, Y., Opthof, T., Kamiya, K., Yasui, K., Liu, W., Lu, Z., Kodama, I., Pacing-induced heart failure causes a reduction of delayed rectifier potassium currents along with decreases in calcium and transient outward currents in rabbit ventricle. Cardiovasc Res 48 (2000), 300–309.
17. + current: a potential mechanism of the proarrhythmic effects of methanesulfonanilideclass III agents. Cardiovasc Res 43 (1999), 135–147.
18. Yang, W.P., Levesque, P.C., Little, W.A., Conder, M.L., Shalaby, F.Y., Blanar, M.A., KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias. Proc Natl Acad Sci U S A 94 (1997), 4017–4021.
19. Diness, T.G., Yeh, Y.H., Qi, X.Y., Chartier, D., Tsuji, Y., Hansen, R.S., Olesen, S.P., Grunnet, M., Nattel, S., Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome. Cardiovasc Res 79 (2008), 61–69.
20. Carlsson, L., The anaesthetised methoxamine-sensitised rabbit model of torsades de pointes. Pharmacol Ther 119 (2008), 160–167.
21. Kühl, U., Melzner, B., Schäfer, B., Schultheiss, H.P., Strauer, B.E., The Ca-channel as cardiac autoantigen. Eur Heart J 12:Suppl D (1991), 99–104.
22. Karnabi, E., Qu, Y., Wadgaonkar, R., Mancarella, S., Yue, Y., Chahine, M., Clancy, R.M., Buyon, J.P., Boutjdir, M., Congenital heart block: identification of autoantibody binding site on the extracellular loop (domain I, S5-S6) of alpha(1D) L-type Ca channel. J Autoimmun 34 (2010), 80–86.
23. Xiao, H., Wang, M., Du, Y., Yuan, J., Zhao, G., Tu, D., Liao, Y.H., Agonist-like autoantibodies against calcium channel in patients with dilated cardiomyopathy. Heart Vessels 27 (2012), 486–492.
24. Xiao, H., Wang, M., Du, Y., Yuan, J., Cheng, X., Chen, Z., Zou, A., Wei, F., Zhao, G., Liao, Y.H., Arrhythmogenic autoantibodies against calcium channel lead to sudden death in idiopathic dilated cardiomyopathy. Eur J Heart Fail 13 (2011), 264–270.
25. Korkmaz, S., Zitron, E., Bangert, A., et al. Provocation of an autoimmune response to cardiac voltage-gated sodium channel NaV1.5 induces cardiac conduction defects in rats. J Am Coll Cardiol 62 (2013), 340–349.
26. Arsenos, P., Gatzoulis, K.A., Dilaveris, P., Gialernios, T., Sideris, S., Lazaros, G., Archontakis, S., Tsiachris, D., Kartsagoulis, E., Stefanadis, C., The rate-corrected QT interval calculated from 24-hour Holter recordings may serve as a significant arrhythmia risk stratifier in heart failure patients. Int J Cardiol 147 (2011), 321–323.
27. Tsuji, Y., Heijman, J., Nattel, S., Dobrev, D., Electrical storm: recent pathophysiological insights and therapeutic consequences. Basic Res Cardiol, 108, 2013, 336.
28. Collura, C.A., Johnson, J.N., Moir, C., Ackerman, M.J., Left cardiac sympathetic denervation for the treatment of long QT syndrome and catecholaminergic polymorphic ventricular tachycardia using video-assisted thoracic surgery. Heart Rhythm 6 (2009), 752–759.
29. Chapman, A.P., Antoniw, P., Spitali, M., West, S., Stephens, S., King, D.J., Therapeutic antibody fragments with prolonged in vivo half-lives. Nat Biotechnol 17 (1999), 780–783.