Autoimmunity against the second extracellular loop of beta 1-adrenergic receptors induces early afterdepolarization and decreases in K-channel density in rabbits

Journal of the American College of Cardiology

Volumn 43, Issue 6, 2004, Pages 1090-1100

  Fukuda, Yukiko ^a   Miyoshi, Shunichiro ^a   Tanimoto, Kojiro ^a   Oota, Kenichi ^a   Fujikura, Kana ^a   Iwata, Michikado ^a   Baba, Akiyasu ^a   Hagiwara, Yoko ^a   Yoshikawa, Tsutomu ^a   Mitamura, Hideo ^a   Ogawa, Satoshi ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Action potential duration; APD; Bovine serum albumin; BSA; EAD; Early after depolarization; ECG; Electrocardiogram electrocardiograph electrocardiographic; Hyperpolarization dependent current; ICaL; If; L type calcium current

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; BETA 1 ADRENERGIC RECEPTOR; INWARDLY RECTIFYING POTASSIUM CHANNEL; SYNTHETIC PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; EXPERIMENTAL MODEL; HEART DEPOLARIZATION; HEART LEFT VENTRICLE COMPLIANCE; HEART RIGHT VENTRICLE FUNCTION; HEART VENTRICLE TACHYCARDIA; IMMUNOPROPHYLAXIS; LETHALITY; MICROELECTRODE; MUSCLE ACTION POTENTIAL; NONHUMAN; PATCH CLAMP; PREDICTION; PRIORITY JOURNAL; SPECIES COMPARISON; SUDDEN DEATH; TACHYCARDIA INDUCED CARDIOMYOPATHY; THORAX ELECTRIC FIELD;

ACTION POTENTIALS; ANIMALS; AUTOIMMUNITY; CARDIOMYOPATHIES; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; MALE; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; PEPTIDE FRAGMENTS; POTASSIUM CHANNELS; RABBITS; RECEPTORS, ADRENERGIC, BETA-1; TACHYCARDIA, VENTRICULAR;

EID: 12144286530     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2003.09.057     Document Type: Article

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