Efficient Delivery of DOX to Nuclei of Hepatic Carcinoma Cells in the Subcutaneous Tumor Model Using pH-Sensitive Pullulan-DOX Conjugates

ACS Applied Materials and Interfaces

Volumn 7, Issue 29, 2015, Pages 15855-15865

  Li, Huanan ^b   Cui, Yani ^a   Sui, Junhui ^a   Bian, Shaoquan ^a   Sun, Yong ^a   Liang, Jie ^a   Fan, Yujiang ^a   Zhang, Xingdong ^a  

^a SICHUAN UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

doxorubicin; hepatic carcinoma; nanoparticles; pH sensitive; pullulan

Indexed keywords

CELL DEATH; CELL MEMBRANES; CELL PROLIFERATION; CELLS; MOLECULAR BIOLOGY; NANOPARTICLES; NUCLEIC ACIDS; PH SENSORS; TUMORS;

ASIALOGLYCOPROTEIN RECEPTORS; DOXORUBICIN; ENHANCED PERMEATION AND RETENTIONS; HEPATIC CARCINOMA; PH SENSITIVE; PULLULANS; RECEPTOR-MEDIATED ENDOCYTOSIS; SUBCUTANEOUS TUMOR MODELS;

CYTOLOGY;

ANTINEOPLASTIC ANTIMETABOLITE; DELAYED RELEASE FORMULATION; DOXORUBICIN; GLUCAN; NANOCAPSULE; PULLULAN;

ADMINISTRATION AND DOSAGE; ANIMAL; BAGG ALBINO MOUSE; CARCINOMA, HEPATOCELLULAR; CELL NUCLEUS; CHEMISTRY; DELAYED RELEASE FORMULATION; DIFFUSION; DRUG EFFECTS; HELA CELL LINE; HEPG2 CELL LINE; HUMAN; LIVER; MOUSE; NUDE MOUSE; PATHOLOGY; PH; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL NUCLEUS; DELAYED-ACTION PREPARATIONS; DIFFUSION; DOXORUBICIN; GLUCANS; HELA CELLS; HEP G2 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; LIVER; MICE; MICE, INBRED BALB C; MICE, NUDE; NANOCAPSULES;

EID: 84938675578     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.5b03150     Document Type: Article

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