Rhinovirus-induced airway disease: A model to understand the antiviral and Th2 epithelial immune dysregulation in childhood asthma

Journal of Investigative Medicine

Volumn 63, Issue 6, 2015, Pages 792-795

  Perez, Geovanny F ^a,b   Rodriguez Martinez, Carlos E ^c,d,e   Nino, Gustavo ^a,b  

^a CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^b GEORGE WASHINGTON UNIVERSITY   (United States)

^c UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

^d UNIVERSIDAD EL BOSQUE   (Colombia)

^e HOSPITAL MILITAR CENTRAL   (Colombia)

Author keywords

innate antiviral immunity; interferons; microbiome; rhinovirus; thymic stromal lymphopoietin

Indexed keywords

INTERFERON; THYMIC STROMAL LYMPHOPOIETIN; ANTIVIRUS AGENT;

ALLERGIC REACTION; ASTHMA; HOST RESISTANCE; HUMAN; IMMUNE DYSREGULATION; INNATE IMMUNITY; NONHUMAN; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESPIRATORY SYSTEM; RESPIRATORY TRACT DISEASE; REVIEW; RHINOVIRUS; RHINOVIRUS INFECTION; VIRUS IMMUNITY; BIOLOGICAL MODEL; BREATHING DISORDER; CHILD; EPITHELIUM; IMMUNOLOGY; PATHOLOGY; PHYSIOLOGY; TH2 CELL; VIROLOGY;

RHINOVIRUS;

ANTIVIRAL AGENTS; ASTHMA; CHILD; EPITHELIUM; HUMANS; MODELS, BIOLOGICAL; RESPIRATION DISORDERS; RHINOVIRUS; TH2 CELLS;

EID: 84938651439     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.1097/JIM.0000000000000209     Document Type: Review

References (45)

1. Lemanske RF Jr, Jackson DJ, Gangnon RE, Rhinovirus illnesses during infancy predict subsequent childhood wheezing. J Allergy Clin Immunol. 2005; 116 (3): 571-577
2. Jackson DJ, Gangnon RE, Evans MD, Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med. 2008; 178 (7): 667-672
3. Calişkan M, Bochkov YA, Kreiner-Møller E, Rhinovirus wheezing illness and genetic risk of childhood-onset asthma. N Engl J Med. 2013; 368 (15): 1398-1407
4. Kennedy JL, Shaker M, McMeen V, Comparison of viral load in individuals with and without asthma during infections with rhinovirus. Am J Respir Crit Care Med. 2014; 189 (5): 532-539
5. Saba TG, Chung Y, Hong JY, Rhinovirus-induced macrophage cytokine expression does not require endocytosis or replication. Am J Respir Cell Mol Biol. 2014; 50 (5): 974-984
6. Schneider D, Hong JY, Popova AP, Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness. J Immunol. 2012; 188 (6): 2894-2904
7. Jackson DJ, Evans MD, Gangnon RE, Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life. Am J Respir Crit Care Med. 2012; 185 (3): 281-285
8. Lee WM, Lemanske RF Jr, Evans MD, Human rhinovirus species and season of infection determine illness severity. Am J Respir Crit Care Med. 2012; 186 (9): 886-891
9. Wang Q, Nagarkar DR, Bowman ER, Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses. J Immunol. 2009; 183 (11): 6989-6997
10. Wark PA, Johnston SL, Bucchieri F, Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med. 2005; 201 (6): 937-947
11. Uller L, Leino M, Bedke N, Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma. Thorax. 2010; 65 (7): 626-632
12. Lewis TC, Henderson TA, Carpenter AR, Nasal cytokine responses to natural colds in asthmatic children. Clin Exp Allergy. 2012; 42 (12): 1734-1744
13. Proud D, Turner RB, Winther B, Gene expression profiles during in vivo human rhinovirus infection: insights into the host response. Am J Respir Crit Care Med. 2008; 178 (9): 962-968
14. Tatematsu M, Seya T, Matsumoto M,. Beyond dsRNA: Toll-like receptor 3 signalling in RNA-induced immune responses. Biochem J. 2014; 458 (2): 195-201
15. Ivashkiv LB, Donlin LT,. Regulation of type I interferon responses. Nat Rev Immunol. 2014; 14 (1): 36-49
16. Yoo JK, Kim TS, Hufford MM, Viral infection of the lung: host response and sequelae. J Allergy Clin Immunol. 2013; 132 (6): 1263-1276
17. Chen G, Korfhagen TR, Karp CL, Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity. Am J Respir Crit Care Med. 2014; 189 (3): 301-313
18. Pillai DK, Sankoorikal BJ, Johnson E, Directional secretomes reflect polarity-specific functions in an in vitro model of human bronchial epithelium. Am J Respir Cell Mol Biol. 2014; 50 (2): 292-300
19. Dvorak A, Tilley AE, Shaykhiev R, Do airway epithelium air-liquid cultures represent the in vivo airway epithelium transcriptome? Am J Respir Cell Mol Biol. 2011; 44 (4): 465-473
20. Wang Q, Miller DJ, Bowman ER,. MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness. PLoS Pathog. 2011; 7 (5): e1002070
21. Slater L, Bartlett NW, Haas JJ, Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium. PLoS Pathog. 2010; 6 (11): e1001178
22. Spann KM, Baturcam E, Schagen J, Viral and host factors determine innate immune responses in airway epithelial cells from children with wheeze and atopy. Thorax. 2014; 69 (20): 928-925
23. Parsons KS, Hsu AC, Wark PA,. TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection. Clin Exp Allergy. 2014; 44 (1): 91-101
24. Mallia P, Message SD, Gielen V, Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation. Am J Respir Crit Care Med. 2011; 183 (6): 734-742
25. Contoli M, Message SD, Laza-Stanca V, Role of deficient type III interferon-lambda production in asthma exacerbations. Nat Med. 2006; 12 (9): 1023-1026
26. Sykes A, Edwards MR, Macintyre J, Rhinovirus 16-induced IFN-α and IFN-β are deficient in bronchoalveolar lavage cells in asthmatic patients. J Allergy Clin Immunol. 2012; 129 (6): 1506-1514
27. Baraldo S, Contoli M, Bazzan E, Deficient antiviral immune responses in childhood: distinct roles of atopy and asthma. J Allergy Clin Immunol. 2012; 130 (6): 1307-1314
28. Miller EK, Hernandez JZ, Wimmenauer V, A mechanistic role for type III IFN-λ1 in asthma exacerbations mediated by human rhinoviruses. Am J Respir Crit Care Med. 2012; 185 (5): 508-516
29. Ziegler SF,. Thymic stromal lymphopoietin and allergic disease. J Allergy Clin Immunol. 2012; 130 (4): 845-852
30. Chen ZG, Zhang TT, Li HT, Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite. PLoS One. 2013; 8 (1): e51268
31. Al Shami A, Spolski R, Kelly J, A role for TSLP in the development of inflammation in an asthma model. J Exp Med. 2005; 202 (6): 829-839
32. Zhou B, Comeau MR, De Smedt T, Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol. 2005; 6 (10): 1047-1053
33. Gauvreau GM, O'Byrne PM, Boulet LP, Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. N Engl J Med. 2014; 370 (22): 2102-2110
34. Mahmutovic-Persson I, Akbarshahi H, Bartlett NW, Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma. Allergy. 2014; 69 (3): 348-358
35. Nagarkar DR, Bowman ER, Schneider D, Rhinovirus infection of allergen-sensitized and-challenged mice induces eotaxin release from functionally polarized macrophages. J Immunol. 2010; 185 (4): 2525-2535
36. Perez GF, Pancham K, Huseni S, Rhinovirus infection in young children is associated with elevated airway TSLP levels. Eur Respir J. 2014; 44 (4): 1075-1078
37. Ege MJ, Mayer M, Normand AC, Exposure to environmental microorganisms and childhood asthma. N Engl J Med. 2011; 364 (8): 701-709
38. Beck JM, Young VB, Huffnagle GB,. The microbiome of the lung. Transl Res. 2012; 160 (4): 258-266
39. Dickson RP, Erb-Downward JR, Huffnagle GB,. The role of the bacterial microbiome in lung disease. Expert Rev Respir Med. 2013; 7 (3): 245-257
40. Francis OE, Bendall M, Manimaran S, Pathoscope: species identification and strain attribution with unassembled sequencing data. Genome Res. 2013; 23 (10): 1721-1729
41. Molyneaux PL, Mallia P, Cox MJ, Outgrowth of the bacterial airway microbiome after rhinovirus exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013; 188 (10): 1224-1231
42. Mallia P, Footitt J, Sotero R, Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012; 186 (11): 1117-1124
43. George SN, Garcha DS, Mackay AJ, Human rhinovirus infection during naturally occurring COPD exacerbations. Eur Respir J. 2014; 44 (1): 87-96
44. Kloepfer KM, Lee WM, Pappas TE, Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations. J Allergy Clin Immunol. 2014; 133 (5): 1301-1307
45. Rohde G, Message SD, Haas JJ, CXC chemokines and antimicrobial peptides in rhinovirus-induced experimental asthma exacerbations. Clin Exp Allergy. 2014; 44 (7): 930-939