메뉴 건너뛰기




Volumn 6, Issue , 2015, Pages

NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; DECITABINE; NR2F1 PROTEIN; ORPHAN NUCLEAR RECEPTOR; RETINOIC ACID; RETINOIC ACID RECEPTOR BETA; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG; CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR 1; HOMEODOMAIN PROTEIN; RETINOIC ACID RECEPTOR;

EID: 84938626001     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7170     Document Type: Article
Times cited : (248)

References (48)
  • 1
    • 80052867880 scopus 로고    scopus 로고
    • ERK1/2 and p38alpha/beta signaling in tumor cell quiescence: Opportunities to control dormant residual disease
    • Sosa, M. S., Avivar-Valderas, A., Bragado, P., Wen, H. C. & Aguirre-Ghiso, J. A. ERK1/2 and p38alpha/beta signaling in tumor cell quiescence: opportunities to control dormant residual disease. Clin. Cancer Res. 17, 5850-5857 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 5850-5857
    • Sosa, M.S.1    Avivar-Valderas, A.2    Bragado, P.3    Wen, H.C.4    Aguirre-Ghiso, J.A.5
  • 2
    • 84906937205 scopus 로고    scopus 로고
    • Mechanisms of disseminated cancer cell dormancy: An awakening field
    • Sosa, M. S., Bragado, P. & Aguirre-Ghiso, J. A. Mechanisms of disseminated cancer cell dormancy: an awakening field. Nat. Rev. Cancer 14, 611-622 (2014).
    • (2014) Nat. Rev. Cancer , vol.14 , pp. 611-622
    • Sosa, M.S.1    Bragado, P.2    Aguirre-Ghiso, J.A.3
  • 3
    • 67651003108 scopus 로고    scopus 로고
    • Computational identification of a p38SAPK-regulated transcription factor network required for tumor cell quiescence
    • Adam, A. P., et al. Computational identification of a p38SAPK-regulated transcription factor network required for tumor cell quiescence. Cancer Res. 69, 5664-5672 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 5664-5672
    • Adam, A.P.1
  • 4
    • 84859218238 scopus 로고    scopus 로고
    • Chromatin-modifying enzymes as modulators of reprogramming
    • Onder, T. T., et al. Chromatin-modifying enzymes as modulators of reprogramming. Nature 483, 598-602 (2012).
    • (2012) Nature , vol.483 , pp. 598-602
    • Onder, T.T.1
  • 5
    • 69349094006 scopus 로고    scopus 로고
    • A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
    • Marion, R. M., et al. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 460, 1149-1153 (2009).
    • (2009) Nature , vol.460 , pp. 1149-1153
    • Marion, R.M.1
  • 6
    • 84887219089 scopus 로고    scopus 로고
    • TGF-beta2 dictates disseminated tumour cell fate in target organs through TGF-beta-RIII and p38alpha/beta signalling
    • Bragado, P., et al. TGF-beta2 dictates disseminated tumour cell fate in target organs through TGF-beta-RIII and p38alpha/beta signalling. Nat. Cell Biol. 15, 1351-1361 (2013).
    • (2013) Nat. Cell Biol. , vol.15 , pp. 1351-1361
    • Bragado, P.1
  • 7
    • 84859994398 scopus 로고    scopus 로고
    • Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer
    • Kim, R. S., et al. Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer. PLoS ONE 7, e35569 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e35569
    • Kim, R.S.1
  • 8
    • 0028345176 scopus 로고
    • Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: Evidence for a role in segmental patterning of the diencephalon
    • Qiu, Y., et al. Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon. Proc. Natl Acad. Sci. USA 91, 4451-4455 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 4451-4455
    • Qiu, Y.1
  • 9
    • 49749101235 scopus 로고    scopus 로고
    • Overexpression of COUP-TF1 in murine embryonic stem cells reduces retinoic acid-associated growth arrest and increases extraembryonic endoderm gene expression
    • Zhuang, Y. & Gudas, L. J. Overexpression of COUP-TF1 in murine embryonic stem cells reduces retinoic acid-associated growth arrest and increases extraembryonic endoderm gene expression. Differentiation 76, 760-771 (2008).
    • (2008) Differentiation , vol.76 , pp. 760-771
    • Zhuang, Y.1    Gudas, L.J.2
  • 10
    • 84868484735 scopus 로고    scopus 로고
    • Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest
    • Rada-Iglesias, A., et al. Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest. Cell Stem Cell 11, 633-648 (2012).
    • (2012) Cell Stem Cell , vol.11 , pp. 633-648
    • Rada-Iglesias, A.1
  • 11
    • 3042825295 scopus 로고    scopus 로고
    • Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer
    • Fackler, M. J., et al. Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer. Cancer Res. 64, 4442-4452 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 4442-4452
    • Fackler, M.J.1
  • 12
    • 1642494850 scopus 로고    scopus 로고
    • Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck
    • Ginos, M. A., et al. Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck. Cancer Res. 64, 55-63 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 55-63
    • Ginos, M.A.1
  • 13
    • 32044453343 scopus 로고    scopus 로고
    • X chromosomal abnormalities in basal-like human breast cancer
    • Richardson, A. L., et al. X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell 9, 121-132 (2006).
    • (2006) Cancer Cell , vol.9 , pp. 121-132
    • Richardson, A.L.1
  • 14
    • 84655164992 scopus 로고    scopus 로고
    • Expression profiling-based subtyping identifies novel non-small cell lung cancer subgroups and implicates putative resistance to pemetrexed therapy
    • Hou, J., et al. Expression profiling-based subtyping identifies novel non-small cell lung cancer subgroups and implicates putative resistance to pemetrexed therapy. J. Thorac. Oncol. 7, 105-114.
    • J. Thorac. Oncol. , vol.7 , pp. 105-114
    • Hou, J.1
  • 15
    • 84863723010 scopus 로고    scopus 로고
    • The mutational landscape of lethal castration-resistant prostate cancer
    • Grasso, C. S., et al. The mutational landscape of lethal castration-resistant prostate cancer. Nature 487, 239-243 (2012).
    • (2012) Nature , vol.487 , pp. 239-243
    • Grasso, C.S.1
  • 16
    • 77954255681 scopus 로고    scopus 로고
    • Integrative genomic profiling of human prostate cancer
    • Taylor, B. S., et al. Integrative genomic profiling of human prostate cancer. Cancer Cell 18, 11-22 (2010).
    • (2010) Cancer Cell , vol.18 , pp. 11-22
    • Taylor, B.S.1
  • 17
    • 84879644550 scopus 로고    scopus 로고
    • The gene desert mammary carcinoma susceptibility locus Mcs1a regulates Nr2f1 modifying mammary epithelial cell differentiation and proliferation
    • Smits, B. M., et al. The gene desert mammary carcinoma susceptibility locus Mcs1a regulates Nr2f1 modifying mammary epithelial cell differentiation and proliferation. PLoS Genet. 9, e1003549 (2013).
    • (2013) PLoS Genet , vol.9 , pp. e1003549
    • Smits, B.M.1
  • 18
    • 84863410298 scopus 로고    scopus 로고
    • A gene signature identified using a mouse model of androgen receptor-dependent prostate cancer predicts biochemical relapse in human disease
    • Thompson, V. C., et al. A gene signature identified using a mouse model of androgen receptor-dependent prostate cancer predicts biochemical relapse in human disease. Int. J. Cancer 131, 662-672 (2011).
    • (2011) Int. J. Cancer , vol.131 , pp. 662-672
    • Thompson, V.C.1
  • 19
    • 77957757417 scopus 로고    scopus 로고
    • A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs.
    • Kim, J., et al. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell 143, 313-324 (2010).
    • (2010) Cell , vol.143 , pp. 313-324
    • Kim, J.1
  • 20
    • 5644222639 scopus 로고    scopus 로고
    • Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth
    • Aguirre-Ghiso, J. A., Ossowski, L. & Rosenbaum, S. K. Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth. Cancer Res. 64, 7336-7345 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 7336-7345
    • Aguirre-Ghiso, J.A.1    Ossowski, L.2    Rosenbaum, S.K.3
  • 21
    • 0037379794 scopus 로고    scopus 로고
    • ERK(MAPK) activity as a determinant of tumor growth and dormancy; Regulation by p38(SAPK)
    • Aguirre-Ghiso, J. A., Estrada, Y., Liu, D. & Ossowski, L. ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK). Cancer Res. 63, 1684-1695 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 1684-1695
    • Aguirre-Ghiso, J.A.1    Estrada, Y.2    Liu, D.3    Ossowski, L.4
  • 22
    • 0035172910 scopus 로고    scopus 로고
    • Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo
    • Aguirre-Ghiso, J. A., Liu, D., Mignatti, A., Kovalski, K. & Ossowski, L. Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. Mol. Biol. Cell 12, 863-879 (2001).
    • (2001) Mol. Biol. Cell , vol.12 , pp. 863-879
    • Aguirre-Ghiso, J.A.1    Liu, D.2    Mignatti, A.3    Kovalski, K.4    Ossowski, L.5
  • 23
    • 48749105093 scopus 로고    scopus 로고
    • ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo
    • Schewe, D. M. & Aguirre-Ghiso, J. A. ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo. Proc. Natl Acad. Sci. USA 105, 10519-10524 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 10519-10524
    • Schewe, D.M.1    Aguirre-Ghiso, J.A.2
  • 24
    • 0036596352 scopus 로고    scopus 로고
    • EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma
    • Liu, D., Aguirre Ghiso, J., Estrada, Y. & Ossowski, L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell 1, 445-457 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 445-457
    • Liu, D.1    Aguirre Ghiso, J.2    Estrada, Y.3    Ossowski, L.4
  • 25
    • 0037061762 scopus 로고    scopus 로고
    • Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo
    • Aguirre Ghiso, J. A. Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo. Oncogene 21, 2513-2524 (2002).
    • (2002) Oncogene , vol.21 , pp. 2513-2524
    • Aguirre Ghiso, J.A.1
  • 26
    • 0020621220 scopus 로고
    • Changes in malignant phenotype of a human carcinoma conditioned by growth environment
    • Ossowski, L. & Reich, E. Changes in malignant phenotype of a human carcinoma conditioned by growth environment. Cell 33, 323-333 (1983).
    • (1983) Cell , vol.33 , pp. 323-333
    • Ossowski, L.1    Reich, E.2
  • 27
    • 63449100807 scopus 로고    scopus 로고
    • ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome
    • Huang, S., et al. ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. Cancer Cell 15, 328-340 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 328-340
    • Huang, S.1
  • 28
    • 84856044714 scopus 로고    scopus 로고
    • Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties
    • Bragado, P., et al. Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties. PLoS ONE 7, e29974 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e29974
    • Bragado, P.1
  • 29
    • 0030457645 scopus 로고    scopus 로고
    • TGF-beta mediated G1 arrest in a human melanoma cell line lacking p15INK4B: Evidence for cooperation between p21Cip1/WAF1 and p27Kip1
    • Florenes, V. A., et al. TGF-beta mediated G1 arrest in a human melanoma cell line lacking p15INK4B: evidence for cooperation between p21Cip1/WAF1 and p27Kip1. Oncogene 13, 2447-2457 (1996).
    • (1996) Oncogene , vol.13 , pp. 2447-2457
    • Florenes, V.A.1
  • 30
    • 50149117285 scopus 로고    scopus 로고
    • Control of the reversibility of cellular quiescence by the transcriptional repressor HES1
    • Sang, L., Coller, H. A. & Roberts, J. M. Control of the reversibility of cellular quiescence by the transcriptional repressor HES1. Science 321, 1095-1100 (2008).
    • (2008) Science , vol.321 , pp. 1095-1100
    • Sang, L.1    Coller, H.A.2    Roberts, J.M.3
  • 31
    • 84925626474 scopus 로고    scopus 로고
    • Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways
    • Chery, L., et al. Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways. Oncotarget 5, 9939-9951 (2014).
    • (2014) Oncotarget , vol.5 , pp. 9939-9951
    • Chery, L.1
  • 32
    • 37349079197 scopus 로고    scopus 로고
    • Systemic spread is an early step in breast cancer
    • Husemann, Y., et al. Systemic spread is an early step in breast cancer. Cancer Cell 13, 58-68 (2008).
    • (2008) Cancer Cell , vol.13 , pp. 58-68
    • Husemann, Y.1
  • 33
    • 39749176127 scopus 로고    scopus 로고
    • Predicting features of breast cancer with gene expression patterns
    • Lu, X., et al. Predicting features of breast cancer with gene expression patterns. Breast Cancer Res. Treat. 108, 191-201 (2008).
    • (2008) Breast Cancer Res. Treat. , vol.108 , pp. 191-201
    • Lu, X.1
  • 34
    • 84861527388 scopus 로고    scopus 로고
    • The genomic and transcriptomic architecture of 2, 000 breast tumours reveals novel subgroups
    • Curtis, C., et al. The genomic and transcriptomic architecture of 2, 000 breast tumours reveals novel subgroups. Nature 486, 346-352 (2012).
    • (2012) Nature , vol.486 , pp. 346-352
    • Curtis, C.1
  • 35
    • 0033982598 scopus 로고    scopus 로고
    • Orphan receptor COUP-TF is required for induction of retinoic acid receptor beta, growth inhibition, and apoptosis by retinoic acid in cancer cells
    • Lin, B., et al. Orphan receptor COUP-TF is required for induction of retinoic acid receptor beta, growth inhibition, and apoptosis by retinoic acid in cancer cells. Mol. Cell. Biol. 20, 957-970 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 957-970
    • Lin, B.1
  • 36
    • 18744374448 scopus 로고    scopus 로고
    • RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: Evidence for a role in retinoid-mediated growth inhibition
    • Afonja, O., et al. RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition. Oncogene 21, 7850-7860 (2002).
    • (2002) Oncogene , vol.21 , pp. 7850-7860
    • Afonja, O.1
  • 37
    • 3042670072 scopus 로고    scopus 로고
    • Suppression of growth and tumorigenicity in the prostate tumor cell line M12 by overexpression of the transcription factor SOX9
    • Drivdahl, R., et al. Suppression of growth and tumorigenicity in the prostate tumor cell line M12 by overexpression of the transcription factor SOX9. Oncogene 23, 4584-4593 (2004).
    • (2004) Oncogene , vol.23 , pp. 4584-4593
    • Drivdahl, R.1
  • 39
    • 0023518566 scopus 로고
    • Growth of a human carcinoma (HEp3) in nude mice: Rapid and efficient metastasis
    • Ossowski, L., Russo, H., Gartner, M. & Wilson, E. L. Growth of a human carcinoma (HEp3) in nude mice: rapid and efficient metastasis. J. Cell. Physiol. 133, 288-296 (1987).
    • (1987) J. Cell. Physiol. , vol.133 , pp. 288-296
    • Ossowski, L.1    Russo, H.2    Gartner, M.3    Wilson, E.L.4
  • 40
    • 84885071003 scopus 로고    scopus 로고
    • Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling
    • Ghiaur, G., et al. Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling. Proc. Natl Acad. Sci. USA 110, 16121-16126 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 16121-16126
    • Ghiaur, G.1
  • 41
    • 33646713430 scopus 로고    scopus 로고
    • RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation
    • Purton, L. E., et al. RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation. J. Exp. Med. 203, 1283-1293 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 1283-1293
    • Purton, L.E.1
  • 42
    • 50249103813 scopus 로고    scopus 로고
    • Requirement for COUPTFI and II in the temporal specification of neural stem cells in CNS development
    • Naka, H., Nakamura, S., Shimazaki, T. & Okano, H. Requirement for COUPTFI and II in the temporal specification of neural stem cells in CNS development. Nat. Neurosci. 11, 1014-1023 (2008).
    • (2008) Nat. Neurosci. , vol.11 , pp. 1014-1023
    • Naka, H.1    Nakamura, S.2    Shimazaki, T.3    Okano, H.4
  • 43
    • 84863337757 scopus 로고    scopus 로고
    • Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
    • Tsai, H. C., et al. Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell 21, 430-446.
    • Cancer Cell , vol.21 , pp. 430-446
    • Tsai, H.C.1
  • 44
    • 0026503190 scopus 로고
    • Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor
    • Aslakson, C. J. & Miller, F. R. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res. 52, 1399-1405 (1992).
    • (1992) Cancer Res. , vol.52 , pp. 1399-1405
    • Aslakson, C.J.1    Miller, F.R.2
  • 45
    • 84865281435 scopus 로고    scopus 로고
    • Reversal by RARalpha agonist Am580 of c-Myc-induced imbalance in RARalpha/RARgamma expression during MMTV-Myc tumorigenesis
    • Bosch, A., et al. Reversal by RARalpha agonist Am580 of c-Myc-induced imbalance in RARalpha/RARgamma expression during MMTV-Myc tumorigenesis. Breast Cancer Res. 14, R121 (2012).
    • (2012) Breast Cancer Res. , vol.14 , pp. R121
    • Bosch, A.1
  • 46
    • 0002460807 scopus 로고    scopus 로고
    • Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling
    • Aguirre Ghiso, J. A., Kovalski, K. & Ossowski, L. Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. J. Cell Biol. 147, 89-104 (1999).
    • (1999) J. Cell Biol. , vol.147 , pp. 89-104
    • Aguirre Ghiso, J.A.1    Kovalski, K.2    Ossowski, L.3
  • 47
    • 0036894603 scopus 로고    scopus 로고
    • A quantitative analysis of rate-limiting steps in the metastatic cascade using human-specific real-time polymerase chain reaction
    • Zijlstra, A., et al. A quantitative analysis of rate-limiting steps in the metastatic cascade using human-specific real-time polymerase chain reaction. Cancer Res. 62, 7083-7092 (2002).
    • (2002) Cancer Res , vol.62 , pp. 7083-7092
    • Zijlstra, A.1
  • 48
    • 84875887547 scopus 로고    scopus 로고
    • MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency
    • Gaspar-Maia, A., et al. MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency. Nat. Commun. 4, 1565 (2013).
    • (2013) Nat. Commun. , vol.4 , pp. 1565
    • Gaspar-Maia, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.