Ascorbic acid modulates cell migration in differentiated HL-60 cells and peripheral blood leukocytes

Molecular Nutrition and Food Research

Volumn 59, Issue 8, 2015, Pages 1513-1523

  Schwager, Joseph ^a   Bompard, Albine ^a   Weber, Peter ^a   Raederstorff, Daniel ^a  

^a DSM NUTRITIONAL PRODUCTS LTD   (Switzerland)

Author keywords

Chemotaxis; Innate immune response; L ascorbic acid; Leukocytes

Indexed keywords

ASCORBIC ACID; BIOLOGICAL MARKER; CALCIFEDIOL; CD66 ANTIGENS; CELL ADHESION MOLECULE; CHEMOKINE RECEPTOR CXCR2; DIMETHYL SULFOXIDE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; INTERLEUKIN 8; LEUKOCYTE ANTIGEN; RETINOIC ACID; SOLVENT;

AGONISTS; CELL CULTURE; CELL MOTION; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECTS; HL 60 CELL LINE; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; LEUKOCYTE; LEUKOPOIESIS; METABOLISM; MONOCYTE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS;

ANTIGENS, CD; ASCORBIC ACID; BIOMARKERS; CALCIFEDIOL; CELL ADHESION MOLECULES; CELL MOVEMENT; CELLS, CULTURED; CHEMOTAXIS, LEUKOCYTE; DIMETHYL SULFOXIDE; HL-60 CELLS; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-8; LEUKOCYTES; LEUKOPOIESIS; MONOCYTES; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; RECEPTORS, INTERLEUKIN-8B; SOLVENTS; TRETINOIN;

EID: 84938557904     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201400893     Document Type: Article

References (50)

1. Nathan, C., Neutrophils and immunity: challenges and opportunities. Nat. Rev. Immunol. 2006, 6, 173-182.
2. Phillipson, M., Kubes, P., The neutrophil in vascular inflammation. Nat. Med. 2011, 17, 1381-1390.
3. Foxmann, E. F., Campbell, J. J., Butcher, E. C., Multistep Navigation and the combinatorial control of leukocyte chemotaxis. J. Cell Biol. 1997, 139, 1349-1360.
4. Washko, P., Rotrosen, D., Levine, M., Ascorbic acid transport and accumulation in human neutrophils. J. Biol. Chem. 1989, 264, 18996-19002.
5. Wintergerst, E. S., Maggini, S., Hornig, D. H., Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann. Nutr. Metab. 2006, 50, 85-94.
6. Becker, E. L., Stimulated neutrophil locomotion: chemokinesis and chemotaxis. Arch. Pathol. Lab. Med. 1977, 101, 509-513.
7. Boxer, L. A., Watanabe, A. M., Rister, M., Besch, H. R., Jr. et al., Correction of leukocyte function in Chediak-Higashi syndrome by ascorbate. N. Engl. J. Med. 1976, 295, 1041-1045.
8. Gallin, J. I., Elin, R. J., Hubert, R. T., Fauci, A. S. et al., Efficacy of ascorbic acid in Chediak-Higashi syndrome (CHS): studies in humans and mice. Blood 1979, 53, 226-234.
9. Weening, R. S., Schoorel, E. P., Roos, D., vanSchaik, M. L. et al., Effect of ascorbate on abnormal neutrophil, platelet and lymphocytic function in a patient with the Chediak-Higashi syndrome. Blood 1981, 57, 856-865.
10. Yegin, O., Sanal, O., Yeralan, O., Gurgey, A., Berkel, A. I., Defective lymphocyte locomotion in Chediak-Higashi syndrome. Am. J. Dis. Children 1983, 137, 771-773.
11. Anderson, R., Theron, A., Effects of ascorbate on leucocytes: part III. In vitro and in vivo stimulation of abnormal neutrophil motility by ascorbate. South African Med. J. 1979, 56, 429-433.
12. Goetzl, E. J., Austen, K. F., Stimulation of human neutrophil leukocyte aerobic glucose metabolism by purified chemotactic factors. J. Clin. Invest. 1974, 53, 591-599.
13. Goetzl, E. J., Wasserman, S. I., Gigli, I., Austen, K. F., Enhancement of random migration and chemotactic response of human leukocytes by ascorbic acid. J. Clin. Invest. 1974, 53, 813-818.
14. Johnston, C. S., Huang, S. N., Effect of ascorbic acid nutriture on blood histamine and neutrophil chemotaxis in guinea pigs. J. Nutr. 1991, 121, 126-130.
15. Boxer, L. A., Vanderbilt, B., Bonsib, S., Jersild, R. et al., Enhancement of chemotactic response and microtubule assembly in human leukocytes by ascorbic acid. J. Cell. Physiol. 1979, 100, 119-126.
16. Scheinberg, M. A., The effect of vitamin C on certain monocyte cell functions. An in vitro and in vivo approach. Int. J. Vit. Nutr. Res. 1983, 24, 119-120.
17. Vohra, K., Khan, A. J., Telang, V., Rosenfeld, W., Evans, H. E., Improvement of neutrophil migration by systemic vitamin C in neonates. J. Perinatol. 1990, 10, 134-136.
18. Boxer, L. A., Yoder, M., Bonsib, S., Schmidt, M. et al., Effects of a chemotactic factor, N-formylmethionyl peptide, on adherence, superoxide anion generation, phagocytosis, and microtubule assembly of human polymorphonuclear leukocytes. J. Lab. Clin. Med. 1979, 93, 506-514.
19. Anderson, R., Oosthuizen, R., Maritz, R., Theron, A., VanRensburg, A. J., The effects of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers. Am. J. Clin. Nutr. 1980, 33, 71-76.
20. Hermanowicz, A., Sliwinski, Z., Kaczor, R., Effect of long-term therapy with sulphasalazine, levamisole, corticosteroids and ascorbic acid and of disease activity on polymorphonuclear leukocyte function in patients with ulcerative colitis. Hepato-Gastroenterol. 1985, 32, 81-86.
21. Johnston, C. S., Martin, L. J., Cai, X., Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis. J. Am. College Nutr. 1992, 11, 172-176.
22. Boyum, A., Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand. J. Clin. Lab. Invest. 1968, 97, 77-89.
23. Breitman, T. R., Selonick, S. E., Collins, S. J., Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc. Natl. Acad. Sci. USA 1980, 77, 2936-2940.
24. Sham, R. L., Phatak, P. D., Belanger, K. A., Packman, C. H., Functional properties of HL60 cells matured with all-trans-retinoic acid and DMSO: differences in response to interleukin-8 and fMLP. Leuk. Res. 1995, 19, 1-6.
25. Mangelsdorf, D. J., Koeffler, H. P., Donaldson, C. A., Pike, J. W., Haussler, M. R., 1, 25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells. J. Cell Biol. 1984, 98, 391-398.
26. Wilkinson, P. C., How do leucocytes perceive chemical gradients? FEMS Microbiol. Immunol. 1990, 2, 303-311.
27. Levine, M., Padayatty, S. J., Espey, M. G., Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries. Adv. Nutr. 2011, 2, 78-88.
28. Gomez-Cambronero, J., Horn, J., Paul, C. C., Baumann, M. A., Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway. J. Immunol. 2003, 171, 6846-6855.
29. Brown, G., Bunce, C. M., Rowlands, D. C., Williams, G. R., All-trans retinoic acid and 1 alpha, 25-dihydroxyvitamin D3 co-operate to promote differentiation of the human promyeloid leukemia cell line HL60 to monocytes. Leukemia 1994, 8, 806-815.
30. Bunce, C. M., Wallington, L. A., Harrison, P., Williams, G. R., Brown, G., Treatment of HL60 cells with various combinations of retinoids and 1 alpha, 25 dihydroxyvitamin D3 results in differentiation towards neutrophils or monocytes or a failure to differentiate and apoptosis. Leukemia 1995, 9, 410-418.
31. Fontana, J. A., Wright, D. G., Schiffman, E., Corcoran, B. A., Deisseroth, A. B., Development of chemotactic responsiveness in myeloid precursor cells: studies with a human leukemia cell line. Proc. Natl. Acad. Sci. USA 1980, 77, 3664-3668.
32. Mills, K. I., Woodgate, L. J., Gilkes, A. F., Walsh, V. et al., Inhibition of mitochondrial function in HL60 cells is associated with an increased apoptosis and expression of CD14. Biochem. Biophys. Res. Comm. 1999, 263, 294-300.
33. Kang, H. K., Suh, J. H., Lee, J. J., Yoon, S. H. et al., Induction of the differentiation of HL-60 promyelocytic leukemia cells by L-ascorbic acid. Free Rad. Res. 2003, 37, 773-779.
34. Ma, Y., Chapman, J., Levine, M., K, P. et al., High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cacner and reduced toxicity of chemotherapy. Sci. Transl. Med. 2014, 6, 222ra (DOI:10.1126/scitranslmed.3007154).
35. Chen, Q., Espey, M. G., Sun, A. Y., Lee, J. H. et al., Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proc. Natl. Acad. Sci. USA 2007, 104, 8749-8754.
36. Hewison, M., An update on vitamin D and human immunity. Clin. Endocrinol. 2012, 76, 315-325.
37. Niggli, V., Signaling to migration in neutrophils: importance of localized pathways. Int. J. Biochem. Cell Biol. 2003, 35, 1619-1638.
38. Grant, M. M., Mistry, N., Lunec, J., Griffiths, H. R., Dose-dependent modulation of the T cell proteome by ascorbic acid. Br. J. Nutr. 2007, 97, 19-26.
39. Fulop, T., Larbi, A., Douziech, N., Fortin, C. et al., Signal transduction and functional changes in neutrophils with aging. Aging Cell 2004, 3, 217-226.
40. Dallegri, F., Lanzi, G., Patrone, F., Effects of ascorbic acid on neutrophil locomotion. Int. Arch. Allergy Appl. Immunol. 1980, 61, 40-45.
41. Smith, M. J., Walker, J. R., The effects of some antirheumatic drugs on an in vitro model of human polymorphonuclear leucocyte chemokinesis. Br. J. Pharmacol. 1980, 69, 473-478.
42. Stadler, N., Eggermann, J., Voo, S., Kranz, A., Waltenberger, J., Smoking-induced monocyte dysfunction is reversed by vitamin C supplementation in vivo. Arterioscl. Thromb. Vasc. Biol. 2007, 27, 120-126.
43. Nieman, D. C., Henson, D. A., McAnulty, S. R., McAnulty, L. et al., Influence of vitamin C supplementation on oxidative and immune changes after an ultramarathon. J. Appl. Physiol. 2002, 92, 1970-1977.
44. Schwager, J., Schulze, J., Modulation of interleukin production by ascorbic acid. Vet. Immunol. Immunopathol. 1998, 64, 45-57.
45. Sharma, P., Raghavan, S. A., Saini, R., Dikshit, M., Ascorbate-mediated enhancement of reactive oxygen species generation from polymorphonuclear leukocytes: modulatory effect of nitric oxide. J. Leukocyte Biol. 2004, 75, 1070-1078.
46. Luo, H. R., Loison, F., Constitutive neutrophil apoptosis: mechanisms and regulation. Am. J. Hematol. 2008, 83, 288-295.
47. Ferron-Celma, I., Mansilla, A., Hassan, L., Garcia-Navarro, A. et al., Effect of vitamin C administration on neutrophil apoptosis in septic patients after abdominal surgery. J. Surg. Res. 2009, 153, 224-230.
48. Griffiths, H. R., Willetts, R. S., Grant, M. M., Mistry, N. et al., In vivo vitamin C supplementation increases phosphoinositol transfer protein expression in peripheral blood mononuclear cells from healthy individuals. Br. J. Nutr. 2009, 101, 1432-1439.
49. Washko, P., Rotrosen, D., Levine, M., Ascorbic acid in human neutrophils. Am. J. Clin.Nutr. 1991, 54, 1221S-1227S.
50. Washko, P. W., Wang, Y., Levine, M., Ascorbic acid recycling in human neutrophils. J. Biol. Chem. 1993, 268, 15531-15535.