Does tranexamic acid alter the risk of thromboembolism following primary total knee arthroplasty with sequential earlier anticoagulation? A large, single center, prospective cohort study of consecutive cases

Thrombosis Research

Volumn 136, Issue 2, 2015, Pages 234-238

  Xie, Jinwei ^a   Ma, Jun ^a   Kang, Pengde ^a   Zhou, Zongke ^a   Shen, Bin ^a   Yang, Jing ^a   Pei, Fuxing ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

anti coagulation; anti fibrinolysis; Total knee arthroplasty; venous thromboembolism

Indexed keywords

ENOXAPARIN; RIVAROXABAN; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

ADULT; AGED; ARTICLE; CALF MUSCULAR VEIN THROMBOSIS; CARDIOVASCULAR MORTALITY; CHEMOPROPHYLAXIS; COHORT ANALYSIS; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; ECHOGRAPH; ECHOGRAPHY; EPIDEMIOLOGY; FEMALE; HUMAN; INCIDENCE; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROPHYLAXIS; PROSPECTIVE STUDY; SUPERFICIAL VENOUS THROMBOSIS; THROMBOPROPHYLAXIS; TOTAL KNEE REPLACEMENT; VENOUS THROMBOEMBOLISM; KNEE REPLACEMENT; PROCEDURES; REHABILITATION;

ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; COHORT STUDIES; FEMALE; HUMANS; MALE; PROSPECTIVE STUDIES; TRANEXAMIC ACID; VENOUS THROMBOEMBOLISM;

EID: 84938557164     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2015.05.014     Document Type: Article

References (32)

1. J. Ma, Z. Huang, B. Shen, and F. Pei Blood management of staged bilateral total knee arthroplasty in a single hospitalization period J Orthop Surg Res 9 2014 116
2. G. Benoni, and H. Fredin Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomized, double-blind study of 86 patients J Bone Joint Surg Br 78 1996 434 440
3. F.D. Cushner, and R.J. Friedman Blood loss in total knee arthroplasty Clin Orthop Relat Res 269 1991 98 101
4. Z. Haien, J. Yong, M. Baoan, and et al. Post-operative auto-transfusion in total hip or knee arthroplasty: a meta-analysis of randomized controlled trials PLoS One 8 2013 (e55073)
5. J.P. Allain, S.L. Stramer, A.B. Carneiro-Proietti, and et al. Transfusion-transmitted infectious diseases Biologicals 37 2009 71 77
6. E.C. Vamvakas, and M.A. Blajchman Transfusion related mortality: the ongoing risks of allogeneic blood transfusion and Transfusion-transmitted infectious diseases Blood 113 2009 3406 3417
7. G.E. Hill, W.H. Frawley, K.E. Griffith, J.E. Forestner, and J.P. Minei Allogeneic blood transfusion increases the risk of postoperative bacterial infection: a meta-analysis J Trauma 54 2003 908 914
8. J.L. Carson, D.G. Altman, A. Duff, and et al. Risk of bacterial infection associated with allogeneic blood transfusion among patients undergoing hip fracture repair Transfusion 39 1999 694 700
9. E.T. Newman, T.S. Watters, J.S. Lewis, and et al. Impact of perioperative allogeneic and autologous blood transfusion on acute wound infection following total knee and total hip arthroplasty J Bone Joint Surg Am 96 2014 279 284
10. J. Kambayashi, M. Sakon, M. Yokota, E. Shiba, T. Kawasaki, and T. Mori Activation of coagulation and fibrinolysis during surgery, analyzed by molecular markers Thromb Res 60 1990 157 167
11. N.R. Fahmy, and D.G. Patel Hemostatic changes and postoperative deep-vein thrombosis associated with use of a pneumatic tourniquet J Bone Joint Surg Am 63 1981 461 465
12. L. Klenerman, R. Chakrabarti, I. Mackie, M. Brozovic, and Y. Stirling Changes in haemostatic system after application of a tourniquet Lancet 1 1977 970 972
13. Z. Huang, J. Ma, B. Shen, and F. Pei Combination of intravenous and topical application of tranexamic acid in primary total knee arthroplasty: a prospective randomized controlled trial J Arthroplasty 29 2014 2342 2346
14. C. Yue, P. Kang, P. Yang, J. Xie, and F. Pei Topical application of tranexamic acid in primary total hip arthroplasty: a randomized double-blind controlled trial J Arthroplasty 29 2014 2452 2456
15. K. Ker, P. Edwards, P. Perel, H. Shakur, and I. Roberts Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis BMJ 344 2012 e3054
16. E. Gomez-Barrena, M. Ortega-Andreu, N.G. Padilla-Eguiluz, H. Pérez-Chrzanowska, and R. Figueredo-Zalve Topical intra-articular compared with intravenous tranexamic Acid to reduce blood loss in primary total knee replacement: a double-blind, randomized, controlled, noninferiority clinical trial J Bone Joint Surg Am 96 2014 1937 1944
17. M. Lange, H. Van Aken, and M. Westphal Prevention and treatment of major blood loss N Engl J Med 357 2007 1260
18. S. Hiippala, L. Strid, M. Wennestrand, V. Arvela, and et al. Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty Br J Anaesth 74 1995 534 537
19. P.C. Lin, C.H. Hsu, W.S. Chen, and et al. Does tranexamic acid save blood in minimally invasive total knee arthroplasty? Clin Orthop Relat Res 469 2011 1995 2002
20. Q. Wu, H.A. Zhang, S.L. Liu, T. Meng, X. Zhou, and P. Wang Is tranexamic acid clinically effective and safe to prevent blood loss in total knee arthroplasty? A meta-analysis of 34 randomized controlled trials Eur J Orthop Surg Traumatol 25 2015 525 541
21. C.M. Duncan, B.P. Gillette, A.K. Jacob, R.J. Sierra, J. Sanchez-Sotelo, and H.M. Smith Venous Thromboembolism and Mortality Associated With Tranexamic Acid Use During Total Hip and Knee Arthroplasty J Arthroplasty 30 2015 272 276
22. J. Poeran, R. Rasul, S. Suzuki, T. Danninger, M. Mazumdar, M. Opperer, and et al. Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety BMJ 349 2014 g4829
23. J.L. Gillet, M.R. Perrin, and F.A. Allaert Short-term and mid-term outcome of isolated symptomatic muscular calf vein thrombosis J Vasc Surg 46 2007 513 519
24. J.P. Galanaud, M.A. Sevestre, C. Genty, and et al. Comparison of the clinical history of symptomatic isolated muscular calf vein thrombosis versus deep calf vein thrombosis J Vasc Surg 52 2010 932 938
25. M. Izumi, M. Ikeuchi, K. Aso, and et al. Less deep vein thrombosis due to transcutaneous fibular nerve stimulation in total knee arthroplasty: a randomized controlled trial Knee Surg Sports Traumatol Arthrosc 2014 10.1007/s00167-014-3141-z [in press]
26. N.E. Sharrock, G. Go, T.P. Sculco, C.S. Ranawat, M.J. Maynard, and P.C. Harpel Changes in circulatory indices of thrombosis and fibrinolysis during total knee arthroplasty performed under tourniquet J Arthroplasty 10 1995 523 528
27. O. Reikerås, and T. Clementsen Time course of thrombosis and fibrinolysis in total knee arthroplasty with tourniquet application. Local versus systemic activations J Thromb Thrombolysis 28 2009 425 428
28. M.J. Maynard, T.P. Sculco, and B. Ghelman Progression and regression of deep vein thrombosis after total knee arthroplasty Clin Orthop Relat Res 273 1991 125 130
29. A. Blanié, L. Bellamy, Y. Rhayem, and et al. Duration of postoperative fibrinolysis after total hip or knee replacement: a laboratory follow-up study Thromb Res 131 2013 e6 e11
30. N. Prasad, V. Padmanabhan, and A. Mullaji Comparison between two methods of drain clamping after total knee arthroplasty Arch Orthop Trauma Surg 125 2005 381 384
31. J.R. Lieberman, and M.J. Pensak Prevention of venous thromboembolic disease after total hip and knee arthroplasty J Bone Joint Surg Am 95 2013 1801 1811
32. Y. Falck-Ytter, C.W. Francis, N.A. Johanson, and et al. Prevention of VTE in orthopedic surgery patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Chest 141 2012 e278S e325S