MEK/ERK signaling pathway is required for enterovirus 71 replication in immature dendritic cells

Virology Journal

Volumn 11, Issue 1, 2014, Pages

  Shi, Weifeng ^a   Hou, Xueling ^a   Peng, Hongjun ^a   Zhang, Li ^a   Li, Yuanyuan ^a   Gu, Zhiwen ^a   Jiang, Qingbo ^a   Shi, Mei ^a   Ji, Yun ^a   Jiang, Jingting ^a  

^a THE THIRD AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Enterovirus 71; Immature dendritic cells; MEK ERK; SOS1; Virus replication

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; B7 ANTIGEN; BETA INTERFERON; CD83 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 2; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MYC PROTEIN; PROTEIN C FOS; PROTEIN C JUN; SOS PROTEIN; TRANSCRIPTION FACTOR ELK 1; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE;

ARTICLE; CELL COUNT; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; ENTEROVIRUS 71; ENTEROVIRUS INFECTION; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMATURE DENDRITIC CELL; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; VIRUS REPLICATION; CELL CULTURE; ENTEROVIRUS A; GENE EXPRESSION PROFILING; HOST PATHOGEN INTERACTION; LUMINESCENCE; PHOSPHORYLATION; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PROTEIN PROCESSING; SECRETION (PROCESS); VIROLOGY; WESTERN BLOTTING;

HUMAN ENTEROVIRUS 71;

BLOTTING, WESTERN; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; ENTEROVIRUS A, HUMAN; GENE EXPRESSION PROFILING; HOST-PATHOGEN INTERACTIONS; HUMANS; LUMINESCENT MEASUREMENTS; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROTEIN PROCESSING, POST-TRANSLATIONAL; VIRUS REPLICATION;

EID: 84938521127     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/s12985-014-0227-7     Document Type: Article

References (47)

1. Lin JY, Chen TC, Weng KF, Chang SC, Chen LL, Shih SR: Viral and host proteins involved in picornavirus life cycle. J Biomed Sci 2009, 16:103.
2. Oprisan G, Combiescu M, Guillot S, Caro V, Combiescu A, Delpeyroux F, Crainic R: Natural genetic recombination between co-circulating heterotypic enteroviruses. J Gen Virol 2002, 83:2193-2200.
3. Solomon T, Lewthwaite P, Perera D, Cardosa MJ, McMinn P, Ooi MH: Virology, epidemiology, pathogenesis, and control of enterovirus 71. Lancet Infect Dis 2010, 10:778-790.
4. Huang YP, Lin TL, Hsu LC, Chen YJ, Tseng YH, Hsu CC, Fan WB, Yang JY, Chang FY, Wu HS: Genetic diversity and C2-like subgenogroup strains of enterovirus 71, Taiwan, 2008. Virol J 2010, 7:277.
5. Huang Y, Deng T, Yu S, Gu J, Huang C, Xiao G, Hao Y: Effect of meteorological variables on the incidence of hand, foot, and mouth disease in children: a time-series analysis in Guangzhou. China BMC Infect Dis 2013, 13:134.
6. Wang SM, Lei HY, Huang KJ, Wu JM, Wang JR, Yu CK, Su IJ, Liu CC: Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema. J Infect Dis 2003, 188:564-570.
7. Ooi MH, Wong SC, Lewthwaite P, Cardosa MJ, Solomon T: Clinical features, diagnosis, and management of enterovirus 71. Lancet Neurol 2010, 9:1097-1105.
8. Lee TC, Guo HR, Su HJ, Yang YC, Chang HL, Chen KT: Diseases caused by enterovirus 71 infection. Pediatr Infect Dis J 2009, 28:904-910.
9. Lei X, Liu X, Ma Y, Sun Z, Yang Y, Jin Q, He B, Wang J: The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses. J Virol 2010, 84:8051-8061.
10. Chung YC, Ho MS, Wu JC, Chen WJ, Huang JH, Chou ST, Hu YC: Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge. Vaccine 2008, 26:1855-1862.
11. Kyriakis JM, Avruch J: Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. Physiol Rev 2012, 92:689-737.
12. Levy DE, Marie IJ, Durbin JE: Induction and function of type I and III interferon in response to viral infection. Curr Opin Virol 2011, 1:476-486.
13. Krishna M, Narang H: The complexity of mitogen-activated protein kinases (MAPKs) made simple. Cell Mol Life Sci 2008, 65:3525-3544.
14. Chico LK, Van Eldik LJ, Watterson DM: Targeting protein kinases in central nervous system disorders. Nat Rev Drug Discov 2009, 8:892-909.
15. Cuenda A, Rousseau S: p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta 2007, 1773:1358-1375.
16. Porta H, Cancino-Rodezno A, Soberon M, Bravo A: Role of MAPK p38 in the cellular responses to pore-forming toxins. Peptides 2011, 32:601-606.
17. Takeuchi O, Akira S: Innate immunity to virus infection. Immunol Rev 2009, 227:75-86.
18. Tung WH, Hsieh HL, Yang CM: Enterovirus 71 induces COX-2 expression via MAPKs, NF-kappaB, and AP-1 in SK-N-SH cells: Role of PGE(2) in viral replication. Cell Signal 2010, 22:234-246.
19. Katsuma S, Mita K, Shimada T: ERK- and JNK-dependent signaling pathways contribute to Bombyx mori nucleopolyhedrovirus infection. J Virol 2007, 81:13700-13709.
20. Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S: Interplay between influenza A virus and the innate immune signaling. Microbes Infect 2010, 12:81-87.
21. Waithman J, Mintern JD: Dendritic cells and influenza A virus infection. Virulence 2012, 3:603-608.
22. Belkaid Y: Regulatory T cells and infection: a dangerous necessity. Nat Rev Immunol 2007, 7:875-888.
23. Wang B, Zhang H, Zhu M, Luo Z, Peng Y: MEK1-ERKs signal cascade is required for the replication of Enterovirus 71 (EV71). Antiviral Res 2012, 93:110-117.
24. Zhang H, Feng H, Luo L, Zhou Q, Luo Z, Peng Y: Distinct effects of knocking down MEK1 and MEK2 on replication of herpes simplex virus type 2. Virus Res 2010, 150:22-27.
25. Hou W, Gibbs JS, Lu X, Brooke CB, Roy D, Modlin RL, Bennink JR, Yewdell JW: Viral infection triggers rapid differentiation of human blood monocytes into dendritic cells. Blood 2012, 119:3128-3131.
26. Cantisani R, Sammicheli C, Tavarini S, D'Oro U, Wack A, Piccioli D: Surface molecules on stimulated plasmacytoid dendritic cells are sufficient to cross-activate resting myeloid dendritic cells. Hum Immunol 2011, 72:1018-1021.
27. Kadowaki N: The divergence and interplay between pDC and mDC in humans. Front Biosci 2009, 14:808-817.
28. Lin YW, Wang SW, Tung YY, Chen SH: Enterovirus 71 infection of human dendritic cells. Exp Biol Med (Maywood) 2009, 234:1166-1173.
29. Dejnirattisai W, Duangchinda T, Lin CL, Vasanawathana S, Jones M, Jacobs M, Malasit P, Xu XN, Screaton G, Mongkolsapaya J: A complex interplay among virus, dendritic cells, T cells, and cytokines in dengue virus infections. J Immunol 2008, 181:5865-5874.
30. Kinchington PR, Leger AJ, Guedon JM, Hendricks RL: Herpes simplex virus and varicella zoster virus, the house guests who never leave. Herpesviridae 2012, 3:5.
31. Stefanidou M, Ramos I, Mas Casullo V, Trepanier JB, Rosenbaum S, Fernandez-Sesma A, Herold BC: Herpes simplex virus 2 (HSV-2) prevents dendritic cell maturation, induces apoptosis, and triggers release of proinflammatory cytokines: potential links to HSV-HIV synergy. J Virol 2013, 87:1443-1453.
32. Tung WH, Hsieh HL, Lee IT, Yang CM: Enterovirus 71 modulates a COX-2/PGE2/cAMP-dependent viral replication in human neuroblastoma cells: role of the c-Src/EGFR/p42/p44 MAPK/CREB signaling pathway. J Cell Biochem 2011, 112:559-570.
33. Tung WH, Tsai HW, Lee IT, Hsieh HL, Chen WJ, Chen YL, Yang CM: Japanese encephalitis virus induces matrix metalloproteinase-9 in rat brain astrocytes via NF-kappaB signalling dependent on MAPKs and reactive oxygen species. Br J Pharmacol 2010, 161:1566-1583.
34. Ceballos-Olvera I, Chavez-Salinas S, Medina F, Ludert JE, del Angel RM: JNK phosphorylation, induced during dengue virus infection, is important for viral infection and requires the presence of cholesterol. Virology 2010, 396:30-36.
35. Fejer G, Freudenberg M, Greber UF, Gyory I: Adenovirus-triggered innate signalling pathways. Eur J Microbiol Immunol 2011, 1:279-288.
36. Albarnaz JD, De Oliveira LC, Torres AA, Palhares RM, Casteluber MC, Rodrigues CM, Cardozo PL, De Souza AM, Pacca CC, Ferreira PC, Kroon EG, Nogueira ML, Bonjardim CA: MEK/ERK activation plays a decisive role in yellow fever virus replication: implication as an antiviral therapeutic target. Antiviral Res 2014, 111C:82-92.
37. Wang HY, Yang SL, Liang HF, Li CH: HBx protein promotes oval cell proliferation by up-regulation of cyclin D1 via activation of the MEK/ERK and PI3K/Akt pathways. Int J Mol Sci 2014, 15:3507-3518.
38. Popik W, Pitha PM: Inhibition of CD3/CD28-mediated activation of the MEK/ERK signaling pathway represses replication of X4 but not R5 human immunodeficiency virus type 1 in peripheral blood CD4(+) T lymphocytes. J Virol 2000, 74:2558-2566.
39. Rojas JM, Oliva JL, Santos E: Mammalian son of sevenless Guanine nucleotide exchange factors: old concepts and new perspectives. Genes Cancer 2011, 2:298-305.
40. Simon MA, Bowtell DD, Dodson GS, Laverty TR, Rubin GM: Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell 1991, 67:701-716.
41. Guerrero C, Rojas JM, Chedid M, Esteban LM, Zimonjic DB, Popescu NC, Font de Mora J, Santos E: Expression of alternative forms of Ras exchange factors GRF and SOS1 in different human tissues and cell lines. Oncogene 1996, 12:1097-1107.
42. Pierre S, Bats AS, Coumoul X: Understanding SOS (Son of Sevenless). Biochem Pharmacol 2011, 82:1049-1056.
43. Poltorak M, Meinert I, Stone JC, Schraven B, Simeoni L: Sos1 regulates sustained TCR-mediated Erk activation. Eur J Immunol 2014, 44:1535-1540.
44. Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H: Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol 2011, 7:33-42.
45. Hafner S: SARS attacks! Microbes Infect 2013, 15:85-87.
46. Guo JP, Pang J, Wang XW, Shen ZQ, Jin M, Li JW: In vitro screening of traditionally used medicinal plants in China against enteroviruses. World J Gastroenterol 2006, 12:4078-4081.
47. Peng H, Shi M, Zhang L, Li Y, Sun J, Wang X, Xu X, Zhang X, Mao Y, Ji Y, Jiang J, Shi W: Activation of JNK1/2 and p38 MAPK signaling pathways promotes enterovirus 71 infection in immature dendritic cells. BMC Microbiol 2014, 14:147.