NZ28-induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells

Cancer Immunology, Immunotherapy

Volumn 64, Issue 5, 2015, Pages 599-608

  Schilling, Daniela ^a,b   Kühnel, Annett ^a   Tetzlaff, Fabian ^a   Konrad, Sarah ^a   Multhoff, Gabriele ^a,b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Heat shock factor 1 (HSF1); MICA B; Natural killer (NK) cells; NKG2D; NVP AUY922; NZ28

Indexed keywords

ANTINEOPLASTIC AGENT; CD56 ANTIGEN; CD94 ANTIGEN; HEAT SHOCK TRANSCRIPTION FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUMINESPIB; MAJOR HISTOCOMPATIBILITY CLASS I CHAIN RELATED PROTEIN A; MAJOR HISTOCOMPATIBILITY CLASS I CHAIN RELATED PROTEIN B; NATURAL KILLER CELL RECEPTOR NKG2D; NZ 28; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; 5-(2,4-DIHYDROXY-5-ISOPROPYLPHENYL)-4-(4-MORPHOLIN-4-YLMETHYLPHENYL)ISOXAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE; DNA BINDING PROTEIN; EMETINE; HEAT SHOCK PROTEIN 90; HEAT SHOCK TRANSCRIPTION FACTOR; HLA ANTIGEN CLASS 1; ISOXAZOLE DERIVATIVE; KLRK1 PROTEIN, HUMAN; MHC CLASS I-RELATED CHAIN A; MICB ANTIGEN; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY K; NZ28 COMPOUND; RESORCINOL DERIVATIVE; SMALL INTERFERING RNA; SP1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ARTICLE; CANCER CELL; CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; METASTASIS; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BREAST TUMOR; FEMALE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LUNG TUMOR; LYMPHOCYTE ACTIVATION; RNA INTERFERENCE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CYTOTOXICITY, IMMUNOLOGIC; DNA-BINDING PROTEINS; EMETINE; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTOCOMPATIBILITY ANTIGENS CLASS I; HSP90 HEAT-SHOCK PROTEINS; HUMANS; ISOXAZOLES; KILLER CELLS, NATURAL; LUNG NEOPLASMS; LYMPHOCYTE ACTIVATION; NF-KAPPA B; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; RESORCINOLS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS;

EID: 84938421637     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-015-1665-9     Document Type: Article

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