Targeted next-generation sequencing reveals high frequency of mutations in epigenetic regulators across treatment-naïve patient melanomas

Clinical Epigenetics

Volumn 7, Issue 1, 2015, Pages

  Lee, Jonathan J ^a   Sholl, Lynette M ^a   Lindeman, Neal I ^a   Granter, Scott R ^a   Laga, Alvaro C ^a   Shivdasani, Priyanka ^a   Chin, Gary ^a   Luke, Jason J ^b   Ott, Patrick A ^b   Hodi, F Stephen ^b   Mihm, Martin C ^b   Lin, Jennifer Y ^b   Werchniak, Andrew E ^b   Haynes, Harley A ^b   Bailey, Nancy ^b   Liu, Robert ^a   Murphy, George F ^a   Lian, Christine G ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

5 hydroxymethylcytosine; DNA demethylation; Epigenetics; Isocitrate dehydrogenase 2 (IDH2); MECOM (MDS1 and EV1 complex locus); Melanoma; MLL2; Next generation sequencing (NGS); Ten eleven translocation (TET)

Indexed keywords

B RAF KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; ISOCITRATE DEHYDROGENASE 1; NEUROFIBROMIN; PROTEIN P53;

5' UNTRANSLATED REGION; ADULT; AGED; ARTICLE; BIOINFORMATICS; BRAF GENE; CDKN2A GENE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CLINICAL ARTICLE; CONTROLLED STUDY; CUTANEOUS MELANOMA; DEMETHYLATION; DNA METHYLATION; EPIGENETICS; GENE DELETION; GENE IDENTIFICATION; GENE INSERTION; HISTONE MODIFICATION; HUMAN; HUMAN TISSUE; IDH1 GENE; MECOM GENE; MELANOMA; MISSENSE MUTATION; MLL2 GENE; MUTATION RATE; NEXT GENERATION SEQUENCING; NF1 GENE; NONSENSE MUTATION; ONCOGENE N RAS; PRIORITY JOURNAL; REGULATOR GENE; RNA PROCESSING; SOMATIC MUTATION; TET2 GENE; TP53 GENE; TUMOR GENE; TUMOR SUPPRESSOR GENE; ULTRAVIOLET B RADIATION;

EID: 84938414877     PISSN: 18687075     EISSN: 18687083     Source Type: Journal    
DOI: 10.1186/s13148-015-0091-3     Document Type: Article

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