Oxytocin differentially effects 3β-hydroxysteroid dehydrogenase and 5α-reductase activities in prostate cancer cell lines

Peptides

Volumn 71, Issue , 2015, Pages 149-155

  Assinder, Stephen J ^a   Davies, Kathryn ^a   Surija, Jonathan ^a   Liu Fu, Frank ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

3 Oxo 5alpha steroid delta 4 dehydrogenase; De novo steroidogenesis; Hydroxy delta 5 steroid dehydrogenase; Progesterone reductase; Steroid 5 alpha reductase

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ANDROGEN; ANDROSTANOLONE; OXYTOCIN; PREGNENOLONE; PROGESTERONE; STEROID 5ALPHA REDUCTASE; TESTOSTERONE; 3 BETA-HYDROXYSTEROID OXIDOREDUCTASE-DELTA(5) 3-KETOSTEROID ISOMERASE; 3BETA HYDROXY DELTA5 STEROID DEHYDROGENASE; MULTIENZYME COMPLEX; STEROID DELTA ISOMERASE; TUMOR PROTEIN;

ARTICLE; ASSAY; CELL LYSATE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LNCAP CELL LINE; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE CANCER CELL LINE; STEROIDOGENESIS; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; PROSTATE TUMOR; TUMOR CELL LINE;

3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; CELL LINE, TUMOR; ENZYME ACTIVATION; HUMANS; MALE; MULTIENZYME COMPLEXES; NEOPLASM PROTEINS; OXYTOCIN; PROGESTERONE REDUCTASE; PROSTATIC NEOPLASMS; STEROID ISOMERASES;

EID: 84938375212     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2015.07.015     Document Type: Article

References (50)

1. S.J. Assinder, and H.D. Nicholson Prostate disease: prostate hyperplasia, prostate cancer and prostatitis F.R. Kandeel, R.S. Swerdloff, J.L. Pryor, Male Reproductive Dysfunction: Pathophysiology and Treatment 2007 Informa Healthcare New York 499 518
2. A. Hussain, and N. Dawson Management of advanced/metastatic prostate cancer: 2000 update Oncology 14 2000 1677 1688
3. R.B. Montgomery, E.A. Mostaghel, R. Vessella, D.L. Hess, T.F. Kalhorn, C.S. Higano, and et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth Cancer 68 2008 4447 4454
4. E.A. Mostaghel Steroid hormone synthetic pathways in prostate cancer Trans. Androl. Urol. 3 2013 212 227
5. J.A. Locke, E.S. Guns, A.A. Lubik, H.H. Adomat, S.C. Hendy, and et al. Androgen levels increase by intratumoral de novo steroidogenesis during progression of castrate resistant prostate cancer Cancer Res. 68 2008 6407 6415
6. C.G. Leon, J.A. Locke, H.H. Adomat, S.L. Etinger, A.L. Twiddy, and et al. Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model Prostate 70 2010 390 400
7. J. Hofland, W.M. van Weerden, N.F.J. Dits, and et al. Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer Cancer Res. 70 2010 1256 1264
8. M. Stanborough, G.J. Bubley, K. Ross, and et al. Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer Cancer Res. 66 2006 2815 2825
9. M.V. Fiandolo, J. Wilton, and J.L. Mohler Roles for the backdoor pathway of androgen metabolism in prostate cancer response to castration and drug treatment Int. J. Biol. Sci. 10 2014 596 601
10. J.A. Locke, C.C. Nelson, H.H. Adomat, and et al. Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts J. Steroid Biochem. Mol. Biol. 115 2009 126 136
11. T. Kosaka, M. Akira, and M. Oya Is DHT production by 5α-reductase friend of foe in prostate cancer? Front. Oncol. 4 2014 247 10.3389/fonc.2014.00247
12. S.J. Assinder, C. Johnson, K. King, and H.D. Nicholson Regulation of 5α-reductase isoforms by oxytocin in the rat ventral prostate Endocrinology 145 2004 5767 5773
13. S.J. Assinder Oxytocin increases 5α-reductase activity of human prostate epithelial cells, but not stromal cells Prostate 68 2008 115 121
14. J. Frayne, and H.D. Nicholson Effect of oxytocin on testosterone production by isolated rat Leydig cells is mediated via a specific oxytocin receptor Biol. Reprod. 52 1995 1268 1273
15. E.L. Petrova-Souvandjieva Influence of oxytocin on steroidogenic activity of the rat adrenal cortex Folia Med. (Plovdiv) 46 2004 47 50
16. A.K. Berndston, C.J. Weaver, and J.E. Fortune Differential effects of oxytocin on steroid production by bovine granulosa cells Mol. Cell. Endocrinol. 116 1996 191 198
17. P. Cassoni, T. Marrocco, A. Sapino, E. Allia, and G. Bussolati Evidence of oxytocin/oxytocin receptor interplay in human prostate gland and carcinomas Int. J. Oncol. 25 2004 899 904
18. S.J. Assinder Oxytocin in the pathophysiology of prostate cancer H. Jastrow, D. Feuerbach, Handbook of Oxytocin Research: Synthesis, Storage and Release, Actions and Drug Forms. 2009 Nova Science NY 155 170
19. P.R. Billard, L. Ming-Fong, and A.K. Shafiq Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol Mol. Cell. Endocrinol. 295 2008 115 120
20. A.A. Lubik, J.H. Gunter, B.G. Hollier, S. Ettinger, L. Fazli, N. Stylianou, S.C. Hendy, H.H. Adomat, M.E. Gleave, M. Pollak, A. Herington, and C.C. Nelson IGF2 increases de novo steroidogenesis in prostate cancer Endocr. Relat. Cancer 20 2013 173 186
21. M. Atsushi, K. Eitetsu, I. Kouji, M. Kazutaka, T. Masashi, H. Seijiro, D. Jinlu, T.K. Evan, and N. Mikio Prostate cancer stromal cells and LNCaP cells coordinately activate the androgen receptor through synthesis of testosterone and dihydrotestosterone from dehydroepiandrosterone Endocr. Relat. Cancer 16 2009 1139 1155
22. M. Manning, K. Miteva, S. Pancheva, S. Stoev, N.C. Wo, and W.Y. Chan Design and synthesis of highly selective in vitro and in vivo uterine receptor antagonists of oxytocin: comparisons with atosiban Int. J. Pept. Protein Res. 46 1995 244 252
23. H. Levy, H.W. Deane, and B.L. Rubin Visualization of steroid-3beta-o1-dehydrogenase activity in tissues of intact and hypophysectomized rats Endocrinology 65 1959 932
24. H.S. Choi, J.W. Kim, Y.N. Cha, and et al. A quantitative nitroblue tetrazolium assay for determining intracellular superoxide anion production in phagocytic cells J. Immunoass. Immunochem. 27 2007 31 44
25. D.J. McCarthy, and G.K. Smyth Testing significance relative to fold-change threshold is a TREAT Bioinformatics 25 2009 765 771
26. S.A. Bustin, V. Benes, J.A. Garson, J. Hellemans, J. Huggett, and et al. The MIQE guidelines minimum information for publication of quantitative real-time PCR experiments Clin. Chem. 55 2009 611 622
27. A. Struneck, S. Hynie, and V. Klenerov Role of oxytocin/oxytocin receptor system in regulation of cell growth and neoplastic processes Folia Biol. (Praha) 55 2009 159 165
28. N.C. Tom, and S.J. Assinder Oxytocin: recent developments Biomol. Concepts 1 2010 367 380
29. P. Cassoni, A. Sapino, N. Fortunati, L. Munaron, B. Chini, and G. Bussoloti Oxytocin inhibits the proliferation of MDA-MB231 human breast cancer cells via cyclin adenosine monophosphate and protein kinase A Int. J. Cancer 72 1997 340 344
30. P. Cassoni, E. Fulcheri, M.L. Carcangiu, A. Stella, S. Deaglio, and G. Bussolati Oxytocin receptors in human adenocarcinomas of the endometrium: presence and biological significance J. Pathol. 210 2000 470 477
31. T. Morita, K. Shibata, F. Kikkawa, H. Kajiyama, K. Ino, and S. Mizutani Oxytocin inhibits the progression of human carcinoma cells in vitro and in vivo Int. J. Cancer 109 2004 525 532
32. P. Cassoni, A. Sapino, N. Fortunati, and G. Bussolati Presence and significance of oxytocin receptors in human neuroblastomas and glial tumors Int. J. Cancer 77 1998 695 700
33. C. Péqueux, C. Breton, J.-C. Hendrick, M.-T. Hagelstein, H. Martens, R. Winkler, V. Geenen, and J.-J. Legros Oxytocin synthesis and oxytocin receptor expression by cell lines of human small cell carcinoma of the lung stimulate tumor growth through autocrine/paracrine signaling Cancer Res. 62 2002 4623 4629
34. P. Cassoni, A. Sapino, S. Deaglio, B. Bussolati, M. Volante, L. Munaron, A. Albini, A. Torrisi, and G. Bussolati Oxytocin is a growth factor for Kaposi's sarcoma cells: evidence of endocrine-immunological cross-talk Cancer Res. 62 2002 2406 2413
35. M. Petersson Opposite effects of oxytocin on proliferation of osteosarcoma cell lines Regul. Pept. 150 2008 50 54
36. K. Whittington, B. Connors, K. King, S. Assinder, K. Hogarth, and H. Nicholson The effect of oxytocin on cell proliferation in the human prostate is modulated by gonadal steroids: implications for benign prostatic hyperplasia and carcinoma of the prostate Prostate 67 2007 1132 1142
37. P. Cassoni, T. Marrocco, B. Bussolati, E. Allia, L. Munaron, and et al. Oxytocin induces proliferation and migration in immortalized human dermal microvascular endothelial cells and human breast tumor-derived endothelial cells Mol. Cancer Res. 4 2006 351 360
38. J.A. Copland, Y.-J. Jeng, Z. Strakova, K.L. Ives, M.R. Hellmich, and M.S. Soloff Demonstration of functional oxytocin receptors in human breast Hs578T cells and their up-regulation through a protein kinase C-dependent pathway Endocrinology 140 1999 2258 2267
39. M.-C. Déry, P. Chaudhry, V. Leblanc, S. Parent, A.-M. Fortier, and E. Asselin Oxytocin increases invasive properties of endometrial cancer cells through phosphatidylinositol 3-kinase/AKT-dependent up-regulation of cyclooxygenase-1,-2, and X-linked inhibitor of apoptosis protein Biol. Reprod. 85 2011 1133 1142
40. S.-C. Lee, and L. Levine Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types J. Biol. Chem. 250 1975 548 552
41. G. Gimpl, and F. Farenholz The oxytocin receptor system: structure, function and regulation Physiol. Rev. 81 2001 629 683
42. B. Chini, and M. Manning Agonist selectivity in the oxytocin/vasopressin receptor family: new insights and challenges Biochem. Soc. Trans. 35 2008 737 741
43. M. Zhong, M.L. Boseman, A.C. Millena, and S.A. Khan Oxytocin induces the migration of prostate cancer cells: involvement of the Gi-coupled signaling pathway Mol. Cancer Res. 8 2010 1164 1172
44. Z. Strakova, and M.S. Soloff Coupling of the oxytocin receptor to G proteins in the rat myometrium during labour: Gi-receptor interaction Am. J. Physiol. 272 1997 E870 E876
45. A. Reversi, V. Rimoldi, T. Marrocco, and et al. The oxytocin receptor antagonist atosiban inhibits cell growth via a "biased agonist" mechanism J. Biol. Chem. 280 2004 16311 16318
46. J.A. Copland, K.L. Ives, D.J. Simmons, and et al. Functional oxytocin receptors discovered in human osteoblasts Endocrinology 140 1999 4371 4374
47. M. Ohmichi, K. Koike, A. Nohara, Y. Kanda, and et al. Oxytocin stimulates mitogen-activated protein kinase activity in cultured human puerperal uterine myometrial cells Endocrinology 136 1995 2082 2087
48. C.P. El-Haibi, P. Sharma, R. Singh, P. Gupta, and et al. Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5 Mol. Cancer 12 2013 64 10.1186/1476-4598-12-64
49. H.D. Nicholson, and L. Jenkin 5α-reductase activity is increased by oxytocin in the rat testis A. Bartke, Function of Somatic Cells in the Testis 1994 Serona Symposia/Springer-Verlag New York 278 285
50. M.H. Imanieh, F. Bagheri, A.M. Alizadeh, and S. Askani-Esfahani Oxytocin has therapeutic effects on cancer, a hypothesis Eur. J. Pharmacol. 741 2014 112 113