Oxytocin synthesis and oxytocin receptor expression by cell lines of human small cell carcinoma of the lung stimulate tumor growth through autocrine/paracrine signaling

Cancer Research

Volumn 62, Issue 16, 2002, Pages 4623-4629

  Péqueux, Christel ^a   Breton, Christophe ^b   Hendrick, Jean Claude ^a   Hagelstein, Marie Thérèse ^a   Martens, Henri ^a   Winkler, Rosita ^a   Geenen, Vincent ^a   Legros, Jean Jacques ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIV LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

OXYTOCIN; OXYTOCIN ANTAGONIST; OXYTOCIN RECEPTOR; RNA; VASOPRESSIN;

ARTICLE; AUTOCRINE EFFECT; CARCINOGENESIS; CELL GROWTH; CONTROLLED STUDY; DISSOCIATION CONSTANT; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; LUNG SMALL CELL CANCER; NUCLEOTIDE SEQUENCE; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SEQUENCE ANALYSIS; TUMOR GROWTH;

ANIMALS; CARCINOMA, SMALL CELL; CELL DIVISION; CHO CELLS; CRICETINAE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; NEUROPHYSINS; OXYTOCIN; RECEPTORS, OXYTOCIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; VASOPRESSINS;

EID: 0037102226     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Small cell lung cancer: Diagnosis, treatment and natural history
2. Products of vasopressin gene expression in small-cell carcinoma of the lung
3. The syndrome of inappropriate secretion of antidiuretic hormone
4. Ectopic secretion of neurohypophyseal peptides in patients with malignancy
5. The radioimmunoassay of human neurophysins: Contribution to the understanding of the physiopathology of neurohypophyseal function
6. Neurophysins as markers of vasopressin and oxytocin release. A study in carcinoma of the lung
7. Vasopressin and oxytocin production by non-neuroendocrine lung carcinomas: An apparent low incidence of gene expression
8. Tumor biosynthesis of vasopressin and oxytocin
9. Factors regulating the production of vasopressin-associated human neurophysin by small-cell carcinoma of the lung: Evaluation by computer-enhanced quantitative immunocytochemistry
10. Vasopressin gene related products are markers of human breast cancer
11. Vasopressin mRNA and neurophysin-related cell-surface antigen (NRSA) in small-cell carcinoma
12. Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma
13. Neurohypophyseal peptides as regulators of growth and development. A review
14. Neuropeptides as growth regulators
15. Multiple neuropeptides mobilise calcium in small cell lung cancer: Effects of vasopressin, bradykinin, cholecystokinin, galanin and neurotensin
16. All three vasopressin receptor sub-types are expressed by small-cell carcinoma
17. Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide
18. Novel plasma extraction procedure and development of a specific enzyme-immunoassay of oxytocin: Application to clinical and biological investigations of small cell carcinoma of the lung
19. Oxytocin and oxytocin-analogue F314 inhibit cell proliferation and tumor growth of rat and mouse mammary carcinomas
20. Immunolocalization and gene expression of oxytocin receptors in carcinomas and non-neoplastic tissues of the breast
21. Oxytocin receptor within the breast: Biological function and distribution
22. Antiproliferative effect of oxytocin through specific oxytocin receptors in human neuroblastoma and astrocytoma cell lines
23. Presence and significance of oxytocin receptors in human neuroblastomas and glial tumors
24. MCF-7 breast cancer cells express normal forms of all vasopressin receptors plus an abnormal V2R
25. Oxytocin does not induce a rise in intracellular free calcium in human breast cancer cells
26. Interaction of vasopressin and oxytocin with human breast carcinoma cells
27. Oxytocin receptors in human adenocarcinomas of the endometrium: Presence and biological significance
28. Investigation of the oxytocin receptor expression in human breast cancer tissue using newly established monoclonal antibodies
29. Demonstration of functional oxytocin receptors in human breast Hs578T cells and their up-regulation through a protein kinase C-dependent pathway
30. Activation of functional oxytocin receptors stimulates cell proliferation in human trophoblast and choriocarcinoma cell lines
31. 2(9)]OVT: A selective oxytocin receptor ligand
32. Solid-phase synthesis of 16 potent (selective and nonselective) in vivo antagonists of oxytocin
33. 1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4-yl)-4H-3, 1-benzoxazin-2(1H)-one (L-371, 257): A new, orally bioavailable, non-peptide oxytocin antagonist
34. Development of vasopressor specific vasotocin analogues with prolonged effects
35. Effects of F-180, a new selective vasoconstrictor peptide, compared with terlipressin and vasopressin on systemic and splanchnic hemodynamics in a rat model of portal hypertension
36. Monoclonal antibodies to oxytocin: Production and characterization
37. Release of immunoreactive oxytocin and neurophysin I by cultured luteinizing bovine granulosa cells
38. Comparison of three immunoassays in the screening and characterization of monoclonal antibodies against arginine-vasopressin
39. Oxytocin receptor messenger ribonucleic acid: Characterization, regulation, and cellular localization in the rat pituitary gland
40. Vasopressin-neurophysin and bipolar depression
41. Structure and expression of a human oxytocin receptor
42. Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor
43. Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor
44. Characterization and localization of oxytocin receptors in the rat testis
45. Identification of the vasopressin producing and oxytocin producing neurons in the hypothalamic magnocellular neurosecretory system of the rat
46. The oxytocin/oxytocin receptor system: Expect the unexpected
47. Oxytocin inhibits proliferation of human breast cancer cell lines
48. Oxytocin and oxytocin receptor in human breast cancer
49. Expression of functional neurohypophysial peptide receptors by murine immature and cytotoxic T-cell lines
50. Oxytocin is a growth factor for Kaposi's sarcoma cells: Evidence of endocrine-immunological cross-talk
51. Localization of the human oxytocin receptor in caveolin-1 enriched domains turns the receptor-mediated inhibition of cell growth into a proliferative response