Enhancing Glioblastoma-Specific Penetration by Functionalization of Nanoparticles with an Iron-Mimic Peptide Targeting Transferrin/Transferrin Receptor Complex

Molecular Pharmaceutics

Volumn 12, Issue 8, 2015, Pages 2947-2961

  Kang, Ting ^a   Jiang, Mengyin ^a   Jiang, Di ^a   Feng, Xingye ^a   Yao, Jianhui ^a   Song, Qingxiang ^b   Chen, Hongzhuan ^b   Gao, Xiaoling ^b   Chen, Jun ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

blood brain barrier; CRT peptide; glioblastoma therapy; nanoparticles; penetration

Indexed keywords

CYCLOPEPTIDE; IRON; MACROGOL; NANOCARRIER; PACLITAXEL; PEPTIDE CRT; TRANSFERRIN; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG; CD71 ANTIGEN; LEUKOCYTE ANTIGEN; MACROGOL DERIVATIVE; NANOPARTICLE; PEPTIDE FRAGMENT;

ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOCOMPATIBILITY; BLOOD BRAIN BARRIER; BRAIN CAPILLARY ENDOTHELIAL CELL; CELL PROLIFERATION; CONJUGATION; CONTROLLED STUDY; DEPOLYMERIZATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG PENETRATION; ELECTRIC RESISTANCE; GLIOBLASTOMA; GROWTH INHIBITION; HALF LIFE TIME; IC50; IN VITRO STUDY; LIGHT SCATTERING; MALE; MOUSE; NANOENCAPSULATION; NANOMEDICINE; NANOPHARMACEUTICS; NONHUMAN; PARTICLE SIZE; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; RAT; ZETA POTENTIAL; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BAGG ALBINO MOUSE; BRAIN; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; METABOLISM; NUDE MOUSE; PATHOLOGY; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION; X RAY PHOTOELECTRON SPECTROSCOPY;

ANIMALS; ANTIGENS, CD; APOPTOSIS; BLOOD-BRAIN BARRIER; BRAIN; CELL PROLIFERATION; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; GLIOBLASTOMA; IRON; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NANOPARTICLES; PACLITAXEL; PEPTIDE FRAGMENTS; PHOTOELECTRON SPECTROSCOPY; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFERRIN; TISSUE DISTRIBUTION; TRANSFERRIN;

EID: 84938373022     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00222     Document Type: Article

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